DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and SCN9A

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001352465.1 Gene:SCN9A / 6335 HGNCID:10597 Length:1988 Species:Homo sapiens


Alignment Length:2610 Identity:819/2610 - (31%)
Similarity:1169/2610 - (44%) Gaps:868/2610 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|..|..:|||::|.:..: :||.|::|   ...|.||..|.:|::
Human    47 PKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNK---GKTIFRFNATPALYM 108

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|:||.||:.:.|..:..|...:|.|||.||||:.|.   :..:..||.|..||:.|.::||:|
Human   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILA 173

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.:.::|:||:||||||||||...|.|..:.:||::.||||||||||||:|::||||||:.||
Human   174 RGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 238

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDT----D 296
            :.|.::|::||.||:|||.||||..||::||.|::||.|.             .:..|:|    .
Human   239 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN-------------SLENNETLESIM 290

  Fly   297 NWLYDEDEL------------PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTF 349
            |.|..|::.            .:|||..|.:..||..|.|:.:|.||::|||:||.|.|:.|..|
Human   291 NTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALF 355

  Fly   350 QLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDL 414
            :|:|.|||||:|...|...|...:.||.||:|.||||||||:|||||::|||:.:...||.|:  
Human   356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQ-- 418

  Fly   415 LDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGS 479
                         ..|..:::....||:.:..:.:..|:......||.:..|..|         |
Human   419 -------------KELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSE---------S 461

  Fly   480 NGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGSGGSNNPMAPTP 541
            :.:.:|..|          .||.||.:....:.||:....|::   .||:||.|..|..      
Human   462 SSETSKLSS----------KSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIR------ 510

  Fly   542 KGRISFQDSGMGVK-----------NPNMLYPSDYKGQLIANSGQPSSNSS-----------GVN 584
              |.||.   :||:           .||. .|...:|.|.  |.:.||.:|           |..
Human   511 --RKSFH---LGVEGHRRAHEKRLSTPNQ-SPLSIRGSLF--SARRSSRTSLFSFKGRGRDIGSE 567

  Fly   585 RESSQDDSGVVDDHE-------------EQDTTN-DMGHVSTVELALSPREVRLIKCNGNIARIK 635
            .|.:.|:..:..|:|             |:.::| .....|...|.::.:....:.|||.::.:.
Human   568 TEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD 632

  Fly   636 NHNVYAL-------------------------HQE--FSSEVVVIDDLPDRNC------------ 661
            ..:...|                         |::  .||.::..|.|.|.|.            
Human   633 GRSALMLPNGQLLPEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILT 697

  Fly   662 ----------DRCVHW------------CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704
                      .:|..|            |:.|  |::|:.|:|.:|.||..:||||:||||||.|
Human   698 NTVEELEESRQKCPPWWYRFAHKFLIWNCSPY--WIKFKKCIYFIVMDPFVDLAITICIVLNTLF 760

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIF 768
            :|||||.|:|.|:|.|.:||.|||.||..|.::||:|:.. ::|..||||||.||||.||:::..
Human   761 MAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFL 825

  Fly   769 ELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSK 833
            ..|:||||||..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|
Human   826 ADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 890

  Fly   834 DYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTL 895
            .|..  .|.:.| .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:::..:
Human   891 SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVYMMVM 952

  Fly   896 VMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAE 960
            |:||.:||||||||||:||:|:.|.:.:|                                    
Human   953 VIGNLVVLNLFLALLLSSFSSDNLTAIEE------------------------------------ 981

  Fly   961 KFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHD 1025
                                                                             
Human   982 ----------------------------------------------------------------- 981

  Fly  1026 GLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTP 1090
                                                                             
Human   982 ----------------------------------------------------------------- 981

  Fly  1091 FVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQ 1155
                                                        ||.||:.:.......:|    
Human   982 --------------------------------------------DPDANNLQIAVTRIKKG---- 998

  Fly  1156 DNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSL 1220
                            :.|.|.                                           
Human   999 ----------------INYVKQ------------------------------------------- 1004

  Fly  1221 NSMSIEQDELLSQQGNLREELLNCDQK--ELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQ 1283
                           .|||.:|....|  ::.:.:::.|:|          |..:....|     
Human  1005 ---------------TLREFILKAFSKKPKISREIRQAEDL----------NTKKENYIS----- 1039

  Fly  1284 PENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGAS 1348
              |.|:.|.|:..|    |.||.::|....:|::                 |.:||         
Human  1040 --NHTLAEMSKGHN----FLKEKDKISGFGSSVD-----------------KHLME--------- 1072

  Fly  1349 ERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKI 1413
                                                                |.|          
Human  1073 ----------------------------------------------------DSD---------- 1075

  Fly  1414 CDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPI 1478
                                      .||                                    
Human  1076 --------------------------GQS------------------------------------ 1078

  Fly  1479 STLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE 1543
                         |:|.|      ||::                   |.|..|.      :|.:|
Human  1079 -------------FIHNP------SLTV-------------------TVPIAPG------ESDLE 1099

  Fly  1544 PPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTL 1608
            .....::||                                                        
Human  1100 NMNAEELSS-------------------------------------------------------- 1108

  Fly  1609 DKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYV 1673
            |..:.:...|....||.                                         .|  |.|
Human  1109 DSDSEYSKVRLNRSSSS-----------------------------------------EC--STV 1130

  Fly  1674 DDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC----MDTQSA 1734
            |:...|   ..:.|..:||.         :..|:.||...|.        |..||    :::...
Human  1131 DNPLPG---EGEEAEAEPMN---------SDEPEACFTDGCV--------WRFSCCQVNIESGKG 1175

  Fly  1735 KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVE 1799
            |.|..:|.....:|:...||.|::::|..||..|.||||.:::.||:|.:|.:.:..|..||::|
Human  1176 KIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1240

  Fly  1800 MILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQ 1862
            |:|||:|.|:..|||:.|..|||:||.||:.:|:...  ..:|..::|||||||||||||:||::
Human  1241 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFE 1305

  Fly  1863 GMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM-GELLPITEVNDKWDC 1926
            |||:|||||:.|||||.|||||||:||||||||||..|.|||::|:|.. |...|.::|.::.:|
Human  1306 GMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSEC 1370

  Fly  1927 -----IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYI 1986
                 :.||..|.|.|:.||:||:|||:|||||||:||..:|..|||:..||.||:.|.:||.||
Human  1371 FALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYI 1435

  Fly  1987 YFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIK 2051
            |||:||:.||||||||||||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.
Human  1436 YFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIP 1498

  Fly  2052 RPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
            ||.|......:||..::.|:|:|.|||.|||:||.:|...|...:..:|...|..|..:|..|.:
Human  1499 RPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECV 1563

  Fly  2117 VKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAK 2181
            :|::.||::||||.||:|||::|:.||.|:.:.|::....:||||.||:|:.||||||||:|.||
Human  1564 LKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAK 1628

  Fly  2182 GIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFR 2246
            |||.|||||::|||||||||.||.|:.|||||.|||.|..||.:..::||.||:|||.||..||:
Human  1629 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQ 1693

  Fly  2247 LMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAI 2307
            :.|||||:.:|..:: .:|||||| .:|  ....|:||:|.:.|.||.|:||||:::|:|||||:
Human  1694 ITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAV 1758

  Fly  2308 ILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVAL 2372
            |||||:.|.:|....:.|||.||||..|.|:||.|||||.||:||||.|:|||||.|:|||.|.|
Human  1759 ILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQL 1823

  Fly  2373 VSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRI 2437
            ::.:||:..|::|||||||.|..|.|||...|.|:   |:.||:.:|....|::...|.:::|..
Human  1824 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDS---LRSQMEERFMSANPSKVSYEPITTTLK 1885

  Fly  2438 WKRQEKAAKTIQTGWKEYLRRKREKERS--------------------------NSG----DSAT 2472
            .|:::.:|..||..::.|..|:..|..|                          ||.    |:.:
Human  1886 RKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATS 1950

  Fly  2473 QTSSPGGWQS 2482
            .|:||..:.|
Human  1951 STTSPPSYDS 1960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 105/234 (45%)
Ion_trans 705..902 CDD:278921 107/200 (54%)
Ion_trans 1768..2019 CDD:278921 147/258 (57%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 123/238 (52%)
GPHH 2331..2386 CDD:293510 32/54 (59%)
SCN9ANP_001352465.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55 1/7 (14%)
I. /evidence=ECO:0000305 112..410 141/310 (45%)
Ion_trans 125..410 CDD:306908 136/297 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..543 25/103 (24%)
Na_trans_cytopl 488..681 CDD:314757 38/206 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..611 8/45 (18%)
II. /evidence=ECO:0000305 726..989 146/477 (31%)
Ion_trans 743..956 CDD:306908 118/215 (55%)
Na_trans_assoc 982..1187 CDD:310839 67/616 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1102..1148 14/156 (9%)
III. /evidence=ECO:0000305 1180..1488 166/309 (54%)
Ion_trans 1191..1466 CDD:306908 151/274 (55%)
Na_channel_gate 1458..1510 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1497..1795 151/297 (51%)
Ion_trans 1514..1770 CDD:306908 132/255 (52%)
GPHH 1774..1837 CDD:318993 37/62 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1934..1988 7/27 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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