DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaCP60E and tpcn1

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	XP_695923.4	Gene:	tpcn1 / 567534	ZFINID:	ZDB-GENE-060526-199	Length:	811	Species:	Danio rerio

Alignment Length:	852	Identity:	168/852 - (19%)
Similarity:	308/852 - (36%)	Gaps:	279/852 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1738 TRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMIL 1802
            |.|...:|::.:.||..:..|.:...:::.|.              .|..:.|..|      |.|
Zfish   112 TAVLLMLLSLSEAPAVPFLRLDVYVHATLELL--------------ALVMVAFELC------MKL 156

  Fly  1803 KWLALGFSKYFTSFWTILD---FIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAIS-RWQG 1863
            :|  |||..:.....|::.   ..|.|:....:|:.:..:|:|      .|||||:..:. |:.|
Zfish   157 RW--LGFHTFIRHKRTMVKTSVLFIQFIEAIVVLVRQTSHLRV------TRALRPIFLVDCRYCG 213

  Fly  1864 -MRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCI 1927
             :|..:..:..::|...::||:.|.|.:||:|:|...|..                      :..
Zfish   214 AVRRNLRQIFQSLPPFIDILLLLLFFMVIFAILGFCLFSA----------------------NTA 256

  Fly  1928 EQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFI 1992
            :..::.:.:.|      :....||..|.|.   :||           .|....|.::.|:|::::
Zfish   257 DHYFSTLENSI------VSLFVLLTTANFP---DVM-----------MPAYSKNRWSCIFFIVYL 301

  Fly  1993 VCGSFFTLNLFIGVIIDNFNMLKK-KYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKV-IKR--- 2052
            ....:|.:||.:.|:.|.||.::| |::.  |.:....:.:|.:..:  :.|::|..| :|:
Zfish   302 SIELYFIMNLLLAVVFDTFNGVEKMKFKS--LLLHKRSAIEHAFQLL--VSRQRPDGVSLKQFDG 362

  Fly  2053 ----------PINHFLAM------------------FYD-------------------------- 2063
                      |.:.||..                  ||:
Zfish   363 LMRFYHPRMTPRDRFLTFKALNHSGAPMLSLQDFYKFYEVIGLKWKARRSGEHWFDDLPRTALLI 427

  Fly  2064 ------LSNSRRFEIA---------IFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113
                  |..|:.|:.|         |::|:..|||..||....       ::..|...|.|::|:
Zfish   428 FKGINLLVKSKAFQYAMYLVVAVNGIWILVETNMLNDGISWTR-------VVPWSYIIFLTIYGI 485

  Fly  2114 EAIVKIVGL-RYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLI 2177
            |.::||.|| ...||:..||:|||.:.:.:..|:    |.:...:.|....|  |.|..::|||.
Zfish   486 EVLLKITGLGPITYFSSGWNLFDFSVTVFAFLGL----IALAFDMEPFYFIV--VLRPLQLLRLF 544

  Fly  2178 KAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV-------------------- 2222
            |..:..|.:|..:....|.:.::|..|.:..:.:||:||..|.:|
Zfish   545 KIKQRYRNVLDTMFELFPRMASLGLTLIIFYYSFAIVGMEFFADVIYPNCCDNSTVAASYRQINV 609

  Fly  2223 ------KLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGH 2281
                  :||.....:.||.....|...||.|.....|...:|.:..|.......
Zfish   610 TTGNRTELQEGYYYLNNFNNILSSFVTLFELTVVNNWYITMEGVTSQTTHWSRL----------- 663

  Fly  2282 PLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFI 2346
                  ||.:|.|:: |:|:.:.:|.||:.|                 :|.:.:|:
Zfish   664 ------YFMTFYIVT-MVVMTIIVAFILDAF-----------------VFRMNYSR--------- 695

  Fly  2347 HFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQL 2411
                     .:.:|   :..|.:...:.|...:|:...:..||    ..||.||    ..|...|
Zfish   696 ---------KNREP---LDDPEDEKGIVFETEVSQTEALQTLD----FYKHTLG----VTNLTSL 740

  Fly  2412 QEQMDVKFKKQFPT-------RKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRK--------RE 2461
            |: |.|..::...|       |...:...|.::::.:      ||..::||.|..        ||
Zfish   741 QD-MCVALERSGQTSLVFLGRRSRTKSDLSMKMYEEE------IQEWYEEYSRTNLQTDGTFHRE 798

  Fly  2462 KERSNSG 2468
            .:..::|
Zfish   799 LDSPDAG 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	54/256 (21%)
		Na_channel_gate	2009..2063	CDD:240441	15/86 (17%)
		Ion_trans	2085..2320	CDD:278921	60/261 (23%)
		GPHH	2331..2386	CDD:293510	6/54 (11%)
tpcn1	XP_695923.4	Ion_trans	139..325	CDD:278921	52/255 (20%)
tpcn1	XP_695923.4	Ion_trans	477..688	CDD:278921	57/251 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900