Protein Alignment NaCP60E and CACNA1I

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_066919.2
• Gene: CACNA1I / 8911
• HGNCID: 1396
• Length: 2223
• Species: Homo sapiens
• Alignment Length: 2937
• Identity: 627/2937 - (21%)
• Similarity: 1019/2937 - (34%)
• Gaps: 1063/2937 - (36%)

  Fly   113 SPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEA--------------EYIFLAIYSIE 163
            || |..|:.:..|.:|:...|..||.||:.|.|.:..::.              ::||: .:::|
Human    67 SP-RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAME 129

  Fly   164 MVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVG--NLAGLRTFRVLRALKTVSIMP 226
            ||:|::|.| :..|..||.:.||.|||.::.:|.....:::.  ||:.:||.||||.||.::.:|
Human   130 MVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVP 193

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW 291
            .::.::|.||.:...|..|:.|..|...:|.:..:|::.|.|||:|..:
Human   194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLE---------------- 242

  Fly   292 VNDTDNWLY-------------DEDELPVLCGNLTG----------------ARHC--------- 318
                :|:..             ::||:|.:| :|:|                .|.|
Human   243 ----ENFTIQGDVALPPYYQPEEDDEMPFIC-SLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYD 302

  Fly   319 ------------------PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVL 365
                              .:..||.....||:.|..||||..::.:..||:|||:.|..:...|:
Human   303 FGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367

  Fly   366 ATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTFS-- 424
            ......:..:|.:::..|||::|||.|.|:|..:.|    |..:..|:|::.|    ..||.:
Human   368 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL----SSSTVASY 428

  Fly   425 ------FDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRK--------------------- 462
                  ::.....|..:.:..|::       .|..|...::||:
Human   429 AEPGDCYEEIFQYVCHILRKAKRR-------ALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRH 486

  Fly   463 ---KTKG-GKEGGTNG-------NGNGSNGDDNKSHSATPSPGP---SPRHSATERPSALTMQAQ 513
               |||| |.||...|       :|..|.|:|:......|...|   :|.......|:.|
Human   487 YHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPATL----- 546

  Fly   514 KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSS 578
                           .|..::.|......||   :.||:|                ..:|||..|
Human   547 ---------------ASDPASCPCCQHEDGR---RPSGLG----------------STDSGQEGS 577

  Fly   579 NS-SGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYAL 642
            .| |....|...|..|.  ...|...::::|.
Human   578 GSGSSAGGEDEADGDGA--RSSEDGASSELGK--------------------------------- 607

  Fly   643 HQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAM 707
                       ::..:...|..|..|.|.  |.:.:..|..:|....|...|.:.|::||..:.:
Human   608 -----------EEEEEEQADGAVWLCGDV--WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI 659

  Fly   708 EHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELV 771
            |||...|...|.|::.|.||||:|..|.|:||.|... |:....:||||.:||..|:.:|:.:..
Human   660 EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQAD 724

  Fly   772 DGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYT 836
            .||||||..||||||||.:....::..|.:::.|:..:....::|::.|:||:::||.:|...::
Human   725 GGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789

  Fly   837 PEKFDPDPVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGAST---CFAIFLPTLV 896
            ......|.|| |.||:....:.:.:|:||..| |...|::.|       |||   ....|:..:.
Human   790 LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-------ASTSPWASLYFVALMT 847

  Fly   897 MGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEK 961
            .||:::.||.:|:|:..|.:|.
Human   848 FGNYVLFNLLVAILVEGFQAEG------------------------------------------- 869

  Fly   962 FQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDG 1026
                  ||.::::.  ..|::..:|..||                                |.:|
Human   870 ------DANRSYSD--EDQSSSNIEEFDK--------------------------------LQEG 894

  Fly  1027 LHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPF 1091
            |         |.:|| |:...:...|......|:|          .||........|....|
Human   895 L---------DSSGD-PKLCPIPMTPNGHLDPSLP----------LGGHLGPAGAAGPAPRL--- 936

  Fly  1092 VQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQD 1156
                                                   |...||
Human   937 ---------------------------------------SLQPDP-------------------- 942

  Fly  1157 NSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLN 1221
                                 :|....|                            |.||..||.
Human   943 ---------------------MLVALGS----------------------------RKSSVMSLG 958

  Fly  1222 SMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPEN 1286
            .||.:|..|.|.:                                           ||..| |..
Human   959 RMSYDQRSLSSSR-------------------------------------------SSYYG-PWG 979

  Fly  1287 ETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLS--NLSEPSPAADEATKAIMEHIAIITGASE 1349
                                    ||.....|:.|  :|....|:|        ||.:::  ::|
Human   980 ------------------------RSAAWASRRSSWNSLKHKPPSA--------EHESLL--SAE 1010

  Fly  1350 RSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKIC 1414
            |...                                                         .::|
Human  1011 RGGG---------------------------------------------------------ARVC 1018

  Fly  1415 DQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPIS 1479
            :                .:|.:..|..:|
Human  1019 E----------------VAADEGPPRAAP------------------------------------ 1031

  Fly  1480 TLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEP 1544
                         ||.|
Human  1032 -------------LHTP------------------------------------------------ 1035

  Fly  1545 PTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLD 1609
                                |..|.|     ..|..||.|.|          .||.:     :||
Human  1036 --------------------HAHHIH-----HGPHLAHRHRH----------HRRTL-----SLD 1060

  Fly  1610 KAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVD 1674
            ...|...|.... :.||...::..|...|...|......|...:  ..||::.::
Human  1061 NRDSVDLAELVP-AVGAHPRAAWRAAGPAPGHEDCNGRMPSIAK--DVFTKMGDR---------- 1112

  Fly  1675 DLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTR 1739
                |.|...:...:..:.|      :..|:.|...|..|    ..|..|.:.....::     |
Human  1113 ----GDRGEDEEEIDYTLCF------RVRKMIDVYKPDWC----EVREDWSVYLFSPEN-----R 1158

  Fly  1740 VRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKW 1804
            .|....|::....|::.||..||.:.||:..|...::...|.:..|...|:.|..|||.||.||.
Human  1159 FRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV 1223

  Fly  1805 LALGF----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISR 1860
            ::||.    ..|..|.|.:||..:||||:..:::.     ..:.|.|||.||.||.|||||.|||
Human  1224 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISR 1288

  Fly  1861 WQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWD 1925
            ..|:::||..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|:.     :....:.::.|
Human  1289 APGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-----VDTRNITNRSD 1348

  Fly  1926 CIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
            |:..||.|::.|..||::|...::|..:|:.:||:.:|.:.:||..||.||....|.:..:||:.
Human  1349 CMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFIS 1413

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPIN 2055
            |::..|||.||:|:||:::||:..::..|.       .|:::.....:::| .||.:|..:.|..
Human  1414 FLLIVSFFVLNMFVGVVVENFHKCRQHQEA-------EEARRREEKRLRRL-EKKRRKAQRLPYY 1470

  Fly  2056 ----HFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
                |...:.:.:..|...:|.|..:|.||::||.:|||:||.::...|:..|..|||||.|||:
Human  1471 ATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV 1535

  Fly  2117 VKIV--GLRYHYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLI 2177
            :|:|  ||| .:|...||..|..:||.|:.||.:|:|.|:  |||:||::|::||.||.|:|:|:
Human  1536 LKLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLL 1599

  Fly  2178 KAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQG-----ALDDMVNFQTF 2237
            |.|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.:....     .:.....|:.|
Human  1600 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENF 1664

  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAIT--YFTSFIIISYMIV 2300
            |.:...||::.|...||.:::..:   .||.     |...:|...|..::  ||.||::.:..::
Human  1665 GMAFLTLFQVSTGDNWNGIMKDTL---RDCT-----HDERSCLSSLQFVSPLYFVSFVLTAQFVL 1721

  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365
            ||:.:|:::::.:.:::|     .::|.||                      |....|:...|:.
Human  1722 INVVVAVLMKHLDDSNKE-----AQEDAEM----------------------DAELELEMAHGLG 1759

  Fly  2366 KPNNVALVSFNLP---------------------ISKGNKIHCLDILHALVKHVL-GHVEETDN- 2407
            ....:...|...|                     .|...:...||.:..::|..| |.:...||
Human  1760 PGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNL 1824

  Fly  2408 ----FKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS- 2467
                |.........  ||....::|:::.         |..|.::.:            :||:|
Human  1825 SGSIFHHYSSPAGC--KKCHHDKQEVQLA---------ETEAFSLNS------------DRSSSI 1866

  Fly  2468 --GDSAT---QTSSPGGWQSKLSALN-------------FFHLQVSRRGTACSSRASS------- 2507
              ||..:   .|:.|.|.:.....|:             ||.|.    .||.|....:
Human  1867 LLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLS----STAVSPDPENFLCEMEE 1927

  Fly  2508 -----------RKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGK-RGSIFVE 2560
                       ..||:|..:....:.:.|.|.:|......|    ....|:..|.|. .|::
Human  1928 IPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPA----VSASQKGPEKGTGTGTL--- 1985

  Fly  2561 APRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTAT------- 2618
             |:.:.:.|:            .||.||.|:.......|.:.||..||.|.:|.|..|
Human  1986 -PKIALQGSW------------ASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLT 2037

  Fly  2619 ---APATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVS 2680
               :|....||.|.:....       .|.:|:.:|..|.      ..|||.:...||.::.:..|
Human  2038 LSDSPRRALGPPAPAPGPR-------AGLSPAARRRLSL------RGRGLFSLRGLRAHQRSHSS 2089

  Fly  2681 EASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVG- 2744
            ..|      |.|.   .||..|:                        |.|.....|...|.|.|
Human  2090 GGS------TSPG---CTHHDSM------------------------DPSDEEGRGGAGGGGAGS 2121

  Fly  2745 -----LDMLS-------KQPPPQIRITTGSVESSMDTCAMP--------------TVQIMVDSPK 2783
                 |..||       ..|||...:|.....||..:.|.|              :.....|..|
Human  2122 EHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSK 2186

  Fly  2784 DPPRGDFSSAPI 2795
            |||    ..||:
Human  2187 DPP----GRAPL 2194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	76/317 (24%)
		Ion_trans	687..902	CDD:459842	73/220 (33%)
		Ion_trans	1751..2019	CDD:459842	100/276 (36%)
		Na_channel_gate	2009..2063	CDD:240441	10/57 (18%)
		Ion_trans	2067..2320	CDD:459842	96/263 (37%)
		GPHH	2332..2378	CDD:465306	4/45 (9%)
CACNA1I	NP_066919.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		I	66..401		90/357 (25%)
		Ion_trans	78..409	CDD:459842	87/353 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	467..536		14/68 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..616		16/125 (13%)
		II	626..865		80/245 (33%)
		Ion_trans	639..866	CDD:459842	77/233 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	899..936		9/47 (19%)
		III	1157..1434		101/286 (35%)
		Ion_trans	1169..1441	CDD:459842	100/276 (36%)
		IV	1472..1733		96/269 (36%)
		Ion_trans	1486..1741	CDD:459842	96/268 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1758..1784		2/25 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1868..1897		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1937..1960		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2013..2062		13/55 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2076..2223		33/156 (21%)