Protein Alignment Tpc2 and TPC1

DIOPT Version :9

• Sequence 1: NP_001246511.1
• Gene: Tpc2 / 37983
• FlyBaseID: FBgn0035078
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_011610.3
• Gene: TPC1 / 852988
• SGDID: S000003328
• Length: 314
• Species: Saccharomyces cerevisiae
• Alignment Length: 318
• Identity: 84/318 - (26%)
• Similarity: 153/318 - (48%)
• Gaps: 51/318 - (16%)

  Fly    14 VGGGIAGAATRTITQPLDVLKIRFQMQVEPVTNHK--GSKYRGVIHAFKSVYAEEGMRGMFRGHN 76
            :.|.::|...|:||.|:|.:|||  :|:.|....|  ||:   |:...:|:...||:|..::|:.
Yeast    21 LAGAVSGLLARSITAPMDTIKIR--LQLTPANGLKPFGSQ---VMEVARSMIKNEGIRSFWKGNI 80

  Fly    77 SGQVLSISYALVQFWSYEQLRSMAHQFDYWRERPF-----LMFFICGGIAGCLGAVAAQPFDVVR 136
            .|.:|.::|...||.||    |:.:::    ..||     |...:.|..||...::.:.||||:|
Yeast    81 PGSLLYVTYGSAQFSSY----SLFNRY----LTPFGLEARLHSLVVGAFAGITSSIVSYPFDVLR 137

  Fly   137 TQMVAADPSSRRSQMNTFTGLRKVYKMEGWMGLSRGLPFTLVQVFPLVGANFLFYKYLNAAVLMA 201
            |::||   :::...|:....:|.::|:||..|..:|...::..:  .:.|:.:|..|....:..
Yeast   138 TRLVA---NNQMHSMSITREVRDIWKLEGLPGFFKGSIASMTTI--TLTASIMFGTYETIRIYC- 196

  Fly   202 KPPDQRQEIHGA-----FLFLN---GALSGVLAKMIVYPADLLKKRIQLMAFKQERKTFGRNPEC 258
               |:.::...|     ...||   |.:.||:||:|.:|.:.:::|:|.|..|...| |.|:
Yeast   197 ---DENEKTTAAHKKWELATLNHSAGTIGGVIAKIITFPLETIRRRMQFMNSKHLEK-FSRH--- 254

  Fly   259 PTILGCI---------TTTFREEGIGGFYKGMLPTLLKAGLMSAVYFSIYDMFKRHYI 307
            .::.|..         ....::||:...|:|:|..|.|....:.|.|..|:. ..||:
Yeast   255 SSVYGSYKGYGFARIGLQILKQEGVSSLYRGILVALSKTIPTTFVSFWGYET-AIHYL 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tpc2	NP_001246511.1	PTZ00169	23..304	CDD:240302	80/304 (26%)
		Mito_carr	23..99	CDD:278578	26/77 (34%)
		Mito_carr	108..194	CDD:278578	23/90 (26%)
		Mito_carr	216..307	CDD:278578	28/102 (27%)
TPC1	NP_011610.3	Mito_carr	16..105	CDD:395101	29/96 (30%)
		PTZ00169	21..285	CDD:240302	75/289 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341940
Domainoid	1	1.000	53	1.000	Domainoid score	I2797
eggNOG	1	0.900	-	-		E1_KOG0752
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1857
OMA	1	1.010	-	-		QHG55227
OrthoFinder	1	1.000	-	-		FOG0001923
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24089
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890