DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and CACNA1B

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_000709.1 Gene:CACNA1B / 774 HGNCID:1389 Length:2339 Species:Homo sapiens


Alignment Length:3013 Identity:643/3013 - (21%)
Similarity:1081/3013 - (35%) Gaps:964/3013 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            :|:::   :::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||
Human    44 LYKQS---IAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATI 105

  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189
            :.|||.||            |:|.:::.|..|:.|:..|..|||||.||:.:|.:||||.||.:|
Human   106 IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMD 170

  Fly   190 FVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCL 253
            |||:.:| .||.|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:
Human   171 FVVVLTGILATAGTDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234

  Fly   254 MVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318
            ::||:..|:.|||:....|                  :.|.||  .....:.|  ||....||.|
Human   235 LMFAIIGLEFYMGKFHKAC------------------FPNSTD--AEPVGDFP--CGKEAPARLC 277

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFF 382
            ..:..|......||.|.|||||.::::||.||.||::.|.:: ||...|.....:..:|..::..
Human   278 EGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342

  Fly   383 GSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447
            |||:::||:|.|::..:.:|.|  ..|.::..|..|......        ::|| ...:.|...:
Human   343 GSFFMLNLVLGVLSGEFAKERE--RVENRRAFLKLRRQQQIE--------RELN-GYLEWIFKAE 396

  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512
            .|:||...:                       |.::.       ||....:.:||::        
Human   397 EVMLAEEDR-----------------------NAEEK-------SPLDVLKRAATKK-------- 423

  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP- 576
                                |.|.:....:|...|.|                    :...|.| 
Human   424 --------------------SRNDLIHAEEGEDRFAD--------------------LCAVGSPF 448

  Fly   577 --SSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNV 639
              :|..||....||                                                   
Human   449 ARASLKSGKTESSS--------------------------------------------------- 462

  Fly   640 YALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704
            |...:|                             ..|:..:.::|:...|...:...:.|||..
Human   463 YFRRKE-----------------------------KMFRFFIRRMVKAQSFYWVVLCVVALNTLC 498

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768
            :||.|:.........|.....||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::
Human   499 VAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVW 563

  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828
            ..:.     |:||||.|||||:.|:.:.|::::.|:..:::::.::.:|..:|.:.|.:||::||
Human   564 AAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628

  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAE--EEQGASTCFAI 890
            |||...:..:    |..|..||:.|..:.:.:|:||.|| |...::..:.::  ..:|..:.|..
Human   629 QLFGGQFNFQ----DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 689

  Fly   891 FLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIR---------- 944
            .:.|| .||:.:||:|||:.: |..|::||...:||:.|.:....::::.:::..          
Human   690 IVLTL-FGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANIS 753

  Fly   945 -KKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVL--AETKFHRLSYQE 1006
             ..||:...:....:.::..|:.|...:|..:.|..:.       |....|  |.|:..|...:.
Human   754 IAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEM-------DPEERLRFATTRHLRPDMKT 811

  Fly  1007 SMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMAT 1071
            .::||:. .:.|     .||....|.|....:..:.||.:.             ||         
Human   812 HLDRPLV-VELG-----RDGARGPVGGKARPEAAEAPEGVD-------------PP--------- 848

  Fly  1072 TGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDP 1136
                                     |..|                           ::...|..|
Human   849 -------------------------RRHH---------------------------RHRDKDKTP 861

  Fly  1137 YANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQR 1201
            .|.||       :|.::.:..|......||...             |....|.:.......:|:|
Human   862 AAGDQ-------DRAEAPKAESGEPGAREERPR-------------PHRSHSKEAAGPPEARSER 906

  Fly  1202 SLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLR 1266
            ......|...|.|..|                                    ..||..::..:..
Human   907 GRGPGPEGGRRHHRRG------------------------------------SPEEAAEREPRRH 935

  Fly  1267 RISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAAD 1331
            |   ..|.:.||.:....:.|....|                 :....:..|:..:..||:....
Human   936 R---AHRHQDPSKECAGAKGERRARH-----------------RGGPRAGPREAESGEEPARRHR 980

  Fly  1332 EATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEK 1396
            ...||...|.|:....:|:.|.:                  :.::.|.|                
Human   981 ARHKAQPAHEAVEKETTEKEATE------------------KEAEIVEA---------------- 1011

  Fly  1397 QRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKR 1461
                |::..:.|.      |...|...:|.............|:                     
Human  1012 ----DKEKELRNH------QPREPHCDLETSGTVTVGPMHTLPS--------------------- 1045

  Fly  1462 LSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMAT 1526
             :.:::|||.||:                                  .::..|:    .::|   
Human  1046 -TCLQKVEEQPED----------------------------------ADNQRNV----TRMG--- 1068

  Fly  1527 PPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHA 1591
                 :.||       :|.|:..|..:.|.|    |.|      ||.:                 
Human  1069 -----SQPP-------DPNTIVHIPVMLTGP----LGE------ATVV----------------- 1094

  Fly  1592 HSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPS 1656
                        |...:|         .||.:.|..:..:                         
Human  1095 ------------PSGNVD---------LESQAEGKKEVEA------------------------- 1113

  Fly  1657 AFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFR 1721
                             ||:...|          |.....|.:                      
Human  1114 -----------------DDVMRSG----------PRPIVPYSS---------------------- 1129

  Fly  1722 CPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED-INLD--KNKTLKR 1783
                |.|:...:.     :|.....:|....||..:||:|..|||.|..|| :..|  :|..|| 
Human  1130 ----MFCLSPTNL-----LRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALK- 1184

  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV--FVSVFSLLIEENENLKV 1842
               ::::.|..:|..||::|.:.||.    ..||...|.|||||:|  .:..|:....:.:::..
Human  1185 ---YLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINT 1246

  Fly  1843 LRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKC 1907
            ::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::.||.|.||||.|
Human  1247 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC 1311

  Fly  1908 VNEMGELLPITEVNDKWDC-----------IE-QNYTWINSKITFDHVGMGYLALLQVATFEGWM 1960
            .:|..||        :.||           :| |...|......:|:|....|.|..|:|.|||.
Human  1312 TDESKEL--------ERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWP 1368

  Fly  1961 EVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGG 2021
            .|:..:|||...:..|    :.|.:::..:|||:|    .||.:|:|:.:||..|   :::.:..
Human  1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVF----PFFFVNIFVALIIITF---QEQGDKV 1426

  Fly  2022 VLEMFLTESQK---HYYTAMKKLGRKKPQK-----------VIKRPINHFLAMFYDLSNSRRFEI 2072
            :.|..|.::::   .:..:.|.|.|..||.           |:..|                ||.
Human  1427 MSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPP----------------FEY 1475

  Fly  2073 AIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDF 2136
            .|..:|.||.:.:.::.||.|:....:|:..|..||::|.:|.::||:... .:||...||||||
Human  1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDF 1540

  Fly  2137 LLVLASIFGILMEDI-----MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPA 2196
            :.||.||..||:.:|     .|:|..       :|:||..|:::|::....||.||:..|.|..|
Human  1541 VTVLGSITDILVTEIAETNNFINLSF-------LRLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1598

  Fly  2197 LFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWND 2255
            |..:..|:.::.|||||:||.:|||:    ||||..      ||:||.:::.||||..|...|::
Human  1599 LPYVCLLIAMLFFIYAIIGMQVFGNI----ALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHE 1659

  Fly  2256 VLESLMIQPPDCDPFIHGHTNG-NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEE 2319
            ::.|.:.... ||.    ..|. .||.. .|..||.|||.:...:::|:::|:|::||....::.
Human  1660 IMLSCLSNQA-CDE----QANATECGSD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1718

  Fly  2320 EIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPI 2379
            .| :....|:.|...|::|||.|...|.::.:.:.:..:.||||:.|  |..||   ||..|:||
Human  1719 SI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPI 1782

  Fly  2380 SKGN-KIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK 2443
            |..: .:|....|.||::..|.........|  |.|.|.:.      |||:.:|     |....:
Human  1783 SNEDMTVHFTSTLMALIRTALEIKLAPAGTK--QHQCDAEL------RKEISVV-----WANLPQ 1834

  Fly  2444 AAKTI-----------QTGWKEY---LRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFH-LQ 2493
              ||:           .|..|.|   :.....|:...:.|...|  :||| .|::..::.|| |:
Human  1835 --KTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQ--APGG-LSQMGPVSLFHPLK 1894

  Fly  2494 VSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDE-------- 2550
            .:...|..:....:|...|...::.||. .|...|..    ||..|.|....|:..:        
Human  1895 ATLEQTQPAVLRGARVFLRQKSSTSLSN-GGAIQNQE----SGIKESVSWGTQRTQDAPHEARPP 1954

  Fly  2551 ----------LGKRGSIFVEAPRAS------------------RRRSFYNFFLRHQDAVDDSLTS 2587
                      :|:.|::.|:....|                  |..|........|...|   .|
Human  1955 LERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTD---AS 2016

  Fly  2588 PSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATG----------C-------------GPAAT 2629
            |       |..:.:|.:.....:...|:|...|...          |             ||:.:
Human  2017 P-------MKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLS 2074

  Fly  2630 SASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQ----SALRVNKNAFVS----EASAPE 2686
            :..|.....|||.|..|..........::...|||.|.:    |:....|..|.|    ....| 
Human  2075 ADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREP- 2138

  Fly  2687 VIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGN-----------GNG 2740
               .:|.|...:||.|.:               ..:|.....:.|.||:|:           |.|
Human  2139 ---PKPKPSLSSHPTSPT---------------AGQEPGPHPQGSGSVNGSPLLSTSGASTPGRG 2185

  Fly  2741 FGVGLDMLSKQP-PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRG----------DFSSAP 2794
               |...|.:.| .|:..||..:..||....|.....:...||....||          |..|.|
Human  2186 ---GRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP 2247

  Fly  2795 IDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQ--DETAQFESLPDRQRXPPVNTPLRDSEK 2857
            :    ||                 ..:...|...||  |..|...:||:        ..|...|.
Human  2248 L----AP-----------------GSRIGSDPYLGQRLDSEASVHALPE--------DTLTFEEA 2283

  Fly  2858 RSSRGSRSSSSSTSSIRSCSSSS 2880
            .::...|  ||.||.:.|.:|.|
Human  2284 VATNSGR--SSRTSYVSSLTSQS 2304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/220 (35%)
Ion_trans 705..902 CDD:278921 55/205 (27%)
Ion_trans 1768..2019 CDD:278921 84/275 (31%)
Na_channel_gate 2009..2063 CDD:240441 10/67 (15%)
Ion_trans 2085..2320 CDD:278921 83/247 (34%)
GPHH 2331..2386 CDD:293510 21/60 (35%)
CACNA1BNP_000709.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
I 82..359 99/299 (33%)
Ion_trans 112..367 CDD:278921 91/279 (33%)
Binding to the beta subunit. /evidence=ECO:0000250 379..396 3/25 (12%)
II 468..712 67/277 (24%)
Ion_trans 499..720 CDD:278921 64/225 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..1038 53/421 (13%)
DUF3628 <822..929 CDD:289100 30/241 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1076 7/74 (9%)
III 1137..1419 93/302 (31%)
Ion_trans 1167..1425 CDD:278921 84/276 (30%)
IV 1456..1711 89/287 (31%)
Ion_trans 1488..1719 CDD:278921 83/247 (34%)
GPHH 1727..1791 CDD:293510 21/63 (33%)
Ca_chan_IQ 1793..1867 CDD:285917 19/88 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1968 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1981..2206 47/256 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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