Protein Alignment NaCP60E and CACNA1H

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_006721026.1
• Gene: CACNA1H / 8912
• HGNCID: 1395
• Length: 2358
• Species: Homo sapiens
• Alignment Length: 3063
• Identity: 661/3063 - (21%)
• Similarity: 1062/3063 - (34%)
• Gaps: 1090/3063 - (35%)

  Fly   116 RRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVI 166
            |..|:.:..|.:|::..|..|:.||:.|.|....|:.|              :|| |.:::||||
Human    90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFAVEMVI 153

  Fly   167 KIIAKGFLLNKYTYLRNPWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGL 228
            |::|.| |..:..||.:.||.|||.::.:|   |:..|..| :|:.:||.||||.|:.::.:|.:
Human   154 KMVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV-SLSAIRTVRVLRPLRAINRVPSM 216

  Fly   229 KTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKC------VRQ------VPTDWT 281
            :.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|      ||.      .|...|
Human   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQT 281

  Fly   282 NVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARH----CPFEY-------------------- 322
            .....:..|..:..||.:..       |.::.|.|.    |...:
Human   282 EEGEENPFICSSRRDNGMQK-------CSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACIN 339

  Fly   323 ------VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVF 381
                  ||.....||::|..||||..::.:..||:|||:.|.::...|:......:..:|.:::.
Human   340 WNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLII 404

  Fly   382 FGSFYLINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTF-SFDPSVLNVKKLNK---N 438
            .|||::|||.|.|:|..:.|    |:::..|:|.:.|   .:|||. ||.......::|.|   :
Human   405 VGSFFMINLCLVVIATQFSETKQRESQLMREQRARHL---SNDSTLASFSEPGSCYEELLKYVGH 466

  Fly   439 NKKKIDSRKGVLLASYSKKKTR-RKKTKGGKEGGTNGNGNGSNGDDNKSHSAT------------ 490
            ..:|:..|.   |..|::.::| |||.   ......|.|.|........|:|:
Human   467 IFRKVKRRS---LRLYARWQSRWRKKV---DPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHH 525

  Fly   491 ---------------PSPG------------PSPRHSATERPSALTMQA--------QKQYQQME 520
                           |.||            |||.......|.|.::.:        :...::..
Human   526 HHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERAR 590

  Fly   521 QQHKLA---------------------KSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSD 564
            ..|..|                     .||.|......:|.|||:.:....|.|...|
Human   591 VAHAAATAAASLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGP------- 648

  Fly   565 YKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVS----------------TV 613
                |..||..|           .:....||.:|   ......||:|                |.
Human   649 ----LSLNSPDP-----------YEKIPHVVGEH---GLGQAPGHLSGLSVPCPLPSPPAGTLTC 695

  Fly   614 ELALSPREVRLIK-CNGNIARIKN-----HNVYALHQEFSSEVVVIDDLPDRNCDRCVHW----- 667
            ||...|...|.:: ..|.::..::     ..||    ||:.:|        |:.||   |
Human   696 ELKSCPYCTRALEDPEGELSGSESGDSDGRGVY----EFTQDV--------RHGDR---WDPTRP 745

  Fly   668 --CTDYES-------------------------WLQFQNCLYKVVRDPLFELAITLCIVLNTAFL 705
              .||...                         |:.|...|.::|....|...|.:.|::||..:
Human   746 PRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSM 810

  Fly   706 AMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSKDFFLCG--------WNIFDLLIVTAS 762
            .:|:|...|...|||::.|.||||:|..|.::||:|       ||        :||||.:||..|
Human   811 GVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLA-------CGPLGYIRNPYNIFDGIIVVIS 868

  Fly   763 LLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIG 827
            :.:|:.:...||||||..||||||||.:....::..|.:::.|:..:.....:|::.|:||:::|
Human   869 VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILG 933

  Fly   828 MQLFSKDYTPEKFDPDPVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAI 890
            |.||...::.:....|.|| |.||:....:.:.:|:||..| |...|::.|.:.....|    ..
Human   934 MHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAA----LY 994

  Fly   891 FLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKE 955
            |:..:..||:::.||.:|:|:..|.:|         |:.:                   |.|..|
Human   995 FVALMTFGNYVLFNLLVAILVEGFQAE---------GDAN-------------------RSDTDE 1031

  Fly   956 RKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQ 1020
                                             ||..|..|..||:|...::....:.
Human  1032 ---------------------------------DKTSVHFEEDFHKLRELQTTELKMC------- 1056

  Fly  1021 IPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTC 1085
                        .|.....|.|..:..|....:..|:.:..||.:|
Human  1057 ------------SLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS------------------- 1090

  Fly  1086 QNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQR-------S 1143
               :||:.|...|.            |||             :.:|:..||...||:       |
Human  1091 ---SPFLDAAPSLP------------DSR-------------RGSSSSGDPPLGDQKPPASLRSS 1127

  Fly  1144 GCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEE 1208
            .|..:....:.   ||||            ...|.|.|:||.:
Human  1128 PCAPWGPSGAW---SSRR------------SSWSSLGRAPSLK---------------------- 1155

  Fly  1209 AEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMR 1273
               ||...|        |::.|||.:|                         ||
Human  1156 ---RRGQCG--------ERESLLSGEG-------------------------KG----------- 1173

  Fly  1274 SRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIM 1338
                                       |.:.|.|:             ..:.|.|.|
Human  1174 ---------------------------STDDEAED-------------GRAAPGPRA-------- 1190

  Fly  1339 EHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDED 1403
                               .||            ||::|
Human  1191 -------------------TPL------------RRAES-------------------------- 1198

  Fly  1404 FSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERV 1468
                                                         :||
Human  1199 ---------------------------------------------LDP----------------- 1201

  Fly  1469 EEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPAT 1533
                   :|:.                                                ||  |.
Human  1202 -------RPLR------------------------------------------------PA--AL 1209

  Fly  1534 PPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQR 1598
            |||..:.                             ....:.|.|:...
Human  1210 PPTKCRD-----------------------------RDGQVVALPSDFF---------------- 1229

  Fly  1599 RRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTE 1663
                              .|.:||...||:..           :.|:.:.
Human  1230 ------------------LRIDSHREDAAELD-----------DDSEDSC--------------- 1250

  Fly  1664 KPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC 1728
                ||                               :..||.:...||.|..    |..|.:..
Human  1251 ----CL-------------------------------RLHKVLEPYKPQWCRS----REAWALYL 1276

  Fly  1729 MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFC 1793
            ...|:     |.|.:...|:....|:..|||.||.:.:|:..|..::|...|.:..|...|:.|.
Human  1277 FSPQN-----RFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFT 1336

  Fly  1794 LIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTL 1849
            .|||.||::|.:|||.    ..|..|.|.:||.::|.||:..:::.     ..:.|.|||.||.|
Human  1337 AIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLL 1401

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL 1914
            |.|||||.|||..|:::||..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|..
Human  1402 RTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEG----- 1461

  Fly  1915 LPIT-EVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQR 1978
             |.| .::.|..|...:|.|:..|..||::|...::|..:::.:||:.:|.|.:||.|||.||.:
Human  1462 -PDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525

  Fly  1979 EANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGR 2043
            ..|.:..:||:.|::..|||.||:|:||:::||:..::..|.       .|:::.....:::|.|
Human  1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA-------EEARRREEKRLRRLER 1583

  Fly  2044 KKPQKVI----------KRPINHFLAMFYDLSNSRR----------FEIAIFVLIFLNMLTMGIE 2088
            ::..|.:          :||      .:.|.|.:||          .::.|..:|.:|::||.:|
Human  1584 RRRSKALPVAVAVAEAQRRP------YYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSME 1642

  Fly  2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM 2152
            ||:||.::...|:..|..||.||..||.:|:|...: .:|...||..|..:||.|:.||.:|:|.
Human  1643 HYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1707

  Fly  2153 ID--LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILG 2215
            :.  |||:||::|::||.||.|:|:|:|.|.|:|.||..:|.:||.:.|:|.|..|:.||||.||
Human  1708 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALG 1772

  Fly  2216 MSLFGNVKLQ-----GALDDMVNFQTFGRSMQLLFRLMTSAGWN----DVLESLMIQPPDCDPFI 2271
            :.|||.::..     ..|.....|..||.:...|||:.|...||    |.|.....:...|..::
Human  1773 VELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYL 1837

  Fly  2272 HGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQE--EEIGI-VEDDLEMFYI 2333
                      |.|:..||.:|::::..:::|:.:|:::::..::::|  |:..: .|.:|||
Human  1838 ----------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--- 1889

  Fly  2334 RWSKYDPHATQFIHFSQLSDFIASLDPPL------GISKPNNVA-LVSFNLPISKGNKIHCL-DI 2390
               ...|.:.:.:...:         |||      ....||.|| .||.:..:|..|..:.. .:
Human  1890 ---AQGPGSARRVDADR---------PPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPV 1942

  Fly  2391 LHALVKHVLGHVEETDNFKQLQE-QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKE 2454
            :.|...|.          :.||| :|:.     :.....|..|:|......:..|:..|...
Human  1943 VPASAPHP----------RPLQEVEMET-----YGAGTPLGSVASVHSPPAESCASLQIPLA--- 1989

  Fly  2455 YLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACS---SRASSRKSSRASDA 2516
                               .|||......|.||       |.||||.|   ||...|:.:..:|:
Human  1990 -------------------VSSPARSGEPLHAL-------SPRGTARSPSLSRLLCRQEAVHTDS 2028

  Fly  2517 --------SDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNF 2573
                    .|..:.|.|....|:..|:                  :|......||:.|..|...
Human  2029 LEGKIDSPRDTLDPAEPGEKTPVRPVT------------------QGGSLQSPPRSPRPASVRT- 2074

  Fly  2574 FLRH---QDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSD 2635
             .:|   |..|.....:|......|.:......|:..|::.....||........|.|....|..
Human  2075 -RKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLR 2138

  Fly  2636 RHQAVGG-------GSAPSRKRASSFIRKKPPLER---GLSAQSALRVNKNAFVSEASAPEVIVT 2690
            |..:|..       |.|..:.|.|:.:....|.|.   |..|:.||...:...:|    |..|..
Human  2139 RLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMS----PPCISV 2199

  Fly  2691 RPSPEQQTHPHSLSLRPDNATLVHVLVHRES---EEYKEEDESSPSVSGNGNGFGVGLDMLSKQP 2752
            .|..|.:.     |.||..|......:.|.:   |.....|...|:     .|.|.|.|..:|..
Human  2200 EPPAEDEG-----SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPT-----EGSGAGGDPAAKGE 2254

  Fly  2753 PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDTSQVFYDY 2817
                  ..|......:...:|:               |:..|: |:|.|     .||.   |.|.
Human  2255 ------RWGQASCRAEHLTVPS---------------FAFEPL-DLGVP-----SGDP---FLDG 2289

  Fly  2818 NPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSSTSSIRSCSSSSSS 2882
            :.....:.:.:........|. |:.:...||..|   .|||  ||      ...::..|......
Human  2290 SHSVTPESRASSSGAIVPLEP-PESEPPMPVGDP---PEKR--RG------LYLTVPQCPLEKPG 2342

  Fly  2883 SAASAAAP 2890
            |.::..||
Human  2343 SPSATPAP 2350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	81/304 (27%)
		Ion_trans	687..902	CDD:459842	72/224 (32%)
		Ion_trans	1751..2019	CDD:459842	102/277 (37%)
		Na_channel_gate	2009..2063	CDD:240441	9/63 (14%)
		Ion_trans	2067..2320	CDD:459842	89/276 (32%)
		GPHH	2332..2378	CDD:465306	10/52 (19%)
CACNA1H	XP_006721026.1	Ion_trans	99..430	CDD:459842	92/340 (27%)
		Ion_trans	792..1019	CDD:459842	76/237 (32%)
		Ion_trans	1293..1565	CDD:459842	102/277 (37%)
		Ion_trans	1621..1852	CDD:459842	84/240 (35%)
		PHA03247	<1890..2357	CDD:223021	116/590 (20%)