DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and scn5lab

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001038588.1 Gene:scn5lab / 566868 ZFINID:ZDB-GENE-060908-3 Length:1954 Species:Danio rerio


Alignment Length:2608 Identity:850/2608 - (32%)
Similarity:1191/2608 - (45%) Gaps:836/2608 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYE--ETFCVVSKRFRKNYIHRFTGTKSLF 107
            |:.:|.:|.|..|||.|...|..:.|.|||:||.|.::  .||.|::|   ...|.||:.|.:|:
Zfish    49 PKPRADLEAGKQLPRIFGDIPSALVGVPLEDIDPFYFQNRRTFIVLNK---GKAIFRFSATSALY 110

  Fly   108 LFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEA---EYIFLAIYSIEMVIKII 169
            :|.|:.|.||..:.|..:..|...:|.|||.||.|:||:|..:.|   ||.|..||:.|.:|||:
Zfish   111 IFSPFHPIRRASIRILVHSLFSLFIMCTILTNCCFMAMSEPAQWAKYVEYTFTGIYTFESLIKIL 175

  Fly   170 AKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINA 234
            |:||.:..:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.|
Zfish   176 ARGFCIGPFTFLRDPWNWLDFSVILMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

  Fly   235 LLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ--------VPT-----------DW 280
            |:.|.::||:||.||:|||.||||..||::||.||.||||.        :||           .|
Zfish   241 LIQSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKCVRSASQCLNTTLPTYNNSTFICNNRSW 305

  Fly   281 TNVSHTDWQIWVNDTDNWLYDE---DELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFM 342
            .::..     :.|:.||:...|   |.|  :|||.:.|..||..:.||..|.|||:|||:||.|.
Zfish   306 ASLEE-----FFNNEDNFFKVEGAKDAL--ICGNASDAGKCPDGFECLKTGRNPNYGYTSFDTFG 363

  Fly   343 WSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITN 407
            |:.|:.|:|:|.|||||:|:..|.:.|...:.||.||:|.|||||:||:|||||::|||:.:.|.
Zfish   364 WAFLSLFRLMTQDYWENLYHHTLRSAGKAYMVFFVVVIFLGSFYLVNLILAVVAMAYEEQNQATI 428

  Fly   408 EERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNK--KKIDSRKGVLLASYS------KKKTRRKKT 464
            .|..      :.:..|.     |.:::|.|..:  :|....:.:|.|..|      |.|..|:|:
Zfish   429 AEAL------QKEQEFQ-----LAMEQLKKEQQAAQKAQETESILTADVSPFSTQDKAKLERRKS 482

  Fly   465 KGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQ-------YQQMEQQ 522
            ......||        |:| |.....|..|....||...|  .|:::|:::       ::.:.:.
Zfish   483 SRPLSEGT--------GED-KPAKLDPIEGIKQTHSLLVR--TLSLRARRESAVSIFNFRPVNKD 536

  Fly   523 HKLAKSGSGGSNNP---------MAPTPKGRISFQDSGMGVKNPNMLYPS-DYKGQLIANSGQPS 577
            .:|..:....||:.         ..|..:.|.|.|.|..  .:....:|| :..|:|:....|..
Zfish   537 SELDFADDEFSNHGDSDSRGGALALPWSRRRTSAQSSCS--HSSQFFFPSFNINGKLMVAVEQNG 599

  Fly   578 SNSSG-------------VNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNG 629
            .:|.|             ...|..:::||       |:::|::   |::.|...|.|.|      
Zfish   600 ISSQGPLTPMTPLTPLPACTMEKLKEESG-------QNSSNEL---SSMLLPQLPPEGR------ 648

  Fly   630 NIARIKNHNVYALHQEFSSEVVVIDDLPD-----RNCDRCVH--------WCTDYESWLQFQNCL 681
                         .:..|:...:.|.:.:     :.|..|.:        | |....||:.:..:
Zfish   649 -------------DRALSATSYITDAMEELEEAQQKCHPCWYVFAHKYLVW-TCSPRWLKVKEWV 699

  Fly   682 YKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-D 745
            ..:|.||..:||||:||||||.|:|:||:.|::.|...|.|||.|||.|||.|.::|::||.. .
Zfish   700 KIMVMDPFLDLAITICIVLNTLFMALEHYPMTDEFNRMLSVGNLVFTGIFTAEMVLKIIALDPYY 764

  Fly   746 FFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALG 810
            :|..||||||.|||:.||:::....|:||||||..|||||.|||:||.|:..|:.||.:::||||
Zfish   765 YFQQGWNIFDSLIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 829

  Fly   811 NLTLILVIVIYIFAVIGMQLFSKDY--TPEKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPL 872
            ||||:|.|:::||||:|||||.|:|  ...|...| .:|||:..||||||:::||:|||||||.:
Zfish   830 NLTLVLAIIVFIFAVVGMQLFGKNYDLCVCKISKDCTLPRWHMKDFFHSFLIVFRVLCGEWIETM 894

  Fly   873 WDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIE 937
            ||||   |..|...|..:|:..:|:||.:||||||||||:||:::.| |..:|.||.:.|..:|.
Zfish   895 WDCM---EVAGQPLCILVFMLVMVIGNLVVLNLFLALLLSSFSADNL-SAPDEDGEMNNLQIAIA 955

  Fly   938 RVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRL 1002
            |::..:...||...|.....|..:.|:    |::|.|.                     .|..||
Zfish   956 RIQRGMLWLRQALCDFFNGNFKRRRQK----AKEAKAM---------------------LKLKRL 995

  Fly  1003 SYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESA 1067
            :.                                            |||                
Zfish   996 TQ--------------------------------------------QAH---------------- 1000

  Fly  1068 MMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNST 1132
                      ...||||                   :||.                         
Zfish  1001 ----------WAEGNGT-------------------AGVI------------------------- 1011

  Fly  1133 DTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSG 1197
                   ::.||.|| ...||...|.:                   ||.|         :..:.|
Zfish  1012 -------ERSSGAGS-GEDDSYMTNPN-------------------LTIS---------VPIAPG 1040

  Fly  1198 QSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKG 1262
            :|.                                                 .:|.:||:|    
Zfish  1041 ESD-------------------------------------------------VEFPEEEDE---- 1052

  Fly  1263 TKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPS 1327
                                                    |::.||                |.|
Zfish  1053 ----------------------------------------EEDEEE----------------EAS 1061

  Fly  1328 PAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRR 1392
            .::||..:                       |..|.|...||                       
Zfish  1062 ASSDEEPE-----------------------PCKPRDDTSLS----------------------- 1080

  Fly  1393 SLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFD 1457
                     |..:|  ::||                                             
Zfish  1081 ---------EGSTI--DLRK--------------------------------------------- 1089

  Fly  1458 RFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKL 1522
                          |.||:                                              
Zfish  1090 --------------PGEEE---------------------------------------------- 1094

  Fly  1523 GMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHS 1587
                                                                             
Zfish  1095 ----------------------------------------------------------------- 1094

  Fly  1588 QAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDAT 1652
                                            :.:|..|.:|..                     
Zfish  1095 --------------------------------DEYSEMAEEAMD--------------------- 1106

  Fly  1653 QKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDH 1717
                                                                 |::|||..|..|
Zfish  1107 -----------------------------------------------------PENCFPDVCVRH 1118

  Fly  1718 FYFRCPWFMSCMDTQSA----KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKN 1778
            |        .|.|..::    :.|.|:|.....:|:...||.|::.:|..||..|.||||.:|:.
Zfish  1119 F--------KCCDINTSEGLGRAWWRLRKTCYQIVEHSWFETFIIFMILLSSGALAFEDIYIDQR 1175

  Fly  1779 KTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLK 1841
            |.:|.:|.:.:..|..||::||.|||:|.||.||||::|..|||:||.||:.||:...  ..:..
Zfish  1176 KVVKVILEYADKIFTYIFILEMSLKWIAYGFRKYFTNYWCWLDFLIVDVSLVSLVANTLGYSDFA 1240

  Fly  1842 VLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFK 1906
            .::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||..|.|||.:
Zfish  1241 AIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1305

  Fly  1907 CVNEMGELLPITEVNDKWDCIEQN---YTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVD 1968
            |||..|.:...:::|::.:|:|.|   |.|...|:.||:||.|||||||||||:||||:|..|||
Zfish  1306 CVNRTGFIYNSSDINNRSECLEMNSTQYYWTKVKVNFDNVGAGYLALLQVATFKGWMEIMYAAVD 1370

  Fly  1969 ARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH 2033
            :|.|:.||.:|.:||.|:||||||:.||||||||||||||||||..|:|..|  .::|:||.||.
Zfish  1371 SRAVEEQPIKENSLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKRKLGG--QDIFMTEEQKK 1433

  Fly  2034 YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFF 2098
            ||.||||||.|||||.|.||.|.....|:||.:.:.|:|.|.:||.|||:||.:|..:|..::..
Zfish  1434 YYNAMKKLGSKKPQKPIPRPPNPVQGFFFDLVSKQAFDILIMLLIILNMVTMMVETDEQSPSIKH 1498

  Fly  2099 ILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLR 2163
            ||:..|..|..:|..|.|:||:.||.::|||.||:|||::|:.||.||::.||:....:||||.|
Zfish  1499 ILDCINLVFIVIFTSECILKIIALRCYFFTVSWNIFDFVVVILSIVGIVLADIIEKYFVSPTLFR 1563

  Fly  2164 VVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGAL 2228
            |:|:.|||||||||:.|||||.|||||::|||||||||.||.|:.|||||.||:.|..||.||.:
Zfish  1564 VIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMANFAYVKKQGGI 1628

  Fly  2229 DDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPP-DCDPFI-HGHTN--GNCGHPLLAITYF 2289
            |||.||:|||.||..||::.|||||:::|..::..|| :|||.| |..||  ||||.|.:.||:|
Zfish  1629 DDMFNFETFGNSMICLFQITTSAGWDNLLSPILNTPPEECDPEIPHTGTNARGNCGKPSVGITFF 1693

  Fly  2290 TSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDF 2354
            .::||||::||:|||||||||||:.|.:|....:.|||.||||..|.|:||.|||||.:.:||||
Zfish  1694 VTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDPEATQFIEYLKLSDF 1758

  Fly  2355 IASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKF 2419
            ..:|..||.|.|||.:.|:|.:||:..|:||||||||.|..|.|||...|.|..||   ||:.||
Zfish  1759 ADTLSEPLRIGKPNKIKLISMDLPMVSGDKIHCLDILFAFTKRVLGESGEMDALKQ---QMEEKF 1820

  Fly  2420 KKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS------------NSGDSAT 2472
            ....|::...|.:::|...|::|.:|..||..::.:|.|::.|:.|            .:|||:.
Zfish  1821 MMANPSKISYEPITTTLRRKQEEVSAIMIQRSYRRHLIRRQLKQASLLYRQMTMPDADKAGDSSP 1885

  Fly  2473 Q-----------------------TSSPGGWQSKLSALN-FFHLQVSRRGTACSSRASSRKSSRA 2513
            :                       ||||..:.|...|.: .||..:       ....:...|...
Zfish  1886 ESQGLIVSMIMENYATEAEITISATSSPPSYDSVTRATSEIFHALI-------PEETNEILSEHL 1943

  Fly  2514 SDASDLSE 2521
            :||...||
Zfish  1944 ADAEKESE 1951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 114/243 (47%)
Ion_trans 705..902 CDD:278921 104/200 (52%)
Ion_trans 1768..2019 CDD:278921 151/255 (59%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 133/238 (56%)
GPHH 2331..2386 CDD:293510 28/54 (52%)
scn5labNP_001038588.1 Ion_trans 154..427 CDD:278921 134/279 (48%)
Na_trans_cytopl 478..566 CDD:288761 18/98 (18%)
Ion_trans 723..918 CDD:278921 102/197 (52%)
Na_trans_assoc 944..1143 CDD:284034 75/823 (9%)
Ion_trans 1165..1419 CDD:278921 150/253 (59%)
Na_channel_gate 1411..1463 CDD:240441 30/53 (57%)
Ion_trans 1485..1723 CDD:278921 132/237 (56%)
GPHH 1735..1790 CDD:293510 28/54 (52%)
IQ 1841..1863 CDD:197470 6/21 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.920

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