DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaCP60E and TPC1

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_567258.1	Gene:	TPC1 / 825655	AraportID:	AT4G03560	Length:	733	Species:	Arabidopsis thaliana

Alignment Length:	672	Identity:	136/672 - (20%)
Similarity:	242/672 - (36%)	Gaps:	209/672 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1810 SKYFTSF------WTILDFIIVFVSVFS--LLIEENEN--------------------LKVLRSL 1846
            ::|:..|      |::..|.::|::.|.  |..|:|..                    ..::..:
plant    61 ARYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEV 125

  Fly  1847 RTLRALR-----PLRAISRWQGMRIVVNALMYAIPSIFNVLLV--CLVFWLIFSIMGVQFFGGKF 1904
            .||..|.     |:    .::|.||...:.:..:.....|:|.  .||.:|..|.:...|...:.
plant   126 ITLAILLVHTFFPI----SYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYLSPLAFDFLPFRI 186

  Fly  1905 FKCVNEMGELLPITEVNDKWDCIEQNY-TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVD 1968
            ...|..:..:|.|.|:.|....:.... |::|.      :.:..|.||    |..|:..:.....
plant   187 APYVRVIIFILSIRELRDTLVLLSGMLGTYLNI------LALWMLFLL----FASWIAFVMFEDT 241

  Fly  1969 ARGVDLQPQREANLY-----------------AY-------IYFVIFIVCGSFFTLNLFIGVIID 2009
            .:|:.:.....|.||                 ||       ::||::::.|.:|..||.:.|:.|
plant   242 QQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYD 306

  Fly  2010 NFNMLKKKYEGGVLEM---------FLTESQKH----------------YYTAMKKLGRKKPQKV 2049
            :|.....|...|:.:|         .|.:|.|:                .|..:.|:.:::
plant   307 SFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEE---- 367

  Fly  2050 IKRPINHFLAMFYDLSNSRRFEI----------AIFVLIFLNMLTMGIEHYDQ------------ 2092
                   |..:|.:|.::|.|:|          ||.:......:....||:.|
plant   368 -------FGLIFDELDDTRDFKINKDEFADLCQAIALRFQKEEVPSLFEHFPQIYHSALSQQLRA 425

  Fly  2093 -------PHAVFFIL------------------------EVSNAFFTTVFGLEAIVKIVGLRYHY 2126
                   .:|:.|||                        :|:...|..::.||..:||    |.|
plant   426 FVRSPNFGYAISFILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKI----YTY 486

  Fly  2127 -FTVPW----NVFDFLLVLASIFGILMEDIMIDLPISPTL------LRVVRVFRIGRILRLIKAA 2180
             |...|    |.||||:....:.|   |......|...|.      :|.:.:.|:.|::||:...
plant   487 GFENYWREGANRFDFLVTWVIVIG---ETATFITPDENTFFSNGEWIRYLLLARMLRLIRLLMNV 548

  Fly  2181 KGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF------GNVKL---QGALDD--MVNF 2234
            :..|..:...:..:|:|......:..:..||..:|:.:|      ||.||   :.|.||  :.||
plant   549 QRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNF 613

  Fly  2235 QTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMI 2299
            ..:...|..||.|:....|...:||            :....|.    ..:||||.||.:|:.::
plant   614 NDYPNGMVTLFNLLVMGNWQVWMES------------YKDLTGT----WWSITYFVSFYVITILL 662

  Fly  2300 VINMYIAIILEN-FNQAHQEEE 2320
            ::|:.:|.:||. |.:...|||
plant   663 LLNLVVAFVLEAFFTELDLEEE 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	51/268 (19%)
		Na_channel_gate	2009..2063	CDD:240441	12/78 (15%)
		Ion_trans	2085..2320	CDD:278921	68/300 (23%)
		GPHH	2331..2386	CDD:293510
TPC1	NP_567258.1	Ion_trans	124..311	CDD:278921	41/200 (21%)
		EFh	326..391	CDD:238008	11/75 (15%)
		EF-hand_7	327..392	CDD:290234	11/75 (15%)
		Ion_trans	456..675	CDD:278921	59/241 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I3264
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810