Protein Alignment NaCP60E and CACNA1E

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_016857732.1
• Gene: CACNA1E / 777
• HGNCID: 1392
• Length: 2458
• Species: Homo sapiens
• Alignment Length: 2973
• Identity: 633/2973 - (21%)
• Similarity: 1103/2973 - (37%)
• Gaps: 937/2973 - (31%)

  Fly   100 FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEA 152
            ||..:|||:|...:..|:....:.....|:|.::|||:.|||.||            |:..:|:.
Human   208 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 272

  Fly   153 EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTF 213
            |..|:.|:..|..|||:|.||:.:|.:||||.||.:||:|:.|| .||.|....   :|..||..
Human   273 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAV 337

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|...|
Human   338 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------ 396

  Fly   279 DWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFM 342
                        ::|::.  :.:..:.|..|    |.:.||..|.|. .:|  ||.|.|.|||.:
Human   397 ------------FMNNSG--ILEGFDPPHPC----GVQGCPAGYECKDWIG--PNDGITQFDNIL 441

  Fly   343 WSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT 406
            :::||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|
Human   442 FAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE-- 504

  Fly   407 NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGG 471
            ..|.::..:..|......        ::|| ..:..||..:.|:||            :..|..|
Human   505 RVENRRAFMKLRRQQQIE--------RELN-GYRAWIDKAEEVMLA------------EENKNAG 548

  Fly   472 TNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNP 536
            |                                 |||
Human   549 T---------------------------------SAL---------------------------- 552

  Fly   537 MAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQ 601
                                           :::..:....|.:..:.|:||  |...||
Human   553 -------------------------------EVLRRATIKRSRTEAMTRDSS--DEHCVD----- 579

  Fly   602 DTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVH 666
                    :|:|...|:...::..|.:|        ..|..|:|....:
Human   580 --------ISSVGTPLARASIKSAKVDG--------VSYFRHKERLLRI---------------- 612

  Fly   667 WCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIF 731
                         .:..:|:..:|...:...:.||||.:|:.||...:...:.|.....:|..:|
Human   613 -------------SIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLF 664

  Fly   732 TFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQ 790
            ..|..:|:..:. :.:|...:|.||..:...|:.::::.:..     |:||||.|||||:.|:.:
Human   665 LLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITK 729

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFH 855
            .|.:::.|:..::|::.::.:|..:|.:.|.:||::|||||...:   .|: |..|..||:.|..
Human   730 YWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF---NFN-DGTPSANFDTFPA 790

  Fly   856 SFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSE 917
            :.|.:|:||.|| |.|.:::.:|::....:....||:...|.: ||:.:||:|||:.: |..|::
Human   791 AIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 855

  Fly   918 ELKSKKEEVGEESKLARSIERVRDL-------IRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQ 975
            ||...::|..|......::::.:::       :....::|:.|......|.....:.:.::.|..
Human   856 ELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHM 920

  Fly   976 TLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTG 1040
            ::..|....|.           |..::|.||::||.        :.|..:.|
Human   921 SVWEQRTSQLR-----------KHMQMSSQEALNRE--------EAPTMNPL------------- 953

  Fly  1041 DLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSG 1105
                      :||.|.|...|                        .|..|.:....|....::.|
Human   954 ----------NPLNPLSSLNP------------------------LNAHPSLYRRPRAIEGLALG 984

  Fly  1106 VSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEA 1170
            ::.::::...                                .:||.||:.:...|..:.::...
Human   985 LALEKFEEER--------------------------------ISRGGSLKGDGGDRSSALDNQRT 1017

  Fly  1171 FLKYQKSLLTRSPSY-----RKSLDRLSQSSG---------------QSQ-RSLLKSEEAEMRRH 1214
            .|    ||..|.|.:     ..:.|...|.:|               ||| ||..:....|.:..
Human  1018 PL----SLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKES 1078

  Fly  1215 SSGQSLNSMSIEQ--DELLSQQGNLREELL-NCDQKELFQFLQEEEELQKGTKLRRISNVMRSRR 1276
            ||.....|.|.|:  ||.:..:|....||. |...||  ..:|||    :...|||.:::|.||.
Human  1079 SSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKE--PTIQEE----RAQDLRRTNSLMVSRG 1137

  Fly  1277 PSSQMGQPENET--MVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIME 1339
            .....|..|.:|  ::.|.|.            |:.:.....|:      ||..::::   |::.
Human  1138 SGLAGGLDEADTPLVLPHPEL------------EVGKHVVLTEQ------EPEGSSEQ---ALLG 1181

  Fly  1340 HIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDF 1404
            ::.:..|        .|:....|    |||.:...:...:..:...:|.:.          |.|
Human  1182 NVQLDMG--------RVISQSEP----DLSCITANTDKATTESTSVTVAIP----------DVD- 1223

  Fly  1405 SISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVE 1469
                           |.|....:.::..:..:|.|.:.                          .
Human  1224 ---------------PLVDSTVVHISNKTDGEASPLKE--------------------------A 1247

  Fly  1470 EVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATP 1534
            |:.|:|:     .:|.:|..:                           :|::.|.|..|
Human  1248 EIREDEE-----EVEKKKQKK---------------------------EKRETGKAMVP------ 1274

  Fly  1535 PTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRR 1599
                                                                             
Human  1275 ----------------------------------------------------------------- 1274

  Fly  1600 RMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEK 1664
                                  ||                                |.|...|..
Human  1275 ----------------------HS--------------------------------SMFIFSTTN 1285

  Fly  1665 PWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCM 1729
            |
Human  1286 P---------------------------------------------------------------- 1286

  Fly  1730 DTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKRVLYWINFS 1791
                      :|.|...:|:...||..:|::|.||||.|..||   .|.::||    ||.:.::.
Human  1287 ----------IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK----VLRYFDYV 1337

  Fly  1792 FCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV------FVSVFSLLIEENENLKVLRSL 1846
            |..:|..||::|.:..|.    ..||...|.||||::|      |....:|...:..::|.::||
Human  1338 FTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSL 1402

  Fly  1847 RTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM 1911
            |.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||:::.||.|.||||.|.:..
Human  1403 RVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSS 1467

  Fly  1912 GELLPITEVNDKWDCIEQNYT-------------WINSKITFDHVGMGYLALLQVATFEGWMEVM 1963
            .:    ||.    :|| .||.             |...:..:|::....|.|..|:|.|||.:|:
Human  1468 KD----TEK----ECI-GNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVL 1523

  Fly  1964 ADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLT 2028
            ..:||....|..|.|...:...|::|::.|...||.:|:|:.:||..|   :::.:..:.|..|.
Human  1524 QHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF---QEQGDKMMEECSLE 1585

  Fly  2029 ESQK---HYYTAMKKLGRKKPQK--VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIE 2088
            ::::   .:..:.|.|.|..||.  ..:..:.||:.       |..||..|..:|.||.:.:.::
Human  1586 KNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV-------SPSFEYTIMAMIALNTVVLMMK 1643

  Fly  2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM 2152
            :|..|......|:..|..||.||.||.::|::...: :||...||:|||:.|:.||..|::.|..
Human  1644 YYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSK 1708

  Fly  2153 IDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMS 2217
            : :..|...:..:::||..|:::|::....||.||:..|.|..||..:..|:.::.|||||:||.
Human  1709 L-VNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ 1772

  Fly  2218 LFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHG----HTN 2276
            :|||:||  :..::...||::|..|:.||||..|...|.:::.|.:.: ..|:|....    :.|
Human  1773 VFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE-KGCEPDTTAPSGQNEN 1836

  Fly  2277 GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPH 2341
            ..||.. ||..||.|||.....:::|:::|:|::||....::..| :....|:.|...|::||..
Human  1837 ERCGTD-LAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRVWAEYDRA 1899

  Fly  2342 ATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL-- 2399
            |...||::::.:.:..:.||||:.|  |:.||   ||..|:|:::...:|....|.||::..|
Human  1900 ACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDI 1964

  Fly  2400 ----GHVEETDNFKQLQEQ------------------------------------MDV----KFK 2420
                |..:......:||::                                    ||.    |.|
Human  1965 KIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVK 2029

  Fly  2421 KQFPTRKELEIVSSTRIWKRQEKAA--KTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSK 2483
            ||   |::||...:..:::|.|.::  :.|....|.....:::.....||.|...:.||
Human  2030 KQ---RQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSP------ 2085

  Fly  2484 LSALNFFHLQVSRRGTACSSRA---------------SSRKSSRASD-----ASDLSELAGPW-- 2526
            ||..:.|.|       ||...|               |..||.:.|:     .||..|.||..
Human  2086 LSPQDIFQL-------ACMDPADDGQFQERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRA 2143

  Fly  2527 LNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVH 2591
            .::|.:.|.  .:||.|                   .:|.||||        ..:.|..::.|..
Human  2144 SSMPRLTVD--PQVVTD-------------------PSSMRRSF--------STIRDKRSNSSWL 2179

  Fly  2592 RKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIR 2656
            .:.:|..::..|..|...|..:|...:|....    :.|...||.|::.|      |:|..|..|
Human  2180 EEFSMERSSENTYKSRRRSYHSSLRLSAHRLN----SDSGHKSDTHRSGG------RERGRSKER 2234

  Fly  2657 KKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRES 2721
            |.      |.:....|.|.....::|.       ..|||:                      |:|
Human  2235 KH------LLSPDVSRCNSEERGTQAD-------WESPER----------------------RQS 2264

  Fly  2722 EEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPP 2786
            ....|....:|:..|.|:        ||:...|.:..|:....|......:|        ||..|
Human  2265 RSPSEGRSQTPNRQGTGS--------LSESSIPSVSDTSTPRRSRRQLPPVP--------PKPRP 2313

  Fly  2787 RGDFSS--APIDDVGAPIDVNVQGD--TSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPP 2847
            ...:||  .....:..|.|.:.:|.  |||.. :.|....|:...:...:.:|..| |.|....|
Human  2314 LLSYSSLIRHAGSISPPADGSEEGSPLTSQAL-ESNNACLTESSNSPHPQQSQHAS-PQRYISEP 2376

  Fly  2848 VNTPLRDSEKRSSRGSRSSSSSTSSIRSCSSSSSSSAASAAAPSARRT 2895
            . ..|.:....|..|...:.:..:::   ::|...|....:||..|.:
Human  2377 Y-LALHEDSHASDCGEEETLTFEAAV---ATSLGRSNTIGSAPPLRHS 2420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	87/263 (33%)
		Ion_trans	687..902	CDD:459842	62/222 (28%)
		Ion_trans	1751..2019	CDD:459842	91/293 (31%)
		Na_channel_gate	2009..2063	CDD:240441	10/58 (17%)
		Ion_trans	2067..2320	CDD:459842	84/259 (32%)
		GPHH	2332..2378	CDD:465306	17/50 (34%)
CACNA1E	XP_016857732.1	Ion_trans	233..507	CDD:459842	97/301 (32%)
		Ion_trans	620..859	CDD:459842	71/242 (29%)
		Ion_trans	1298..1532	CDD:459842	78/246 (32%)
		Ion_trans	1622..1879	CDD:459842	84/259 (32%)
		GPHH	1888..1941	CDD:465306	18/52 (35%)
		Ca_chan_IQ	1951..2027	CDD:462591	9/75 (12%)
		PHA03307	2123..>2345	CDD:223039	64/311 (21%)