DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Cacna1s

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_446325.1 Gene:Cacna1s / 682930 RGDID:70983 Length:1850 Species:Rattus norvegicus


Alignment Length:2879 Identity:562/2879 - (19%)
Similarity:946/2879 - (32%) Gaps:1264/2879 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC----IFLAMTET--------VEEAEYIF 156
            ::||.....:|.|:.|:.:...:.|:..::.||..||    ::|.|.|.        :|:.||.|
  Rat    29 RALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL------------AG 209
            |.::|||..:||||.|||.::..|||:.||.|||:::..|..|..:|..|:            ||
  Rat    94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAG 158

  Fly   210 -----LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
                 ||.|||||.|:.||.:|.|:.::|::..:...|..:..|.:|.::::|:..|:::.|::.
  Rat   159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223

  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVCLCVGENPNH 333
            ..|                  :...||.....|:|.|..|......|.|... ..|......|||
  Rat   224 KTC------------------YFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNH 270

  Fly   334 GYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFGSFYLINLMLAVV 395
            |.|:||||.:||||.:|.|:::.|.:|...|....|   |.  .:|..::..|||:::||:|   
  Rat   271 GITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPW--IYFVTLILLGSFFILNLVL--- 330

  Fly   396 ALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTR 460
                                                                |||...::|::.:
  Rat   331 ----------------------------------------------------GVLSGEFTKEREK 343

  Fly   461 RKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKL 525
            .|                |.|                           |.|..::.||:|:    
  Rat   344 AK----------------SRG---------------------------TFQKLREKQQLEE---- 361

  Fly   526 AKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQD 590
                                                  |.:|.:           |.:.:....|
  Rat   362 --------------------------------------DLRGYM-----------SWITQGEVMD 377

  Fly   591 DSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDD 655
                |||..|...:.|.|...|..|                     :.:..|::       :|..
  Rat   378 ----VDDLREGKLSLDEGGSDTESL---------------------YEIEGLNK-------IIQF 410

  Fly   656 LPD-RNCDRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRN 718
            :.. |..:|...| |.|             :|:..:|...:.|.:.|||..:|.|||.......:
  Rat   411 IRHWRQWNRVFRWKCHD-------------LVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTH 462

  Fly   719 ALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLS 775
            ..||.|:|..::||.|.::|:..|. :.:|:..:|.||..:|.:.:|:|:  ||:       |:|
  Rat   463 LQDVANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEIL--LVESGAMTPLGIS 525

  Fly   776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKF 840
            |||.:||||:.|:.:.||::..|::.::::|.::.:|.|:|.:.:.|||::|||||...|   .|
  Rat   526 VLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRY---DF 587

  Fly   841 DPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFM 901
            :...|.|.||::|..:.:.:|::|.|| |...:::.:.|   ....|...|. .|:...|.||::
  Rat   588 EDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCI-YFIILFVCGNYI 651

  Fly   902 VLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQI 965
            :||:|||:.: |...:|.|.|.:                    :.|.:|||.||           
  Rat   652 LLNVFLAIAVDNLAEAESLTSAQ--------------------KAKAEERKRRK----------- 685

  Fly   966 VLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTI 1030
                               :.||                                          
  Rat   686 -------------------MSRG------------------------------------------ 689

  Fly  1031 VDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
                       ||::                                                  
  Rat   690 -----------LPDK-------------------------------------------------- 693

  Fly  1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
                                                                             
  Rat   694 ----------------------------------------------------------------- 693

  Fly  1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSI 1225
               |||        ::|.:|      |.|::..:..|....:.||.:|                 
  Rat   694 ---SEE--------ERSTMT------KKLEQKPKGEGIPTTAKLKIDE----------------- 724

  Fly  1226 EQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMV 1290
                                                                             
  Rat   725 ----------------------------------------------------------------- 724

  Fly  1291 EHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADE 1355
                       ||..:.|:|              :|.|:||                        
  Rat   725 -----------FESNVNEVK--------------DPYPSAD------------------------ 740

  Fly  1356 VVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAP 1420
                 .|.|                                    ||                  
  Rat   741 -----FPGD------------------------------------DE------------------ 746

  Fly  1421 FVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIES 1485
                                                                |:|          
  Rat   747 ----------------------------------------------------EDE---------- 749

  Fly  1486 EKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQI 1550
                                                      |.:||:|        .|..||::
  Rat   750 ------------------------------------------PEIPASP--------RPRPLAEL 764

  Fly  1551 SSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQ 1615
            .          |.|          :|.|.|                                   
  Rat   765 Q----------LKE----------KAVPIP----------------------------------- 774

  Fly  1616 SARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGG 1680
                        :|||                                                 
  Rat   775 ------------EASS------------------------------------------------- 778

  Fly  1681 RRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVL 1745
                                                 |:...|             ..::|....
  Rat   779 -------------------------------------FFIFSP-------------TNKIRVLCH 793

  Fly  1746 TVVDTPAFEWFVLVLIFASSITLCFED-INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809
            .:|:...|..|:|:.|..||..|..|| |..|..:  .::|.:.::.|..:|.||::||....|.
  Rat   794 RIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILEYFDYVFTAVFTVEIVLKMTTYGA 856

  Fly  1810 ----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNA 1870
                ..:..:::.|||.::|.||:.|:.:|.:. :.|::.||.||.|||||||:|.:|::.||..
  Rat   857 FLHKGSFCRNYFNILDLLVVAVSLISMGLESSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920

  Fly  1871 LMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNY---- 1931
            :..||.:|.|::||..:...:|:.:|||.|.|||:.|    .:|..:||.    :|....|    
  Rat   921 VFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSC----NDLSKMTEE----ECRGYYYIYKD 977

  Fly  1932 -----------TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985
                       .||::...||:|....::|..|:|||||.:::..|:|:...|..|.....:...
  Rat   978 GDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMA 1042

  Fly  1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK-- 2048
            |:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|.:  
  Rat  1043 IFFIIYIILIAFFMMNIFVGFVIVTFQ------EQGETEYKNCELDKNQRQCVQYALKARPLRCY 1101

  Fly  2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113
            :.|.|..:  .::|.:::| .||..:|.||.||.:.:|::||:|...:..|.::.|..||.:|.|
  Rat  1102 IPKNPYQY--QVWYVVTSS-YFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTL 1163

  Fly  2114 EAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL---------------L 2162
            |.|:|::..:.. ||..||||||||:|:.||..:::.:|...|..|..|               .
  Rat  1164 EMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESA 1228

  Fly  2163 RV----VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223
            |:    .|:||:.|:::|:..|:|:|.||:..:.|..||..:..|:.::.||||::||.:||.:.
  Rat  1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA 1293

  Fly  2224 LQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDP---FIHGHTNGNCGHPL 2283
            :...  ::...|||||.:::.||||..|...|.::|.:.. ....|||   :..|.... || ..
  Rat  1294 MVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS-YGKRCDPESDYAPGEEYA-CG-TN 1355

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            .|..||.||.::...::||:::|:|::||:...::..| :....|:.|...|::|||.|...|..
  Rat  1356 FAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKAIWAEYDPEAKGRIKH 1419

  Fly  2349 SQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNF 2408
            ..:...:..:.||||..|  |:.||   ||..|:|::....:.....|.|||:..| .::...||
  Rat  1420 LDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL-KIKTEGNF 1483

  Fly  2409 KQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGW 2452
            :|..|::....||               ||||...                     |...||..:
  Rat  1484 EQANEELRAIIKK---------------IWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHF 1533

  Fly  2453 KEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDAS 2517
            :::::|:.|..               |::.|...:   .:|...|                    
  Rat  1534 RKFMKRQEEYY---------------GYRPKKDTV---QIQAGLR-------------------- 1560

  Fly  2518 DLSELAGPWLNLPLMLVSG----ADEVVKDIKQQNDELG---KRGSIFVEA-----------PRA 2564
            .:.|.|.|.::   ..:||    .:|:.:.:.:...|.|   :.|.:|.:.           |..
  Rat  1561 TIEEEAAPEIH---RAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVM 1622

  Fly  2565 SRRR--SFYNFFLRHQDA---VDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASST-------- 2616
            :.:|  .|....:...::   ::|...:|..| ..|..||.|..:|.|..:.:..::        
  Rat  1623 ANQRPLQFAEMEMEELESPVFLEDFPQNPGTH-PLARANTNNANANVAYGNSSHRNSPVFSSIRY 1686

  Fly  2617 -------ATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVN 2674
                   |..|.|..||.:...|.|         ...||.....       |||.:|.:.     
  Rat  1687 ERELLEEAGRPVTREGPFSQPCSVS---------GVNSRSHVDK-------LERQMSQRR----- 1730

  Fly  2675 KNAFVSEASAPEVIVTRPSP---EQQTHPHSLSLRPDNATLVHVLVHRE-------------SEE 2723
                :.:...|      |||   .|:.||                ||.|             ||.
  Rat  1731 ----MPKGQVP------PSPCQLSQEKHP----------------VHEEGKGPRSWSTETSDSES 1769

  Fly  2724 YKEEDE-------SSPS---------VSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAM 2772
            ::|...       ::|:         |.|       |||.|:..  ....:.||  ::..|.|.|
  Rat  1770 FEERVPRNSAHKCTAPATTMLIQEALVRG-------GLDSLAAD--ANFVMATG--QALADACQM 1823

  Fly  2773 PTVQIMV--------DSPK 2783
            ...::.|        :|||
  Rat  1824 EPEEVEVAATELLKRESPK 1842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 76/239 (32%)
Ion_trans 705..902 CDD:278921 66/208 (32%)
Ion_trans 1768..2019 CDD:278921 84/270 (31%)
Na_channel_gate 2009..2063 CDD:240441 9/55 (16%)
Ion_trans 2085..2320 CDD:278921 82/259 (32%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
Cacna1sNP_446325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 99/373 (27%)
Ion_trans 50..345 CDD:306908 97/369 (26%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 6/69 (9%)
II. /evidence=ECO:0000305 418..664 81/264 (31%)
Ion_trans 431..672 CDD:306908 79/246 (32%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..717 18/278 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..758 16/235 (7%)
III. /evidence=ECO:0000305 786..1068 91/292 (31%)
Ion_trans 798..1075 CDD:306908 92/293 (31%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 30/94 (32%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 90/284 (32%)
Ion_trans 1117..1392 CDD:306908 90/278 (32%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 19/68 (28%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 13/43 (30%)
GPHH 1393..1463 CDD:318993 21/70 (30%)
Ca_chan_IQ 1465..1536 CDD:312334 18/86 (21%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 4/19 (21%)
CAC1F_C 1558..1838 CDD:318975 62/361 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1697..1779 25/128 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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