DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and cacna1eb

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_017206700.4 Gene:cacna1eb / 567702 ZFINID:ZDB-GENE-070705-133 Length:2164 Species:Danio rerio


Alignment Length:2838 Identity:625/2838 - (22%)
Similarity:1040/2838 - (36%) Gaps:1000/2838 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 TGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEAE 153
            |..:|||:|...:..|:....|.....|:|.::|||:.|||.|:            |::.:|:.|
Zfish    46 TVNRSLFIFAENNMIRKYAKRIIEWPPFEYMILATIIANCIVLSLEQHLPGEDKTPMSKRLEKTE 110

  Fly   154 YIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTFR 214
            ..|:.|:..|..||::|.||:.:|.:||||.||.:||:|:.|| .||.|..:.   :|..||..|
Zfish   111 PYFIGIFCFEAGIKLVALGFVFHKGSYLRNGWNVMDFIVVLSGILATAGSHMNIPVDLRTLRAVR 175

  Fly   215 VLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTD 279
            |||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|.:.|:      
Zfish   176 VLRPLKLVSGIPSLQIVLKSIIKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHHTCL------ 234

  Fly   280 WTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWS 344
                  .|..|..|:|    .|..|:...|    |.|.||.:|.|......||.|.|.|||.:::
Zfish   235 ------ADLDILDNET----VDSSEVDFAC----GVRKCPDKYTCSGSWIGPNDGITQFDNILFA 285

  Fly   345 MLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408
            :||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|....
Zfish   286 VLTVFQCITMEGWTAVLYNTNDALGPTWNWIYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVEN 350

  Fly   409 ER-----------KKDL------LDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSK 456
            .|           :::|      :|..::         :.:::.|||:.:   |...||..:.||
Zfish   351 RRAFMKLRRQQQVERELNGYRAWIDRAEE---------VMLQEENKNSGR---SALDVLKRATSK 403

  Fly   457 KKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQ 521
            |..||:                ..|::..|..:|.:.|..||                       
Zfish   404 KNARRR----------------GPGEEKYSEISTVAGGSRPR----------------------- 429

  Fly   522 QHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRE 586
                                          :|::.|.                            
Zfish   430 ------------------------------VGMRTPR---------------------------- 436

  Fly   587 SSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVV 651
                                                     .|..|.::..              
Zfish   437 -----------------------------------------RGPAAYLRRK-------------- 446

  Fly   652 VIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESF 716
                                |..|:|.  :.::|:...|...:...:.|||..:::.||...|..
Zfish   447 --------------------ERMLRFS--IRRMVKTDSFYWIVLSLVALNTISVSIVHHNQPEWL 489

  Fly   717 RNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLS 775
            .........||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::....     |:|
Zfish   490 TVIQYYTEFVFLGLFLAEMFLKMYGLGFRLYFHSSFNCFDCGVIVGSIFEVVWGFFRPGVSFGIS 554

  Fly   776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFS-----KDY 835
            |||.|||||:.|:.:.|::::.|:..::|::.::.:|..:|.:.|.:||::|||||.     :||
Zfish   555 VLRALRLLRIFKITKYWSSLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFIFEDY 619

  Fly   836 TPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGA------STCFAIFLP 893
            ||..||..|.          |.|.:|:||.|| |.|.:::.:|:   ||.      |:.:  |:.
Zfish   620 TPTNFDTFPA----------SIMTVFQILTGEDWNEVMYNGIRS---QGGVHYGMWSSIY--FIV 669

  Fly   894 TLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEE--------SKLARSIERVRDLIRKKR-- 947
            ..:.||:.:||:|||:.: |..|::||..::||..||        .:...|..|.|..:.:||  
Zfish   670 LTLFGNYTLLNVFLAIAVDNLANAQELTKEEEEEEEEFFNQRYKSREFGLSERRRRPYLYRKRAI 734

  Fly   948 -----------------QERKDRKERKFA---EKFQQIVLDAQQAHA-------QTLSHQAAVG- 984
                             |..:::....||   |:.::|.:...:..|       |..|.:...| 
Zfish   735 HRGRPSPAEAEEEAAGKQAAEEQPVNAFAGRRERRKKINMSVWEQRANQLRKRRQMASREVLFGG 799

  Fly   985 -LERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQL 1048
             .|..|.||    :..|:   |.|::...|        |||                 |||....
Zfish   800 PTEDQDTPG----SDHHQ---QHSLSTETS--------PLH-----------------LPESPMS 832

  Fly  1049 QAHPL--PPTSDSM----PPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107
            ...||  ||.|.::    ||..|            .::|:|          .|.|          
Zfish   833 VGMPLPEPPMSITIPLPEPPESE------------PLSGSG----------LEER---------- 865

  Fly  1108 TQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFL 1172
                                        |.||:..:             |:.||     |..|  
Zfish   866 ----------------------------PSANNHHA-------------NTERR-----HRVA-- 882

  Fly  1173 KYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL 1237
                         ||.  |.:.::|       .:|....:||                       
Zfish   883 -------------RKF--RAAAAAG-------VAEGGRHKRH----------------------- 902

  Fly  1238 REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSF 1302
                                               |.|...::....||.            |.|
Zfish   903 -----------------------------------RHRESRTEARNAENH------------QQF 920

  Fly  1303 EKELEEIKRSTTSLERK-LSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSY 1366
            |::.|:.:..|...:.| :.|:.:|....:...:...|.:..:||.|:.|...|           
Zfish   921 ERQAEDGEGKTEEAQSKHMMNMCDPERQIENQEECQREFVCDLTGLSQASGHQE----------- 974

  Fly  1367 DLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAA 1431
                                               ||                            
Zfish   975 -----------------------------------ED---------------------------- 976

  Fly  1432 TSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGP 1496
                ||:..::..||.|.| |:.:......:|.||                              
Zfish   977 ----QAESQEAQLLRHKED-FSTESKYMTEVSDIE------------------------------ 1006

  Fly  1497 DQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLK--SSIEPPTLAQISSLKTTPPL 1559
                       :..||.|   |.:           ....||||  ||.:|               
Zfish  1007 -----------NNGSYLN---QDE-----------CMTETSLKRESSSQP--------------- 1031

  Fly  1560 AALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSS 1624
                         .::.||                               ...||:....     
Zfish  1032 -------------LLEMAP-------------------------------MTVSFKDVEA----- 1047

  Fly  1625 GAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN 1689
                       :::.|.:.......|...                 .|.||.. ||.:::     
Zfish  1048 -----------SLSDKADDDDDDDMDDDD-----------------DYEDDEN-GGEKST----- 1078

  Fly  1690 DPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFE 1754
                     |:|..: ||..|..|..:.....|             |:         ||....||
Zfish  1079 ---------ASKPER-PDSMFIFKSKNPIRRIC-------------HY---------VVTLRYFE 1111

  Fly  1755 WFVLVLIFASSITLCFED---INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKY 1812
            ..:|::|.||||.|..||   .:.::||    ||.:.::.|..:|..|||:|.:..|.    ..|
Zfish  1112 MTILLVIVASSIALAAEDPVCTSSERNK----VLRYFDYVFTGVFTFEMIIKMIDQGLILHDGSY 1172

  Fly  1813 FTSFWTILDFIIVF--VSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAI 1875
            |...|.|||||:|.  :..|:|...:..::|.::|||.||.||||:.|.|...::.|.:.::.::
Zfish  1173 FRDMWNILDFIVVVGALIAFALTNNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSL 1237

  Fly  1876 PSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNY-------- 1931
            .::||:|:|..:|..||:::.||.|.||||.|.: .||         .:.:|  |.|        
Zfish  1238 KNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDGSMG---------TQKEC--QGYYIDYGRDR 1291

  Fly  1932 ------TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
                  .|...:..:|:|....|.|..|:|.|||.:|:..:||....|..|.|...:...|::||
Zfish  1292 KEVKKREWRRHEFHYDNVLWALLTLFTVSTGEGWPQVLQHSVDVTEEDHGPSRGNRMEMSIFYVI 1356

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK---HYYTAMKKLGRKKPQ--KVI 2050
            :.|...||.:|:|:.:||..|   :::.:..:.|..|.::::   .:..:.|.|.|..||  :.:
Zfish  1357 YFVVFPFFFVNIFVALIIITF---QEQGDKMMEECNLEKNERACIDFAISAKPLTRYMPQNRQTL 1418

  Fly  2051 KRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEA 2115
            :..:.||:.       |..||..:.|:|.||.:.:.:::|..|.|...:|:..|..||.:|.||.
Zfish  1419 QYRLWHFVV-------SPSFEYTVLVMIALNTVVLMMKYYSAPTAYDIVLKHLNTAFTVLFSLEC 1476

  Fly  2116 IVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL-LRVVRVFRIGRILRLIK 2178
            |:||:...: :||...||:|||:.||.||     .:|::||....|: :..:::||..|:::|::
Zfish  1477 ILKIMAFGFMNYFRDTWNIFDFITVLGSI-----TEIVVDLQSVNTINMSFLKLFRAARLIKLLR 1536

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKL--QGALDDMVNFQTFGRSM 2241
            ....||.||:..|.|..||..:..|:.::.|||||:||.:|||:||  :..::...||:||..::
Zfish  1537 QGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLNDESHINQHNNFKTFFGAL 1601

  Fly  2242 QLLFRLMTSAGWNDVLESLMIQPPDCD-------PFIHGHTNGNCGHPLLAITYFTSFIIISYMI 2299
            .||||..|...|.:::.| .::..:|:       ||......|.||.. .|..||.|||..|..:
Zfish  1602 MLLFRSATGESWQEIMLS-CLEGKECEPDPSITPPFTSPDHEGGCGTD-FAYFYFVSFIFFSSFL 1664

  Fly  2300 VINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGI 2364
            ::|:::|:|::||....::..| :....|:.|...|.:||..|...||::.:.:.:..:.||||:
Zfish  1665 MLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRIWGEYDRAACGRIHYNAMYEMLTHMSPPLGL 1728

  Fly  2365 SK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQF- 2423
            .|  |..:|   ||..|:|:.:...:|....|.:|::..|..........:||..|:::.:..| 
Zfish  1729 GKKCPAKIAYKRLVLMNMPVDEDMTVHFTSTLMSLIRTALEIKIARGGEDRLQLDMELQKEISFI 1793

  Fly  2424 -------------PTRKELE-----IVSSTRI--WKRQEKAAKTIQTGWKEYLRRKREKERSNS- 2467
                         |..|:.:     |.:|..|  :.:|.||.|         ||.:.|.:|:.: 
Zfish  1794 WPHLSQKTLDLLVPINKDTDMTVGKIYASRMIMDFFKQSKAKK---------LRLQVEAQRAAAL 1849

  Fly  2468 ---GDSATQTSSPGGW--QSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSE--LAGP 2525
               ..||....:.||:  .|.:|........:::|          ..||...|||.:.|  |.|.
Zfish  1850 PLISHSAGSALTSGGFVALSPISPQELLLQPITQR----------TDSSEDYDASQVDESGLNGV 1904

  Fly  2526 WLNLPLMLVSGAD--------------EVVKDIKQQNDELGK-RGSIFVEAPRASRRRSFYNFFL 2575
            |         |.|              :......:|...:.| ||     .|:..|      ..|
Zfish  1905 W---------GEDRPPEHAFRARHKSYKAAVSHSEQTQYMEKVRG-----RPKEQR------LLL 1949

  Fly  2576 RHQDAVDDSLT-SPS---VHRKTAMNNTTN----TTSNSASTSG----TASSTATAPATGCGPAA 2628
            ..:::...|.: |||   ||..|...|::.    :||.|::.||    :.:||.:.|.....|..
Zfish  1950 SPKNSNSKSRSRSPSEERVHGVTRQGNSSESPVPSTSESSTPSGKRRLSQTSTCSRPHISYSPLV 2014

  Fly  2629 TSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQS--------------ALRVNKNAF- 2678
            :....|         |.|:...... ....|.:::.|...|              |.:..|:.| 
Zfish  2015 SHTQSS---------SQPTNNNEED-EEDDPAVQQMLGCCSTALWDDSAEDQDARARQQEKSHFE 2069

  Fly  2679 VSEASAPEVIVTRPSPEQ-----QTHPHSLSLRPDNATLVHVL 2716
            |.|.....|   |..|.:     |...||    ||:||.:..|
Zfish  2070 VDEFLGSSV---RRYPSESFLALQEEEHS----PDSATAMETL 2105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 89/262 (34%)
Ion_trans 687..902 CDD:459842 65/232 (28%)
Ion_trans 1751..2019 CDD:459842 93/291 (32%)
Na_channel_gate 2009..2063 CDD:240441 10/58 (17%)
Ion_trans 2067..2320 CDD:459842 89/263 (34%)
GPHH 2332..2378 CDD:465306 16/50 (32%)
cacna1ebXP_017206700.4 None

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