Protein Alignment pain and LOC1270502

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_309204.5
• Gene: LOC1270502 / 1270502
• VectorBaseID: AGAMI1_005893
• Length: 1140
• Species: Anopheles gambiae
• Alignment Length: 1075
• Identity: 258/1075 - (24%)
• Similarity: 404/1075 - (37%)
• Gaps: 311/1075 - (28%)

  Fly    13 AQLAGALAK--QDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGCRDFIE------ACI--DH 67
            |:|...||:  :||.::...||.                          |||      .||  .|
Mosquito    90 ARLQPVLAQMLEDIARYRTYLDR--------------------------FIERFQAENECIVPKH 128

  Fly    68 GSQVNYINKKLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTPLNSLAKNLTDENAP 132
            ..| |..:.....|.|.|||...|...|..||. |....:.:...:.| |.|..|.:
Mosquito   129 NPQ-NKSDTANPSAPIHYAALQLDEDFLEWLLA-RSATDINLRNSFKQ-TALTLLCE-------- 182

  Fly   133 DVYSCMQLLLDYGASPNIVDQGEFTPLHH-VLRKSKVKAG-------KKELIQLFLDHPELDIDS 189
            :...||:..:.  |.|    .|....:.. |||..|.||.       .|...:|.|.|.|...::
Mosquito   183 EYVQCMRKQMQ--ACP----PGRLGKIRTVVLRLLKAKADFNICSSHMKLPFELLLKHCETHDET 241

  Fly   190 YRNGEVRRLLQAQFPELKLP-----------EERHTG-------PEIDIQTLQRTLRDGDETLFE 236
                   ||...|..|| :|           .||..|       .::.::.|:..||..|.:
Mosquito   242 -------RLFVEQCVEL-VPCALAISSVNDRNERVVGFYNNNPNVQVTVELLELFLRHNDRS--- 295

  Fly   237 QQFAEYLQNLKGGADN-----QLNAH---QEEYFGLLQESIKRGRQRAFDVILSTGMDINSRPGR 293
             .|..:|...:..|.|     :|..|   .::....::..:.||.:..|.|       :..:|||
Mosquito   296 -NFTTHLAGFEIDASNVKKVIRLLLHTACDQKMADCVRLIVDRGERHIFKV-------LPRKPGR 352

  Fly   294 ---------ANE-ANLVETAVIYGNWQ---------------ALERLLKEPNLRLTPDSKLLNAV 333
                     |.| ||.||.:..:| ||               .|:.|||:  :.|..|..||..:
Mosquito   353 NAAAKEGPVAEEGANSVELSRRFG-WQESIDVQKGSELEHRVELKGLLKK--VCLMADLPLLQLL 414

  Fly   334 IGRL-------DEP--------PYDGSSHQR----------CFELLINSDRVDINEADSGRLVPL 373
            :.::       |:|        .||   ::|          |.|.|...:.:.:::.|:.....|
Mosquito   415 LAKISDLIVLNDDPLLVVTLAKAYD---YKRRVEERNALLACAEFLATQETIHMSKRDNSGNTSL 476

  Fly   374 FFAVKYRNTSAMQKLLKNG-AYIGSKSAFGTLPIKDMPPEVLEEHFDSCITTNGERP-GDQNFEI 436
            ..|:||...|....||:.. .|:|.::.....|:..........:.|.||..:.:|. .|:|
Mosquito   477 HLALKYGFDSVALALLRQRYTYLGMRNNDNLTPLDYGTFAFWRSYLDQCIEVDSKRSIPDRN--- 538

  Fly   437 IIDYKNLM-------------------------RQERDS-GLNQLQD--------------EMAP 461
            :|.: ||.                         |.:|.| .|.|..|              ||..
Mosquito   539 VIRF-NLQGFHSPALSMTSAVSADGTPAASDRSRNKRSSWKLIQRVDQTYCQPHKFTRTVTEMTT 602

  Fly   462 IAFIAESKEMRHLLQHPLISSFLFLKWHRLSVIFYLNFLIYSLFTASIITYTLLKFHESDQRALT 526
            :..||:|||::.||.||::.:|:.:||.||....|||.|:.:|   :||.:.............:
Mosquito   603 LRQIAQSKELKRLLVHPVVYTFIMVKWTRLCHWNYLNLLLTAL---TIIFFGNYSLTACSVEGPS 664

  Fly   527 AFFGLLSWLGISYLILRECIQWIMSPVRYFWSITNIME-VALITLSIFTCMESSFDKETQRVLAV 590
            ....|||.||:..:.:||.:| ::...|.:.|..|..: :..:.:|:...      .....:|:.
Mosquito   665 TVLWLLSLLGVVCVAIRETLQ-LLFLRRSYLSFENAQDLINAVAMSVVLA------NGCNGLLSS 722

  Fly   591 FTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEED 655
            |.::..:|:...|:|||...|::|.|.|.:.||.:|||||.|:...:..|...|::.:    .||
Mosquito   723 FVVISFAMQLTFLLGSLQSNSLATMMYMFKTVSKNFLKSFLLFMPLIGAFIYAFHLTY----NED 783

  Fly   656 QSKSATPCPPLGKKEGKD-EEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQFTSIYTYLIFLLFV 719
            ....|..|      |..| .|:.||.|.....|.|||:||.||||:|.:|.|.. ...|:|:||:
Mosquito   784 PEDHAQVC------ERDDCSEENFNNFRTFWNATIKTLVMTTGEFEAAAIDFEG-GKMLLFILFM 841

  Fly   720 IFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSICQ 784
            .|..||:.||:|||||||...|:.::||.....:..:|.:||                      :
Mosquito   842 FFAPIVILNLINGLAVSDIAAIREESELISISKKVMLLEQYE----------------------R 884

  Fly   785 RLMNIYPNYL---------------------SLRQISV----LPNDGNKVLIPMSDPFEMRTLKK 824
            .:.|:||.:|                     ..|:|.|    ||....|...|: :|.....|..
Mosquito   885 GVANVYPGWLRRCFPRPFFAEYDCRIHVKTKEYRKIEVHLRELPTKAGKGTAPV-NPGGAAALNN 948

  Fly   825 ASFQ---------QLPLSAAVPQKKLLDPPLRLLPC-----CCSLLTGKCSQMSGRVVKRALEVI 875
            |..:         |:|.|....::|::..||..:|.     .|:.:      ...||.:.||.:
Mosquito   949 AKSRLHGSSQCSVQIPPSGKPAKQKVVGKPLPKIPWIPQGDSCNFI------FDVRVFRLALFM- 1006

  Fly   876 DQKNAAEQRRKQEQINDSRLKLIEYKLEQLIQLVQ 910
                     |..:.|.|..|.:||  .:|.:..:|
Mosquito  1007 ---------RLDQSIVDEALTIIE--RQQALASIQ 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430	44/186 (24%)
		ANK repeat	82..111	CDD:293786	9/28 (32%)
		ANK repeat	113..152	CDD:293786	8/38 (21%)
		ANKYR	<243..>406	CDD:440430	47/221 (21%)
		ANK repeat	324..366	CDD:293786	11/66 (17%)
		ANK repeat	368..393	CDD:293786	7/25 (28%)
		Ion_trans	495..746	CDD:459842	80/252 (32%)
LOC1270502	XP_309204.5	None