DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and CACNA1E

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_016857732.1 Gene:CACNA1E / 777 HGNCID:1392 Length:2458 Species:Homo sapiens


Alignment Length:2973 Identity:633/2973 - (21%)
Similarity:1103/2973 - (37%) Gaps:937/2973 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEA 152
            ||..:|||:|...:..|:....:.....|:|.::|||:.|||.||            |:..:|:.
Human   208 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 272

  Fly   153 EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTF 213
            |..|:.|:..|..|||:|.||:.:|.:||||.||.:||:|:.|| .||.|....   :|..||..
Human   273 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAV 337

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|...|      
Human   338 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------ 396

  Fly   279 DWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFM 342
                        ::|::.  :.:..:.|..|    |.:.||..|.|. .:|  ||.|.|.|||.:
Human   397 ------------FMNNSG--ILEGFDPPHPC----GVQGCPAGYECKDWIG--PNDGITQFDNIL 441

  Fly   343 WSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT 406
            :::||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|  
Human   442 FAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE-- 504

  Fly   407 NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGG 471
            ..|.::..:..|......        ::|| ..:..||..:.|:||            :..|..|
Human   505 RVENRRAFMKLRRQQQIE--------RELN-GYRAWIDKAEEVMLA------------EENKNAG 548

  Fly   472 TNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNP 536
            |                                 |||                            
Human   549 T---------------------------------SAL---------------------------- 552

  Fly   537 MAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQ 601
                                           :::..:....|.:..:.|:||  |...||     
Human   553 -------------------------------EVLRRATIKRSRTEAMTRDSS--DEHCVD----- 579

  Fly   602 DTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVH 666
                    :|:|...|:...::..|.:|        ..|..|:|....:                
Human   580 --------ISSVGTPLARASIKSAKVDG--------VSYFRHKERLLRI---------------- 612

  Fly   667 WCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIF 731
                         .:..:|:..:|...:...:.||||.:|:.||...:...:.|.....:|..:|
Human   613 -------------SIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLF 664

  Fly   732 TFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQ 790
            ..|..:|:..:. :.:|...:|.||..:...|:.::::.:..     |:||||.|||||:.|:.:
Human   665 LLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITK 729

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFH 855
            .|.:::.|:..::|::.::.:|..:|.:.|.:||::|||||...:   .|: |..|..||:.|..
Human   730 YWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF---NFN-DGTPSANFDTFPA 790

  Fly   856 SFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSE 917
            :.|.:|:||.|| |.|.:::.:|::....:....||:...|.: ||:.:||:|||:.: |..|::
Human   791 AIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 855

  Fly   918 ELKSKKEEVGEESKLARSIERVRDL-------IRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQ 975
            ||...::|..|......::::.:::       :....::|:.|......|.....:.:.::.|..
Human   856 ELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHM 920

  Fly   976 TLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTG 1040
            ::..|....|.           |..::|.||::||.        :.|..:.|             
Human   921 SVWEQRTSQLR-----------KHMQMSSQEALNRE--------EAPTMNPL------------- 953

  Fly  1041 DLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSG 1105
                      :||.|.|...|                        .|..|.:....|....::.|
Human   954 ----------NPLNPLSSLNP------------------------LNAHPSLYRRPRAIEGLALG 984

  Fly  1106 VSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEA 1170
            ::.::::...                                .:||.||:.:...|..:.::...
Human   985 LALEKFEEER--------------------------------ISRGGSLKGDGGDRSSALDNQRT 1017

  Fly  1171 FLKYQKSLLTRSPSY-----RKSLDRLSQSSG---------------QSQ-RSLLKSEEAEMRRH 1214
            .|    ||..|.|.:     ..:.|...|.:|               ||| ||..:....|.:..
Human  1018 PL----SLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKES 1078

  Fly  1215 SSGQSLNSMSIEQ--DELLSQQGNLREELL-NCDQKELFQFLQEEEELQKGTKLRRISNVMRSRR 1276
            ||.....|.|.|:  ||.:..:|....||. |...||  ..:|||    :...|||.:::|.||.
Human  1079 SSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKE--PTIQEE----RAQDLRRTNSLMVSRG 1137

  Fly  1277 PSSQMGQPENET--MVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIME 1339
            .....|..|.:|  ::.|.|.            |:.:.....|:      ||..::::   |::.
Human  1138 SGLAGGLDEADTPLVLPHPEL------------EVGKHVVLTEQ------EPEGSSEQ---ALLG 1181

  Fly  1340 HIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDF 1404
            ::.:..|        .|:....|    |||.:...:...:..:...:|.:.          |.| 
Human  1182 NVQLDMG--------RVISQSEP----DLSCITANTDKATTESTSVTVAIP----------DVD- 1223

  Fly  1405 SISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVE 1469
                           |.|....:.::..:..:|.|.:.                          .
Human  1224 ---------------PLVDSTVVHISNKTDGEASPLKE--------------------------A 1247

  Fly  1470 EVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATP 1534
            |:.|:|:     .:|.:|..:                           :|::.|.|..|      
Human  1248 EIREDEE-----EVEKKKQKK---------------------------EKRETGKAMVP------ 1274

  Fly  1535 PTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRR 1599
                                                                             
Human  1275 ----------------------------------------------------------------- 1274

  Fly  1600 RMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEK 1664
                                  ||                                |.|...|..
Human  1275 ----------------------HS--------------------------------SMFIFSTTN 1285

  Fly  1665 PWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCM 1729
            |                                                                
Human  1286 P---------------------------------------------------------------- 1286

  Fly  1730 DTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKRVLYWINFS 1791
                      :|.|...:|:...||..:|::|.||||.|..||   .|.::||    ||.:.::.
Human  1287 ----------IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK----VLRYFDYV 1337

  Fly  1792 FCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV------FVSVFSLLIEENENLKVLRSL 1846
            |..:|..||::|.:..|.    ..||...|.||||::|      |....:|...:..::|.::||
Human  1338 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSL 1402

  Fly  1847 RTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM 1911
            |.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||:::.||.|.||||.|.:..
Human  1403 RVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSS 1467

  Fly  1912 GELLPITEVNDKWDCIEQNYT-------------WINSKITFDHVGMGYLALLQVATFEGWMEVM 1963
            .:    ||.    :|| .||.             |...:..:|::....|.|..|:|.|||.:|:
Human  1468 KD----TEK----ECI-GNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVL 1523

  Fly  1964 ADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLT 2028
            ..:||....|..|.|...:...|::|::.|...||.:|:|:.:||..|   :::.:..:.|..|.
Human  1524 QHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF---QEQGDKMMEECSLE 1585

  Fly  2029 ESQK---HYYTAMKKLGRKKPQK--VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIE 2088
            ::::   .:..:.|.|.|..||.  ..:..:.||:.       |..||..|..:|.||.:.:.::
Human  1586 KNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV-------SPSFEYTIMAMIALNTVVLMMK 1643

  Fly  2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM 2152
            :|..|......|:..|..||.||.||.::|::...: :||...||:|||:.|:.||..|::.|..
Human  1644 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSK 1708

  Fly  2153 IDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMS 2217
            : :..|...:..:::||..|:::|::....||.||:..|.|..||..:..|:.::.|||||:||.
Human  1709 L-VNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ 1772

  Fly  2218 LFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHG----HTN 2276
            :|||:||  :..::...||::|..|:.||||..|...|.:::.|.:.: ..|:|....    :.|
Human  1773 VFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE-KGCEPDTTAPSGQNEN 1836

  Fly  2277 GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPH 2341
            ..||.. ||..||.|||.....:::|:::|:|::||....::..| :....|:.|...|::||..
Human  1837 ERCGTD-LAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRVWAEYDRA 1899

  Fly  2342 ATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL-- 2399
            |...||::::.:.:..:.||||:.|  |:.||   ||..|:|:::...:|....|.||::..|  
Human  1900 ACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDI 1964

  Fly  2400 ----GHVEETDNFKQLQEQ------------------------------------MDV----KFK 2420
                |..:......:||::                                    ||.    |.|
Human  1965 KIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVK 2029

  Fly  2421 KQFPTRKELEIVSSTRIWKRQEKAA--KTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSK 2483
            ||   |::||...:..:::|.|.::  :.|....|.....:::.....||.|...:.||      
Human  2030 KQ---RQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSP------ 2085

  Fly  2484 LSALNFFHLQVSRRGTACSSRA---------------SSRKSSRASD-----ASDLSELAGPW-- 2526
            ||..:.|.|       ||...|               |..||.:.|:     .||..|.||..  
Human  2086 LSPQDIFQL-------ACMDPADDGQFQERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRA 2143

  Fly  2527 LNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVH 2591
            .::|.:.|.  .:||.|                   .:|.||||        ..:.|..::.|..
Human  2144 SSMPRLTVD--PQVVTD-------------------PSSMRRSF--------STIRDKRSNSSWL 2179

  Fly  2592 RKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIR 2656
            .:.:|..::..|..|...|..:|...:|....    :.|...||.|::.|      |:|..|..|
Human  2180 EEFSMERSSENTYKSRRRSYHSSLRLSAHRLN----SDSGHKSDTHRSGG------RERGRSKER 2234

  Fly  2657 KKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRES 2721
            |.      |.:....|.|.....::|.       ..|||:                      |:|
Human  2235 KH------LLSPDVSRCNSEERGTQAD-------WESPER----------------------RQS 2264

  Fly  2722 EEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPP 2786
            ....|....:|:..|.|:        ||:...|.:..|:....|......:|        ||..|
Human  2265 RSPSEGRSQTPNRQGTGS--------LSESSIPSVSDTSTPRRSRRQLPPVP--------PKPRP 2313

  Fly  2787 RGDFSS--APIDDVGAPIDVNVQGD--TSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPP 2847
            ...:||  .....:..|.|.:.:|.  |||.. :.|....|:...:...:.:|..| |.|....|
Human  2314 LLSYSSLIRHAGSISPPADGSEEGSPLTSQAL-ESNNACLTESSNSPHPQQSQHAS-PQRYISEP 2376

  Fly  2848 VNTPLRDSEKRSSRGSRSSSSSTSSIRSCSSSSSSSAASAAAPSARRT 2895
            . ..|.:....|..|...:.:..:::   ::|...|....:||..|.:
Human  2377 Y-LALHEDSHASDCGEEETLTFEAAV---ATSLGRSNTIGSAPPLRHS 2420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/224 (33%)
Ion_trans 705..902 CDD:278921 57/204 (28%)
Ion_trans 1768..2019 CDD:278921 83/276 (30%)
Na_channel_gate 2009..2063 CDD:240441 10/58 (17%)
Ion_trans 2085..2320 CDD:278921 77/241 (32%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
CACNA1EXP_016857732.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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