DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and SCN3A

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_008853.3 Gene:SCN3A / 6328 HGNCID:10590 Length:2000 Species:Homo sapiens


Alignment Length:2635 Identity:829/2635 - (31%)
Similarity:1182/2635 - (44%) Gaps:851/2635 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||..|:.:.....:......||:           |:..:.:|.|..||..:...|..|..:|||:
Human    26 EKRAAEEKAKKPKKEQDNDDENK-----------PKPNSDLEAGKNLPFIYGDIPPEMVSEPLED 79

  Fly    76 IDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|. :|.::||.|::|   ...|.||:.|.:|::..|.:|.|::.:.|..:..|...:|.|||.|
Human    80 LDPYYINKKTFIVMNK---GKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTN 141

  Fly   140 CIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201
            |:|:.::   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.||...|.|..
Human   142 CVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEF 206

  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266
            :::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||::||
Human   207 VDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

  Fly   267 ELRNKCVRQVPTD--------------------WTNV--SHTDWQIWVNDTDN-WLYDEDELPVL 308
            .|||||::..|:|                    :.||  |..:|:.::.|..: ::.|..:.|:|
Human   272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLL 336

  Fly   309 CGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSV 373
            |||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|||||:|.:.|...|...:
Human   337 CGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM 401

  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKN 438
            .||.:|:|.|||||:||:|||||::|||:.:.|.||        .:.....|...:..:||..:.
Human   402 IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEE--------AEQKEAEFQQMLEQLKKQQEE 458

  Fly   439 NKKKI--------------------DSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDD 483
            .:...                    .|.:...|:|.|.|:.|.::.|..:.....||..|.....
Human   459 AQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSF 523

  Fly   484 NKSHSATPSPGPSPRHSATERPSAL-TMQAQKQYQQME--QQHKLAKSGSGGSNNPMAPTPKGRI 545
            .||.|          ..:.:|.|.| :|...:.....:  ..|:...|..|...:|...:.....
Human   524 PKSES----------EDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIF 578

  Fly   546 SFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHV 610
            ||:.....|.:.|     |:         ....:|:..:.||.:|...|...|.|:..:|    |
Human   579 SFRGRAKDVGSEN-----DF---------ADDEHSTFEDSESRRDSLFVPHRHGERRNSN----V 625

  Fly   611 STVELALSPREV----------RLIKCNGNIA--------------------------RIKNHNV 639
            |  :.::|.|.|          ..:.|||.::                          |.:..:.
Human   626 S--QASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSS 688

  Fly   640 YALHQEFSSE--------------VVVIDDLPD--RNCDRCVH--------W-CTDYESWLQFQN 679
            |.:..|...:              ...:::|.:  :.|..|.:        | |.|  :||:.::
Human   689 YQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCD--AWLKVKH 751

  Fly   680 CLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK 744
            .:..:|.||..:||||:||||||.|:||||:.|:|.|.:.|.|||.|||.|||.|.::|::|:..
Human   752 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDP 816

  Fly   745 -DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGA 808
             .:|..||||||.:||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.:::||
Human   817 YYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 881

  Fly   809 LGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIE 870
            ||||||:|.|:::||||:|||||.|.|..  .|.:.| .:|||:.|||||||:::||:|||||||
Human   882 LGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIE 946

  Fly   871 PLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARS 935
            .:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:.|.:..:: .|.:.|..:
Human   947 TMWDCM---EVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD-NEMNNLQIA 1007

  Fly   936 IERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFH 1000
            :.|:        |:..|..:.|..|.||:...                     .||.|       
Human  1008 VGRM--------QKGIDYVKNKMRECFQKAFF---------------------RKPKV------- 1036

  Fly  1001 RLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYE 1065
                                |.:|:|                                   ...:
Human  1037 --------------------IEIHEG-----------------------------------NKID 1046

  Fly  1066 SAMMATTGGSFSSV-----NGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIEL 1125
            |.|...||...|..     :||||                  :|||.|                 
Human  1047 SCMSNNTGIEISKELNYLRDGNGT------------------TSGVGT----------------- 1076

  Fly  1126 LGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLD 1190
                                                                             
Human  1077 ----------------------------------------------------------------- 1076

  Fly  1191 RLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQE 1255
                                      |.|:....|::::.:|...|                   
Human  1077 --------------------------GSSVEKYVIDENDYMSFINN------------------- 1096

  Fly  1256 EEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEKELEEIKRSTTSLE 1317
                                 ||..:..|   ..|..|:|:|:..   |.|.||||.|....:  
Human  1097 ---------------------PSLTVTVP---IAVGESDFENLNTEEFSSESELEESKEKLNA-- 1135

  Fly  1318 RKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAA 1382
                                       |.:||.|..| ||||                       
Human  1136 ---------------------------TSSSEGSTVD-VVLP----------------------- 1149

  Fly  1383 QRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRR 1447
             |:.                                                             
Human  1150 -REG------------------------------------------------------------- 1152

  Fly  1448 KVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSY 1512
                              |:.|..|||:                                     
Human  1153 ------------------EQAETEPEED------------------------------------- 1162

  Fly  1513 ENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAA 1577
                                                    ||                       
Human  1163 ----------------------------------------LK----------------------- 1164

  Fly  1578 PTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTE 1642
                                                                             
Human  1165 ----------------------------------------------------------------- 1164

  Fly  1643 QSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPD 1707
                                                                           |:
Human  1165 ---------------------------------------------------------------PE 1166

  Fly  1708 DCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED 1772
            .||.:.|...|    |:.....:....|.|..:|....::|:...||.|::.:|..||..|.|||
Human  1167 ACFTEGCIKKF----PFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFED 1227

  Fly  1773 INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE- 1836
            |.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:... 
Human  1228 IYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANAL 1292

  Fly  1837 -NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFF 1900
             ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||..|
Human  1293 GYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1357

  Fly  1901 GGKFFKCVN-EMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEV 1962
            .|||:.||| ..|.:..|::||:..||  :.:...|.|.|:.||:||.|||||||||||:|||::
Human  1358 AGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDI 1422

  Fly  1963 MADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFL 2027
            |..|||:|.|.|||..|.|||.|:||||||:.||||||||||||||||||..|||:.|  .::|:
Human  1423 MYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QDIFM 1485

  Fly  2028 TESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ 2092
            ||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.|||:||.:|..||
Human  1486 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQ 1550

  Fly  2093 PHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPI 2157
            ...:..:|...|..|..:|..|.::|:|.||::|||:.||:|||::|:.||.|:.:.:::....:
Human  1551 GKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV 1615

  Fly  2158 SPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV 2222
            ||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.|||.|..|
Human  1616 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1680

  Fly  2223 KLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCGHPL 2283
            |.:..:|||.||:|||.||..||::.|||||:.:|..:: ..|||||| .||  ....|:||:|.
Human  1681 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1745

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            :.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|.|:||.|||||.|
Human  1746 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEF 1810

  Fly  2349 SQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQE 2413
            |:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||...|.|   .|:.
Human  1811 SKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD---ALRI 1872

  Fly  2414 QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS----------- 2467
            ||:.:|....|::...|.:::|...|::|.:|..||..::.||.::|.|..|::           
Human  1873 QMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRID 1937

  Fly  2468 --------------------GDSATQTSSPGGWQS 2482
                                .|.::.|:||..:.|
Human  1938 LPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDS 1972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/241 (47%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 154/255 (60%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/238 (53%)
GPHH 2331..2386 CDD:293510 32/54 (59%)
SCN3ANP_008853.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 6/42 (14%)
I. /evidence=ECO:0000305 110..455 149/352 (42%)
Ion_trans 149..434 CDD:278921 132/284 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..528 10/34 (29%)
Na_trans_cytopl 510..629 CDD:288761 29/148 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..631 13/63 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..681 0/18 (0%)
II. /evidence=ECO:0000305 742..1014 141/285 (49%)
Ion_trans 777..972 CDD:278921 103/197 (52%)
Na_trans_assoc 998..1200 CDD:284034 73/827 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1162 21/176 (12%)
III. /evidence=ECO:0000305 1188..1499 175/312 (56%)
Ion_trans 1223..1477 CDD:278921 152/253 (60%)
Na_channel_gate 1469..1521 CDD:240441 32/53 (60%)
IV. /evidence=ECO:0000305 1508..1806 153/297 (52%)
Ion_trans 1543..1781 CDD:278921 124/237 (52%)
ChtBD1 1708..>1743 CDD:302575 15/34 (44%)
GPHH 1793..1848 CDD:293510 32/54 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1949..2000 5/24 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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