DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and cacna1eb

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_017206695.2 Gene:cacna1eb / 567702 ZFINID:ZDB-GENE-070705-133 Length:2168 Species:Danio rerio


Alignment Length:2842 Identity:623/2842 - (21%)
Similarity:1040/2842 - (36%) Gaps:1004/2842 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 TGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEAE 153
            |..:|||:|...:..|:....|.....|:|.::|||:.|||.|:            |::.:|:.|
Zfish    46 TVNRSLFIFAENNMIRKYAKRIIEWPPFEYMILATIIANCIVLSLEQHLPGEDKTPMSKRLEKTE 110

  Fly   154 YIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTFR 214
            ..|:.|:..|..||::|.||:.:|.:||||.||.:||:|:.|| .||.|..:.   :|..||..|
Zfish   111 PYFIGIFCFEAGIKLVALGFVFHKGSYLRNGWNVMDFIVVLSGILATAGSHMNIPVDLRTLRAVR 175

  Fly   215 VLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTD 279
            |||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|.:.|:      
Zfish   176 VLRPLKLVSGIPSLQIVLKSIIKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHHTCL------ 234

  Fly   280 WTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWS 344
                  .|..|..|:|    .|..|:...|    |.|.||.:|.|......||.|.|.|||.:::
Zfish   235 ------ADLDILDNET----VDSSEVDFAC----GVRKCPDKYTCSGSWIGPNDGITQFDNILFA 285

  Fly   345 MLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408
            :||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|....
Zfish   286 VLTVFQCITMEGWTAVLYNTNDALGPTWNWIYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVEN 350

  Fly   409 ER-----------KKDL------LDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSK 456
            .|           :::|      :|..::         :.:::.|||:.:   |...||..:.||
Zfish   351 RRAFMKLRRQQQVERELNGYRAWIDRAEE---------VMLQEENKNSGR---SALDVLKRATSK 403

  Fly   457 KKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQ 521
            |..||:                ..|::..|..:|.:.|..||                       
Zfish   404 KNARRR----------------GPGEEKYSEISTVAGGSRPR----------------------- 429

  Fly   522 QHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRE 586
                                          :|::.|.                            
Zfish   430 ------------------------------VGMRTPR---------------------------- 436

  Fly   587 SSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVV 651
                                                     .|..|.::..              
Zfish   437 -----------------------------------------RGPAAYLRRK-------------- 446

  Fly   652 VIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESF 716
                                |..|:|.  :.::|:...|...:...:.|||..:::.||...|..
Zfish   447 --------------------ERMLRFS--IRRMVKTDSFYWIVLSLVALNTISVSIVHHNQPEWL 489

  Fly   717 RNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLS 775
            .........||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::....     |:|
Zfish   490 TVIQYYTEFVFLGLFLAEMFLKMYGLGFRLYFHSSFNCFDCGVIVGSIFEVVWGFFRPGVSFGIS 554

  Fly   776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFS-----KDY 835
            |||.|||||:.|:.:.|::::.|:..::|::.::.:|..:|.:.|.:||::|||||.     :||
Zfish   555 VLRALRLLRIFKITKYWSSLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFIFEDY 619

  Fly   836 TPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGA------STCFAIFLP 893
            ||..||..|.          |.|.:|:||.|| |.|.:::.:|:   ||.      |:.:  |:.
Zfish   620 TPTNFDTFPA----------SIMTVFQILTGEDWNEVMYNGIRS---QGGVHYGMWSSIY--FIV 669

  Fly   894 TLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEE--------SKLARSIERVRDLIRKKR-- 947
            ..:.||:.:||:|||:.: |..|::||..::||..||        .:...|..|.|..:.:||  
Zfish   670 LTLFGNYTLLNVFLAIAVDNLANAQELTKEEEEEEEEFFNQRYKSREFGLSERRRRPYLYRKRAI 734

  Fly   948 -----------------QERKDRKERKFA---EKFQQIVLDAQQAHA-------QTLSHQAAVG- 984
                             |..:::....||   |:.::|.:...:..|       |..|.:...| 
Zfish   735 HRGRPSPAEAEEEAAGKQAAEEQPVNAFAGRRERRKKINMSVWEQRANQLRKRRQMASREVLFGG 799

  Fly   985 -LERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQL 1048
             .|..|.||    :..|:   |.|::...|        |||                 |||....
Zfish   800 PTEDQDTPG----SDHHQ---QHSLSTETS--------PLH-----------------LPESPMS 832

  Fly  1049 QAHPL--PPTSDSM----PPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107
            ...||  ||.|.::    ||..|            .::|:|          .|.|          
Zfish   833 VGMPLPEPPMSITIPLPEPPESE------------PLSGSG----------LEER---------- 865

  Fly  1108 TQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFL 1172
                                        |.||:..:             |:.||     |..|  
Zfish   866 ----------------------------PSANNHHA-------------NTERR-----HRVA-- 882

  Fly  1173 KYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL 1237
                         ||.  |.:.::|       .:|....:||                       
Zfish   883 -------------RKF--RAAAAAG-------VAEGGRHKRH----------------------- 902

  Fly  1238 REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSF 1302
                                               |.|...::....||.            |.|
Zfish   903 -----------------------------------RHRESRTEARNAENH------------QQF 920

  Fly  1303 EKELEEIKRSTTSLERK-LSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSY 1366
            |::.|:.:..|...:.| :.|:.:|....:...:...|.:..:||.|:.|...|           
Zfish   921 ERQAEDGEGKTEEAQSKHMMNMCDPERQIENQEECQREFVCDLTGLSQASGHQE----------- 974

  Fly  1367 DLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAA 1431
                                               ||                            
Zfish   975 -----------------------------------ED---------------------------- 976

  Fly  1432 TSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGP 1496
                ||:..::..||.|.| |:.:......:|.||                              
Zfish   977 ----QAESQEAQLLRHKED-FSTESKYMTEVSDIE------------------------------ 1006

  Fly  1497 DQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLK--SSIEPPTLAQISSLKTTPPL 1559
                       :..||.|   |.:           ....||||  ||.:|               
Zfish  1007 -----------NNGSYLN---QDE-----------CMTETSLKRESSSQP--------------- 1031

  Fly  1560 AALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSS 1624
                         .::.||                               ...||:....     
Zfish  1032 -------------LLEMAP-------------------------------MTVSFKDVEA----- 1047

  Fly  1625 GAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN 1689
                       :::.|.:.......|...                 .|.||.. ||.:::     
Zfish  1048 -----------SLSDKADDDDDDDMDDDD-----------------DYEDDEN-GGEKST----- 1078

  Fly  1690 DPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFE 1754
                     |:|..: ||..|..|..:.....|             |:         ||....||
Zfish  1079 ---------ASKPER-PDSMFIFKSKNPIRRIC-------------HY---------VVTLRYFE 1111

  Fly  1755 WFVLVLIFASSITLCFED---INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKY 1812
            ..:|::|.||||.|..||   .:.::||    ||.:.::.|..:|..|||:|.:..|.    ..|
Zfish  1112 MTILLVIVASSIALAAEDPVCTSSERNK----VLRYFDYVFTGVFTFEMIIKMIDQGLILHDGSY 1172

  Fly  1813 FTSFWTILDFIIVFVSVFSLLI------EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNAL 1871
            |...|.|||||:|..::.:..:      .:..::|.::|||.||.||||:.|.|...::.|.:.:
Zfish  1173 FRDMWNILDFIVVVGALIAFALTNLLGNNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCV 1237

  Fly  1872 MYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNY---- 1931
            :.::.::||:|:|..:|..||:::.||.|.||||.|.: .||         .:.:|  |.|    
Zfish  1238 VTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDGSMG---------TQKEC--QGYYIDY 1291

  Fly  1932 ----------TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYI 1986
                      .|...:..:|:|....|.|..|:|.|||.:|:..:||....|..|.|...:...|
Zfish  1292 GRDRKEVKKREWRRHEFHYDNVLWALLTLFTVSTGEGWPQVLQHSVDVTEEDHGPSRGNRMEMSI 1356

  Fly  1987 YFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK---HYYTAMKKLGRKKPQ- 2047
            ::||:.|...||.:|:|:.:||..|   :::.:..:.|..|.::::   .:..:.|.|.|..|| 
Zfish  1357 FYVIYFVVFPFFFVNIFVALIIITF---QEQGDKMMEECNLEKNERACIDFAISAKPLTRYMPQN 1418

  Fly  2048 -KVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVF 2111
             :.::..:.||:.       |..||..:.|:|.||.:.:.:::|..|.|...:|:..|..||.:|
Zfish  1419 RQTLQYRLWHFVV-------SPSFEYTVLVMIALNTVVLMMKYYSAPTAYDIVLKHLNTAFTVLF 1476

  Fly  2112 GLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL-LRVVRVFRIGRIL 2174
            .||.|:||:...: :||...||:|||:.||.||     .:|::||....|: :..:::||..|::
Zfish  1477 SLECILKIMAFGFMNYFRDTWNIFDFITVLGSI-----TEIVVDLQSVNTINMSFLKLFRAARLI 1536

  Fly  2175 RLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKL--QGALDDMVNFQTF 2237
            :|::....||.||:..|.|..||..:..|:.::.|||||:||.:|||:||  :..::...||:||
Zfish  1537 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLNDESHINQHNNFKTF 1601

  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDCD-------PFIHGHTNGNCGHPLLAITYFTSFIII 2295
            ..::.||||..|...|.:::.| .::..:|:       ||......|.||.. .|..||.|||..
Zfish  1602 FGALMLLFRSATGESWQEIMLS-CLEGKECEPDPSITPPFTSPDHEGGCGTD-FAYFYFVSFIFF 1664

  Fly  2296 SYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDP 2360
            |..:::|:::|:|::||....::..| :....|:.|...|.:||..|...||::.:.:.:..:.|
Zfish  1665 SSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRIWGEYDRAACGRIHYNAMYEMLTHMSP 1728

  Fly  2361 PLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFK 2420
            |||:.|  |..:|   ||..|:|:.:...:|....|.:|::..|..........:||..|:::.:
Zfish  1729 PLGLGKKCPAKIAYKRLVLMNMPVDEDMTVHFTSTLMSLIRTALEIKIARGGEDRLQLDMELQKE 1793

  Fly  2421 KQF--------------PTRKELE-----IVSSTRI--WKRQEKAAKTIQTGWKEYLRRKREKER 2464
            ..|              |..|:.:     |.:|..|  :.:|.||.|         ||.:.|.:|
Zfish  1794 ISFIWPHLSQKTLDLLVPINKDTDMTVGKIYASRMIMDFFKQSKAKK---------LRLQVEAQR 1849

  Fly  2465 SNS----GDSATQTSSPGGW--QSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSE-- 2521
            :.:    ..||....:.||:  .|.:|........:::|          ..||...|||.:.|  
Zfish  1850 AAALPLISHSAGSALTSGGFVALSPISPQELLLQPITQR----------TDSSEDYDASQVDESG 1904

  Fly  2522 LAGPWLNLPLMLVSGAD--------------EVVKDIKQQNDELGK-RGSIFVEAPRASRRRSFY 2571
            |.|.|         |.|              :......:|...:.| ||     .|:..|     
Zfish  1905 LNGVW---------GEDRPPEHAFRARHKSYKAAVSHSEQTQYMEKVRG-----RPKEQR----- 1950

  Fly  2572 NFFLRHQDAVDDSLT-SPS---VHRKTAMNNTTN----TTSNSASTSG----TASSTATAPATGC 2624
             ..|..:::...|.: |||   ||..|...|::.    :||.|::.||    :.:||.:.|....
Zfish  1951 -LLLSPKNSNSKSRSRSPSEERVHGVTRQGNSSESPVPSTSESSTPSGKRRLSQTSTCSRPHISY 2014

  Fly  2625 GPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQS--------------ALRVNK 2675
            .|..:....|         |.|:...... ....|.:::.|...|              |.:..|
Zfish  2015 SPLVSHTQSS---------SQPTNNNEED-EEDDPAVQQMLGCCSTALWDDSAEDQDARARQQEK 2069

  Fly  2676 NAF-VSEASAPEVIVTRPSPEQ-----QTHPHSLSLRPDNATLVHVL 2716
            :.| |.|.....|   |..|.:     |...||    ||:||.:..|
Zfish  2070 SHFEVDEFLGSSV---RRYPSESFLALQEEEHS----PDSATAMETL 2109

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 78/223 (35%)
Ion_trans 705..902 CDD:278921 61/214 (29%)
Ion_trans 1768..2019 CDD:278921 83/278 (30%)
Na_channel_gate 2009..2063 CDD:240441 10/58 (17%)
Ion_trans 2085..2320 CDD:278921 82/245 (33%)
GPHH 2331..2386 CDD:293510 18/59 (31%)
cacna1ebXP_017206695.2 Ion_trans 70..349 CDD:306908 99/298 (33%)
Ion_trans 463..698 CDD:306908 74/249 (30%)
Ion_trans 1108..1387 CDD:306908 91/296 (31%)
Ion_trans 1432..1689 CDD:306908 89/263 (34%)
GPHH 1690..1760 CDD:318993 20/70 (29%)
Ca_chan_IQ 1762..1836 CDD:312334 12/73 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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