back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and SCN2A

DIOPT Version :10

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_066287.2	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens

Alignment Length:	2594	Identity:	824/2594 - (31%)
Similarity:	1181/2594 - (45%)	Gaps:	815/2594 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72
            |..|...|..|.:|..:..:.|.|.:...  .|.|  |:..:.:|.|..||..:...|..|...|
Human    17 FTRESLAAIEQRIAEEKAKRPKQERKDED--DENG--PKPNSDLEAGKSLPFIYGDIPPEMVSVP 77

  Fly    73 LEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            ||::|. :|.::||.|::|   ...|.||:.|.:|::..|::|.|::.:.|..:..|:..:|.||
Human    78 LEDLDPYYINKKTFIVLNK---GKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTI 139

  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198
            |.||:|:.|:   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.|||..|.
Human   140 LTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV 204

  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263
            |..:::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
Human   205 TEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 269

  Fly   264 YMGELRNKCVRQVP---------TDWTN-------------VSHTDWQIWVNDTDNWLYDEDEL- 305
            :||.|||||::..|         |.:.|             ||..:|..::.|..::.:.|.:.
Human   270 FMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQND 334

  Fly   306 PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGP 370
            .:||||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|:|||:|.:.|...|.
Human   335 ALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK 399

  Fly   371 MSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERK------KDLLDH------------ 417
            ..:.||.:|:|.||||||||:|||||::|||:.:.|.||.:      :.:|:.
Human   400 TYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAA 464

  Fly   418 -------RDDS------TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKE 469
                   ||.|      .||...||  ..||:..::|::.:|         :||.::|:..|.:|
Human   465 AAASAESRDFSGAGGIGVFSESSSV--ASKLSSKSEKELKNR---------RKKKKQKEQSGEEE 518

  Fly   470 GGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSN 534
                     .|....||.|.........|.|.  ..|.||.:     ::....|:...|..|...
Human   519 ---------KNDRVRKSESEDSIRRKGFRFSL--EGSRLTYE-----KRFSSPHQSLLSIRGSLF 567

  Fly   535 NPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHE 599
            :|...:.....||:.....:.:.|     |:         ....:|:..:.:|.:|...|...|.
Human   568 SPRRNSRASLFSFRGRAKDIGSEN-----DF---------ADDEHSTFEDNDSRRDSLFVPHRHG 618

  Fly   600 EQDTTN--DMGHVSTVELALSPREVRL---IKCNGNIARIKNHNVYA----------------LH 643
            |:..:|  .....|.| |.:.|...::   :.|||.::.:...:...                ..
Human   619 ERRHSNVSQASRASRV-LPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRK 682

  Fly   644 QEFSSEVVVIDDLPD-------------------------RNC--------DRCVHW-CTDYESW 674
            :..||..|.:|.|.|                         :.|        :.|:.| |.  :.|
Human   683 RRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCC--KPW 745

  Fly   675 LQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKL 739
            |:.::.:..||.||..:||||:||||||.|:||||:.|:|.|.:.|.|||.|||.|||.|..:|:
Human   746 LKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810

  Fly   740 MALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIII 803
            :|:.. .:|..||||||..||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.
Human   811 IAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIG 875

  Fly   804 STIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILC 865
            :::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.:||||||:::||:||
Human   876 NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLC 940

  Fly   866 GEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEES 930
            |||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:.|.:..:: .|.:
Human   941 GEWIETMWDCM---EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD-NEMN 1001

  Fly   931 KLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLA 995
            .|..::.|:        |:..|..:||..|..|:..:..|:|                     |.
Human  1002 NLQIAVGRM--------QKGIDFVKRKIREFIQKAFVRKQKA---------------------LD 1037

  Fly   996 ETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSM 1060
            |.|                       ||.|
Human  1038 EIK-----------------------PLED----------------------------------- 1044

  Fly  1061 PPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIEL 1125

Human  1045 ----------------------------------------------------------------- 1044

  Fly  1126 LGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLD 1190
                        .|:::..|        :.::::...|                       |.|:
Human  1045 ------------LNNKKDSC--------ISNHTTIEIG-----------------------KDLN 1066

  Fly  1191 RLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQE 1255
            .|...:|.:.              ..|.|:....:::.:.:|...|
Human  1067 YLKDGNGTTS--------------GIGSSVEKYVVDESDYMSFINN------------------- 1098

  Fly  1256 EEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEKELEEIKRSTTSLE 1317
                                 ||..:..|   ..|..|:|:|:..   |.|.::||.|....:
Human  1099 ---------------------PSLTVTVP---IAVGESDFENLNTEEFSSESDMEESKEKLNA-- 1137

  Fly  1318 RKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAA 1382
                                       |.:||.|..|
Human  1138 ---------------------------TSSSEGSTVD---------------------------- 1147

  Fly  1383 QRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRR 1447
                                              |.||             |...||
Human  1148 ----------------------------------IGAP-------------AEGEQP-------- 1157

  Fly  1448 KVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSY 1512
                                 |..|||
Human  1158 ---------------------EVEPEE-------------------------------------- 1163

  Fly  1513 ENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAA 1577
                                        |:|
Human  1164 ----------------------------SLE---------------------------------- 1166

  Fly  1578 PTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTE 1642

Human  1167 ----------------------------------------------------------------- 1166

  Fly  1643 QSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPD 1707
                                                                           |:
Human  1167 ---------------------------------------------------------------PE 1168

  Fly  1708 DCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLC 1769
            .||.:.|...  |:|     |   ::....|.|..:|.....:|:...||.|::.:|..||..|.
Human  1169 ACFTEDCVRK--FKC-----CQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226

  Fly  1770 FEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLI 1834
            ||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||..
Human  1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTA 1291

  Fly  1835 EE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGV 1897
            ..  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||
Human  1292 NALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGV 1356

  Fly  1898 QFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WINSKITFDHVGMGYLALLQVATF 1956
            ..|.|||:.|:| ..||:..::.||:..:|   ||.|.|  |.|.|:.||:||:|||:|||||||
Human  1357 NLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATF 1421

  Fly  1957 EGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGG 2021
            :|||::|..|||:|.|:|||:.|.|||.|:||||||:.||||||||||||||||||..|||:.|
Human  1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG- 1485

  Fly  2022 VLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMG 2086
             .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.|||:||.
Human  1486 -QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMM 1549

  Fly  2087 IEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDI 2151
            :|..||...:..||...|..|..:|..|.::|::.|||:|||:.||:|||::|:.||.|:.:.::
Human  1550 VETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614

  Fly  2152 MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGM 2216
            :....:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.||
Human  1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679

  Fly  2217 SLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDP---FIHGHTNG 2277
            |.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.. ||||||   .......|
Human  1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKG 1744

  Fly  2278 NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHA 2342
            :||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|.|:||.|
Human  1745 DCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809

  Fly  2343 TQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDN 2407
            ||||.|::||||..:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||...|.|
Human  1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD- 1873

  Fly  2408 FKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSN 2466
              .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.||.:::.|:.|:
Human  1874 --ALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSS 1930

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.