DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and CACNA1A

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_075461.2 Gene:CACNA1A / 773 HGNCID:1388 Length:2512 Species:Homo sapiens


Alignment Length:2942 Identity:664/2942 - (22%)
Similarity:1103/2942 - (37%) Gaps:864/2942 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 RKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------M 145
            |:|.:   |..:|||||...:..|:....|.....|:|.::|||:.|||.||            |
Human    68 RQNCL---TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 129

  Fly   146 TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVGNLAG 209
            :|.:::.|..|:.|:..|..|||||.||..:|.:||||.||.:||||:.:| .||:|.|. :|..
Human   130 SERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DLRT 193

  Fly   210 LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVR 274
            ||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|||:....|..
Human   194 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258

  Fly   275 QVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFD 339
            :                  .||:   .:.|.|..||....||.||....|....|.||:|.|.||
Human   259 E------------------GTDD---IQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFD 302

  Fly   340 NFMWSMLTTFQLITLDYWEN-VYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEA 403
            |.::::||.||.||::.|.: :||...|:....:..:|..::..|||:::||:|.|::..:.:|.
Human   303 NILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKER 367

  Fly   404 EITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK 468
            |  ..|.::..|..|......        ::|| ...:.|...:.|:||                
Human   368 E--RVENRRAFLKLRRQQQIE--------RELN-GYMEWISKAEEVILA---------------- 405

  Fly   469 EGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGS 533
            |..|:|                                             ||:|..    .|..
Human   406 EDETDG---------------------------------------------EQRHPF----DGAL 421

  Fly   534 NNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVD 596
            .         |.:.:.|     ..::|.|.:.:.||  ||:.|.|.:.:|               
Human   422 R---------RTTIKKS-----KTDLLNPEEAEDQLADIASVGSPFARAS--------------- 457

  Fly   597 DHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC 661
                                        ||.    |:::|...:  |::                
Human   458 ----------------------------IKS----AKLENSTFF--HKK---------------- 472

  Fly   662 DRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKV 726
                      |..::|.  :.::|:...|...:...:.|||..:|:.|:...|...:.|.....:
Human   473 ----------ERRMRFY--IRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFI 525

  Fly   727 FTSIFTFECIVKLMAL-SKDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRV 785
            |..:|..|..:|:..| ::.:|...:|.||..::..|:.::|:.::.     |:||||.|||||:
Human   526 FLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNF 850
            .|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::|||||...:   .|| :..|..||
Human   591 FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF---NFD-EGTPPTNF 651

  Fly   851 NDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-N 912
            :.|..:.|.:|:||.|| |.|.::|.::::........|:|:...|.: ||:.:||:|||:.: |
Human   652 DTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 716

  Fly   913 SFNSEEL-----KSKKEEVGEESKL----ARSIERVRDL--------IRKKRQERKDRK---ERK 957
            ..|::||     ..::||.....||    |:.:..|..|        ::::::.:|..|   |::
Human   717 LANAQELTKVEADEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQR 781

  Fly   958 FAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIP 1022
            .:|..:|.:|.:::|....:.         .|:....|.|:..|...:..::||:          
Human   782 TSEMRKQNLLASREALYNEMD---------PDERWKAAYTRHLRPDMKTHLDRPL---------- 827

  Fly  1023 LHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQN 1087
                   :||          |:                                           
Human   828 -------VVD----------PQ------------------------------------------- 832

  Fly  1088 LTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGD 1152
                   |.|..:...|..:....|.|           |||..:.|              |.|  
Human   833 -------ENRNNNTNKSRAAEPTVDQR-----------LGQQRAED--------------FLR-- 863

  Fly  1153 SLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSS- 1216
                 ...||    ||.|          |.||....||        ::|....|:|||:.|... 
Human   864 -----KQARY----HDRA----------RDPSGSAGLD--------ARRPWAGSQEAELSREGPY 901

  Fly  1217 GQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQK-GTKLRRISNVMRSRRPSSQ 1280
            |:       |.|. .:::|:|.:.          .|.:.|.|..| |...||..:.....| .|:
Human   902 GR-------ESDH-HAREGSLEQP----------GFWEGEAERGKAGDPHRRHVHRQGGSR-ESR 947

  Fly  1281 MGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIIT 1345
            .|.|......||.......:..|:..|:      ..||:..:.....||..              
Human   948 SGSPRTGADGEHRRHRAHRRPGEEGPED------KAERRARHREGSRPARG-------------- 992

  Fly  1346 GASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAA-----QRQSVKLKRRSLEKQRKIDEDFS 1405
            |..|....|              ....||.....|.|     .|:..|.:|   .::||.::.  
Human   993 GEGEGEGPD--------------GGERRRRHRHGAPATYEGDARREDKERR---HRRRKENQG-- 1038

  Fly  1406 ISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEE 1470
                               ..:.|:..:.|..:|.|.. |.|:..|.....|..|...|......
Human  1039 -------------------SGVPVSGPNLSTTRPIQQD-LGRQDPPLAEDIDNMKNNKLATAESA 1083

  Fly  1471 VPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPP 1535
            .|                     ||                         .||.|..|..||   
Human  1084 AP---------------------HG-------------------------SLGHAGLPQSPA--- 1099

  Fly  1536 TSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRR 1600
             .:.:|.:|..:..|.::.|.|..||......:   ....:.|.|..|..:|..           
Human  1100 -KMGNSTDPGPMLAIPAMATNPQNAASRRTPNN---PGNPSNPGPPKTPENSLI----------- 1149

  Fly  1601 MEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTA-PDATQKPSAFTRLTEK 1664
            :.:|..|...:|  ::||...|::  .|...|....:.....|....| ||...|.....:..|:
Human  1150 VTNPSGTQTNSA--KTARKPDHTT--VDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEE 1210

  Fly  1665 PWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCM 1729
                     ||      |...|    |...|.|.:.......:   |.:...|:.....:|..| 
Human  1211 ---------DD------RGEDG----PKPMPPYSSMFILSTTN---PLRRLCHYILNLRYFEMC- 1252

  Fly  1730 DTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCL 1794
                                       :|::|..|||.|..|| .:..|.....||.:.::.|..
Human  1253 ---------------------------ILMVIAMSSIALAAED-PVQPNAPRNNVLRYFDYVFTG 1289

  Fly  1795 IFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEEN---ENLKVLRSLRTLRAL 1852
            :|..||::|.:.||.    ..||...|.|||||:|..::.:.....|   :::..::|||.||.|
Human  1290 VFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1354

  Fly  1853 RPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI 1917
            |||:.|.|...::.|.:.::.::.::||:|:|.::|..||:::.||.|.||||.|.:|..|.  .
Human  1355 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF--E 1417

  Fly  1918 TEVNDKWDCIEQNYT------WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQP 1976
            .:...|:...|:|..      |...:..:|:|....|.|..|:|.|||.:|:..:|||...:..|
Human  1418 KDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1482

  Fly  1977 ----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH---- 2033
                :.|.:::..:|||:|    .||.:|:|:.:||..|.....|    ::|.:..|..:.    
Human  1483 SPGYRMEMSIFYVVYFVVF----PFFFVNIFVALIIITFQEQGDK----MMEEYSLEKNERACID 1539

  Fly  2034 YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFF 2098
            :..:.|.|.|..||.  |:...:.:..|.   .|..||..|..:|.||.:.:.::.|....|...
Human  1540 FAISAKPLTRHMPQN--KQSFQYRMWQFV---VSPPFEYTIMAMIALNTIVLMMKFYGASVAYEN 1599

  Fly  2099 ILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLL 2162
            .|.|.|..||::|.||.::|::... .:||...||:|||:.||.||..||:.:  ...|.:...|
Human  1600 ALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE--FGNPNNFINL 1662

  Fly  2163 RVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKL--- 2224
            ..:|:||..|:::|::....||.||:..|.|..||..:..|:.::.|||||:||.:|||:.:   
Human  1663 SFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVE 1727

  Fly  2225 -------QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHP 2282
                   :..:.:..||:||.:::.||||..|...|::::.|.:...| ||. ..|.....||:.
Human  1728 DEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP-CDK-NSGILTRECGNE 1790

  Fly  2283 LLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIH 2347
             .|..||.|||.:...:::|:::|:|::||....::..| :....|:.:...|::|||.|...:.
Human  1791 -FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEYVRVWAEYDPAAWGRMP 1853

  Fly  2348 FSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL------GH 2401
            :..:...:..:.||||:.|  |..||   |:..:||::..|.:|....|.||::..|      |.
Human  1854 YLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGG 1918

  Fly  2402 VEETDNFKQLQEQMDVKFKKQ----FP--TRKELEIV----SSTRI-------------WKRQEK 2443
            .:        ::|||.:.:|:    :|  ::|.|:::    .||.:             :.||.|
Human  1919 AD--------KQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSK 1975

  Fly  2444 AAKTIQTGWKEYLRRKREKE-------RSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTAC 2501
            |.|         |:..||::       :.....|.||...||  |:.|.:...      ..|.|.
Human  1976 AKK---------LQAMREEQDRTPLMFQRMEPPSPTQEGGPG--QNALPSTQL------DPGGAL 2023

  Fly  2502 SSRASSRKSSRA---SDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPR 2563
            .:..|..|.|.:   ..|.::.:..|.|                     :.|.|           
Human  2024 MAHESGLKESPSWVTQRAQEMFQKTGTW---------------------SPEQG----------- 2056

  Fly  2564 ASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAA 2628
                                    |......:..|:.:.........|.:.|....|..|.|.||
Human  2057 ------------------------PPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAA 2097

  Fly  2629 TSASDSDRHQAVGGGSAPSRKRAS--SFIRKKPPLERGLS--AQSALRVNKNAFVSEASAPEVIV 2689
            :.......:|...|     |.|.:  |.|....|::|..|  ...|.|::           :..:
Human  2098 SMPRLPAENQRRRG-----RPRGNNLSTISDTSPMKRSASVLGPKARRLD-----------DYSL 2146

  Fly  2690 TRPSPEQQTHPHSLSLRPDNATLVHVLVHRESE----EYKEEDESSPSVSGNGNGFGVGLDMLSK 2750
            .|..||:....|  ..|.|.:       ||.||    .|.:.|          .|.|..|.|   
Human  2147 ERVPPEENQRHH--QRRRDRS-------HRASERSLGRYTDVD----------TGLGTDLSM--- 2189

  Fly  2751 QPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPID-DVGAPIDVNVQGDTSQVF 2814
                    ||.|                         ||..|...| :.|.|.|...:.......
Human  2190 --------TTQS-------------------------GDLPSKERDQERGRPKDRKHRQHHHHHH 2221

  Fly  2815 YDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSSTSSIRSCSSS 2879
            :.::|..        .|:....:..||..|          :..|..|.|||.|.....:  ....
Human  2222 HHHHPPP--------PDKDRYAQERPDHGR----------ARARDQRWSRSPSEGREHM--AHRQ 2266

  Fly  2880 SSSSAASAAAPSARRTS 2896
            .|||.:.:.|||...||
Human  2267 GSSSVSGSPAPSTSGTS 2283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 79/220 (36%)
Ion_trans 705..902 CDD:278921 58/204 (28%)
Ion_trans 1768..2019 CDD:278921 83/267 (31%)
Na_channel_gate 2009..2063 CDD:240441 11/57 (19%)
Ion_trans 2085..2320 CDD:278921 78/245 (32%)
GPHH 2331..2386 CDD:293510 17/59 (29%)
CACNA1ANP_075461.2 I 85..363 101/299 (34%)
Ion_trans 115..371 CDD:278921 93/279 (33%)
Binding to the beta subunit. /evidence=ECO:0000250 383..400 3/25 (12%)
II 473..717 70/249 (28%)
Ion_trans 504..725 CDD:278921 67/224 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..1224 118/697 (17%)
III 1234..1517 90/320 (28%)
Ion_trans 1264..1523 CDD:278921 82/265 (31%)
Ion_trans 1586..1827 CDD:278921 78/245 (32%)
GPHH 1835..1898 CDD:293510 17/62 (27%)
Ca_chan_IQ 1900..1974 CDD:285917 15/81 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1994..2037 12/50 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2512 69/382 (18%)
polyglutamine repeat 2319..2331
Peptidase_C53 2352..>2424 CDD:283255
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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