DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tpc2 and SLC25A19

DIOPT Version :9

Sequence 1:NP_001246511.1 Gene:Tpc2 / 37983 FlyBaseID:FBgn0035078 Length:323 Species:Drosophila melanogaster
Sequence 2:NP_001119593.1 Gene:SLC25A19 / 60386 HGNCID:14409 Length:320 Species:Homo sapiens


Alignment Length:306 Identity:103/306 - (33%)
Similarity:162/306 - (52%) Gaps:12/306 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PENSVVVQLMQAVGGGIAGAATRTITQPLDVLKIRFQMQVEPVT-NHKGSKYRGVIHAFKSVYAE 65
            |:.....:...||.|.::|..||.:..|.||:|||||:|.|.:: :...:||.|::.|.:.:..|
Human     8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQE 72

  Fly    66 EGMRGMFRGHNSGQVLSISYALVQFWSYEQLRSMAHQFDYWRERPFLMFFICGGIAGCLGAVAAQ 130
            ||....::||...|:|||.|..|||.|:|.|..:.|:...:..|.|.:.|:|||:|.|:..:...
Human    73 EGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137

  Fly   131 PFDVVRTQMVAADPSSRRSQMNTFTGLR----KVYKMEGWMGLSRGLPFTLVQVFPLVGANFLFY 191
            |.||:||:..|      :.:...:..||    .:|:.||.....:||..||:.:||..|..|..|
Human   138 PVDVLRTRFAA------QGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCY 196

  Fly   192 KYLNAAVLMAKPPDQRQEIHGAFLFLNGALSGVLAKMIVYPADLLKKRIQLMAFKQERKTFGRNP 256
            ..|......|.|.:.::..:...| |.|:.:||::|.:.||.||.|||:|:..|:..|..||:..
Human   197 SSLKHLYKWAIPAEGKKNENLQNL-LCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVR 260

  Fly   257 ECPTILGCITTTFREEGIGGFYKGMLPTLLKAGLMSAVYFSIYDMF 302
            ....::.|.....::||..||:||:.|:||||.|.:...|..|:.|
Human   261 RYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFF 306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tpc2NP_001246511.1 PTZ00169 23..304 CDD:240302 98/285 (34%)
Mito_carr 23..99 CDD:278578 32/76 (42%)
Mito_carr 108..194 CDD:278578 28/89 (31%)
Mito_carr 216..307 CDD:278578 33/87 (38%)
SLC25A19NP_001119593.1 Solcar 1 13..106 36/92 (39%)
Mito_carr 16..111 CDD:278578 37/94 (39%)
PTZ00169 20..293 CDD:240302 96/279 (34%)
Solcar 2 116..202 29/91 (32%)
Mito_carr 118..203 CDD:278578 28/90 (31%)
Solcar 3 214..309 34/94 (36%)
Mito_carr 216..306 CDD:278578 33/90 (37%)
Substrate recognition. /evidence=ECO:0000250 241..246 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142884
Domainoid 1 1.000 85 1.000 Domainoid score I8165
eggNOG 1 0.900 - - E1_KOG0752
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 209 1.000 Inparanoid score I3683
Isobase 1 0.950 - 0 Normalized mean entropy S1857
OMA 1 1.010 - - QHG55227
OrthoDB 1 1.010 - - D1454699at2759
OrthoFinder 1 1.000 - - FOG0001923
OrthoInspector 1 1.000 - - otm41704
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24089
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2188
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.820

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