Protein Alignment NaCP60E and cacna1sa

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_005168332.1
• Gene: cacna1sa / 570683
• ZFINID: ZDB-GENE-090514-1
• Length: 1778
• Species: Danio rerio
• Alignment Length: 2787
• Identity: 539/2787 - (19%)
• Similarity: 909/2787 - (32%)
• Gaps: 1163/2787 - (41%)

  Fly    68 MYGKPLEEIDTFIY-EETFCVVSKRFRKNYIHRFTGT-------KSLFLFYPWSPARRVCVYIAT 124
            |.|.....:.:||. |||.    ||.::..:.:...|       :||......:|.|:.|:.|..
Zfish     1 MEGNGEAPMSSFIMDEETL----KRKQREKLKKLQATGGNPRPARSLLFLTLKNPFRKACINIVE 61

  Fly   125 NQFFDYCVMATILFNCIFLAM------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNK 177
            .:.|:..::.||..||:.||:            ...:|..|||||.|:::|..:||:|.|||.:.
Zfish    62 WKPFEIIILLTIFANCVALAVFMPMPEEDTNNTNSNLESLEYIFLIIFTMECFLKIVAYGFLFHA 126

  Fly   178 YTYLRNPWNWLDFVVITSGYATIGME-VGNLAG---------------LRTFRVLRALKTVSIMP 226
            ..||||.||.||||::|.|..|:.:: :.:::|               ||.|||||.|:.||.:|
Zfish   127 DAYLRNCWNILDFVIVTMGLFTVVVDFINSISGVEAPVEQKGGFDMKALRAFRVLRPLRLVSGVP 191

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW 291
            .|:.:::::|.|...|..:..|..|.:.::|:..|:::..::...|.           ||
Zfish   192 SLQVVMSSILKSMLPLFHISLLVFFMVTIYAIIGLELFKCKMHKTCY-----------HT----- 240

  Fly   292 VNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE--NPNHGYTNFDNFMWSMLTTFQLITL 354
              .||.....:|.....|......|.|..... .|.|:  .||:|.|:|||..:||||.:|.||.
Zfish   241 --GTDIIATGDDAQAAPCAQAGNGRRCTLNGT-ECRGDWPGPNNGITHFDNLGFSMLTVYQCITT 302

  Fly   355 DYWENVYNMVLATCG---PMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLD 416
            ..|.:|...|....|   |.  .:|..::..|||:::||:|
Zfish   303 QGWTDVLYWVNDAIGMEWPW--LYFVTLILLGSFFILNLVL------------------------ 341

  Fly   417 HRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNG 481
                                           |||...::|:  |.|.::.|
Zfish   342 -------------------------------GVLCGEFTKE--REKSSRSG-------------- 359

  Fly   482 DDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRIS 546
                                             :||.:.::.:
Zfish   360 ---------------------------------EYQILRERQQ---------------------- 369

  Fly   547 FQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGH 609
                          :..|.||.:  |..:....::..|......||.|       |.:|..::..
Zfish   370 --------------FDEDLKGYMEWITQAEVMDNDQEGQGLLPLQDGS-------ETETLYELDI 413

  Fly   610 VSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESW 674
            ::  :|....|..|  :.|....|                             :|..|
Zfish   414 LN--KLMFYVRHAR--RWNRFFRR-----------------------------KCRVW------- 438

  Fly   675 LQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKL 739
                      |:..||...:.|.:..||..:|.|||...:|..|..|..||...|:|..|..:|:
Zfish   439 ----------VKSKLFYWLVILLVFFNTLAIATEHHQQPDSLTNFQDNTNKALLSLFAVEMFLKM 493

  Fly   740 MALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVL 798
            .|:. ..:|:..:|.||..:|:..:|::|...:|     |:||||.:||||::|:.:.|||:..|
Zfish   494 YAMGLPSYFMSLFNRFDCFVVSVGILELILVRMDVMSVMGISVLRCIRLLRIIKITRHWTTLSNL 558

  Fly   799 LSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRI 863
            ::.:::::.::.:|.|:|.:.|.|||::|||:|...:   .|..|.|.|.||::|..:.:.:|:|
Zfish   559 VASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKF---NFPDDRVRRSNFDNFPQALITVFQI 620

  Fly   864 LCGE-WIEPLWDCMRAEEEQGASTCFAI-----FLPTLVMGNFMVLNLFLALLL-NSFNSEELKS 921
            |.|| |...::|.:.|   .|......|     |:...:.||:::||:|||:.: |...:|.|.|
Zfish   621 LTGEGWNYVMYDGIMA---HGGPAIPGILVSIYFIILFICGNYILLNVFLAIAVDNLAEAESLTS 682

  Fly   922 KKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLE 986
            .::|..||.|..|       |:|:
Zfish   683 AQKEKAEEKKRKR-------LLRE----------------------------------------- 699

  Fly   987 RGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAH 1051
                                                                  :||::
Zfish   700 ------------------------------------------------------NLPDK------ 704

  Fly  1052 PLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREE 1116
                                                                             
Zfish   705 ----------------------------------------------------------------- 704

  Fly  1117 ATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTR 1181
                                                                             
Zfish   705 ----------------------------------------------------------------- 704

  Fly  1182 SPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQ 1246
                           |:.:::||..:.||.|....|
Zfish   705 ---------------GEEEKALLAKKLAEQRAKIDG----------------------------- 725

  Fly  1247 KELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKR 1311
                        :....||:                                :..||..:.|||
Zfish   726 ------------IPTTAKLK--------------------------------VDEFESNVNEIK- 745

  Fly  1312 STTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQ 1376
                         :|.|.||                             .|.|
Zfish   746 -------------DPFPPAD-----------------------------FPGD------------ 756

  Fly  1377 SVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQ 1441
                                    ||
Zfish   757 ------------------------DE--------------------------------------- 758

  Fly  1442 SPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSL 1506
                                           |||
Zfish   759 -------------------------------EEE------------------------------- 761

  Fly  1507 KSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHA 1571
                                 |.:|.:|        .|..:|.:...:|..|:
Zfish   762 ---------------------PEIPLSP--------RPRPMADLQLKETEVPM------------ 785

  Fly  1572 TSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALA 1636
                                                                             
Zfish   786 ----------------------------------------------------------------- 785

  Fly  1637 MAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATK 1701
                        |:|:                                        .|..:|
Zfish   786 ------------PEAS----------------------------------------AFFLFG--- 795

  Fly  1702 AAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSI 1766
                |.:.|.:.|:                              .:::...|...:|:.|..|||
Zfish   796 ----PQNKFRKLCH------------------------------RIINATTFTNIILLFILLSSI 826

  Fly  1767 TLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSF----WTILDFIIVFV 1827
            :|..|| .:|......:||.:.::.|..:|..|::||....|...:..||    :.|||.|:|.|
Zfish   827 SLAAED-PIDPMSFRNQVLAYADYVFTSVFTAEIVLKMTTYGAFLHKGSFCRNSFNILDLIVVGV 890

  Fly  1828 SVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIF 1892
            |:.|:.:|.:. :.|::.||.||.|||||||:|.:|::.||..:..||.:|.|::||.::...:|
Zfish   891 SLLSMGMESSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLDFMF 954

  Fly  1893 SIMGVQFFGGKFFKCVNEM--------GELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLA 1949
            :.:|||.|.|||..|.:.:        |..:...| |...|.:.....|:||.:.||:|..|.||
Zfish   955 ACIGVQLFKGKFLYCTDPLKMTAEECQGTFIQHQE-NALHDMVVSQRLWMNSDLNFDNVLNGMLA 1018

  Fly  1950 LLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNML 2014
            |..|:|||||.:::..|:|:...::.|....::...|:|:::::..:||.:|:|:|.:|..|.
Zfish  1019 LFTVSTFEGWPDLLYKAIDSNLENMGPVYNNHIEISIFFIVYLILIAFFMMNIFVGFVIVTFQ-- 1081

  Fly  2015 KKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIF 2079
                |.|..|....|..|:....::...:.:|.:.. .|.|.:....:.:..|..||..:|:||.
Zfish  1082 ----EQGEQEYKNCELDKNQRQCVQYALKARPLRCY-IPKNPYQYQVWYIVTSCYFEYLMFLLIM 1141

  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYH-YFTVPWNVFDFLLVLASI 2143
            ||.:.:|::|..|...:..:.:..|..||.:|.:|.|:|:...:.. ||..|||||||::|:.||
Zfish  1142 LNTMCLGMQHCKQSDHITDLADTLNVIFTVLFTVEMILKLGAFKAKGYFGDPWNVFDFVIVVGSI 1206

  Fly  2144 FGILMEDI---------------------------MIDLPISPTLLRVVRVFRIGRILRLIKAAK 2181
            ..:::.:|                           ..::.:|.||.   |:||:.|:::|:...:
Zfish  1207 VDVILSEIDAALAAQGGLYCLTGCSEVNPMQAIADSENMSVSITLF---RLFRVMRLVKLLNRFE 1268

  Fly  2182 GIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV-----NFQTFGRSM 2241
            |||.||:..:.|..||..:..|:.::.||||::||.:||.:.|   ||..:     |||||.:::
Zfish  1269 GIRNLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL---LDGTIINRNNNFQTFPQAV 1330

  Fly  2242 QLLFRLMTSAGWNDVLESLMIQPPDCDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINM 2303
            .||||..|..||::::.. .:....|||   ::.|. ...||.. .||.||.||.::...::||:
Zfish  1331 LLLFRCATGEGWHEIMLG-CLYGQRCDPKSEYLPGE-EYTCGSG-FAILYFMSFYMLCAFLIINL 1392

  Fly  2304 YIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK-- 2366
            ::|:|::||:...::..| :....|:.|...|::|||.||..|....:...:..:.||||..|
Zfish  1393 FVAVIMDNFDYLTRDWSI-LGPQHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFC 1456

  Fly  2367 PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKE 2428
            |:.||   |:|.|:|::....:.....|.|||:..| .::...||:|..|::....||
Zfish  1457 PHRVACKRLISMNMPLNSDGTVTFNATLFALVRTGL-KIKTEGNFEQANEELRAIIKK------- 1513

  Fly  2429 LEIVSSTRIWKRQEK---------------------AAKTIQTGWKEYLRRKRE-------KERS 2465
                    ||||...                     |...||..::::::|:.|       |:..
Zfish  1514 --------IWKRTSMKLLDQVIPALGDDEVTVGKFYATFLIQDHFRKFMKRQEEYYGYRPSKKNK 1570

  Fly  2466 NSGD------SATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAG 2524
            |:.:      |..:.::|             .||.:..|...:.....|....:.:.|......|
Zfish  1571 NTTEIQAGLRSIEEEAAP-------------ELQRAISGDLLNDEEMDRAMEESGEESIYRRAGG 1622

  Fly  2525 PWLN----LPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSL 2585
            .:.|    ..:...:||.:|......|           :...||.|..:.|
Zfish  1623 LFGNHVDPFSMERGTGAAQVTSQRPLQ-----------LADSRADRTETTY-------------- 1662

  Fly  2586 TSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGG--SAPSR 2648
              .|.|   |.||.||..:....:.......|...|:.....|::|....:.....||  |..|.
Zfish  1663 --ASYH---ANNNNTNNNNRRRHSRCEPHFPACISASRLHSPASAAEFLIQQVLTSGGLESLASD 1722

  Fly  2649 KRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQ----THPH 2701
            .|..|..:.:......|..|...|  |:|.:......:.::.:...|..    ||.|
Zfish  1723 WRFVSVTKSEMAAALHLDLQELER--KSAAILNQHKGQCVLRKKKMETSHSDITHCH 1777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	83/278 (30%)
		Ion_trans	687..902	CDD:459842	72/226 (32%)
		Ion_trans	1751..2019	CDD:459842	92/279 (33%)
		Na_channel_gate	2009..2063	CDD:240441	9/53 (17%)
		Ion_trans	2067..2320	CDD:459842	89/288 (31%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)
cacna1sa	XP_005168332.1	Ion_trans	62..356	CDD:459842	97/371 (26%)
		Ion_trans	441..682	CDD:459842	80/246 (33%)
		Ion_trans	810..1087	CDD:459842	94/285 (33%)
		Ion_trans	1131..1409	CDD:459842	88/286 (31%)
		GPHH	1418..1471	CDD:465306	19/52 (37%)
		Ca_chan_IQ	1481..1553	CDD:462591	18/87 (21%)