DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tpc2 and Slc25a48

DIOPT Version :9

Sequence 1:	NP_001246511.1	Gene:	Tpc2 / 37983	FlyBaseID:	FBgn0035078	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_808477.2	Gene:	Slc25a48 / 328258	MGIID:	2145373	Length:	306	Species:	Mus musculus

Alignment Length:	203	Identity:	52/203 - (25%)
Similarity:	89/203 - (43%)	Gaps:	43/203 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LMQAVGGGIAGAATRTITQPLDVLKIRFQMQVEP-------VTNHKGSKYRGVIHAFKSVYAEEG 67
            |...|..|:.|        |::::|||.|||.:|       :.:...:.|:|.:|...::...||
Mouse   112 LTGVVSVGLGG--------PVELIKIRLQMQTQPFREASHGLKSRAVAAYQGPVHCIATIVQMEG 168

  Fly    68 MRGMFRGHNSGQVLS---------ISYALVQFWSYEQLRSMAHQFDYWRERPFLMFFICGGIAGC 123
            :.|::|| .|..:|.         |.|..:..|...:..:....:..|         :.|||||.
Mouse   169 LTGLYRG-ASAMLLRDIPGYCFYFIPYVFLSEWITPEACTGPSPYAAW---------LAGGIAGA 223

  Fly   124 LGAVAAQPFDVVRTQMVAADPSSRRSQMNTFTG----LRKVYKMEGWMGLSRGLPFTLVQVFPLV 184
            :....|.|.|||::: :.||    ...:|.:.|    :.:.|:.||:....||:....|:.||:.
Mouse   224 ISWGTATPMDVVKSR-IQAD----GVYLNKYRGVVDCISQSYQQEGFKVFFRGITVNAVRGFPMS 283

  Fly   185 GANFLFYK 192
            .|.||.|:
Mouse   284 AAMFLGYE 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tpc2	NP_001246511.1	PTZ00169	23..304	CDD:240302	48/190 (25%)
		Mito_carr	23..99	CDD:278578	21/91 (23%)
		Mito_carr	108..194	CDD:278578	26/89 (29%)
		Mito_carr	216..307	CDD:278578
Slc25a48	NP_808477.2	Solcar 1	3..86
		Mito_carr	6..89	CDD:365909
		Solcar 2	101..200		24/96 (25%)
		Mito_carr	107..202	CDD:365909	25/98 (26%)
		Mito_carr	209..299	CDD:365909	27/97 (28%)
		Solcar 3	209..296		27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0752
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900