Protein Alignment NaCP60E and CACNA1C

DIOPT Version :9

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_016875415.1
• Gene: CACNA1C / 775
• HGNCID: 1390
• Length: 2412
• Species: Homo sapiens
• Alignment Length: 3146
• Identity: 637/3146 - (20%)
• Similarity: 1024/3146 - (32%)
• Gaps: 1323/3146 - (42%)

  Fly    69 YGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGT---KSLFLFYPWSPARRVCVYIATNQFFDY 130
            ||||.::..|                      |.|   ::|......:|.||.|:.|...:.|:.
Human   142 YGKPKKQGST----------------------TATRPPRALLCLTLKNPIRRACISIVEWKPFEI 184

  Fly   131 CVMATILFNCIFLAM------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRN 183
            .::.||..||:.||:            ...:|..||:||.|:::|..:|:||.|.|.:...||||
Human   185 IILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 249

  Fly   184 PWNWLDFVVITSGYATIGMEV-----------GNLAG-----LRTFRVLRALKTVSIMPGLKTII 232
            .||.|||:::..|..:..:|.           |..||     ||.|||||.|:.||.:|.|:.::
Human   250 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 314

  Fly   233 NALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ-----VPTDWTNVSHTDWQIWV 292
            |:::.:...|..:..|.:|.::::|:..|:::||::...|..|     ||.
Human   315 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPA-------------- 365

  Fly   293 NDTDNWLYDEDELPVLCGNLTG-ARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
                     ||: |..|...|| .|.|....||....:.|.||.||||||.::|||.||.||::.
Human   366 ---------EDD-PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 420

  Fly   357 WENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDD 420
            |.:| |.|..|....:...:|..:|.||||:::||:|
Human   421 WTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL---------------------------- 457

  Fly   421 STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNK 485
                                       |||...:||::.:.|                :.||
Human   458 ---------------------------GVLSGEFSKEREKAK----------------ARGD--- 476

  Fly   486 SHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHK-----LAKSGSGGSNNPMAPTPKGRI 545
                                    .|..::.||:|:..|     :.::......|
Human   477 ------------------------FQKLREKQQLEEDLKGYLDWITQAEDIDPEN---------- 507

  Fly   546 SFQDSGMGVKNP-NMLYPSDYKGQLIANSGQ--------------PSSNSSGVNRESSQDDSGVV 595
              :|.||..:.| |...|:   |.|....|:              |:|.:..||.|:.   :|..
Human   508 --EDEGMDEEKPRNRGTPA---GMLDQKKGKFAWFSHSTETHVSMPTSETESVNTENV---AGGD 564

  Fly   596 DDHEEQDTTNDMGHVSTVELA-LSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDR 659
            .:.|........|..|.||.| |.|..|..:.....:..::..   ||.|...|..:.......
Human   565 IEGENCGARLAKGSRSAVEPAVLLPWGVTTVNSPWPLEELQTE---ALSQTSPSHRISKSKFSR- 625

  Fly   660 NCDRCVHWCTDYESWLQFQNCLYK---VVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
                  :|    ..|.:|  |..|   .|:..:|...:...:.|||..:|.||:..........|
Human   626 ------YW----RRWNRF--CRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD 678

  Fly   722 VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLSVLR 778
            ..||...::||.|.::|:.:|. :.:|:..:|.||..:|...:|:.|  ||:       |:||||
Human   679 TANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI--LVETKIMSPLGISVLR 741

  Fly   779 GLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            .:||||:.|:.:.|.::..|::.:::::.::.:|.|:|.:.|.||:::|||||...:   .||..
Human   742 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---NFDEM 803

  Fly   844 PVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLN 904
            ...|..|::|..|.:.:|:||.|| |...::|.:.|   ....|...|. .|:...:.||:::||
Human   804 QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLN 867

  Fly   905 LFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLD 968
            :|||:.: |..::|.|.|.::|..||                  :|||........||.|::|
Human   868 VFLAIAVDNLADAESLTSAQKEEEEE------------------KERKKLARTASPEKKQELV-- 912

  Fly   969 AQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDG 1033
                                :||.| .|:|
Human   913 --------------------EKPAV-GESK----------------------------------- 921

  Fly  1034 LEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRL 1098
                     .|:|:|::  :....:|.|.|              .:|    ..:|.|
Human   922 ---------EEKIELKS--ITADGESPPAT--------------KIN----MDDLQP-------- 949

  Fly  1099 QHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYG 1163
                                          ..:.|..||.|.:.:|
Human   950 ------------------------------NENEDKSPYPNPETTG------------------- 965

  Fly  1164 SEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQD 1228
                                                                          |:|
Human   966 --------------------------------------------------------------EED 968

  Fly  1229 ELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHS 1293
            |                         ||.|:..|
Human   969 E-------------------------EEPEMPVG------------------------------- 977

  Fly  1294 EFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358
                                            |.|
Human   978 --------------------------------PRP------------------------------ 980

  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423
                                                                             
Human   981 ----------------------------------------------------------------- 980

  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488
                                                                :|:|.|.::.:.:
Human   981 ----------------------------------------------------RPLSELHLKEKAV 993

  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553
            |
Human   994 P---------------------------------------------------------------- 994

  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618
                                                                             
Human   995 ----------------------------------------------------------------- 994

  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683
                                         .|:|    |||
Human   995 -----------------------------MPEA----SAF------------------------- 1001

  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVV 1748
                    ..|.|          ::.|..:|:                              .:|
Human  1002 --------FIFSS----------NNRFRLQCH------------------------------RIV 1018

  Fly  1749 DTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF---- 1809
            :...|...:|..|..|||:|..|| .:........:|::.:..|..||.:|:.||..|.|.
Human  1019 NDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHK 1082

  Fly  1810 SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYA 1874
            ..:..:::.|||.::|.||:.|..|:.:. :.|::.||.||.|||||||:|.:|::.||..:..|
Human  1083 GSFCRNYFNILDLLVVSVSLISFGIQSSA-INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVA 1146

  Fly  1875 IPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIE----------- 1928
            |.:|.|:::|..:...:|:.:|||.|.||.:.|.:...:    ||...|.:.|.
Human  1147 IRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQ----TEAECKGNYITYKDGEVDHPII 1207

  Fly  1929 QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY-----IYF 1988
            |..:|.|||..||:|....:||..|:|||||.|::..::|:...|..|     :|.|     |:|
Human  1208 QPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP-----IYNYRVEISIFF 1267

  Fly  1989 VIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRP 2053
            :|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|   ::|.
Human  1268 IIYIIIIAFFMMNIFVGFVIVTFQ------EQGEQEYKNCELDKNQRQCVEYALKARP---LRRY 1323

  Fly  2054 I---NHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEA 2115
            |   .|...::| :.||..||..:||||.||.:.:.::||.|.......:.:.|..||.:|.:|.
Human  1324 IPKNQHQYKVWY-VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEM 1387

  Fly  2116 IVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDI-------------------MIDLPI--- 2157
            |:|::..: ..||:.||||||||:|:.||..:::.:.                   ::|:.|
Human  1388 ILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEV 1452

  Fly  2158 --------SPTL---------LRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLG 2205
                    ||::         :...|:||:.|:::|:...:|||.||:..:.|..||..:..|:.
Human  1453 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIV 1517

  Fly  2206 LITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQP 2264
            ::.||||::||.:||.:    ||:|..      |||||.:::.||||..|...|.|::  |...|
Human  1518 MLFFIYAVIGMQVFGKI----ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM--LACMP 1576

  Fly  2265 -----PDCDPFIHGHTNGN--CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIG 2322
                 |:.:|  ...|.|.  ||.. .|:.||.||.::...::||:::|:|::||:...::..|
Human  1577 GKKCAPESEP--SNSTEGETPCGSS-FAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI- 1637

  Fly  2323 IVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKG 2382
            :....|:.|...|::|||.|...|....:...:..:.||||..|  |:.||   |||.|:|::..
Human  1638 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1702

  Fly  2383 NKIHCLDILHALVKHVL------------GHVEETD------NFKQLQEQMDVKFKKQFPTRKEL 2429
            ..:.....|.|||:..|            .|....|      |.:|..|::....||
Human  1703 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK-------- 1759

  Fly  2430 EIVSSTRIWKRQEK---------------------AAKTIQTGWKEYLRR-KREKERSNSGDSAT 2472
                   ||||...                     |...||    ||.|: |:.||:
Human  1760 -------IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----EYFRKFKKRKEQ-------- 1805

  Fly  2473 QTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSG- 2536
                  |...|.|..|...||...|                    .|.:: ||.:.   ..:||
Human  1806 ------GLVGKPSQRNALSLQAGLR--------------------TLHDI-GPEIR---RAISGD 1840

  Fly  2537 ---ADEVVKDIKQ------QNDELGKRGSIF---VEAPRASRRRSFYNFFL-------------- 2575
               .:|:.|.:|:      ::|...:.|.:|   |...::..|.:|...|.
Human  1841 LTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQ 1905

  Fly  2576 ------RHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSA-----STSGTASSTAT--------APA 2621
                  .|:..||.:.| ||.:..|..|...|..:|:|     ..:|..|:.:|        :||
Human  1906 GDTESPSHEKLVDSTFT-PSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPA 1969

  Fly  2622 TGCGPAATSASDSDRH--QAVGGGSAPSRKRASSFIRKKPP-LERGLSAQSA-LRVNKNAFV--- 2679
            ......|...|.:..|  ..:.||:.|.....    |:.|| |.:.|....| ||.:....|
Human  1970 IRVQEVAWKLSSNRMHCCDMLDGGTFPPALGP----RRAPPCLHQQLQGSLAGLREDTPCIVPGH 2030

  Fly  2680 --------------SEASAP------------EVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVH 2718
                          :..:||            ::.:.|.|....|..|.|.||..|.:..|   .
Human  2031 ASLCCSSRVGEWLPAGCTAPQHARERHVPMCEDLELRRDSGSAGTQAHCLLLRRANPSRCH---S 2092

  Fly  2719 RES------EEYKEEDE-------------SSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVE 2764
            |||      :|...:||             |.||:        :..:|||.|.....::|....:
Human  2093 RESQAAMAGQEETSQDETYEVKMNHDTEACSEPSL--------LSTEMLSYQDDENRQLTLPEED 2149

  Fly  2765 SSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQ---------GDTSQVFYDYNPE 2820
            ..             |..:.|.||...||   .:|.....:::         ||.||  ....|.
Human  2150 KR-------------DIRQSPKRGFLRSA---SLGRRASFHLECLKRQKDRGGDISQ--KTVLPL 2196

  Fly  2821 KATDDQGNGQDETAQFESLPDRQRXP-----PVNTPLRDSEKRS----------SRGSRSSSSST 2870
            .....|...   .|....|..|...|     |..||......|.          ..|..||....
Human  2197 HLVHHQALA---VAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLN 2258

  Fly  2871 SSIRS--CSSSSSSSAASAAAPSARR 2894
            ||..|  |.|.:.::.....:.:|||
Human  2259 SSFPSIHCGSWAETTPGGGGSSAARR 2284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	80/241 (33%)
		Ion_trans	705..902	CDD:278921	62/208 (30%)
		Ion_trans	1768..2019	CDD:278921	86/270 (32%)
		Na_channel_gate	2009..2063	CDD:240441	10/56 (18%)
		Ion_trans	2085..2320	CDD:278921	83/287 (29%)
		GPHH	2331..2386	CDD:293510	20/59 (34%)
CACNA1C	XP_016875415.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840