Protein Alignment NaCP60E and SCN7A

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_002967.2
• Gene: SCN7A / 6332
• HGNCID: 10594
• Length: 1682
• Species: Homo sapiens
• Alignment Length: 140
• Identity: 32/140 - (22%)
• Similarity: 45/140 - (32%)
• Gaps: 54/140 - (38%)

  Fly   306 QASNALGKDRGTLSLSG------LPTLCYFDAPTLSSYRDQYNISWTVQSYSPIREYRLFFRLAS 364
            |.|.:|...|..:::||      |.||..|....|.               .|::..|.|
Human   103 QDSGSLHHQRVLINISGLRFETQLGTLAQFPNTLLG---------------DPVKRLRYF----- 147

  Fly   365 KSMHLLHHENPLDNHIYSD--RPATNSHLYSSPFSGSNLKPASNY----------------EARV 411
                     :||.|..:.|  ||:.:..||... ||..|:...|.                ||..
Human   148 ---------DPLRNEYFFDRNRPSFDGILYYYQ-SGGRLRRPVNVSLDVFADEIRFYQLGDEAME 202

  Fly   412 QARNDHGWNK 421
            :.|.|.|:.|
Human   203 RFREDEGFIK 212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	14/70 (20%)
		Ion_trans	687..902	CDD:459842
		Ion_trans	1751..2019	CDD:459842
		Na_channel_gate	2009..2063	CDD:240441
		Ion_trans	2067..2320	CDD:459842
		GPHH	2332..2378	CDD:465306
SCN7A	NP_002967.2	I. /evidence=ECO:0000305|PubMed:35301303	100..401		32/140 (23%)
		Ion_trans	117..403	CDD:459842	28/126 (22%)
		II. /evidence=ECO:0000305|PubMed:35301303	487..758
		Ion_trans	504..717	CDD:459842
		Na_trans_assoc	743..927	CDD:461936
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..871
		III. /evidence=ECO:0000305|PubMed:35301303	916..1224
		Ion_trans	933..1198	CDD:459842
		Na_channel_gate	1194..1246	CDD:240441
		IV. /evidence=ECO:0000305|PubMed:35301303	1233..1531
		Ion_trans	1250..1497	CDD:459842