Protein Alignment pain and LOC1271895

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_310750.6
• Gene: LOC1271895 / 1271895
• VectorBaseID: AGAMI1_004293
• Length: 980
• Species: Anopheles gambiae
• Alignment Length: 997
• Identity: 211/997 - (21%)
• Similarity: 360/997 - (36%)
• Gaps: 320/997 - (32%)

  Fly    59 DFIEACIDHGSQVNYINKK----LDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPL 119
            |.::|.::|||::.|.:..    |..:|.|...      |.|::|
Mosquito   151 DLLDALMEHGSELAYHDTNGFTALHLSAFSGCL------NCASVL-------------------- 189

  Fly   120 NSLAKNLTDENAPDVYSCMQ------------LLLDYGASPNIVDQ---GEFTPLHHVLRKSKVK 169
              :||.:.....|..|:.:|            |||..||..::..:   ||.|.||     ..|:
Mosquito   190 --VAKGIDVNLQPKAYTPLQCAAFGNAAHTALLLLSKGARLDLCTRRPGGEETLLH-----CAVR 247

  Fly   170 AGKKELIQLFLDHPELDIDSYRNGEVRRLLQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDETL 234
            |...:.::||:.. .:|::|.:...:..:              |...::
Mosquito   248 ANALDCVRLFIAE-GMDVNSIKPSGMNAI--------------HLAADL---------------- 281

  Fly   235 FEQQFAEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILST-GMDINSRPG-RANEA 297
                                                 |......|:|:. |.|.|.|.| |..|:
Mosquito   282 -------------------------------------GHVECLRVLLAAPGADPNIRIGIREKES 309

  Fly   298 NLVETAVIYGNWQALERLLKEPNLRLTPDSKLLNAVIGRLDEPPYDGS--SHQRCFELLINSDRV 360
            ..:..|...||...:..||::     ..:::|.|   .|...|.:..|  |...|.:||:.:...
Mosquito   310 TALHLAADEGNAACVALLLEQ-----GAEARLKN---HRGFTPLHLASRTSSLECVDLLLRAGSA 366

  Fly   361 DINEADSGRLVPLFFAVKYRNTSA---MQKLLKNGAYIGSKSAFGTLPI---------------- 406
            |.||.|.....||..|:. |:.||   ::.|:..||.:..|..||..|:
Mosquito   367 DPNEEDFDMRTPLHTAIG-RSESAFHIIETLICWGADVNKKDVFGFTPLHLAALDGLAHCVEILL 430

  Fly   407 ---------------------KDMPPE--VLEEHFDSCIT-TNGERPGDQNFEIIIDYKNLMRQ- 446
                                 :..|..  ::.:.||..:| .:.:.|.::..|:.:|::.:::.
Mosquito   431 FYDADVTAKTKKGTTALNVITRKTPGSLAMITQKFDDAMTLIHSQNPSEKEVELELDFRTILQHC 495

  Fly   447 --ERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRLSVIFYLNFLIYSLFTASI 509
              ...|.||.|.||        ..|||   |||||.|:|:::||.::...:....|...:|...:
Mosquito   496 YPREISYLNTLVDE--------GQKEM---LQHPLCSAFIYIKWGKIRKYYIARLLFCFIFILFL 549

  Fly   510 ITYTL-----------------LKFHESDQR--------ALTAFFGLLSWL---GISYL-ILREC 545
            ..|.|                 ::..|..|:        ....|...:.||   .|::: |.|:.
Mosquito   550 TLYVLTALAHNCYNGSKDMEETIQEQELCQKQSILGNMLRRNPFVMEMQWLVLVAITFVEICRKL 614

  Fly   546 --IQWIMSPVRYFWSITNIMEVALITLSIFTCMESSFDKET---QRVLAVFTILLVSMEFCLLVG 605
              |....|..||...:.||.|..:| :|:|. :...:.|.|   |..:..|.:||......:::|
Mosquito   615 YGITGYSSIRRYVTQMENITEWFII-VSVFV-ISYIYTKRTYTWQNHIGAFAVLLGWTHLMVMIG 677

  Fly   606 SLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKE 670
            .|||  ...::.|..:|...|.|.|..||..::.|::.|.::|..|
Mosquito   678 QLPV--FGAYVAMYTKVQVEFAKLFIAYSCMLVGFTISFCVIFPSS------------------- 721

  Fly   671 GKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAG-----------------SIQFTSIYTYLIFLLF 718
                    ::|..|....|..:||:.||.|..                 |.|.|       |:||
Mosquito   722 --------SSFENPFMGFITVLVMMVGELDLELLINDPDGKDPPFMLELSAQIT-------FVLF 771

  Fly   719 VIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSIC 783
            ::|:|::|.|||.|:||.|.|.:|..|.|:..:.:|.::|..|..|..    |:|  .:..||:.
Mosquito   772 LLFVTVILMNLLVGIAVDDIQALKKTATLSKLVGQTKLISYIESALFN----GWL--PNWLRSLL 830

  Fly   784 QRLMNIYPN-YLSLRQISVLPNDGNKVLIPMSDPFEMRTLKKASFQQLPLSAAVPQKKLLDP--- 844
            .....:.|. |..:  :||.|.:..:..:|.:.......:.|...|||   |||.:...:.|
Mosquito   831 HYTALVSPRAYRVI--LSVKPLNPEEKRLPRNIMMAAYEIAKEKEQQL---AAVGEPTAVPPGAT 890

  Fly   845 -----PLRLLPCCCSLLTGKCSQMS-------------GRVVKRALEVIDQKNAAEQRRKQEQIN 891
                 ..:.||.     :|..|.:|             |....||.:.:|.. |.:..:..|:::
Mosquito   891 GGEPGAAQSLPG-----SGAESPVSPNAPDGGVGGGGGGGEGARATDTLDAL-ATKIDQSAERMS 949

  Fly   892 DSRLKLIEYK--LEQLIQLVQD 911
            |...:|.|.:  |:|..||:.:
Mosquito   950 DVTRELQELRAVLKQNQQLIDE 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430	31/141 (22%)
		ANK repeat	82..111	CDD:293786	5/28 (18%)
		ANK repeat	113..152	CDD:293786	10/50 (20%)
		ANKYR	<243..>406	CDD:440430	40/169 (24%)
		ANK repeat	324..366	CDD:293786	12/43 (28%)
		ANK repeat	368..393	CDD:293786	7/27 (26%)
		Ion_trans	495..746	CDD:459842	69/301 (23%)
LOC1271895	XP_310750.6	None