Protein Alignment pain and trpa1

DIOPT Version :10

• Sequence 1: NP_611979.1
• Gene: pain / 37985
• FlyBaseID: FBgn0060296
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001121434.1
• Gene: trpa1 / 100158526
• XenbaseID: XB-GENE-1004945
• Length: 1144
• Species: Xenopus tropicalis
• Alignment Length: 1052
• Identity: 196/1052 - (18%)
• Similarity: 356/1052 - (33%)
• Gaps: 331/1052 - (31%)

  Fly    17 GALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTP-------GCRDFIEACIDHGSQVNYI 74
            |:|...||     .|..|.......|.|.:......|:|       |..|.::|||.:|::::.
 Frog   215 GSLKCMDI-----ILKKGEEMGYTIDHHINFTNNEKSSPLHLAVQNGNIDVVKACISYGAKIDL- 273

  Fly    75 NKKLDKAAISYAADSRDPGNLAALL--KYRPGNKVQVDRKYG-QLTPLNSLAKNLTDENAPDVYS 136
             ::.|.|...:.|.::....:...:  .|...||: ||...| ..|||:   |::..::.    .
 Frog   274 -RQSDNATALHFAATQGATEIVKFMVSSYSDDNKI-VDLPDGNDETPLH---KSVLFDHV----E 329

  Fly   137 CMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHPELDIDSYRNGEVRRLLQA 201
            ..:.|:..||:.:..|:...|||   |..:...|.|..                      .||.:
 Frog   330 LAEYLISEGANIDSEDKESRTPL---LLATSCSAWKSV----------------------NLLLS 369

  Fly   202 QFPELKLPEERHTGPE-IDIQTLQRTLRDGDETLFEQQFAEYLQNLKGGADNQLNAHQE-EYFGL 264
            :..::||.:  |.|.. :.:..||    .|.......:|.: ::|:|     :|.:.:: |....
 Frog   370 KGADVKLKD--HYGRNFLHLMVLQ----PGGLKNLNSEFLQ-MENIK-----KLVSDEDCEGCTP 422

  Fly   265 LQESIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKL 329
            |..:.:.|...:.:.:|...|.:.|:  ..|:.:.:..|..||.:...:||     ||...|.:|
 Frog   423 LHYACRHGVPNSVNNLLGLNMSLYSK--SKNKRSPLHFAACYGRFNTCQRL-----LRFMSDGRL 480

  Fly   330 LN-------------------AVI------GRLDEPPYDG---------SSHQRCFELLINSDRV 360
            ||                   .::      |.|....:.|         |.:.|..:.|:.:...
 Frog   481 LNDGDEKGMTPLHLAAENGHEKIVFLLLKRGALLLSDHRGWTALHYAALSGYTRTIKTLLETSIG 545

  Fly   361 DINEADSGRLVPLFFAVKYRNTSAMQKLLKNGA----------YIGSKSAFGTLPIKDMP----- 410
            .|::.|..:...:..|.:..:..|:..||:|||          ||.....||.   ||..
 Frog   546 LIDKTDKEQNTAMHLAGREGHAKAVSLLLENGASILLNANGASYIHEAIRFGK---KDTVLVSIQ 607

  Fly   411 ----------------------------PEVLEEHFDSCITTNGERPGDQ---------NFEII- 437
                                        ||..:...|.|:|   |..||:         ||..:
 Frog   608 SERWEEILQTFSHTSSYKCAILEMIYHLPESFKTLLDRCMT---ESIGDKKSPDFHVEYNFTYLQ 669

  Fly   438 --IDYKNLMRQERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRLSV-IFYLNF 499
              :.::...::|.    |...:.:..:..:.:.:.: .||.||:...:|.:||..... ...||.
 Frog   670 CPLSFRKAHKREN----NVHYEPLTTLNAMVQHQRI-DLLSHPVCKEYLLMKWMAYGFKAHLLNL 729

  Fly   500 LIYSLFTASIITYTLL----------------------KFHES-------------------DQR 523
            .||||   .:|..|||                      .|:.|                   |.:
 Frog   730 AIYSL---GLIPLTLLIINAVRPESLAIIEECEHLKRTDFYNSSMKQECANVSRKLDLLQLKDTQ 791

  Fly   524 ALTAFFGLLSWLGISYLILRECIQWIMSPVRYFWSITNIMEVALITLSIF----TCMESSFDKET 584
            ......||:..:.: :.|::|.:|.....:.|....:||::.::...||.    .|.........
 Frog   792 YTRVCMGLVFCMSL-FGIVKEAVQLCQQKLAYIGDGSNIIDWSIYISSIIFVSSLCHSPIVVSGL 855

  Fly   585 QRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFG 649
            |.......:....:.|.:.:....  |...:::|..|:..:.|:...|:...:|.|.|.||:...
 Frog   856 QWQFGAIAVFASWVNFLIYLQRFE--SYGIYIVMFWEILRTLLRIVFLFFFLILAFGLSFYVFLY 918

  Fly   650 KSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGE--FDAG--------SI 704
            ..|                           ||::|..|::::..|:.|:  ::.|        .|
 Frog   919 PQV---------------------------TFSRPYFALMQSFTMMLGDINYEEGFLKPLLDDQI 956

  Fly   705 QFTSIYTYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGR 769
            :: ..:|::..::|.:.:.|:|.|||.||||.|.      ||:....|    |.|....::.|..
 Frog   957 EY-PFFTFIHLIMFTLLIPILLMNLLIGLAVGDI------AEVQRNAC----LKRIAMQVSLHTS 1010

  Fly   770 AGFLLGNHLFRSICQRLMNIYPNYLSLRQISVLPN--------DGNKVLIPMSDPFEMRTLKKAS 826
            ....|.....:.:.:..:.:|||...:..|:...|        |..|..||::|    .|::
 Frog  1011 LEKKLPFWFLKRVDKISITVYPNRPRIWGITFTSNFFHYFSSCDDVKAEIPIND----ETME--- 1068

  Fly   827 FQQLPLSAAVPQKKLLDPPLRLLPCCCSLLTGKCSQMSGRVVKRALEVIDQKNAAEQRRKQEQIN 891
                                                         ||:..|||..:......|..
 Frog  1069 ---------------------------------------------LELWKQKNRLKDLTTMMQKQ 1088

  Fly   892 DSRLKLIEYKLE 903
            :..:|||..|:|
 Frog  1089 NDLIKLIIQKME 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pain	NP_611979.1	ANKYR	2..>182	CDD:440430	39/174 (22%)
		ANK repeat	82..111	CDD:293786	5/30 (17%)
		ANK repeat	113..152	CDD:293786	8/39 (21%)
		ANKYR	<243..>406	CDD:440430	40/207 (19%)
		ANK repeat	324..366	CDD:293786	11/75 (15%)
		ANK repeat	368..393	CDD:293786	5/24 (21%)
		Ion_trans	495..746	CDD:459842	57/305 (19%)
trpa1	NP_001121434.1	ANK repeat	68..101	CDD:293786
		ANKYR	85..385	CDD:440430	45/211 (21%)
		ANK repeat	103..134	CDD:293786
		ANK repeat	136..168	CDD:293786
		ANK repeat	170..201	CDD:293786
		ANK repeat	203..242	CDD:293786	8/31 (26%)
		ANK repeat	247..275	CDD:293786	7/29 (24%)
		ANK repeat	277..312	CDD:293786	8/35 (23%)
		ANK repeat	314..345	CDD:293786	7/37 (19%)
		ANKYR	328..606	CDD:440430	62/328 (19%)
		ANK repeat	347..378	CDD:293786	10/55 (18%)
		ANK repeat	451..485	CDD:293786	12/38 (32%)
		ANK repeat	490..517	CDD:293786	2/26 (8%)
		ANK repeat	519..551	CDD:293786	5/31 (16%)
		ANK repeat	553..578	CDD:293786	5/24 (21%)
		Ion_trans	<819..996	CDD:459842	41/212 (19%)