DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and CACNA1I

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_066919.2 Gene:CACNA1I / 8911 HGNCID:1396 Length:2223 Species:Homo sapiens


Alignment Length:2937 Identity:627/2937 - (21%)
Similarity:1019/2937 - (34%) Gaps:1063/2937 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEA--------------EYIFLAIYSIE 163
            || |..|:.:..|.:|:...|..||.||:.|.|.:..::.              ::||: .:::|
Human    67 SP-RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAME 129

  Fly   164 MVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVG--NLAGLRTFRVLRALKTVSIMP 226
            ||:|::|.| :..|..||.:.||.|||.::.:|.....:::.  ||:.:||.||||.||.::.:|
Human   130 MVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVP 193

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW 291
            .::.::|.||.:...|..|:.|..|...:|.:..:|::.|.|||:|..:                
Human   194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLE---------------- 242

  Fly   292 VNDTDNWLY-------------DEDELPVLCGNLTG----------------ARHC--------- 318
                :|:..             ::||:|.:| :|:|                .|.|         
Human   243 ----ENFTIQGDVALPPYYQPEEDDEMPFIC-SLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYD 302

  Fly   319 ------------------PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVL 365
                              .:..||.....||:.|..||||..::.:..||:|||:.|..:...|:
Human   303 FGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367

  Fly   366 ATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTFS-- 424
            ......:..:|.:::..|||::|||.|.|:|..:.|    |..:..|:|::.|    ..||.:  
Human   368 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL----SSSTVASY 428

  Fly   425 ------FDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRK--------------------- 462
                  ::.....|..:.:..|::       .|..|...::||:                     
Human   429 AEPGDCYEEIFQYVCHILRKAKRR-------ALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRH 486

  Fly   463 ---KTKG-GKEGGTNG-------NGNGSNGDDNKSHSATPSPGP---SPRHSATERPSALTMQAQ 513
               |||| |.||...|       :|..|.|:|:......|...|   :|.......|:.|     
Human   487 YHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPATL----- 546

  Fly   514 KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSS 578
                           .|..::.|......||   :.||:|                ..:|||..|
Human   547 ---------------ASDPASCPCCQHEDGR---RPSGLG----------------STDSGQEGS 577

  Fly   579 NS-SGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYAL 642
            .| |....|...|..|.  ...|...::::|.                                 
Human   578 GSGSSAGGEDEADGDGA--RSSEDGASSELGK--------------------------------- 607

  Fly   643 HQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAM 707
                       ::..:...|..|..|.|.  |.:.:..|..:|....|...|.:.|::||..:.:
Human   608 -----------EEEEEEQADGAVWLCGDV--WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI 659

  Fly   708 EHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELV 771
            |||...|...|.|::.|.||||:|..|.|:||.|... |:....:||||.:||..|:.:|:.:..
Human   660 EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQAD 724

  Fly   772 DGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYT 836
            .||||||..||||||||.:....::..|.:::.|:..:....::|::.|:||:::||.:|...::
Human   725 GGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789

  Fly   837 PEKFDPDPVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGAST---CFAIFLPTLV 896
            ......|.|| |.||:....:.:.:|:||..| |...|::.|       |||   ....|:..:.
Human   790 LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-------ASTSPWASLYFVALMT 847

  Fly   897 MGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEK 961
            .||:::.||.:|:|:..|.:|.                                           
Human   848 FGNYVLFNLLVAILVEGFQAEG------------------------------------------- 869

  Fly   962 FQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDG 1026
                  ||.::::.  ..|::..:|..||                                |.:|
Human   870 ------DANRSYSD--EDQSSSNIEEFDK--------------------------------LQEG 894

  Fly  1027 LHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPF 1091
            |         |.:|| |:...:...|......|:|          .||........|....|   
Human   895 L---------DSSGD-PKLCPIPMTPNGHLDPSLP----------LGGHLGPAGAAGPAPRL--- 936

  Fly  1092 VQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQD 1156
                                                   |...||                    
Human   937 ---------------------------------------SLQPDP-------------------- 942

  Fly  1157 NSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLN 1221
                                 :|....|                            |.||..||.
Human   943 ---------------------MLVALGS----------------------------RKSSVMSLG 958

  Fly  1222 SMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPEN 1286
            .||.:|..|.|.:                                           ||..| |..
Human   959 RMSYDQRSLSSSR-------------------------------------------SSYYG-PWG 979

  Fly  1287 ETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLS--NLSEPSPAADEATKAIMEHIAIITGASE 1349
                                    ||.....|:.|  :|....|:|        ||.:::  ::|
Human   980 ------------------------RSAAWASRRSSWNSLKHKPPSA--------EHESLL--SAE 1010

  Fly  1350 RSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKIC 1414
            |...                                                         .::|
Human  1011 RGGG---------------------------------------------------------ARVC 1018

  Fly  1415 DQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPIS 1479
            :                .:|.:..|..:|                                    
Human  1019 E----------------VAADEGPPRAAP------------------------------------ 1031

  Fly  1480 TLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEP 1544
                         ||.|                                                
Human  1032 -------------LHTP------------------------------------------------ 1035

  Fly  1545 PTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLD 1609
                                |..|.|     ..|..||.|.|          .||.:     :||
Human  1036 --------------------HAHHIH-----HGPHLAHRHRH----------HRRTL-----SLD 1060

  Fly  1610 KAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVD 1674
            ...|...|.... :.||...::..|...|...|......|...:  ..||::.::          
Human  1061 NRDSVDLAELVP-AVGAHPRAAWRAAGPAPGHEDCNGRMPSIAK--DVFTKMGDR---------- 1112

  Fly  1675 DLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTR 1739
                |.|...:...:..:.|      :..|:.|...|..|    ..|..|.:.....::     |
Human  1113 ----GDRGEDEEEIDYTLCF------RVRKMIDVYKPDWC----EVREDWSVYLFSPEN-----R 1158

  Fly  1740 VRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKW 1804
            .|....|::....|::.||..||.:.||:..|...::...|.:..|...|:.|..|||.||.||.
Human  1159 FRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV 1223

  Fly  1805 LALGF----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISR 1860
            ::||.    ..|..|.|.:||..:||||:..:::.     ..:.|.|||.||.||.|||||.|||
Human  1224 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISR 1288

  Fly  1861 WQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWD 1925
            ..|:::||..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|:.     :....:.::.|
Human  1289 APGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-----VDTRNITNRSD 1348

  Fly  1926 CIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
            |:..||.|::.|..||::|...::|..:|:.:||:.:|.:.:||..||.||....|.:..:||:.
Human  1349 CMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFIS 1413

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPIN 2055
            |::..|||.||:|:||:::||:..::..|.       .|:::.....:::| .||.:|..:.|..
Human  1414 FLLIVSFFVLNMFVGVVVENFHKCRQHQEA-------EEARRREEKRLRRL-EKKRRKAQRLPYY 1470

  Fly  2056 ----HFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
                |...:.:.:..|...:|.|..:|.||::||.:|||:||.::...|:..|..|||||.|||:
Human  1471 ATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV 1535

  Fly  2117 VKIV--GLRYHYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLI 2177
            :|:|  ||| .:|...||..|..:||.|:.||.:|:|.|:  |||:||::|::||.||.|:|:|:
Human  1536 LKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLL 1599

  Fly  2178 KAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQG-----ALDDMVNFQTF 2237
            |.|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.:....     .:.....|:.|
Human  1600 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENF 1664

  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAIT--YFTSFIIISYMIV 2300
            |.:...||::.|...||.:::..:   .||.     |...:|...|..::  ||.||::.:..::
Human  1665 GMAFLTLFQVSTGDNWNGIMKDTL---RDCT-----HDERSCLSSLQFVSPLYFVSFVLTAQFVL 1721

  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365
            ||:.:|:::::.:.:::|     .::|.||                      |....|:...|:.
Human  1722 INVVVAVLMKHLDDSNKE-----AQEDAEM----------------------DAELELEMAHGLG 1759

  Fly  2366 KPNNVALVSFNLP---------------------ISKGNKIHCLDILHALVKHVL-GHVEETDN- 2407
            ....:...|...|                     .|...:...||.:..::|..| |.:...|| 
Human  1760 PGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNL 1824

  Fly  2408 ----FKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS- 2467
                |.........  ||....::|:::.         |..|.::.:            :||:| 
Human  1825 SGSIFHHYSSPAGC--KKCHHDKQEVQLA---------ETEAFSLNS------------DRSSSI 1866

  Fly  2468 --GDSAT---QTSSPGGWQSKLSALN-------------FFHLQVSRRGTACSSRASS------- 2507
              ||..:   .|:.|.|.:.....|:             ||.|.    .||.|....:       
Human  1867 LLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLS----STAVSPDPENFLCEMEE 1927

  Fly  2508 -----------RKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGK-RGSIFVE 2560
                       ..||:|..:....:.:.|.|.:|......|    ....|:..|.|. .|::   
Human  1928 IPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPA----VSASQKGPEKGTGTGTL--- 1985

  Fly  2561 APRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTAT------- 2618
             |:.:.:.|:            .||.||.|:.......|.:.||..||.|.:|.|..|       
Human  1986 -PKIALQGSW------------ASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLT 2037

  Fly  2619 ---APATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVS 2680
               :|....||.|.:....       .|.:|:.:|..|.      ..|||.:...||.::.:..|
Human  2038 LSDSPRRALGPPAPAPGPR-------AGLSPAARRRLSL------RGRGLFSLRGLRAHQRSHSS 2089

  Fly  2681 EASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVG- 2744
            ..|      |.|.   .||..|:                        |.|.....|...|.|.| 
Human  2090 GGS------TSPG---CTHHDSM------------------------DPSDEEGRGGAGGGGAGS 2121

  Fly  2745 -----LDMLS-------KQPPPQIRITTGSVESSMDTCAMP--------------TVQIMVDSPK 2783
                 |..||       ..|||...:|.....||..:.|.|              :.....|..|
Human  2122 EHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSK 2186

  Fly  2784 DPPRGDFSSAPI 2795
            |||    ..||:
Human  2187 DPP----GRAPL 2194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 67/290 (23%)
Ion_trans 705..902 CDD:278921 68/202 (34%)
Ion_trans 1768..2019 CDD:278921 93/259 (36%)
Na_channel_gate 2009..2063 CDD:240441 10/57 (18%)
Ion_trans 2085..2320 CDD:278921 89/245 (36%)
GPHH 2331..2386 CDD:293510 6/75 (8%)
CACNA1INP_066919.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
I 66..401 90/357 (25%)
Ion_trans 127..409 CDD:278921 76/303 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..536 14/68 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 16/125 (13%)
II 626..865 80/245 (33%)
Ion_trans 657..866 CDD:278921 72/215 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..936 9/47 (19%)
III 1157..1434 101/286 (35%)
Ion_trans 1202..1441 CDD:278921 91/243 (37%)
IV 1472..1733 96/269 (36%)
Ion_trans 1504..1741 CDD:278921 89/250 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1758..1784 2/25 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1897 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1937..1960 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2062 13/55 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2076..2223 33/156 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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