DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and scn8ab

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001038648.2 Gene:scn8ab / 793996 ZFINID:ZDB-GENE-060906-2 Length:1958 Species:Danio rerio


Alignment Length:2666 Identity:828/2666 - (31%)
Similarity:1191/2666 - (44%) Gaps:877/2666 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NDEKAVAKHQVVAYTQ-RSQVKH-----ENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEH 67
            |.||.:|:.:.....: ||...|     :|:           |:..:.:|.|..:|..:...|.:
Zfish    24 NIEKRIAEEKKKKPVKPRSDSSHRDDDDDNK-----------PKPNSDLEAGKGVPFIYGDVPSN 77

  Fly    68 MYGKPLEEIDTF-IYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYC 131
            |...|||::|.| :.::||.|::|   ...|.||:.|.||::..|::..|::.:.|..:..|...
Zfish    78 MLAVPLEDLDPFYLNKKTFIVLNK---GKTIFRFSATPSLYIISPFNLFRQIAIKILIHSVFSMI 139

  Fly   132 VMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVI 193
            :|.|||.||:|:..:   |..::.||.|..||:.|.:.||:|:||.::.:|:||:|||||||:||
Zfish   140 IMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESLTKIVARGFCIDDFTFLRDPWNWLDFMVI 204

  Fly   194 TSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFAL 258
            :..|.|..:::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||
Zfish   205 SMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 269

  Fly   259 FALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW-VNDTDNWL------YDEDE----------LP 306
            ..||::||.||.|||                || ||.|:.:|      :|.:|          ||
Zfish   270 IGLQLFMGNLRQKCV----------------IWPVNSTETYLANGSKGFDFNEYIMNDTNFYFLP 318

  Fly   307 -----VLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLA 366
                 :||||.:.:..||..|.|:..|.|||:|||:||:|.|:.|..|:|:|.|:|||:|.:.|.
Zfish   319 GMLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQLTLR 383

  Fly   367 TCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLN 431
            ..|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.::.|        
Zfish   384 AAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATIEEAE------QKEAEF-------- 434

  Fly   432 VKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGG--KEGGTNGNGNG----SNGDDNKSHSAT 490
             |.:.:..||:.:..:...:|           |..|  .|.....:|.|    |:.:.:|..|  
Zfish   435 -KAMLEQLKKQQEEAQANAMA-----------TSAGTVSEDAVEDDGGGHLSRSSSEVSKLSS-- 485

  Fly   491 PSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVK 555
                    .||.||.:. ..:.:|:.::.....|:.||.|...:.      :.|..|:|:.:|.|
Zfish   486 --------KSAKERRNR-KKKWRKEQEEKGDSEKVVKSESDDGSK------RSRFRFRDNRLGRK 535

  Fly   556 NPNMLYPSDYKGQLIANSGQP--SSNSS-----GVNRESSQDDSGVVDDHEEQD----------- 602
                  .|.....|::..|.|  |..||     |...|.:.|:...|::.|::.           
Zfish   536 ------ASIMNQSLLSIPGSPFMSRRSSIFSFKGSENEFADDEHSTVEESEDRRGSLFVPYRRSS 594

  Fly   603 -TTNDMGHVSTVELALSP--REVRLIKCNGNIARI-----------------KNH------NVYA 641
             :....|......||..|  :....:.|||.::.|                 :.|      :|..
Zfish   595 YSGYSQGSSRINPLAPHPGCKRNSTVDCNGVVSLIGPGPGRLLPETTEVEGKRKHSGSLMVSVDQ 659

  Fly   642 LHQEFSSE--------VV---VIDDLPD--RNCDRCVH--------W-CTDYESWLQFQNCLYKV 684
            |:..||.:        ||   ::::|.:  |.|..|.:        | |...  |::.:..:..:
Zfish   660 LNTSFSRKERANSAMTVVTNTLVEELEESQRKCPPCWYKFANTFLIWECCPI--WIKIKEIVNLI 722

  Fly   685 VRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFL 748
            |.||..:||||:||||||.|:||||:.|:..|...|.|||.|||.|||.|...||:|:.. .:|.
Zfish   723 VMDPFVDLAITICIVLNTVFMAMEHYPMTPRFEEVLSVGNLVFTGIFTAEMFAKLIAMDPYYYFQ 787

  Fly   749 CGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLT 813
            .||||||..||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.:::|||||||
Zfish   788 EGWNIFDGFIVSLSLVELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLT 852

  Fly   814 LILVIVIYIFAVIGMQLFSKDYTP---EKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDC 875
            |:|.|:::||||:|||||.|.|..   :..:...:|||:.|||||||:::||:|||||||.:|||
Zfish   853 LVLAIIVFIFAVVGMQLFGKSYKDCVCKIAESCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 917

  Fly   876 MRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVR 940
            |   |..|.|.|..:|:..:|:||.:||||||||||:||:::.|.:..:: ||.:.|..|:.|: 
Zfish   918 M---EVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDD-GEMNNLQISVIRI- 977

  Fly   941 DLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQ 1005
                           :|....|:   :..:...|..|..:.   ||..|||  |.:      .|.
Zfish   978 ---------------KKGIAWFK---IHVRLLVAHVLKKKP---LEDEDKP--LDD------MYD 1013

  Fly  1006 ESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMA 1070
            :.:|  :.|:..|.:|...|        |.|      |:                          
Zfish  1014 KKLN--LMGNHTGVEIKCGD--------LNY------PK-------------------------- 1036

  Fly  1071 TTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTD 1135
                     |||||                                                   
Zfish  1037 ---------NGNGT--------------------------------------------------- 1041

  Fly  1136 PYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQ 1200
                  .||.||          |..:|..:|...:|: :..:|..|.|.          :.|:|.
Zfish  1042 ------TSGIGS----------SVGKYMIDEEPMSFI-HNPNLTVRVPI----------AVGESD 1079

  Fly  1201 RSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKL 1265
            ...|.:|:              .|.|.|                                     
Zfish  1080 FENLNTED--------------FSSESD------------------------------------- 1093

  Fly  1266 RRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAA 1330
                                    ||:|          |:|::                      
Zfish  1094 ------------------------VENS----------KDLDD---------------------- 1102

  Fly  1331 DEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLE 1395
                          |.:||.|..|     :.|                                 
Zfish  1103 --------------TSSSEGSTID-----IKP--------------------------------- 1115

  Fly  1396 KQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFK 1460
                 ||                      |.|||                               
Zfish  1116 -----DE----------------------EEMAV------------------------------- 1122

  Fly  1461 RLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMA 1525
                :|.|||                                                       
Zfish  1123 ----VEVVEE------------------------------------------------------- 1128

  Fly  1526 TPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAH 1590
                                                                             
Zfish  1129 ----------------------------------------------------------------- 1128

  Fly  1591 AHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKP 1655
                                                                             
Zfish  1129 ----------------------------------------------------------------- 1128

  Fly  1656 SAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYF 1720
                            |:|                               |:.|:...|...:  
Zfish  1129 ----------------YLD-------------------------------PEACWTDACVARY-- 1144

  Fly  1721 RCPWFMSCMD---TQS-AKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTL 1781
                  .|.|   |:. .|:|..:|.....:|:...||..::.:|..||..|.|||:.:::.||:
Zfish  1145 ------KCCDVPITEGWGKYWWFLRKTCYLIVEHNWFETLIIFMILLSSGALAFEDVYIEQRKTI 1203

  Fly  1782 KRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLR 1844
            :.:|.:.:..|..||::||:|||:|.||.||||:.|..|||.||.||:.||:...  ..:|..::
Zfish  1204 QIILEYADRVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGYSDLGPIK 1268

  Fly  1845 SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN 1909
            |||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||..|.||::.|.|
Zfish  1269 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCFN 1333

  Fly  1910 EMG-ELLPITEVNDKWDC---IEQNYT---WINSKITFDHVGMGYLALLQVATFEGWMEVMADAV 1967
            :.. |...:..||:|.:|   |..|||   |.|.||.||:||.|||||||||||:|||::|..||
Zfish  1334 QTAEEYFQVDVVNNKTECFALINANYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAV 1398

  Fly  1968 DARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK 2032
            |:|.|:.||..|.|:|.||||||||:.||||||||||||||||||..|||:.|  .::|:||.||
Zfish  1399 DSRKVEDQPLYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQK 1461

  Fly  2033 HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVF 2097
            .||.||||||.|||||.|.||:|....|.:|....:.|:|:|.:||.|||:||.:|..||.....
Zfish  1462 KYYNAMKKLGSKKPQKPIPRPLNKIQGMVFDFVTQQAFDISIMMLICLNMVTMMVETDDQSDETE 1526

  Fly  2098 FILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLL 2162
            .||...|..|...|..|.::|:..||::|||..|||||.::|:.||.|:.:.|::....:||||.
Zfish  1527 NILYWINFVFIVAFTGEFVLKLFALRHYYFTNGWNVFDCVVVILSIVGMFLADLIEKYFVSPTLF 1591

  Fly  2163 RVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGA 2227
            ||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.||::|.|||.|..||.:..
Zfish  1592 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKREIG 1656

  Fly  2228 LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIH--GHT-NGNCGHPLLAITYF 2289
            :|||.||:|||.||..||.:.|||||:.:|..::..||||||...  |.| .||||:|.:.|.:|
Zfish  1657 IDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCDPNKENPGTTVKGNCGNPSVGIFFF 1721

  Fly  2290 TSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDF 2354
            ..:||:|::||:|||||||||||:.|.:|....:.|||.|.||..|.|:||.|:|||.|::|.||
Zfish  1722 VMYIIVSFLIVVNMYIAIILENFSVATEESADPLCEDDFESFYEIWEKFDPDASQFITFAKLPDF 1786

  Fly  2355 IASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKF 2419
            ..:|:.||.:.|||.:.|::.:||:..|::|||||||.|..|.|||   ::.:...:::||:.:|
Zfish  1787 ADTLEHPLRVPKPNIIELIAMDLPMVSGDRIHCLDILFAFTKRVLG---DSGDLDMMRQQMEERF 1848

  Fly  2420 KKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKL 2484
            ....|::...|.:::|...|::|.:|..||..::.:|                            
Zfish  1849 VAANPSKVSYEPITTTLRRKQEEVSAIVIQRSYRSHL---------------------------- 1885

  Fly  2485 SALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQND 2549
                      :.||..|..|.::.|........:..|......:||     ..|.|.|..|::.|
Zfish  1886 ----------ASRGFICKRRPANNKLENGGGNQEKKEGTPSTASLP-----SYDSVTKPEKEKQD 1935

  Fly  2550 E 2550
            :
Zfish  1936 D 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 119/270 (44%)
Ion_trans 687..902 CDD:459842 117/218 (54%)
Ion_trans 1751..2019 CDD:459842 159/276 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2067..2320 CDD:459842 134/255 (53%)
GPHH 2332..2378 CDD:465306 20/45 (44%)
scn8abNP_001038648.2 None

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