DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and CACNA1H

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_006721026.1 Gene:CACNA1H / 8912 HGNCID:1395 Length:2358 Species:Homo sapiens


Alignment Length:3063 Identity:661/3063 - (21%)
Similarity:1062/3063 - (34%) Gaps:1090/3063 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 RRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVI 166
            |..|:.:..|.:|::..|..|:.||:.|.|....|:.|              :|| |.:::||||
Human    90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFAVEMVI 153

  Fly   167 KIIAKGFLLNKYTYLRNPWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGL 228
            |::|.| |..:..||.:.||.|||.::.:|   |:..|..| :|:.:||.||||.|:.::.:|.:
Human   154 KMVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV-SLSAIRTVRVLRPLRAINRVPSM 216

  Fly   229 KTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKC------VRQ------VPTDWT 281
            :.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|      ||.      .|...|
Human   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQT 281

  Fly   282 NVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARH----CPFEY-------------------- 322
            .....:..|..:..||.:..       |.::.|.|.    |...:                    
Human   282 EEGEENPFICSSRRDNGMQK-------CSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACIN 339

  Fly   323 ------VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVF 381
                  ||.....||::|..||||..::.:..||:|||:.|.::...|:......:..:|.:::.
Human   340 WNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLII 404

  Fly   382 FGSFYLINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTF-SFDPSVLNVKKLNK---N 438
            .|||::|||.|.|:|..:.|    |:::..|:|.:.|   .:|||. ||.......::|.|   :
Human   405 VGSFFMINLCLVVIATQFSETKQRESQLMREQRARHL---SNDSTLASFSEPGSCYEELLKYVGH 466

  Fly   439 NKKKIDSRKGVLLASYSKKKTR-RKKTKGGKEGGTNGNGNGSNGDDNKSHSAT------------ 490
            ..:|:..|.   |..|::.::| |||.   ......|.|.|........|:|:            
Human   467 IFRKVKRRS---LRLYARWQSRWRKKV---DPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHH 525

  Fly   491 ---------------PSPG------------PSPRHSATERPSALTMQA--------QKQYQQME 520
                           |.||            |||.......|.|.::.:        :...::..
Human   526 HHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERAR 590

  Fly   521 QQHKLA---------------------KSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSD 564
            ..|..|                     .||.|......:|.|||:.:....|.|...|       
Human   591 VAHAAATAAASLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGP------- 648

  Fly   565 YKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVS----------------TV 613
                |..||..|           .:....||.:|   ......||:|                |.
Human   649 ----LSLNSPDP-----------YEKIPHVVGEH---GLGQAPGHLSGLSVPCPLPSPPAGTLTC 695

  Fly   614 ELALSPREVRLIK-CNGNIARIKN-----HNVYALHQEFSSEVVVIDDLPDRNCDRCVHW----- 667
            ||...|...|.:: ..|.::..::     ..||    ||:.:|        |:.||   |     
Human   696 ELKSCPYCTRALEDPEGELSGSESGDSDGRGVY----EFTQDV--------RHGDR---WDPTRP 745

  Fly   668 --CTDYES-------------------------WLQFQNCLYKVVRDPLFELAITLCIVLNTAFL 705
              .||...                         |:.|...|.::|....|...|.:.|::||..:
Human   746 PRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSM 810

  Fly   706 AMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSKDFFLCG--------WNIFDLLIVTAS 762
            .:|:|...|...|||::.|.||||:|..|.::||:|       ||        :||||.:||..|
Human   811 GVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLA-------CGPLGYIRNPYNIFDGIIVVIS 868

  Fly   763 LLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIG 827
            :.:|:.:...||||||..||||||||.:....::..|.:::.|:..:.....:|::.|:||:::|
Human   869 VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILG 933

  Fly   828 MQLFSKDYTPEKFDPDPVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAI 890
            |.||...::.:....|.|| |.||:....:.:.:|:||..| |...|::.|.:.....|    ..
Human   934 MHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAA----LY 994

  Fly   891 FLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKE 955
            |:..:..||:::.||.:|:|:..|.:|         |:.:                   |.|..|
Human   995 FVALMTFGNYVLFNLLVAILVEGFQAE---------GDAN-------------------RSDTDE 1031

  Fly   956 RKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQ 1020
                                             ||..|..|..||:|...::....:.       
Human  1032 ---------------------------------DKTSVHFEEDFHKLRELQTTELKMC------- 1056

  Fly  1021 IPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTC 1085
                        .|.....|.|..:..|....:..|:.:..||.:|                   
Human  1057 ------------SLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS------------------- 1090

  Fly  1086 QNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQR-------S 1143
               :||:.|...|.            |||             :.:|:..||...||:       |
Human  1091 ---SPFLDAAPSLP------------DSR-------------RGSSSSGDPPLGDQKPPASLRSS 1127

  Fly  1144 GCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEE 1208
            .|..:....:.   ||||            ...|.|.|:||.:                      
Human  1128 PCAPWGPSGAW---SSRR------------SSWSSLGRAPSLK---------------------- 1155

  Fly  1209 AEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMR 1273
               ||...|        |::.|||.:|                         ||           
Human  1156 ---RRGQCG--------ERESLLSGEG-------------------------KG----------- 1173

  Fly  1274 SRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIM 1338
                                       |.:.|.|:             ..:.|.|.|        
Human  1174 ---------------------------STDDEAED-------------GRAAPGPRA-------- 1190

  Fly  1339 EHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDED 1403
                               .||            ||::|                          
Human  1191 -------------------TPL------------RRAES-------------------------- 1198

  Fly  1404 FSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERV 1468
                                                         :||                 
Human  1199 ---------------------------------------------LDP----------------- 1201

  Fly  1469 EEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPAT 1533
                   :|:.                                                ||  |.
Human  1202 -------RPLR------------------------------------------------PA--AL 1209

  Fly  1534 PPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQR 1598
            |||..:.                             ....:.|.|:...                
Human  1210 PPTKCRD-----------------------------RDGQVVALPSDFF---------------- 1229

  Fly  1599 RRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTE 1663
                              .|.:||...||:..           :.|:.:.               
Human  1230 ------------------LRIDSHREDAAELD-----------DDSEDSC--------------- 1250

  Fly  1664 KPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC 1728
                ||                               :..||.:...||.|..    |..|.:..
Human  1251 ----CL-------------------------------RLHKVLEPYKPQWCRS----REAWALYL 1276

  Fly  1729 MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFC 1793
            ...|:     |.|.:...|:....|:..|||.||.:.:|:..|..::|...|.:..|...|:.|.
Human  1277 FSPQN-----RFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFT 1336

  Fly  1794 LIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTL 1849
            .|||.||::|.:|||.    ..|..|.|.:||.::|.||:..:::.     ..:.|.|||.||.|
Human  1337 AIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLL 1401

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL 1914
            |.|||||.|||..|:::||..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|..     
Human  1402 RTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEG----- 1461

  Fly  1915 LPIT-EVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQR 1978
             |.| .::.|..|...:|.|:..|..||::|...::|..:::.:||:.:|.|.:||.|||.||.:
Human  1462 -PDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525

  Fly  1979 EANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGR 2043
            ..|.:..:||:.|::..|||.||:|:||:::||:..::..|.       .|:::.....:::|.|
Human  1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA-------EEARRREEKRLRRLER 1583

  Fly  2044 KKPQKVI----------KRPINHFLAMFYDLSNSRR----------FEIAIFVLIFLNMLTMGIE 2088
            ::..|.:          :||      .:.|.|.:||          .::.|..:|.:|::||.:|
Human  1584 RRRSKALPVAVAVAEAQRRP------YYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSME 1642

  Fly  2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM 2152
            ||:||.::...|:..|..||.||..||.:|:|...: .:|...||..|..:||.|:.||.:|:|.
Human  1643 HYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1707

  Fly  2153 ID--LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILG 2215
            :.  |||:||::|::||.||.|:|:|:|.|.|:|.||..:|.:||.:.|:|.|..|:.||||.||
Human  1708 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALG 1772

  Fly  2216 MSLFGNVKLQ-----GALDDMVNFQTFGRSMQLLFRLMTSAGWN----DVLESLMIQPPDCDPFI 2271
            :.|||.::..     ..|.....|..||.:...|||:.|...||    |.|.....:...|..::
Human  1773 VELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYL 1837

  Fly  2272 HGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQE--EEIGI-VEDDLEMFYI 2333
                      |.|:..||.:|::::..:::|:.:|:::::..::::|  |:..: .|.:|||   
Human  1838 ----------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--- 1889

  Fly  2334 RWSKYDPHATQFIHFSQLSDFIASLDPPL------GISKPNNVA-LVSFNLPISKGNKIHCL-DI 2390
               ...|.:.:.:...:         |||      ....||.|| .||.:..:|..|..:.. .:
Human  1890 ---AQGPGSARRVDADR---------PPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPV 1942

  Fly  2391 LHALVKHVLGHVEETDNFKQLQE-QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKE 2454
            :.|...|.          :.||| :|:.     :.....|..|:|......:..|:..|...   
Human  1943 VPASAPHP----------RPLQEVEMET-----YGAGTPLGSVASVHSPPAESCASLQIPLA--- 1989

  Fly  2455 YLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACS---SRASSRKSSRASDA 2516
                               .|||......|.||       |.||||.|   ||...|:.:..:|:
Human  1990 -------------------VSSPARSGEPLHAL-------SPRGTARSPSLSRLLCRQEAVHTDS 2028

  Fly  2517 --------SDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNF 2573
                    .|..:.|.|....|:..|:                  :|......||:.|..|... 
Human  2029 LEGKIDSPRDTLDPAEPGEKTPVRPVT------------------QGGSLQSPPRSPRPASVRT- 2074

  Fly  2574 FLRH---QDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSD 2635
             .:|   |..|.....:|......|.:......|:..|::.....||........|.|....|..
Human  2075 -RKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLR 2138

  Fly  2636 RHQAVGG-------GSAPSRKRASSFIRKKPPLER---GLSAQSALRVNKNAFVSEASAPEVIVT 2690
            |..:|..       |.|..:.|.|:.:....|.|.   |..|:.||...:...:|    |..|..
Human  2139 RLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMS----PPCISV 2199

  Fly  2691 RPSPEQQTHPHSLSLRPDNATLVHVLVHRES---EEYKEEDESSPSVSGNGNGFGVGLDMLSKQP 2752
            .|..|.:.     |.||..|......:.|.:   |.....|...|:     .|.|.|.|..:|..
Human  2200 EPPAEDEG-----SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPT-----EGSGAGGDPAAKGE 2254

  Fly  2753 PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDTSQVFYDY 2817
                  ..|......:...:|:               |:..|: |:|.|     .||.   |.|.
Human  2255 ------RWGQASCRAEHLTVPS---------------FAFEPL-DLGVP-----SGDP---FLDG 2289

  Fly  2818 NPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSSTSSIRSCSSSSSS 2882
            :.....:.:.:........|. |:.:. .||..|   .|||  ||      ...::..|......
Human  2290 SHSVTPESRASSSGAIVPLEP-PESEPPMPVGDP---PEKR--RG------LYLTVPQCPLEKPG 2342

  Fly  2883 SAASAAAP 2890
            |.::..||
Human  2343 SPSATPAP 2350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 72/277 (26%)
Ion_trans 705..902 CDD:278921 67/206 (33%)
Ion_trans 1768..2019 CDD:278921 95/260 (37%)
Na_channel_gate 2009..2063 CDD:240441 9/63 (14%)
Ion_trans 2085..2320 CDD:278921 83/248 (33%)
GPHH 2331..2386 CDD:293510 12/61 (20%)
CACNA1HXP_006721026.1 Ion_trans 149..430 CDD:278921 79/289 (27%)
Ion_trans 810..1019 CDD:278921 71/219 (32%)
Ion_trans 1317..1565 CDD:278921 94/253 (37%)
Ion_trans 1639..1852 CDD:278921 80/222 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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