DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and SCN8A

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001317189.1 Gene:SCN8A / 6334 HGNCID:10596 Length:1980 Species:Homo sapiens


Alignment Length:2658 Identity:823/2658 - (30%)
Similarity:1177/2658 - (44%) Gaps:871/2658 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|:.:...|||:.|. ::.::||.|::   |...:.||:.|.:|::
Human    53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|::..||:.:.|..:..|...:|.|||.||:|:..:   :..:..||.|..||:.|.::||||
Human   115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIA 179

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.::.:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.||
Human   180 RGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT---NVSHT-------DWQI 290
            :.|.::|::||.||:|||.||||..||::||.||||||     .|.   |.|:.       ||:.
Human   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTKGFDWEE 304

  Fly   291 WVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITL 354
            ::|:..|:......| |:||||.:.|..||..|.|:..|.|||:|||:||.|.|:.|..|:|:|.
Human   305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369

  Fly   355 DYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419
            |||||:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.
Human   370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428

  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDN 484
            ::.|         |.:.:..||:.:..:...:|:.:...:.....:.|:|||.:..   |:.:.:
Human   429 EAEF---------KAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPR---SSSEIS 481

  Fly   485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGS-GGSNNPMAPTPKGRI 545
            |..|          .||.||.:....:.||:..:.|::   .|:.||.| .|........|..||
Human   482 KLSS----------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536

  Fly   546 S-----FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTN 605
            .     ...|.:.:.....|...:.|..:.:..|.......|...|.:.|:...|::.|      
Human   537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESE------ 595

  Fly   606 DMGHVSTVELALSPREVR------------------------------LIKCNGNIARI---KNH 637
              |...::.:.:..||.|                              .:.|||.::.|   .:|
Human   596 --GRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSH 658

  Fly   638 NVYALHQEFSSEV-----------------------------------VVIDDLPD--RNCDRCV 665
            ....|..|.::||                                   .::::|.:  |.|..|.
Human   659 IGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCW 723

  Fly   666 H--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
            :        | |..|  |::.:..:..:|.||..:||||:||||||.|:|||||.|:..|.:.|.
Human   724 YKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLA 786

  Fly   722 VGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRV 785
            |||.|||.|||.|..:||:|:.. .:|..||||||..||:.||:::....|:||||||..|||||
Human   787 VGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRV 851

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPR 847
            .|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:||
Human   852 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPR 916

  Fly   848 WNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLN 912
            |:.:||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:
Human   917 WHMHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLS 978

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTL 977
            ||:::.|.:..:: ||.:.|..|:.|:     ||.......|...|           .|||.:. 
Human   979 SFSADNLAATDDD-GEMNNLQISVIRI-----KKGVAWTKLKVHAF-----------MQAHFKQ- 1025

  Fly   978 SHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDL 1042
                    ...|:...|.|.      |::..|...:              ||   |.:....||.
Human  1026 --------READEVKPLDEL------YEKKANCIAN--------------HT---GADIHRNGDF 1059

  Fly  1043 PEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107
            .:                                   |||||                       
Human  1060 QK-----------------------------------NGNGT----------------------- 1066

  Fly  1108 TQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFL 1172
                                              .||.||          |..:|..:|...:|:
Human  1067 ----------------------------------TSGIGS----------SVEKYIIDEDHMSFI 1087

  Fly  1173 KYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL 1237
            . ..:|..|.|                                                      
Human  1088 N-NPNLTVRVP------------------------------------------------------ 1097

  Fly  1238 REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSF 1302
                                                              ..|..|:|:|:    
Human  1098 --------------------------------------------------IAVGESDFENL---- 1108

  Fly  1303 EKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYD 1367
              ..|::           |:.|:|..:.|                                    
Human  1109 --NTEDV-----------SSESDPEGSKD------------------------------------ 1124

  Fly  1368 LSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAAT 1432
                                           |:|:                             |
Human  1125 -------------------------------KLDD-----------------------------T 1129

  Fly  1433 SASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPD 1497
            |:|:.                      ..:.:...|||||                         
Human  1130 SSSEG----------------------STIDIKPEVEEVP------------------------- 1147

  Fly  1498 QLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAAL 1562
                                                                             
Human  1148 ----------------------------------------------------------------- 1147

  Fly  1563 TEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAA 1627
                                                  :|.|:..||                  
Human  1148 --------------------------------------VEQPEEYLD------------------ 1156

  Fly  1628 DASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPM 1692
                                                                             
Human  1157 ----------------------------------------------------------------- 1156

  Fly  1693 TFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAFE 1754
                         ||.||.:.|...  |:|     |   ::....|.|..:|.....:|:...||
Human  1157 -------------PDACFTEGCVQR--FKC-----CQVNIEEGLGKSWWILRKTCFLIVEHNWFE 1201

  Fly  1755 WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTI 1819
            .|::.:|..||..|.||||.:::.||::.:|.:.:..|..||::||:|||.|.||.|:||:.|..
Human  1202 TFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCW 1266

  Fly  1820 LDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVL 1882
            |||:||.||:.||:...  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||
Human  1267 LDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1331

  Fly  1883 LVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL-LPITEVNDKWDC---IEQNYT---WINSKITF 1940
            ||||:||||||||||..|.||:..|.||..|: ..|.:||:|.:|   :|.|.|   |.|.||.|
Human  1332 LVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINF 1396

  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIG 2005
            |:||.|||||||||||:|||::|..|||:|..|.||:.|.|:|.||||||||:.|||||||||||
Human  1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIG 1461

  Fly  2006 VIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRF 2070
            |||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||:|....:.:|....:.|
Human  1462 VIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAF 1524

  Fly  2071 EIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFD 2135
            :|.|.:||.|||:||.:|...|...:..||...|..|...|..|.::|:..||::|||:.||:||
Human  1525 DIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFD 1589

  Fly  2136 FLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200
            |::|:.||.|:.:.||:....:||||.||:|:.||||||||||.|||||.|||||::||||||||
Human  1590 FVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1654

  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPP 2265
            |.||.|:.||::|.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.:||
Human  1655 GLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719

  Fly  2266 DC--DPFIHGH-TNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDD 2327
            ||  |....|. ..|:||:|.:.|.:|.|:||||::||:|||||||||||:.|.:|....:.|||
Human  1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDD 1784

  Fly  2328 LEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILH 2392
            .|.||..|.|:||.|||||.:.:|:||..:|:.||.:.|||.:.|::.:||:..|::|||||||.
Human  1785 FETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILF 1849

  Fly  2393 ALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLR 2457
            |..|.|||...|.|   .|::||:.:|....|::...|.:::|...|::|.:|..:|..::.:| 
Human  1850 AFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHL- 1910

  Fly  2458 RKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASS----------RKSSR 2512
                                                 :|||..|....|:          :|.|.
Human  1911 -------------------------------------ARRGFICKKTTSNKLENGGTHREKKEST 1938

  Fly  2513 ASDASDLSELAGPWLNLPLMLVSGADEVVK--DIKQQNDELGKRGSIFVEAPRASRRR 2568
            .|.||           ||     ..|.|.|  ..|||..|.|:|       .||.|::
Human  1939 PSTAS-----------LP-----SYDSVTKPEKEKQQRAEEGRR-------ERAKRQK 1973

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/229 (49%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 155/259 (60%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 124/237 (52%)
GPHH 2331..2386 CDD:293510 24/54 (44%)
SCN8ANP_001317189.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62 2/8 (25%)
I. /evidence=ECO:0000305 114..442 150/347 (43%)
Ion_trans 131..421 CDD:395416 140/294 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 20/96 (21%)
Na_trans_cytopl 504..702 CDD:403218 31/205 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..602 7/41 (17%)
II. /evidence=ECO:0000305 735..1007 141/282 (50%)
Ion_trans 752..965 CDD:395416 116/215 (54%)
Na_trans_assoc 991..1192 CDD:399489 72/822 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1107..1148 16/303 (5%)
III. /evidence=ECO:0000305 1180..1495 176/316 (56%)
Ion_trans 1197..1473 CDD:395416 159/275 (58%)
Na_channel_gate 1465..1517 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1504..1801 149/296 (50%)
Ion_trans 1522..1776 CDD:395416 132/253 (52%)
GPHH 1788..1835 CDD:407139 21/46 (46%)
IQ 1894..1915 CDD:197470 6/58 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1922..1980 20/75 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.750

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