DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tpc2 and Tpc1

DIOPT Version :9

Sequence 1:	NP_001246511.1	Gene:	Tpc2 / 37983	FlyBaseID:	FBgn0035078	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_650034.1	Gene:	Tpc1 / 41316	FlyBaseID:	FBgn0037852	Length:	332	Species:	Drosophila melanogaster

Alignment Length:	311	Identity:	132/311 - (42%)
Similarity:	189/311 - (60%)	Gaps:	12/311 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENSVVVQLMQAVGGGIAGAATRTITQPLDVLKIRFQMQVEPVTNHKG--------SKYRGVIHAF 59
            ::|...||.|.:.||::.|.||:..|||||||||||:||||:..:..        |||..:..|.
  Fly    22 KHSTREQLHQMLAGGLSAAITRSTCQPLDVLKIRFQLQVEPLGKNAAKEGPGALTSKYTSIGQAV 86

  Fly    60 KSVYAEEGMRGMFRGHNSGQVLSISYALVQFWSYEQLRSMAHQFDYWRERPFLMFFICGGIAGCL 124
            |::|.||||...::|||..|||||.|.:.|||:||||..||.|..|..:...|..|:||..||..
  Fly    87 KTIYREEGMLAFWKGHNPAQVLSIMYGICQFWTYEQLSLMAKQTSYLADHQHLSNFLCGAAAGGA 151

  Fly   125 GAVAAQPFDVVRTQMVAADPSSRRSQMNTFTGLRKVYKMEGWMGLSRGLPFTLVQVFPLVGANFL 189
            ..:.:.|.||:||:::|.|.|  :...|....:..:.:.||..|:.|||...|:|:.||:|.||:
  Fly   152 AVIISTPLDVIRTRLIAQDTS--KGYRNATRAVSAIVRQEGPRGMYRGLSSALLQITPLMGTNFM 214

  Fly   190 FYK-YLNAAVLMAKPPDQRQEIHGAFLFLNGALSGVLAKMIVYPADLLKKRIQLMAFKQERKTFG 253
            .|: :.:.|....:..|:.|......|.| ||.||:|:|.||||.||:|||:|:..|:..|:|||
  Fly   215 AYRLFSDWACAFLEVSDRSQLPTWTLLGL-GASSGMLSKTIVYPFDLIKKRLQIQGFESNRQTFG 278

  Fly   254 RNPECPTILGCITTTFREEGIGGFYKGMLPTLLKAGLMSAVYFSIYDMFKR 304
            :..:|..:..|:..|.|:||:.|.|||:.|||||:.:.:|:||||||..|:
  Fly   279 QTLQCHGVWDCLRLTVRQEGVRGLYKGVAPTLLKSSMTTALYFSIYDKLKQ 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tpc2	NP_001246511.1	PTZ00169	23..304	CDD:240302	124/289 (43%)
		Mito_carr	23..99	CDD:278578	43/83 (52%)
		Mito_carr	108..194	CDD:278578	29/86 (34%)
		Mito_carr	216..307	CDD:278578	45/89 (51%)
Tpc1	NP_650034.1	Mito_carr	29..123	CDD:278578	46/93 (49%)
		PTZ00169	33..329	CDD:240302	127/298 (43%)
		Mito_carr	153..222	CDD:278578	23/70 (33%)
		Mito_carr	233..328	CDD:278578	46/95 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440847
Domainoid	1	1.000	77	1.000	Domainoid score	I3085
eggNOG	1	0.900	-	-		E1_KOG0752
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I1450
Isobase	1	0.950	-	0	Normalized mean entropy	S1857
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106711at6656
OrthoFinder	1	1.000	-	-		FOG0001923
OrthoInspector	1	1.000	-	-		otm24543
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24089
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2188
	11	10.850