DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn7a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001375437.1 Gene:Scn7a / 64155 RGDID:61922 Length:1680 Species:Rattus norvegicus


Alignment Length:2455 Identity:593/2455 - (24%)
Similarity:968/2455 - (39%) Gaps:894/2455 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 VEDGDVLPRKFEPFPEHMYGKPLEEIDTFIY--EETFCVVSKRFRKNYIHRFTGTKSLFLFYPWS 113
            :|.|..||..:...|:....:|||::|.:.|  ..||.|::   |...|.||.....|....|.|
  Rat    44 LEAGKKLPFAYGTLPQGTVSEPLEDVDPYYYVKRNTFMVLN---RNRVIFRFNAVSILCTLSPLS 105

  Fly   114 PARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLL 175
            ..||..:.:..:..|...::.::|.:.|.:.|:   |.:...|...|.||:.|:::|:||:|...
  Rat   106 SLRRAVIKVLVHPLFRLLILISVLTDSILMCMSNLPEWILAVENTLLGIYTFEILVKVIARGIWA 170

  Fly   176 NKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFR 240
            ..:::|.:.||||||.|......|....:.:|...:|.|.||.||.:.:..||::|:..|:...:
  Rat   171 GSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLK 235

  Fly   241 QLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSH--TDWQIWVNDTDNWLYDED 303
            :|...:.|.:|.|.|.:||.:.::||.|::||||....|..:|.:  |..|..:.:.:|:.|.|.
  Rat   236 KLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVMYNGTGSQYHILERENFYYMEG 300

  Fly   304 -ELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLAT 367
             ...:||||.|.|..||..|:|:..|.||::|:|:||||.|::|..|:|:|.||.|.:|:.:|..
  Rat   301 ARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFTSFDNFGWALLAMFRLMTQDYPELLYHQILYA 365

  Fly   368 CGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNV 432
            .|.:.:.||.::.|:.:||:.:|.|.::.::||:|.:..:|| .:|:                  
  Rat   366 SGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRASEE-SRDM------------------ 411

  Fly   433 KKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSP 497
                                                              |:|.|          
  Rat   412 --------------------------------------------------DSKCH---------- 416

  Fly   498 RHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYP 562
                         |..|::   |::|:.|:         |..|                      
  Rat   417 -------------QTVKEF---EEEHEGAE---------METT---------------------- 434

  Fly   563 SDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDD----HEEQDTTNDMGHVSTVELALSPREVR 623
                 |:......|:|.::.::         :::|    |:|:..|             |.:|..
  Rat   435 -----QIEMKKRSPTSINTTLD---------ILEDTALGHKEEPET-------------SRKECP 472

  Fly   624 LIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDP 688
            |  |               ..:|:....:      ..|..|         |::......:::..|
  Rat   473 L--C---------------WYKFTKTCFI------WKCSPC---------WIKLNEFADRIITHP 505

  Fly   689 LFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWN 752
            ||:|.:.:||:||..|||:||..|||...:.|.:||.||..|:|.|.|:|::|:.. .:|...|:
  Rat   506 LFDLFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISWH 570

  Fly   753 IFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILV 817
            |||.::|...|.:::...::.::|...:.|: .:||.:.....|.|:.|:...:.||.:|.|::.
  Rat   571 IFDSILVVLGLTEMLLADIEEITVFILVPLI-FIKLGKYAPPFKNLMRILGRALVALKDLVLLVS 634

  Fly   818 IVIYIFAVIGMQLFSKDYTPEKFDPDPV---------PRWNFNDFFHSFMMIFRILCGEWIEPLW 873
            |.||..||.||:||.:.|      .|.|         .||:.:||.|:::.:||||||||||.||
  Rat   635 IFIYFSAVFGMKLFGRSY------KDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGEWIETLW 693

  Fly   874 DCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIER 938
            :||   |..|.:.|...::..:::||.::|.||:| |::||.|.:..:   ||.:|:        
  Rat   694 ECM---EVAGEAWCIPFYMMVILIGNLLILYLFVA-LVSSFASYDATT---EVSKEA-------- 743

  Fly   939 VRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLS 1003
                           |..:.|..:.::|::.                       ||.:.      
  Rat   744 ---------------KNLQLAVAWIKMVINC-----------------------VLLKI------ 764

  Fly  1004 YQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAM 1068
                                                                             
  Rat   765 ----------------------------------------------------------------- 764

  Fly  1069 MATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTD 1133
                           .|:..|                |||:                        
  Rat   765 ---------------LCKEKT----------------VSTE------------------------ 774

  Fly  1134 TDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQ 1198
                |.||                                      |..||.::::         
  Rat   775 ----ATDQ--------------------------------------TCDPSVKENI--------- 788

  Fly  1199 SQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGT 1263
                             ||.:|:.:|..|                       .||:.::: ..||
  Rat   789 -----------------SGHTLSELSNTQ-----------------------TFLRYKDQ-SSGT 812

  Fly  1264 KLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSP 1328
            :                      :|.|..||..::|                             
  Rat   813 E----------------------KTPVTESESQSLI----------------------------- 826

  Fly  1329 AADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRS 1393
                |:.::.|.:.|.:|.|               |..:|.:...||:|.:.:::.   |:|:.|
  Rat   827 ----ASPSVSETVPIASGES---------------DIENLDNKETRSKSANGSSKE---KMKQSS 869

  Fly  1394 LEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDR 1458
            ..:...:|                                                         
  Rat   870 SSECSTVD--------------------------------------------------------- 877

  Fly  1459 FKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLG 1523
               :::.|..|.|.|.||              ..||              .|.||.         
  Rat   878 ---IAISEEEEMVYEHEK--------------SKLH--------------KNGYER--------- 902

  Fly  1524 MATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQ 1588
                           |||                                               
  Rat   903 ---------------KSS----------------------------------------------- 905

  Fly  1589 AHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQ 1653
                  |||..|                                                     
  Rat   906 ------AGQVSR----------------------------------------------------- 911

  Fly  1654 KPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHF 1718
                                                                             
  Rat   912 ----------------------------------------------------------------- 911

  Fly  1719 YFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR 1783
                       ::::.|.|..:|.....:|:...||.|:.::....:.||..|||.:|:.||:|.
  Rat   912 -----------ESRNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTIKI 965

  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRT 1848
            .|.:.:..|..||::||:|||:|.||..||::.|..|||::|.|...||:.:..|:|..|.|::.
  Rat   966 FLEYGDMIFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIKF 1030

  Fly  1849 LRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMG 1912
            |||   ||.:|:::.|::|:.||:.......:|.||||:.||:||:|||..|.|||::|:: ..|
  Rat  1031 LRA---LRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPTRG 1092

  Fly  1913 ELLPITEVNDKWDC----IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVD 1973
            |...:.||.:|..|    ..::..|.|:|:.||:||.|:|:|.|||||.||:.:|..|:|:.||.
  Rat  1093 ERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVY 1157

  Fly  1974 LQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAM 2038
            :||..|.:|:.|.||:||:|.|.|..|.:.|||||.|||  |:|.:.|...:|:|..||..|.|:
  Rat  1158 MQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFN--KQKIKQGGSNIFITVKQKKQYRAL 1220

  Fly  2039 KKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ-PH---AVFFI 2099
            |||.....||...||.|.|.....|:...|.|.:.|.:||.....|:.|::.:| |.   |||::
  Rat  1221 KKLLYADSQKPAARPRNKFQGFICDVVTHRVFNVIIILLICFQATTIMIQNDEQSPQIETAVFWM 1285

  Fly  2100 LEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPIS------ 2158
                |:.||.:|.||.|:|:...|.||||..|||.||::|:.||.|:|       ||:|      
  Rat  1286 ----NSLFTMLFTLECILKLTAFRCHYFTSAWNVHDFMVVVFSITGLL-------LPLSIGQYFV 1339

  Fly  2159 -PTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV 2222
             |:|::::.:.||..:||..|..|....|:..|::|||||.||..|:.|:.|||||.||..|..|
  Rat  1340 PPSLVQLLLLSRIIHVLRPGKGPKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYV 1404

  Fly  2223 KLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIHGHT--NGNCGHPL 2283
            |.:..::|:.||:|||.||..||::.|.:||:.:|:::. .|..|||| .|:..|  .|:||.|.
  Rat  1405 KKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPS 1469

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            :.|.||.|:|:||::|::|||:.:|:|..:...:.:...:.|||...|:..|:::||..||:|..
  Rat  1470 VGIFYFVSYILISWLIIVNMYVVLIMEFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDS 1534

  Fly  2349 SQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQE 2413
            ::||||.|:|||||.::|||...||:.:||::.|::|||||||.|..|.|:|..|..:   ::..
  Rat  1535 TKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVE---KILS 1596

  Fly  2414 QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKE 2463
            :::..|....|.:...|.:::|...|::..:|..||..:|.|..|:.:|:
  Rat  1597 EIESGFMLANPFKITYEPITTTLKRKQEAVSATIIQRAYKSYRLRQSDKK 1646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 80/221 (36%)
Ion_trans 705..902 CDD:278921 72/206 (35%)
Ion_trans 1768..2019 CDD:278921 112/255 (44%)
Na_channel_gate 2009..2063 CDD:240441 21/53 (40%)
Ion_trans 2085..2320 CDD:278921 99/249 (40%)
GPHH 2331..2386 CDD:293510 25/54 (46%)
Scn7aNP_001375437.1 Ion_trans 117..405 CDD:395416 95/287 (33%)
Ion_trans 504..738 CDD:395416 89/247 (36%)
Na_trans_assoc 742..926 CDD:399489 66/814 (8%)
Ion_trans 932..1203 CDD:395416 116/275 (42%)
Na_channel_gate 1194..1245 CDD:240441 21/52 (40%)
Ion_trans 1249..1496 CDD:395416 104/257 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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