DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1ab

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_073772160.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2463 Species:Danio rerio


Alignment Length:3052 Identity:654/3052 - (21%)
Similarity:1062/3052 - (34%) Gaps:1083/3052 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 RKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------M 145
            |:|.:   |..:|||||...:..|:....|.....|::.::.||:.|||.||            :
Zfish   184 RQNCL---TVNRSLFLFSEDNIVRKYAKKITEWPPFEWMILTTIIANCIVLALEQHLPVGDKTPL 245

  Fly   146 TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVGNLAG 209
            :|.:||.|..|:||:..|..|||:|.||..:|.:||||.||.:||||:.:| .:::|.|: :|..
Zfish   246 SERLEETEPYFIAIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSSVGSEL-DLRT 309

  Fly   210 LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVR 274
            ||..||||.||.||.:|.|:.::.:::.:...|.::..|....:::||:..|:.|||:....|..
Zfish   310 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGVLLFVAILMFAIIGLEFYMGKFHTTCFN 374

  Fly   275 QVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE--NPNHGYTN 337
            .:..:                   :|||..    |    |||.|..... .|.|.  .||:|.|.
Zfish   375 TITGE-------------------MYDERP----C----GARTCDANNT-QCQGYWLGPNYGITQ 411

  Fly   338 FDNFMWSMLTTFQLITLDYW-ENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEE 401
            |||.::::||.||.||::.| :.:|....|.....:..::..::..|||:::||:|.|::..:.:
Zfish   412 FDNVLFAVLTVFQCITMEGWTDMLYYSNDALGSAWNWMYYVPLIIIGSFFMLNLVLGVLSGEFAK 476

  Fly   402 EAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKG 466
            |.|  ..|.:.:.|..:......        ::|| ...:.|...:.|:||.             
Zfish   477 ERE--RVENRSEFLKLKRQQQIE--------RELN-GYLEWICKAEEVILAE------------- 517

  Fly   467 GKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSG 531
                           |||.:.|             ..||:                   .|....
Zfish   518 ---------------DDNDTGS-------------RRRPT-------------------LKKNKA 535

  Fly   532 GSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVD 596
            ...||..              ||         |:.|..:   |.|.:..|         .||..|
Zfish   536 DLLNPQE--------------GV---------DHMGDSV---GSPFARGS---------MSGKGD 565

  Fly   597 DHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC 661
                             |...|.:|.||                                     
Zfish   566 -----------------ETPFSKKERRL------------------------------------- 576

  Fly   662 DRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKV 726
                            :..:.|:|:...|...:...:.|||..:|:.|:...|...:.|.....:
Zfish   577 ----------------RFLIRKMVKTQAFYWTVISLVALNTLCVAVVHYDQPELLSDFLYYAEFI 625

  Fly   727 FTSIFTFECIVKLMAL-SKDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRV 785
            |..:|..|.::|:..| ::.:|...:|.||..::..|:.::::.:|.     |:||||.|||||:
Zfish   626 FLGLFMSEMLIKMYGLGTRPYFHSSFNCFDCAVIVGSIFEVVWAMVKPGTSFGISVLRALRLLRI 690

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNF 850
            .|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::|||||...:..|.    ..|..||
Zfish   691 FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEL----GTPPTNF 751

  Fly   851 NDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-N 912
            :.|..:.|.:|:||.|| |...::|.::::........|::|...|.: ||:.:||:|||:.: |
Zfish   752 DTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDKGMIFSVFFIVLTLFGNYTLLNVFLAIAVDN 816

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTL 977
            ..|::||                        .|..||.::...:|.|.:..:.|.:.....|..|
Zfish   817 LANAQEL------------------------TKDEQEEEEATTQKMALQKAKEVAEVSPLSAANL 857

  Fly   978 SHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDL 1042
            |               :|..|..|:...:|:.                               |.
Zfish   858 S---------------IAAVKSERIDATDSLL-------------------------------DC 876

  Fly  1043 PEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107
            .||                                ..|..|:           :.:..|.:|.:.
Zfish   877 KEQ--------------------------------QKNSKGS-----------KSVWEQRTSEIR 898

  Fly  1108 TQQYDSREEATYTE-SIE---LLGQYNSTDTDPY------ANDQRSGCGSFNRGDSLQDNSSRRY 1162
            .|...:..||.|.| ..|   .:...|..|...:      .|.|.:...:.|:......|...| 
Zfish   899 RQNLMTSREALYNELDAEDHWKMNYRNRPDVKTHLDRPLVVNPQENRNNNTNKPRPDDPNPQER- 962

  Fly  1163 GSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQ 1227
             ||||                          .|......|...........|||.|||:      
Zfish   963 -SEEH--------------------------PSRSHHHHSHHHHHHHHHTHHSSRQSLH------ 994

  Fly  1228 DELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEH 1292
                  ...|.|....||                      :......|||.....:..:|...|.
Zfish   995 ------LPELAETGFECD----------------------VEGAGEHRRPRHHQHRRRDEDGGER 1031

  Fly  1293 SEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVV 1357
            .         .|..:...|..|:          ...|.|...|....|                 
Zfish  1032 G---------RKHRDHHSRGETA----------GGDAEDGQEKRQRRH----------------- 1060

  Fly  1358 LPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRR----SLEKQRKIDEDFSISNEIRKICDQIH 1418
                           |.:.......:|:..:|.|.    ||...|.|.....            |
Zfish  1061 ---------------RHANHGDGDGRRERSRLHRNKKEGSLSTARPIQPGLP------------H 1098

  Fly  1419 APFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRI 1483
            ......|.:.....|:..|..:..|.|   .||:   :|              ||:...:..|| 
Zfish  1099 TESQYSEDLDNLRNSSKMAIHDPDPDL---YDPY---YD--------------PEQANNLLNLR- 1142

  Fly  1484 ESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLA 1548
                       ||| |...||.|..::..|:..|.       .||..|     ||.:.:      
Zfish  1143 -----------GPD-LHDSSLILTDSSKLEHTAID-------MPPIYP-----SLNAKL------ 1177

  Fly  1549 QISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAAS 1613
            |::                                                              
Zfish  1178 QVN-------------------------------------------------------------- 1180

  Fly  1614 FQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTV 1678
             ::|.||....|             :|.|:.:                            ||   
Zfish  1181 -KNANTEPAKEG-------------EKKEEEE----------------------------DD--- 1200

  Fly  1679 GGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTA 1743
            ||  :.:|                                :.|.|.|.||....:...:.|....
Zfish  1201 GG--DEEG--------------------------------HKRIPPFSSCFILSTTNPFRRCCHY 1231

  Fly  1744 VLTVVDTPAFEWFVLVLIFASSITLCFED-INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLAL 1807
            :||:   ..||..:|.:|..|||.|..|| ::.|..:  .:||.:.::.|..:|..||::|.:.|
Zfish  1232 ILTL---RYFEMCILSVIAMSSIALAAEDPVSQDSER--NKVLRYFDYVFTGVFTFEMLIKMVVL 1291

  Fly  1808 GF----SKYFTSFWTILDFIIVFVSVFSLLIE---ENENLKVLRSLRTLRALRPLRAISRWQGMR 1865
            |.    ..||...|..|||::|..::.:....   :.:::.:::|||.||.||||:.|.|...::
Zfish  1292 GLILHEGSYFRDLWNFLDFVVVSGALVAFAFTGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLK 1356

  Fly  1866 IVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNE--------MGELLPITEVND 1922
            .|.:.::.::.::.|:|:|.::|..||:::.||.|.|:||.|.:|        .||.|.....| 
Zfish  1357 AVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFARDCRGEYLVYERDN- 1420

  Fly  1923 KWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDA----RGVDLQPQREANLY 1983
              :...|...|......:|:|....|.|..|:|.|||.:|:..:||:    ||.....:.|.:::
Zfish  1421 --EVKSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIF 1483

  Fly  1984 AYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH----YYTAMKKLGRK 2044
            ..:|||:|    .||.:|:|:.:||..|.....|    ::|.:..|..:.    :....|.|.|.
Zfish  1484 YVVYFVVF----PFFFVNIFVALIIITFQEQGDK----MMEDYSLEKNERACIDFAINAKPLTRH 1540

  Fly  2045 KPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTT 2109
            .||.  |:...:.:..|.   .|..||.:|..||.||.:.:.:::.....|...:|:..|..|||
Zfish  1541 MPQN--KQSFQYRMWQFV---VSPPFEYSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTT 1600

  Fly  2110 VFGLEAIVKIV--GLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGR 2172
            .|.:|:|:||:  |:| ::|...||:|||:.|:.||..||:.:::.:.    ..|..:|:||..|
Zfish  1601 FFFMESILKIIAFGVR-NFFRDAWNIFDFVSVIGSITDILVTELVNNF----INLSFLRLFRAAR 1660

  Fly  2173 ILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKL--QGALDDMVNFQ 2235
            :::|::..:.||.||:..|.|..||..:..|:.::.|||||:||.||||:.|  :||:::..||:
Zfish  1661 LIKLLRQGETIRILLWTFVQSFKALPYVCLLIAILFFIYAIIGMQLFGNLALDDEGAINEHNNFR 1725

  Fly  2236 TFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIV 2300
            ||..::.||||..|...|:|::.|.:...| |:|   ......||.. :|..||.|||.:...::
Zfish  1726 TFFMALMLLFRSATGEAWHDIMLSCLGGMP-CEP---EEVGSECGSN-VAYAYFVSFIFLCSFLM 1785

  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365
            :|:::|:|::||....::..| :....|:.:...|::|||.|...||:..:...:..:|||||:.
Zfish  1786 LNLFVAVIMDNFEYLTRDSSI-LGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLG 1849

  Fly  2366 K--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL------GHVEETDNFKQLQEQMDVKF 2419
            |  |:.||   |:..:||::..|.:|....|.||::..|      |..:        :.|||.:.
Zfish  1850 KKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGAD--------KHQMDAEL 1906

  Fly  2420 KKQ----FP--TRKELEIV-----SSTRI-------------WKRQEKAAKTIQTGWKEYLRRKR 2460
            :|:    :|  ::|.|:::     |:|.:             :.||.||.|.      :.||.::
Zfish  1907 RKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKKL------QALREEQ 1965

  Fly  2461 EK----------------------------ERSNS-----------------GDSATQTSSPGGW 2480
            .:                            |..||                 .....|.|.|..|
Zfish  1966 NRTPLMFQRMEPSPNQEGGPGLNGLPELPQEPVNSLPPEVGMNESQSWVTSRAQEMCQKSVPENW 2030

  Fly  2481 ---------------------------------------------------------QSKLSALN 2488
                                                                     ||..||..
Zfish  2031 NPDRPYPDDHHDSRHNPQTVEMREFGPVGDGYSDTEPYHPMEGHGRTISMPRLSADNQSVRSAAT 2095

  Fly  2489 FFHLQVSRRGTAC-------------------------------------------SSRASSRKS 2510
            .......||.|:.                                           |.|.|.|..
Zfish  2096 ITDTSPMRRSTSSLVHGRSGRGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSL 2160

  Fly  2511 SRASDASDLSELAGPWLNLPLMLVSGADEVVKDI--KQQNDELGK-------------RGSIFVE 2560
            :|.:||.     .|...:|.....||      |:  |::..|.|:             .||  |:
Zfish  2161 ARYTDAD-----TGLGTDLSTTTQSG------DLPPKERERERGRAKDRRHHHHHHHHHGS--VD 2212

  Fly  2561 APRASRRRSFYNFFLRH-QDAVDDSLT-SPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATG 2623
            ..|.|..|.::    || ||..|...: |||..|.....:::.:.|...|||||::     |..|
Zfish  2213 KDRYSHERDYH----RHPQDRSDRQWSRSPSEGRGHRQGSSSVSGSPVPSTSGTST-----PRRG 2268

  Fly  2624 CGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVI 2688
                        |.|.....|.|......|...:|||.  |...|..||                
Zfish  2269 ------------RRQLPQTPSTPRPHVTYSPAVRKPPY--GSPGQGRLR---------------- 2303

  Fly  2689 VTRPSPEQQTHP-HSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQP 2752
              .|||...:.| |    .|.        .||....:......||..:.                
Zfish  2304 --SPSPRNFSPPGH----EPP--------YHRPPSRHASPHPGSPRHAS---------------- 2338

  Fly  2753 PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDTSQVFY-- 2815
            |...|.|                     ||:.|..|.:         .|.| :::||.:  ||  
Zfish  2339 PRSPRHT---------------------SPRSPRHGRW---------GPPD-SLEGDGT--FYER 2370

  Fly  2816 DYNPEKATD--------DQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSS 2869
            ||..|:..:        .|||....:......|...|..|...|     :|...|.||||.|
Zfish  2371 DYEYERHHEPPAYEQSLSQGNPHPHSHPHPRSPRTARHGPQPHP-----RRMPNGYRSSSPS 2427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 84/261 (32%)
Ion_trans 687..902 CDD:459842 60/222 (27%)
Ion_trans 1751..2019 CDD:459842 86/287 (30%)
Na_channel_gate 2009..2063 CDD:240441 11/57 (19%)
Ion_trans 2067..2320 CDD:459842 89/256 (35%)
GPHH 2332..2378 CDD:465306 17/50 (34%)
cacna1abXP_073772160.1 None

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