DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and SCN4A

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_000325.4 Gene:SCN4A / 6329 HGNCID:10591 Length:1836 Species:Homo sapiens


Alignment Length:2613 Identity:822/2613 - (31%)
Similarity:1142/2613 - (43%) Gaps:911/2613 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74
            :::||.:...:...::.:::...|            :.::.:|.|..||..:...|..:.|.|||
Human    29 EQRAVEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPMIYGDPPPEVIGIPLE 81

  Fly    75 EIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138
            ::|.:. .::||.|::|   ...|.||:.|.:|:|..|:|..||..:.:..:..|...:|.|||.
Human    82 DLDPYYSNKKTFIVLNK---GKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILT 143

  Fly   139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
            ||:|:.|::.   .:..||.|..||:.|.:|||:|:||.::.:|:||:|||||||.||...|.|.
Human   144 NCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTE 208

  Fly   201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265
            .:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
Human   209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273

  Fly   266 GELRNKCVRQVP------TDW----------------------------TNVSHTDWQIWVNDTD 296
            |.||.||||..|      |.|                            |..||..|.  .|||.
Human   274 GNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA--TNDTF 336

  Fly   297 NW-LYDEDE----------LPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQ 350
            :| .|..||          ..:||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:
Human   337 DWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFR 401

  Fly   351 LITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLL 415
            |:|.|||||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..|      
Human   402 LMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------ 460

  Fly   416 DHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNG 478
            |...:..|.                        .:|..:.|.:...:|.|..:  |||.      
Human   461 DKEKEEEFQ------------------------QMLEKFKKHQEELEKAKAAQALEGGE------ 495

  Fly   479 SNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKG 543
            ::||              |.|.                                           
Human   496 ADGD--------------PAHG------------------------------------------- 503

  Fly   544 RISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMG 608
                               .|..|.|..:.|:     .|..|:||..|||:.|..||.:..    
Human   504 -------------------KDCNGSLDTSQGE-----KGAPRQSSSGDSGISDAMEELEEA---- 540

  Fly   609 HVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH--- 666
                                              ||:               |.    :|.|   
Human   541 ----------------------------------HQK---------------CPPWWYKCAHKVL 556

  Fly   667 -W--CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728
             |  |.   .||:|:|.::.:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||
Human   557 IWNCCA---PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFT 618

  Fly   729 SIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSW 792
            .|||.|.::||:|:.. ::|..||||||.:|||.||:::....|.||||||..|||||.|||:||
Human   619 GIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683

  Fly   793 TTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFF 854
            .|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.:|||
Human   684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748

  Fly   855 HSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEEL 919
            |||:::||||||||||.:||||   |..|.:.|..:||..:|:||.:||||||||||:||:::.|
Human   749 HSFLIVFRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSL 810

  Fly   920 KSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVG 984
            .:..|: ||.:.|..:|.|::..|             .||:.|...:|     |.:.||      
Human   811 AASDED-GEMNNLQIAIGRIKLGI-------------GFAKAFLLGLL-----HGKILS------ 850

  Fly   985 LERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQ 1049
                                                                      |:.|.| 
Human   851 ----------------------------------------------------------PKDIML- 856

  Fly  1050 AHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSR 1114
                                     |....:|.|                               
Human   857 -------------------------SLGEADGAG------------------------------- 865

  Fly  1115 EEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLL 1179
                                                                             
Human   866 ----------------------------------------------------------------- 865

  Fly  1180 TRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNC 1244
                           .:|::..:..:.|:.|                                  
Human   866 ---------------EAGEAGETAPEDEKKE---------------------------------- 881

  Fly  1245 DQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEI 1309
                     ..||:|:|                                  ||            
Human   882 ---------PPEEDLKK----------------------------------DN------------ 891

  Fly  1310 KRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRR 1374
                                      .|:.|:.:..|               |..|.:|.     
Human   892 --------------------------HILNHMGLADG---------------PPSSLELD----- 910

  Fly  1375 SQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQP 1439
                                                       |..|:                 
Human   911 -------------------------------------------HLNFI----------------- 915

  Fly  1440 NQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSL 1504
             .:|:|..:|...:.:.|.           |:|.||:..:....|..|.|      |..|...:.
Human   916 -NNPYLTIQVPIASEESDL-----------EMPTEEETDTFSEPEDSKKP------PQPLYDGNS 962

  Fly  1505 SLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHF 1569
            |:.||..|                              :||.                       
Human   963 SVCSTADY------------------------------KPPE----------------------- 974

  Fly  1570 HATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALA 1634
                                            |.|:                             
Human   975 --------------------------------EDPE----------------------------- 978

  Fly  1635 LAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGA 1699
                   ||::.. |:..|....||....:.|.||  |||        .|||             
Human   979 -------EQAEEN-PEGEQPEECFTEACVQRWPCL--YVD--------ISQG------------- 1012

  Fly  1700 TKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFAS 1764
                                             ..|.|..:|.|...:|:...||.|::.:|..|
Human  1013 ---------------------------------RGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044

  Fly  1765 SITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSV 1829
            |..|.||||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:
Human  1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSI 1109

  Fly  1830 FSLLIE--ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIF 1892
            .||:..  ....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:|||||
Human  1110 ISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174

  Fly  1893 SIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQ 1952
            |||||..|.|||:.|:| ...|...|:|||:|.:|....:|    |:|.|:.:|:||:|||:|||
Human  1175 SIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239

  Fly  1953 VATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKK 2017
            ||||:|||::|..|||:|..:.|||.|.|||.|:||||||:.||||||||||||||||||..|||
Human  1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1304

  Fly  2018 YEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNM 2082
            ..|  .::|:||.||.||.||||||.|||||.|.||.|....|.|||...:.|:|.|.:||.|||
Human  1305 LGG--KDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367

  Fly  2083 LTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGIL 2147
            :||.:|..:|......||...|..|..:|..|.::|::.||.:||||.||:|||::|:.||.|:.
Human  1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLA 1432

  Fly  2148 MEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYA 2212
            :.|::....:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:
Human  1433 LSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYS 1497

  Fly  2213 ILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG--- 2273
            |.|||.|..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:..   
Human  1498 IFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGT 1562

  Fly  2274 HTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKY 2338
            ...|:||:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:
Human  1563 SVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKF 1627

  Fly  2339 DPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVE 2403
            ||.|||||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...
Human  1628 DPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSG 1692

  Fly  2404 ETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--- 2465
            |.|..||..|:   ||....|::...|.:::|...|.:|..|..||..::.:|.::..|:.|   
Human  1693 EMDALKQTMEE---KFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMY 1754

  Fly  2466 -----NSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGP 2525
                 .|||.|.:       :..|.|.....:.....|.  ||..|..:...|.|       |||
Human  1755 RHSHDGSGDDAPE-------KEGLLANTMSKMYGHENGN--SSSPSPEEKGEAGD-------AGP 1803

  Fly  2526 WLNLPLMLVSGAD 2538
              .:.||.:|.:|
Human  1804 --TMGLMPISPSD 1814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 116/263 (44%)
Ion_trans 705..902 CDD:278921 109/200 (55%)
Ion_trans 1768..2019 CDD:278921 149/257 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 123/238 (52%)
GPHH 2331..2386 CDD:293510 28/54 (52%)
SCN4ANP_000325.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..63 3/35 (9%)
I. /evidence=ECO:0000305 113..454 149/342 (44%)
Ion_trans 152..457 CDD:278921 136/306 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..530 16/123 (13%)
II. /evidence=ECO:0000305 560..832 146/278 (53%)
Ion_trans 595..790 CDD:278921 107/197 (54%)
Na_trans_assoc 816..1026 CDD:284034 76/820 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..886 6/176 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..992 22/200 (11%)
III. /evidence=ECO:0000305 1013..1326 171/314 (54%)
Ion_trans 1048..1304 CDD:278921 147/255 (58%)
Na_channel_gate 1296..1348 CDD:240441 31/53 (58%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1310..1312 0/1 (0%)
IV. /evidence=ECO:0000305 1335..1633 152/297 (51%)
Ion_trans 1370..1609 CDD:278921 123/238 (52%)
GPHH 1620..1675 CDD:293510 28/54 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1836 13/48 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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