DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and SCN1A

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001159435.1 Gene:SCN1A / 6323 HGNCID:10585 Length:2009 Species:Homo sapiens


Alignment Length:2553 Identity:810/2553 - (31%)
Similarity:1173/2553 - (45%) Gaps:794/2553 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|..|..:|||::|. :|.::||.|::|   ...|.||:.|.:|::
Human    49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|::|.|::.:.|..:..|...:|.|||.||:|:.|:   :..:..||.|..||:.|.:|||||
Human   111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.|..:|:||:|||||||.|||..|.|..:::||::.||||||||||||:|::||||||:.||
Human   176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHT-------------- 286
            :.|.::|::||.||:|||.||||..||::||.|||||::..||:.:...|:              
Human   241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLI 305

  Fly   287 -------DWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343
                   ||:.::.|:....:.|..| .:||||.:.|..||..|:|:..|.|||:|||:||.|.|
Human   306 NETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370

  Fly   344 SMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408
            :.|:.|:|:|.|:|||:|.:.|...|...:.||.:|:|.||||||||:|||||::|||:.:.|.|
Human   371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435

  Fly   409 ERKK---------DLLDHRDD----------STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
            |.::         :.|..:.:          |..|.:||.......:.:...|:.|:      |.
Human   436 EAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSK------SA 494

  Fly   455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDD-NKSHSAT----------------------PSPGP- 495
            .:::.||||.|..::.|    |...:.|: .||.|..                      .||.. 
Human   495 KERRNRRKKRKQKEQSG----GEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQS 555

  Fly   496 ---------SPRHSATERPSALTMQAQ-----KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRIS 546
                     |||.::  |.|..:.:.:     .:....:.:|...:......::...|...|...
Human   556 LLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERR 618

  Fly   547 FQDSGMGVKNPNML--YPSDYK-------GQLIANSGQPSSNSSGVNR--------ESSQDDSGV 594
            ..:.....::..||  :|::.|       ..:::..|.||..:|.|.:        :.:.||:|.
Human   619 NSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGT 683

  Fly   595 VDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDR 659
            ..:.|.:...:...|||...|....:..|.:    :||.|..:.|..|.:.            .:
Human   684 TTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------RQ 732

  Fly   660 NCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSES 715
            .|..|.:        | |:.|  ||:.::.:..||.||..:||||:||||||.|:||||:.|::.
Human   733 KCPPCWYKFSNIFLIWDCSPY--WLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 795

  Fly   716 FRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRG 779
            |.|.|.|||.|||.|||.|..:|::|:.. .:|..||||||..|||.||:::....|:||||||.
Human   796 FNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRS 860

  Fly   780 LRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDP 842
            .|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...
Human   861 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS 925

  Fly   843 D-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLF 906
            | .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:|||||
Human   926 DCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLNLF 987

  Fly   907 LALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQ 971
            |||||:||:::.|.:..:: .|.:.|..:::|:...:...:        ||..|..||..:..|:
Human   988 LALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGVAYVK--------RKIYEFIQQSFIRKQK 1043

  Fly   972 AHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEY 1036
                                 :|.|.|                       ||.|           
Human  1044 ---------------------ILDEIK-----------------------PLDD----------- 1053

  Fly  1037 DDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQ 1101
                                                      :|                     
Human  1054 ------------------------------------------LN--------------------- 1055

  Fly  1102 ISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEE 1166
                                                           |:.||...|.:...|   
Human  1056 -----------------------------------------------NKKDSCMSNHTAEIG--- 1070

  Fly  1167 HDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELL 1231
                                |.||.|...:|.:...            .:|.|:....|::.:.:
Human  1071 --------------------KDLDYLKDVNGTTSGI------------GTGSSVEKYIIDESDYM 1103

  Fly  1232 SQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFD 1296
            |...|                                        ||..:..|   ..|..|:|:
Human  1104 SFINN----------------------------------------PSLTVTVP---IAVGESDFE 1125

  Fly  1297 NI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPL 1360
            |: .:.|..|        :.||.....|:|.|.:::.:|..|        ||             
Human  1126 NLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA------------- 1161

  Fly  1361 NPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAME 1425
                                                                             
Human  1162 ----------------------------------------------------------------- 1161

  Fly  1426 AMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPR 1490
                                                          |.||:|:            
Human  1162 ----------------------------------------------PVEEQPV------------ 1168

  Fly  1491 KFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKT 1555
                                                               :|            
Human  1169 ---------------------------------------------------VE------------ 1170

  Fly  1556 TPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTE 1620
                                                            |:.||:           
Human  1171 ------------------------------------------------PEETLE----------- 1176

  Fly  1621 SHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQ 1685
                                                                             
Human  1177 ----------------------------------------------------------------- 1176

  Fly  1686 GAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTV 1747
                                |:.||.:.|...  |:|     |   ::....|.|..:|.....:
Human  1177 --------------------PEACFTEGCVQR--FKC-----CQINVEEGRGKQWWNLRRTCFRI 1214

  Fly  1748 VDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKY 1812
            |:...||.|::.:|..||..|.||||.:|:.||:|.:|.:.:..|..||::||:|||:|.|:..|
Human  1215 VEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTY 1279

  Fly  1813 FTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAI 1875
            ||:.|..|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.||
Human  1280 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAI 1344

  Fly  1876 PSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WI 1934
            |||.|||||||:||||||||||..|.|||:.|:| ..|:...|.:||:..||   ||:|.|  |.
Human  1345 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWK 1409

  Fly  1935 NSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFT 1999
            |.|:.||:||.|||:|||||||:|||::|..|||:|.|:|||:.|.:||.|:||||||:.|||||
Human  1410 NVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1474

  Fly  2000 LNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDL 2064
            |||||||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|.
Human  1475 LNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDF 1537

  Fly  2065 SNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTV 2129
            ...:.|:|:|.:||.|||:||.:|..||...|..||...|..|..:|..|.::|::.||::|||:
Human  1538 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602

  Fly  2130 PWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSL 2194
            .||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::||
Human  1603 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1667

  Fly  2195 PALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLES 2259
            |||||||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..
Human  1668 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732

  Fly  2260 LM-IQPPDCDPFIHGHTN------GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQ 2317
            :: .:||||||   ...|      |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:
Human  1733 ILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1794

  Fly  2318 EEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKG 2382
            |....:.|||.||||..|.|:||.||||:.|.:||.|.|:|:|||.:.:||.:.|::.:||:..|
Human  1795 ESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSG 1859

  Fly  2383 NKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKT 2447
            ::|||||||.|..|.|||...|.|   .|:.||:.:|....|::...:.:::|...|::|.:|..
Human  1860 DRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVI 1921

  Fly  2448 IQTGWKEYLRRKREKERS 2465
            ||..::.:|.::..|:.|
Human  1922 IQRAYRRHLLKRTVKQAS 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/240 (47%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 155/258 (60%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/241 (52%)
GPHH 2331..2386 CDD:293510 25/54 (46%)
SCN1ANP_001159435.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 3/10 (30%)
I. /evidence=ECO:0000305 110..454 150/343 (44%)
Ion_trans 127..433 CDD:306908 142/305 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..529 18/83 (22%)
Na_trans_cytopl 510..705 CDD:314757 32/200 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..627 3/42 (7%)
II. /evidence=ECO:0000305 750..1022 141/277 (51%)
Ion_trans 767..980 CDD:306908 117/215 (54%)
Na_trans_assoc 1006..1213 CDD:310839 67/824 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 11/173 (6%)
III. /evidence=ECO:0000305 1200..1514 176/315 (56%)
Ion_trans 1217..1492 CDD:306908 159/274 (58%)
Na_channel_gate 1484..1536 CDD:240441 32/53 (60%)
IV. /evidence=ECO:0000305 1523..1821 153/300 (51%)
Ion_trans 1540..1796 CDD:306908 133/258 (52%)
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1561..1571 4/9 (44%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1619..1636 4/16 (25%)
GPHH 1800..1863 CDD:318993 30/62 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1986..2009
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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