DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn1a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_110502.2 Gene:Scn1a / 81574 RGDID:69364 Length:2009 Species:Rattus norvegicus


Alignment Length:2555 Identity:813/2555 - (31%)
Similarity:1171/2555 - (45%) Gaps:798/2555 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|..|..:|||::|. :|.::||.|::|   ...|.||:.|.:|::
  Rat    49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|::|.|::.:.|..:..|...:|.|||.||:|:.|:   :..:..||.|..||:.|.:|||||
  Rat   111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.|..:|:||:|||||||.|||..|.|..:::||::.||||||||||||:|::||||||:.||
  Rat   176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHT-------------- 286
            :.|.::|::||.||:|||.||||..||::||.||||||:..||:.:...|:              
  Rat   241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNVTTDYNGTLV 305

  Fly   287 -------DWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343
                   ||:.::.|:....:.|..| .:||||.:.|..||..|:|:..|.|||:|||:||.|.|
  Rat   306 NETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370

  Fly   344 SMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408
            :.|:.|:|:|.|:|||:|.:.|...|...:.||.:|:|.||||||||:|||||::|||:.:.|.|
  Rat   371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435

  Fly   409 ERKK---------DLLDHRDD----------STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
            |.::         :.|..:.:          |..|.:||.......:.:...|:.|:      |.
  Rat   436 EAEQKEAEFQQMLEQLKKQQEAAQQAAAATASEHSREPSAAGRLSDSSSEASKLSSK------SA 494

  Fly   455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSAT-------------------------PSPG 494
            .:::.||||.|..::.|      |...||::.|.:.                         .||.
  Rat   495 KERRNRRKKRKQKEQSG------GEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPH 553

  Fly   495 P----------SPRHSATERPSALTMQAQ-----KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGR 544
            .          |||.::  |.|..:.:.:     .:....:.:|...:......::...|...|.
  Rat   554 QSLLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGE 616

  Fly   545 ISFQDSGMGVKNPNMLYPSDYKGQL---------IANSGQPSSNSSGVNR--------ESSQDDS 592
            ....:.....::..||......|::         ::..|.||..:|.|.:        :.:.||:
  Rat   617 RRNSNLSQTSRSSRMLAGLPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDN 681

  Fly   593 GVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLP 657
            |...:.|.:...:...|||...|....:..|.:    :||.|..:.|..|.:.            
  Rat   682 GTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------ 730

  Fly   658 DRNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMS 713
            .:.|..|.:        | |:.|  ||:.::.:..||.||..:||||:||||||.|:||||:.|:
  Rat   731 RQKCPPCWYKFSNIFLIWDCSPY--WLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMT 793

  Fly   714 ESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVL 777
            |.|.:.|.|||.|||.|||.|..:|::|:.. .:|..||||||..|||.||:::....|:|||||
  Rat   794 EHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVL 858

  Fly   778 RGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKF 840
            |..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.
  Rat   859 RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 923

  Fly   841 DPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLN 904
            ..| .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:|||
  Rat   924 ATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLN 985

  Fly   905 LFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDA 969
            |||||||:||:::.|.:..:: .|.:.|..:::|:...:...:        ||..|..||..:..
  Rat   986 LFLALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGVAYVK--------RKIYEFIQQSFVRK 1041

  Fly   970 QQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGL 1034
            |:                     :|.|.|                       ||.|         
  Rat  1042 QK---------------------ILDEIK-----------------------PLDD--------- 1053

  Fly  1035 EYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQ 1099
                                                        :|                   
  Rat  1054 --------------------------------------------LN------------------- 1055

  Fly  1100 HQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGS 1164
                                                             ||.|:...|.:...| 
  Rat  1056 -------------------------------------------------NRKDNCTSNHTTEIG- 1070

  Fly  1165 EEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDE 1229
                                  |.||.|...:|.:...            .:|.|:....|::.:
  Rat  1071 ----------------------KDLDCLKDVNGTTSGI------------GTGSSVEKYIIDESD 1101

  Fly  1230 LLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSE 1294
            .:|...|                                        ||..:..|   ..|..|:
  Rat  1102 YMSFINN----------------------------------------PSLTVTVP---IAVGESD 1123

  Fly  1295 FDNI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358
            |:|: .:.|..|        :.||.....|:|.|.:::.:|..|        ||           
  Rat  1124 FENLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA----------- 1161

  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423
                                                                             
  Rat  1162 ----------------------------------------------------------------- 1161

  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488
                                                            |.||:|:          
  Rat  1162 ------------------------------------------------PAEEQPV---------- 1168

  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553
                                                                             
  Rat  1169 ----------------------------------------------------------------- 1168

  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618
                                                           || |:.||:         
  Rat  1169 -----------------------------------------------ME-PEETLE--------- 1176

  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683
                                                                             
  Rat  1177 ----------------------------------------------------------------- 1176

  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVL 1745
                                  |:.||.:.|...  |:|     |   ::....|.|..:|....
  Rat  1177 ----------------------PEACFTEGCVQR--FKC-----CQISVEEGRGKQWWNLRRTCF 1212

  Fly  1746 TVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFS 1810
            .:|:...||.|::.:|..||..|.||||.:|:.||:|.:|.:.:..|..||::||:|||:|.|:.
  Rat  1213 RIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQ 1277

  Fly  1811 KYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMY 1873
            .|||:.|..|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.
  Rat  1278 TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLG 1342

  Fly  1874 AIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT-- 1932
            |||||.|||||||:||||||||||..|.|||:.||| ..|:...|||||:..||   ||:|.|  
  Rat  1343 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDTFEITEVNNHSDCLKLIERNETAR 1407

  Fly  1933 WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSF 1997
            |.|.|:.||:||.|||:|||||||:|||::|..|||:|.|:|||:.|.:||.|:||||||:.|||
  Rat  1408 WKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1472

  Fly  1998 FTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFY 2062
            |||||||||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:
  Rat  1473 FTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVF 1535

  Fly  2063 DLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYF 2127
            |....:.|:|:|.:||.|||:||.:|..||...|..||...|..|..:|..|.::|::.||::||
  Rat  1536 DFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYF 1600

  Fly  2128 TVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVV 2192
            |:.||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::
  Rat  1601 TIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM 1665

  Fly  2193 SLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVL 2257
            |||||||||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|
  Rat  1666 SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1730

  Fly  2258 ESLM-IQPPDCDPFIHGHTN------GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQA 2315
            ..:: .:||||||   ...|      |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|
  Rat  1731 APILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1792

  Fly  2316 HQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPIS 2380
            .:|....:.|||.||||..|.|:||.||||:.|.:||.|.|:|:|||.:.:||.:.|::.:||:.
  Rat  1793 TEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMV 1857

  Fly  2381 KGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAA 2445
            .|::|||||||.|..|.|||...|.|   .|:.||:.:|....|::...:.:::|...|::|.:|
  Rat  1858 SGDRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSA 1919

  Fly  2446 KTIQTGWKEYLRRKREKERS 2465
            ..||..::.:|.::..|:.|
  Rat  1920 VIIQRAYRRHLLKRTVKQAS 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 114/240 (48%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 158/258 (61%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/241 (52%)
GPHH 2331..2386 CDD:293510 25/54 (46%)
Scn1aNP_110502.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 3/10 (30%)
I. /evidence=ECO:0000305 110..454 151/343 (44%)
Ion_trans 127..433 CDD:395416 143/305 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..528 17/81 (21%)
Na_trans_cytopl 510..718 CDD:403218 33/219 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..628 3/43 (7%)
II. /evidence=ECO:0000305 750..1022 141/277 (51%)
Ion_trans 767..980 CDD:395416 117/215 (54%)
Na_trans_assoc 1006..1213 CDD:399489 68/824 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 11/173 (6%)
III. /evidence=ECO:0000305 1200..1514 179/315 (57%)
Ion_trans 1217..1492 CDD:395416 162/274 (59%)
Na_channel_gate 1484..1536 CDD:240441 32/53 (60%)
IV. /evidence=ECO:0000305 1523..1821 153/300 (51%)
Ion_trans 1540..1796 CDD:395416 133/258 (52%)
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1561..1571 4/9 (44%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1619..1636 4/16 (25%)
GPHH 1808..1855 CDD:407139 22/46 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1986..2009
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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