DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and CACNA1G

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_061496.2 Gene:CACNA1G / 8913 HGNCID:1394 Length:2377 Species:Homo sapiens


Alignment Length:3017 Identity:642/3017 - (21%)
Similarity:1074/3017 - (35%) Gaps:1059/3017 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEA--------------EYIFLAIYSIE 163
            |..|..|:....|.:|:...|..||.||:.|.|....|:.              ::|| |.:::|
Human    68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVE 131

  Fly   164 MVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL--AGLRTFRVLRALKTVSIMP 226
            ||:|::|.| :..|..||.:.||.|||.::.:|.....:::.|:  :.:||.||||.|:.::.:|
Human   132 MVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVP 195

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW 291
            .::.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|.  :|.:::.....|.:.:
Human   196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF--LPENFSLPLSVDLERY 258

  Fly   292 VNDTDNWLYDEDELPVLC------------------GNLTGARHCPFEYVC-------LCV---- 327
            . .|:|    |||.|.:|                  |:..|...|..:|..       .||    
Human   259 Y-QTEN----EDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQ 318

  Fly   328 -------GE-NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGS 384
                   || ||..|..||||..::.:..||:|||:.|.::...|:......:..:|.:::..||
Human   319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGS 383

  Fly   385 FYLINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDS 445
            |::|||.|.|:|..:.|    |:::..|:|.:.|.:....::|| :|.....:.|.         
Human   384 FFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFS-EPGSCYEELLK--------- 438

  Fly   446 RKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGP------SPRHSATER 504
                 ...|..:|..|:..:..:..|..             .....||.|      .|..|.:..
Human   439 -----YLVYILRKAARRLAQVSRAAGVR-------------VGLLSSPAPLGGQETQPSSSCSRS 485

  Fly   505 PSALTMQAQKQYQQMEQQH---------------KLAKSGSGGSNNPMAPTPK-GRISFQDSGMG 553
            ...|::.....:......|               ::....:.||...|.|.|. ..:|....| |
Human   486 HRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPPG-G 549

  Fly   554 VKNPNMLY------------------PSDYKGQLI---------------------------ANS 573
            .::.:..|                  ||:..|:.:                           |:|
Human   550 AESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASS 614

  Fly   574 GQPS-------------------SNSSGVNRESS-------QDDSGVVDDHEEQDTTNDMGHVST 612
            |.|:                   :.|:|..:.|.       :.|||...    .|:.........
Human   615 GPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACG----PDSCPYCARAGA 675

  Fly   613 VELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYES---- 673
            .|:.|:.||         :....:..||...|:...     .||.|.:..|......|.|.    
Human   676 GEVELADRE---------MPDSDSEAVYEFTQDAQH-----SDLRDPHSRRQRSLGPDAEPSSVL 726

  Fly   674 --WLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECI 736
              |....:...|:|....|...|.:.|::||..:.:|:|...|...|||::.|.||||:|..|.:
Human   727 AFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEML 791

  Fly   737 VKLMALSKDFFLCG-WNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLS 800
            :||:......::.. :||||.:||..|:.:|:.:...||||||..||:|||||.:....::..|.
Human   792 LKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLV 856

  Fly   801 IIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP-RWNFNDFFHSFMMIFRIL 864
            :::.|:..:....::|::.|:||:::||.||...:..|: |.|.:| |.||:....:.:.:|:||
Human   857 VLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER-DGDTLPDRKNFDSLLWAIVTVFQIL 920

  Fly   865 CGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGE 928
            ..| |.:.|::.|.:.....|    ..|:..:..||:::.||.:|:|:..|.:||:..:::..|:
Human   921 TQEDWNKVLYNGMASTSSWAA----LYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981

  Fly   929 ESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGV 993
            .|.:                               |:.:|:|...|                   
Human   982 LSCI-------------------------------QLPVDSQGGDA------------------- 996

  Fly   994 LAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDG-----LEYDDTGDLPEQIQLQAHPL 1053
                           |:..|..|| |. |..||     ||     |.....|:.||   |:...|
Human   997 ---------------NKSESEPDF-FS-PSLDG-----DGDRKKCLALVSLGEHPE---LRKSLL 1036

  Fly  1054 PP-------TSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQY 1111
            ||       |..|:|.:..:.:....|.:....:.:|:         ||....|::.|..|.:  
Human  1037 PPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGS---------AEPGAAHEMKSPPSAR-- 1090

  Fly  1112 DSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQK 1176
                               |:...|:     |...|:         :|||            ..:
Human  1091 -------------------SSPHSPW-----SAASSW---------TSRR------------SSR 1110

  Fly  1177 SLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREEL 1241
            :.|.|:||.:                         ||..||        |:..|||.:|      
Human  1111 NSLGRAPSLK-------------------------RRSPSG--------ERRSLLSGEG------ 1136

  Fly  1242 LNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKEL 1306
                     |..|:|||                                          |.|:| 
Human  1137 ---------QESQDEEE------------------------------------------SSEEE- 1149

  Fly  1307 EEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSV 1371
                              ..|||                |:..|                     
Human  1150 ------------------RASPA----------------GSDHR--------------------- 1159

  Fly  1372 PRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQ 1436
                              .|.|||::.|...|.                                
Human  1160 ------------------HRGSLEREAKSSFDL-------------------------------- 1174

  Fly  1437 AQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRL 1501
                                                                       ||.|::
Human  1175 -----------------------------------------------------------PDTLQV 1180

  Fly  1502 DSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQ 1566
            ..|.                                                :|.....:.:|||
Human  1181 PGLH------------------------------------------------RTASGRGSASEHQ 1197

  Fly  1567 QHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASS 1631
                                 ..:..|.:|:..|...|.   |.......|..|.:.|..     
Human  1198 ---------------------DCNGKSASGRLARALRPD---DPPLDGDDADDEGNLSKG----- 1233

  Fly  1632 ALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPS 1696
                                 ::..|:.| ...|..||           .|:|..||    .|| 
Human  1234 ---------------------ERVRAWIR-ARLPACCL-----------ERDSWSAY----IFP- 1260

  Fly  1697 YGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLI 1761
                          ||                         :|.|.....::....|:..|||:|
Human  1261 --------------PQ-------------------------SRFRLLCHRIITHKMFDHVVLVII 1286

  Fly  1762 FASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDF 1822
            |.:.||:..|...:|.:...:..|...|:.|..:|:.||.:|.:|||:    ..|..|.|.:||.
Human  1287 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDG 1351

  Fly  1823 IIVFVSVFSLLI-----EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVL 1882
            ::|.:||..:|:     ...:.|.:||.||.||.|||||.|||.||:::||..||.::..|.|::
Human  1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIV 1416

  Fly  1883 LVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGY 1947
            ::|..|::||.|:|||.|.||||.|..|     ....:.:|.||.|.:|.|:..|..||::|...
Human  1417 VICCAFFIIFGILGVQLFKGKFFVCQGE-----DTRNITNKSDCAEASYRWVRHKYNFDNLGQAL 1476

  Fly  1948 LALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFN 2012
            ::|..:|:.:||:::|.|.:||.|||.||....|.:..:||:.|::..:||.||:|:||:::||:
Human  1477 MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH 1541

  Fly  2013 MLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPI---------------------NH 2056
            ..::..|.       .|:::.....:::|.:|:...::...|                     :.
Human  1542 KCRQHQEE-------EEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSR 1599

  Fly  2057 FLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVG 2121
            |..:.:.|..|...::.|..:|.||::||.:|||.||..:...|::.|..||.:|.||::.|:|.
Human  1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1664

  Fly  2122 LRY-HYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIKAAKGI 2183
            ..: .:|...||..|..:||.||.||.:|:|.::  |||:||::|::||.||.|:|:|:|.|.|:
Human  1665 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729

  Fly  2184 RKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ-----GALDDMVNFQTFGRSMQL 2243
            |.||..::.:||.:.|:|.|..|:.||:|.||:.|||:::..     ..|.....|:.||.:...
Human  1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLT 1794

  Fly  2244 LFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAII 2308
            |||:.|...||.:::..:   .|||      ....|.:.:::..||.||::.:..:::|:.||::
Human  1795 LFRVSTGDNWNGIMKDTL---RDCD------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1850

  Fly  2309 LENFNQAHQE--EEIGI-VEDDLEMFYIRWSKYDP----------------------------HA 2342
            :::..::::|  ||..: .|.:|||..:....:.|                            ||
Human  1851 MKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHA 1915

  Fly  2343 TQFIHFS-------QLSDFIASL----------------------------------DP--PLG- 2363
            ....|||       ||.|.|:.|                                  ||  ||. 
Human  1916 RSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIPLAE 1980

  Fly  2364 ----------ISKPN-NVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDV 2417
                      :|:|: ::||...:||    :.:|.| :|.||..::..|                
Human  1981 MEALSLTSEIVSEPSCSLALTDDSLP----DDMHTL-LLSALESNMQPH---------------- 2024

  Fly  2418 KFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQS 2482
                  ||    |:.....:..|:...::|.......|:.|        .|.:|.......||  
Human  2025 ------PT----ELPGPDLLTVRKSGVSRTHSLPNDSYMCR--------HGSTAEGPLGHRGW-- 2069

  Fly  2483 KLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSEL------------AGPWLNLPLMLVS 2535
                    .|..::.|:..|..      |:.:|.|.:.:|            |..|..:|.:...
Human  2070 --------GLPKAQSGSVLSVH------SQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPP 2120

  Fly  2536 GADEVV-KDIKQQ----NDE-----LGKRGSIFVE----APRASRRRSFYNFFLRHQDAVDDSLT 2586
            |...:. :.:::|    .|.     ||.|..:..|    :|..:|..||:.          .|.|
Human  2121 GRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWG----------QSST 2175

  Fly  2587 SPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSAS---DSDRHQAVG-----GG 2643
            ....|.::....:.:.|.       .|......|..|.||..|.:|   |::.....|     ||
Human  2176 QAQQHSRSHSKISKHMTP-------PAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGG 2233

  Fly  2644 SAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPD 2708
                        :::||..|.|         |..:..||.:.:...|....||:.|..::|.. |
Human  2234 ------------QEEPPSPRDL---------KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCL-D 2276

  Fly  2709 NATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMP 2773
            :.:..|:             .:.||..|.....|.|.....|..||.|.|.....:... |...|
Human  2277 SGSQPHL-------------GTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR-TPPSP 2327

  Fly  2774 TVQIMVDSPKDPPRGDFSSAPIDDVGA 2800
            .:.:...:|....:...:|.|.|.:.|
Human  2328 GICLRRRAPSSDSKDPLASGPPDSMAA 2354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 71/271 (26%)
Ion_trans 705..902 CDD:278921 64/199 (32%)
Ion_trans 1768..2019 CDD:278921 95/259 (37%)
Na_channel_gate 2009..2063 CDD:240441 8/74 (11%)
Ion_trans 2085..2320 CDD:278921 82/244 (34%)
GPHH 2331..2386 CDD:293510 21/137 (15%)
CACNA1GNP_061496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48
I 68..398 94/338 (28%)
Ion_trans 130..406 CDD:278921 79/283 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..600 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..720 4/25 (16%)
II 729..967 76/242 (31%)
Ion_trans 760..968 CDD:278921 68/212 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1012 8/56 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1230 63/565 (11%)
III 1263..1540 103/281 (37%)
Ion_trans 1293..1547 CDD:278921 95/258 (37%)
IV 1596..1854 89/266 (33%)
Ion_trans 1628..1851 CDD:278921 81/231 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1878..1917 3/38 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2129 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2171..2244 19/110 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2272..2377 20/98 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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