DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and scn8aa

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_005162325.1 Gene:scn8aa / 58152 ZFINID:ZDB-GENE-000828-1 Length:1960 Species:Danio rerio


Alignment Length:2651 Identity:812/2651 - (30%)
Similarity:1172/2651 - (44%) Gaps:894/2651 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTF-IYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:....:|.|..||..:...|..|...|||:.|.| |.::||.|::|   ...|.||:.|.:|::
Zfish    53 PKPNGDLEAGKSLPFIYGDIPPGMVATPLEDFDPFYINQKTFVVLNK---GKTIFRFSATPALYM 114

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|::.|||:.:.|..:..|...:|.|||.||:|:..:   |..::.||.|..||:.|..:||||
Zfish   115 ISPFNLARRIAIKILIHSVFSMFIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESAVKIIA 179

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.::.:|:||:|||||||:||:..|.|..:::||::.||||||||||||:|::||||||:.||
Zfish   180 RGFCIDGFTFLRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCV------RQVPTDWTNVSHTDWQIWVND 294
            :.|.::|::||.||:|||.||||..||::||.||.|||      .::..|.......:|..::.:
Zfish   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPINITEMFPDVNGSRAFNWDEYILN 309

  Fly   295 TDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWE 358
            ..|:.:..|:| .:||||.:.:..||..|.|:..|.|||:|||:||:|.|:.|..|:|:|.|:||
Zfish   310 ETNFYFLPDQLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDFWE 374

  Fly   359 NVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTF 423
            |:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      |.::.|
Zfish   375 NLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATMEEAE------RKEAEF 433

  Fly   424 SFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGT--------NGNGNGSN 480
            .        ..|.:..|::.|::...:..|                .||        :|:|.|  
Zfish   434 K--------AMLEQLKKQQEDAQANAMATS----------------AGTVSEDVVEDDGDGEG-- 472

  Fly   481 GDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQ------QHKLAKSGSGGSNNPMAP 539
               |.|.|::.....|.: ||.||     ...:|:::|.||      ..|..||.|...:     
Zfish   473 ---NLSCSSSEMSKLSSK-SAKER-----RNRKKKWRQKEQDKEKGDSEKFVKSESDDGS----- 523

  Fly   540 TPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP-----SSNSS--------GVNRESSQDD 591
              :.|..|.|:.:|.::..|      ...|::..|.|     :|.||        |...|.:.|:
Zfish   524 --RRRFRFPDNRLGRRSSIM------NQSLLSIPGSPFPSRRNSKSSIFSRCKDGGSENEFADDE 580

  Fly   592 SGVVDDHEEQ---------------------DTTNDMGHVSTV----------ELAL-------S 618
            ...|::::|:                     .|.:..|.||.:          |:.:       |
Zfish   581 HSTVEEYDERRDSFLSPQRRSSYTGFYGKRNSTVDCNGVVSLIGPGPGGRLLPEVIIDKAATDDS 645

  Fly   619 PR---EVRLIKCNGNI-ARIKNHNVYALHQEFSSEVV------VIDDLPD--RNCDRCVH----- 666
            |.   |::. |.:|:: ..::..|.....:|.::.|:      ::::|.:  |.|..|.:     
Zfish   646 PTTDLEIKK-KLSGSLMVSVEQLNTSFGRKERANSVMSALTNTLVEELEESQRKCPPCWYKFANT 709

  Fly   667 ---W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVF 727
               | |...  |:..:..:..:|.||..:||||:||||||.|:||||:.|:..|.:.|.|||.||
Zfish   710 FLIWECGPL--WMSIKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTPQFEHVLSVGNLVF 772

  Fly   728 TSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQS 791
            |.|||.|...||:|:.. .:|..||||||..||:.||:::....|:||||||..|||||.|||:|
Zfish   773 TGIFTAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKS 837

  Fly   792 WTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDF 853
            |.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.|||
Zfish   838 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAQDCELPRWHMNDF 902

  Fly   854 FHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEE 918
            ||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:::.
Zfish   903 FHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADN 964

  Fly   919 LKSKKEEVGEESKLARSIER-----------VRDLI-----RKKRQERK---DRKERKFAEKFQQ 964
            |.:..:: ||.:.|..::.|           ||:|:     ||...|.|   |..:||.      
Zfish   965 LAASDDD-GEMNNLQIAVIRIKKGIAWVKAKVRELVNIILGRKVTDEAKPLDDMYDRKL------ 1022

  Fly   965 IVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHT 1029
                      ..:::...|.:.|.             |.||:                       
Zfish  1023 ----------NCIANHTGVDISRD-------------LDYQK----------------------- 1041

  Fly  1030 IVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQA 1094
                                                              |||||          
Zfish  1042 --------------------------------------------------NGNGT---------- 1046

  Fly  1095 ERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSS 1159
                    :||:                                                     
Zfish  1047 --------TSGI----------------------------------------------------- 1050

  Fly  1160 RRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMS 1224
                                                                     |.|:....
Zfish  1051 ---------------------------------------------------------GSSVGKYM 1058

  Fly  1225 IEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETM 1289
            |:.|.:                    .|:                     ..|:..:..|   ..
Zfish  1059 IDDDHM--------------------SFI---------------------HNPNLTVCVP---IA 1079

  Fly  1290 VEHSEFDNI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAA 1353
            |..|:|:|: .:.|..|.|                :|.|...|:.:            :||.|..
Zfish  1080 VGESDFENLNTEDFSSESE----------------AEGSKELDDIS------------SSEGSTI 1116

  Fly  1354 DEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIH 1418
            |                                                   |..|:.       
Zfish  1117 D---------------------------------------------------IKPEVE------- 1123

  Fly  1419 APFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRI 1483
                  ||:                                    ::|.|||             
Zfish  1124 ------EAV------------------------------------VVETVEE------------- 1133

  Fly  1484 ESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLA 1548
                                                                             
Zfish  1134 ----------------------------------------------------------------- 1133

  Fly  1549 QISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAAS 1613
                                                                             
Zfish  1134 ----------------------------------------------------------------- 1133

  Fly  1614 FQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTV 1678
                                                                      |||    
Zfish  1134 ----------------------------------------------------------YVD---- 1136

  Fly  1679 GGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMD---TQS-AKHWTR 1739
                                       |:.|:.:.|...:        .|.|   |:. .|:|..
Zfish  1137 ---------------------------PEACWTEACIARY--------KCCDVPITEGWGKNWWF 1166

  Fly  1740 VRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKW 1804
            :|.....:|:...||..::.:|..||..|.|||:.:::.||::.:|.:.:..|..||::||:|||
Zfish  1167 LRKTCYLIVEHNWFETLIIFMILLSSGALAFEDVYIEQRKTIRIILEYADMVFTYIFILEMLLKW 1231

  Fly  1805 LALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIV 1867
            :|.||.||||:.|..|||.||.||:.||:...  ..:|..::|||||||||||||:||::|||:|
Zfish  1232 VAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVV 1296

  Fly  1868 VNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGE-LLPITEVNDKWDC---IE 1928
            ||||:.|||||.|||||||:||||||||||..|.||::.|.||..: ...:..||:|.:|   ||
Zfish  1297 VNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFAGKYYYCYNETEKAYFELDVVNNKSECFALIE 1361

  Fly  1929 QNYT---WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
            ||||   |.|.||.||:||.|||||||||||:|||::|..|||:|.|:.||:.|.|:|.||||||
Zfish  1362 QNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRRVEDQPKYEDNIYMYIYFVI 1426

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPIN 2055
            ||:.||||||||||||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|
Zfish  1427 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQN 1489

  Fly  2056 HFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIV 2120
            ....|.:|....:.|:|:|.:||.|||:||.:|..||......||...|..|...|..|.::|:.
Zfish  1490 KLQGMVFDFVTQQVFDISIMILICLNMVTMMVETDDQSQETENILYWINFIFIVAFTSEFVLKLF 1554

  Fly  2121 GLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRK 2185
            .||::|||..||:||.::|:.||.|:.:.|::....:||||.||:|:.||||||||||.|||||.
Zfish  1555 ALRHYYFTNGWNIFDCVVVILSIVGMFLADLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRT 1619

  Fly  2186 LLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTS 2250
            |||||::|||||||||.||.|:.||::|.|||.|..||.:..:|||.||:|||.||..||.:.||
Zfish  1620 LLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKRESGIDDMYNFETFGNSMICLFMITTS 1684

  Fly  2251 AGWNDVLESLMIQPPDCDPFIHG---HTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENF 2312
            |||:.:|..::..||||:|....   ...||||:|.:.|.:|..:||:|::||:|||||||||||
Zfish  1685 AGWDGLLAPILNYPPDCEPTKENPGTSVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILENF 1749

  Fly  2313 NQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNL 2377
            :.|.:|....:.|||.|.||..|.|:||.|:|||.|::|.||..:|:.||.:.|||.:.|::.:|
Zfish  1750 SVATEESADPLCEDDFESFYEIWEKFDPTASQFITFAKLGDFADTLEHPLRVPKPNTIELIAMDL 1814

  Fly  2378 PISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQE 2442
            |:..|::|||||||.|..|.|||   ::.:...:::||:.:|....|::...|.:::|...|::.
Zfish  1815 PMVSGDRIHCLDILFAFTKRVLG---DSGDLDMMRQQMEERFIAANPSKVSFEPITTTLRRKQEH 1876

  Fly  2443 KAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASS 2507
            .:|..||..::.:|.||                                      |..|....||
Zfish  1877 MSAGVIQRAFRAHLIRK--------------------------------------GFICKRLLSS 1903

  Fly  2508 RKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIK---QQNDELGKRG 2555
            .:........|..|......:||     ..|.|.|..|   :::|..||:|
Zfish  1904 SRLENGGTNQDKKEGTPSTASLP-----SYDSVTKPEKEKLEESDSKGKKG 1949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 106/225 (47%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 156/259 (60%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 121/237 (51%)
GPHH 2331..2386 CDD:293510 24/54 (44%)
scn8aaXP_005162325.1 Ion_trans 151..423 CDD:278921 126/271 (46%)
ATP-synt_B 363..>456 CDD:304375 38/122 (31%)
Na_trans_cytopl 498..604 CDD:288761 23/118 (19%)
Ion_trans 750..945 CDD:278921 103/197 (52%)
Na_trans_assoc 971..1172 CDD:284034 67/843 (8%)
Ion_trans 1195..1453 CDD:278921 154/257 (60%)
Na_channel_gate 1445..1497 CDD:240441 31/53 (58%)
Ion_trans 1519..1756 CDD:278921 120/236 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.720

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