DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Cacna1h

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_006524796.1 Gene:Cacna1h / 58226 MGIID:1928842 Length:2367 Species:Mus musculus


Alignment Length:3016 Identity:641/3016 - (21%)
Similarity:1039/3016 - (34%) Gaps:1122/3016 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 RRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVI 166
            |..|:.:..|.:|::..|..|:.||:.|.|....|:.|              :|| |.:::||||
Mouse    90 RSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVECRSERCSILEAFDDFIF-AFFAVEMVI 153

  Fly   167 KIIAKGFLLNKYTYLRNPWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGL 228
            |::|.| |..:..||.:.||.|||.::.:|   |:..|..| :|:.:||.||||.|:.::.:|.:
Mouse   154 KMVALG-LFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNV-SLSAIRTVRVLRPLRAINRVPSM 216

  Fly   229 KTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKC------VRQ------VPTDWT 281
            :.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|      ||.      .|...|
Mouse   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQT 281

  Fly   282 NVSHTDWQIWVNDTDNWLY------DEDELPVLC--------------GNLTGARHC----PFEY 322
            .....:..|..:..||.:.      ...||.|.|              |. .|...|    .:..
Mouse   282 EEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGG-AGRNACINWNQYYN 345

  Fly   323 VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYL 387
            ||.....||::|..||||..::.:..||:|||:.|.::...|:......:..:|.:::..|||::
Mouse   346 VCRSGEFNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFM 410

  Fly   388 INLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTF-SFDPSVLNVKKLNK---NNKKKID 444
            |||.|.|:|..:.|    |.::..|:|.:.|   .:|||. ||.......::|.|   :..:|:.
Mouse   411 INLCLVVIATQFSETKQRENQLMREQRARYL---SNDSTLASFSEPGSCYEELLKYVGHIFRKVK 472

  Fly   445 SRKGVLLASYS---KKKT-----------RRKKTKGGKE------------------------GG 471
            .|...|.|.:.   :||.           ||:..:.|:.                        |.
Mouse   473 RRSLRLYARWQSRWRKKVDPSSTLHGQGPRRRPRRAGRRTASVHHLVYHHHHHHHHHYHFSHGGP 537

  Fly   472 TNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTM-----QAQKQYQQMEQQHKLA----- 526
            ...:.....||.....:..|...|||.|...:..|..::     ..:...::....|.:|     
Mouse   538 RRPSPEPGAGDTRLVRACVPPSPPSPGHGPPDSESVHSIYHADCHVEGPQERARVAHTIATAASL 602

  Fly   527 --KSGSGGSNNP-MAPT------------PKGRISFQDSGMGVKNPNML-YPSDY-KGQLIANS- 573
              .||.|..|.| :.|:            |||..|....|....:|..| .||.| |.|.:... 
Mouse   603 KLASGLGTMNYPTILPSGAVNSKGSTSSRPKGLRSAGTPGATAHSPLSLGSPSPYEKIQHVVGEQ 667

  Fly   574 --GQPSSNSSGVN-------------------------------RESSQDDSGVVDDHEEQDTTN 605
              |:.||:.||::                               .|.|..:||..|.|...:.|.
Mouse   668 GLGRASSHLSGLSVPCPLPSPQAGTLTCELKSCPYCASALEDPEFEFSGSESGDSDAHGVYEFTQ 732

  Fly   606 DMGHVSTVELALSPRE--------------VRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDL 656
            |:.|....:....|.|              :|.....|.:.|:                      
Mouse   733 DVRHGDCRDPVQQPHEGGTPGHGNERWRPPLRTASQPGGLGRL---------------------- 775

  Fly   657 PDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
                             |..|.:.|.::|....|...|...|::||..:.:|:|...:...|||:
Mouse   776 -----------------WASFSSKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPDELTNALE 823

  Fly   722 VGNKVFTSIFTFECIVKLMALSKDFFLCG--------WNIFDLLIVTASLLDIIFELVDGLSVLR 778
            :.|.||||:|..|.::||:|       ||        :||||.::|..|:.:|:.:...||||||
Mouse   824 ISNIVFTSMFALEMLLKLLA-------CGPLGYIRNPYNIFDGIVVIISVWEIVGQADGGLSVLR 881

  Fly   779 GLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            ..||||||||.:....::..|.:::.|:..:....::|::.|:||:::||.||...::.:....|
Mouse   882 TFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTDSGD 946

  Fly   844 PVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLF 906
            .|| |.||:....:.:.:|:||..| |...|::.|.:.....|    ..|:..:..||:::.||.
Mouse   947 TVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAA----LYFVALMTFGNYVLFNLL 1007

  Fly   907 LALLLNSFNSE--ELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDA 969
            :|:|:..|.:|  ..:|..:|....:.|....:::||:                           
Mouse  1008 VAILVEGFQAEGDATRSDTDEDKTSTHLEEDFDKLRDV--------------------------- 1045

  Fly   970 QQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGL 1034
                      ||             .|.|.:.|:                          :....
Mouse  1046 ----------QA-------------TEMKMYSLA--------------------------VTPNG 1061

  Fly  1035 EYDDTGDLPEQI--QLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERR 1097
            ..:..|.||..:  ...|.|:|                                  ||.......
Mouse  1062 HLEGRGSLPPPLITHTAATPMP----------------------------------TPKSSPHLD 1092

  Fly  1098 LQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRY 1162
            :.|.:        .|||..             :|...||...||:|..       ||:.:....:
Mouse  1093 MAHTL--------LDSRRS-------------SSGSVDPQLGDQKSLA-------SLRSSPCAPW 1129

  Fly  1163 GSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQ 1227
            |                             ..|:|.|:||                |.||:    
Mouse  1130 G-----------------------------PNSAGSSRRS----------------SWNSL---- 1145

  Fly  1228 DELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEH 1292
                                                          .|.||              
Mouse  1146 ----------------------------------------------GRAPS-------------- 1150

  Fly  1293 SEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVV 1357
                            :||.:...||:                      ::::|..:.|..||. 
Mouse  1151 ----------------LKRRSQCGERE----------------------SLLSGEGKGSTDDEA- 1176

  Fly  1358 LPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFV 1422
                                                        ||                   
Mouse  1177 --------------------------------------------ED------------------- 1178

  Fly  1423 AMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEK 1487
                    :...|...|..||..|                               .:.||     
Mouse  1179 --------SRPNSGTHPGASPGPR-------------------------------ATPLR----- 1199

  Fly  1488 MPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPAT-PPTSLKSSIEPPTLAQIS 1551
                        |.:||..:||              |...|..||| .||.              
Mouse  1200 ------------RAESLGHRST--------------MDLCPPRPATLLPTK-------------- 1224

  Fly  1552 SLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQS 1616
                             |...:.|....|:...                                
Mouse  1225 -----------------FRDCNGQMVALPSEFF-------------------------------- 1240

  Fly  1617 ARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGR 1681
            .|.:||...||:                                           :.||:     
Mouse  1241 LRIDSHKEDAAE-------------------------------------------FDDDI----- 1257

  Fly  1682 RNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLT 1746
                   .|...|      :..||.:...||.|..    |..|.:.....|:     |:|.:...
Mouse  1258 -------EDSCCF------RLHKVLEPYAPQWCSS----RESWALYLFPPQN-----RLRVSCQK 1300

  Fly  1747 VVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF-- 1809
            |:....|:..|||.||.:.||:..|..::|...|.:..|...|:.|..||||||::|.:|||.  
Mouse  1301 VIAHKMFDHVVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLW 1365

  Fly  1810 --SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQGMRIV 1867
              ..|..|.|.:||.::|.||:..:::.     ..:.|.|||.||.||.|||||.|||..|:::|
Mouse  1366 GEHAYLQSSWNVLDGLLVLVSLVDIIVAVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1430

  Fly  1868 VNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYT 1932
            |..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|     |......:..|.:|...:|.
Mouse  1431 VETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC-----EGTDTRNITTKAECHAAHYR 1490

  Fly  1933 WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSF 1997
            |:..|..||::|...::|..:::.:||:.:|.|.:||.|:|.||.:..|.:..:||:.|::..||
Mouse  1491 WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSF 1555

  Fly  1998 FTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVI-------KRP-- 2053
            |.||:|:||:::||:..::..|.       .|:::.....:::|.|::..|.:       :||  
Mouse  1556 FVLNMFVGVVVENFHKCRQHQEA-------EEARRREEKRLRRLERRRRSKAVPEVEEAQRRPYY 1613

  Fly  2054 --INHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
              .:|.....:.|..|...::.|..:|.||::||.:|||:||.::...|:..|..||.||..||.
Mouse  1614 ADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAA 1678

  Fly  2117 VKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIK 2178
            :|:|...: .:|...||..|..:||.||.||.:|:|.::  |||:||::|::||.||.|:|:|:|
Mouse  1679 LKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLRIARVLKLLK 1743

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ-----GALDDMVNFQTFG 2238
            .|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.::..     ..|.....|..||
Mouse  1744 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFTNFG 1808

  Fly  2239 RSMQLLFRLMTSAGWN----DVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMI 2299
            .:...|||:.|...||    |.|.....:...|..::          |.|:..||.:|::::..:
Mouse  1809 MAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYL----------PALSPVYFVTFVLVAQFV 1863

  Fly  2300 VINMYIAIILENFNQAHQE-EEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPL- 2362
            ::|:.:|:::::..::::| .|...::.::|:...:.|...|.:|     :|.|.......|.| 
Mouse  1864 LVNVVVAVLMKHLEESNKEAREDAEMDAEIELEIAQGSTAQPPST-----AQESQGTEPDTPNLL 1923

  Fly  2363 ---------GISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVE-ETDNFKQLQEQMDV 2417
                     .:|.||:..:..   |::.....|         .|.|..|| ||            
Mouse  1924 VVRKVSVSRMLSLPNDSYMFR---PVAPAAAPH---------SHPLQEVEMET------------ 1964

  Fly  2418 KFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQS 2482
                                           .||                  ..|...||     
Mouse  1965 -------------------------------YTG------------------PVTSAHSP----- 1975

  Fly  2483 KLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQ 2547
                             :...|.|.:..|.||..:.:|:        ||..:|..|         
Mouse  1976 -----------------SLEPRTSFQVPSAASSPARVSD--------PLCALSPRD--------- 2006

  Fly  2548 NDELGKRGSIFVEAPRA-------SRRRSFYNFFLRHQ--DAVDDSL---TSPSVHRKTAMNNTT 2600
                         .||:       .|:.:.:...|..|  ||.:||:   |.|:           
Mouse  2007 -------------TPRSLSLSRILCRQEAMHAESLEGQIDDAGEDSIPDYTEPA----------- 2047

  Fly  2601 NTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSF----IRKKPPL 2661
            ...|.|.:..||..|..      |.|...|.                |.|..:|    |..:||.
Mouse  2048 ENISMSQAPLGTLRSPP------CSPRPASV----------------RTRKHTFGQHCISSRPPT 2090

  Fly  2662 ERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKE 2726
            ..|..|::|                    .|:.|:.:|..| |..|..||..|            
Mouse  2091 LGGDDAEAA--------------------DPADEEVSHITS-SAHPWPATEPH------------ 2122

  Fly  2727 EDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDT---CAMPTVQIMVDSPKDPPRG 2788
            ..|:||:.|                 |.:     |:|.|..|.   |:: ..|..:|.|..|...
Mouse  2123 SPEASPTAS-----------------PAK-----GTVGSGRDPHRFCSV-DAQSFLDKPGRPDAQ 2164

  Fly  2789 DFSSAPIDDVGAPIDVNVQGDTSQVFYDYNP-----------------EKATDDQGNGQDETAQF 2836
            .:||..:|:....::   .|:......:..|                 :..|:|:|:.:...|:.
Mouse  2165 RWSSVELDNGDGHLE---SGEVRARASELEPALGARRKKKMSPPCISIDPPTEDEGSSRPPAAEG 2226

  Fly  2837 ESLPDRQRXPPVNTPLRDSEKRSSRG 2862
            .:...|:|.|.....|......|:.|
Mouse  2227 GNTTLRRRTPSCEAALHRDCPESTEG 2252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/271 (28%)
Ion_trans 705..902 CDD:278921 65/206 (32%)
Ion_trans 1768..2019 CDD:278921 94/259 (36%)
Na_channel_gate 2009..2063 CDD:240441 10/64 (16%)
Ion_trans 2085..2320 CDD:278921 84/247 (34%)
GPHH 2331..2386 CDD:293510 11/64 (17%)
Cacna1hXP_006524796.1 Ion_trans 99..430 CDD:366146 95/334 (28%)
Ion_trans 789..1023 CDD:366146 76/244 (31%)
PHA03307 1058..>1219 CDD:223039 57/503 (11%)
Ion_trans 1304..1576 CDD:366146 102/276 (37%)
Ion_trans 1629..1860 CDD:366146 87/240 (36%)
PHA03247 <1945..2360 CDD:223021 89/522 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.