Protein Alignment NaCP60E and cacna1ia

DIOPT Version :9

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_009297749.2
• Gene: cacna1ia / 566351
• ZFINID: ZDB-GENE-060503-324
• Length: 2122
• Species: Danio rerio
• Alignment Length: 2928
• Identity: 611/2928 - (20%)
• Similarity: 1039/2928 - (35%)
• Gaps: 997/2928 - (34%)

  Fly   127 FFDYCVMATILFNCIFLAMTETVEEAE----------------YIFLAIYSIEMVIKIIAKGFLL 175
            :|:...:..||.||:.|.|.:..|..:                |||   :::|||:|::|.| :.
Zfish    12 WFERISIMVILLNCVTLGMYQPCENIDCTSERCQVLQAFDAFIYIF---FALEMVVKMVALG-IF 72

  Fly   176 NKYTYLRNPWNWLDFVVITSGYATIGMEVGNL--AGLRTFRVLRALKTVSIMPGLKTIINALLHS 238
            .:..||.:.||.|||.::.:|.....:::.|:  :.:||.||||.||.::.:|.::.::|.||.:
Zfish    73 GRRCYLGDTWNRLDFFIVMAGMVEYSLDLQNINFSAIRTVRVLRPLKAINRVPSMRILVNLLLDT 137

  Fly   239 FRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ----------VPTDWTNVSHTDWQIWVN 293
            ...|..|:.|..|...:|.:..:|::.|.|||:|..:          :||.:......|.:.::.
Zfish   138 LPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCYPEENFTLTSGLTLPTPYYQPEEDDERPFIC 202

  Fly   294 D--TDNWLYDEDELPVLCGNLTGARHCPFE-----------------------YVCLCVG----- 328
            .  .||.:....::|   ....|.|.|..:                       .:.|||.
Zfish   203 SLAQDNGIMSCSDVP---ARREGGRECCLDKEDALHRQALGLSAEPLVNGSASAMGLCVNWNQYY 264

  Fly   329 -------ENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFY 386
                   .||:.|..||||..::.:..||:|||:.|..:...|:......:..:|..::..|||:
Zfish   265 TRCHTGHTNPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFIFLIIIGSFF 329

  Fly   387 LINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTFS--FDPSVLNVKKLNKNNKKKIDS 445
            :|||.|.|:|..:.|    |.::..|:|.:.|    ..||.:  .:|.               |.
Zfish   330 MINLCLVVIATQFSETKQREHQLMQEQRARYL----SSSTLASLAEPG---------------DC 375

  Fly   446 RKGVL-LASYSKKKTRRKKT----------------KGGKEGGTNGNGNGSNGDDNKSHSATPSP 493
            .:.:. |..:..:|.||:..                :|..:||....|.|:|.:..:.|..
Zfish   376 YEELFQLVCHILRKARRRSAALYYMLRGKAPPPGGGRGRGKGGAGSIGGGANVNGGEKHHC---- 436

  Fly   494 GPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPN 558
                 |||             |......:.||..|.....:..::|.|:            :.|.
Zfish   437 -----HSA-------------QTSHCIHETKLDHSSENAVSLSISPNPE------------ECPQ 471

  Fly   559 MLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVR 623
            .      ...|....|:.|:..|.    :.:::.|.:::.:..:...|....|..:..|..:...
Zfish   472 C------AAALSLKEGEESTGHSA----NGEEEEGALEETDRDENRLDKKRSSDSDDTLKKKRTC 526

  Fly   624 LIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDP 688
            |.||.                                           :.|.:.:..|:.:|...
Zfish   527 LGKCK-------------------------------------------DVWDEIRVKLWGIVESK 548

  Fly   689 LFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWN 752
            .|...|.:.|::||..:.:|||...:...|.|::.|.||||:||.|.|:||.|.. .::....:|
Zfish   549 YFNRGIMIAILINTISMGIEHHNQPDELTNVLEICNIVFTSMFTLEMILKLTAFGFFEYLRNPYN 613

  Fly   753 IFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILV 817
            |||.:||..|:.:||.:...||||||..|||||:||.:....::..|.:::.|:..:....::|:
Zfish   614 IFDGIIVIISVCEIIGQSDGGLSVLRTFRLLRVIKLVRFMPALRRQLVVLMKTMDNVATFCMLLM 678

  Fly   818 IVIYIFAVIGMQLFSKDYTPEKFDPDPVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEE 880
            :.|:||:::||.:|...::.:....|.|| |.||:....:.:.:|:||..| |...|::.|.:..
Zfish   679 LFIFIFSILGMHIFGCKFSLKTEAGDTVPDRKNFDSLLWAIVTVFQILTQEDWNMVLYNGMASTS 743

  Fly   881 EQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRK 945
            ...|    ..|:..:..||:::.||.:|:|:..|.:|.
Zfish   744 PLAA----LYFVALMTFGNYVLFNLLVAILVEGFQAEG--------------------------- 777

  Fly   946 KRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNR 1010
                                  ||.::::.  ..:::..||..:|.
Zfish   778 ----------------------DANRSYSD--DDRSSCNLEETEKK------------------- 799

  Fly  1011 PVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGS 1075
                                 |.|:..|                |...::.|
Zfish   800 ---------------------DSLQLSD----------------PKISTLTP------------- 814

  Fly  1076 FSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYAND 1140
                ||:   .:|.|...|.                               |.|.|
Zfish   815 ----NGH---LDLAPAPNAR-------------------------------GFYPS--------- 832

  Fly  1141 QRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLK 1205
                                                             :|||.:.|.
Zfish   833 -------------------------------------------------ERLSFALGS------- 841

  Fly  1206 SEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISN 1270
                   |.||..||...|:||..|...:.:|                              ..|
Zfish   842 -------RKSSVSSLGRASLEQTTLCPGRASL------------------------------YHN 869

  Fly  1271 VMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATK 1335
            ..|..||.                    |.|.......:.||:..|
Zfish   870 WGRPARPG--------------------IWSRRSSWNSLGRSSRCL------------------- 895

  Fly  1336 AIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKI 1400
                  .:..|.|.|..:..    .:|.:...|.|.|.
Zfish   896 ------GMGGGGSLRVRSPH----CHPAEQESLLSPPP--------------------------- 923

  Fly  1401 DEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLI 1465
                          ..:|.|.:                |...|..|.:           :.|||
Zfish   924 --------------PPLHPPLL----------------PRHFPPRRER-----------RALSL- 946

  Fly  1466 ERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAV 1530
                |:||      .|::....:|.  ||...:.:..|..|.|...:       |.....||
Zfish   947 ----ELPE------LLQVPGPPLPP--LHPRQRKKSFSGGLGSVGEH-------QDCNGKTP--- 989

  Fly  1531 PATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMA 1595
                      |::|..:.::                                         :...
Zfish   990 ----------SVQPQIINEV-----------------------------------------YPQV 1003

  Fly  1596 GQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTR 1660
            ..|:..|..:..||.:..|:                                    .||.....|
Zfish  1004 NTRKDREDLEDELDYSLCFR------------------------------------IQKMMEVYR 1032

  Fly  1661 LTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWF 1725
                                                         ||.|..::.:..|.|
Zfish  1033 ---------------------------------------------PDWCETREDWSVFLF----- 1047

  Fly  1726 MSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINF 1790
                     ....:.|....:::....|::.||..||::.||:..|...:.:....:..|...|:
Zfish  1048 ---------SPQNKFRLLCQSIIAHKLFDYVVLAFIFSNCITVALERPKILQGSLERLFLTVSNY 1103

  Fly  1791 SFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLK---VLRSLRT 1848
            .|..|||.||.||.:::|.    ..|..|.|.|||..:||||:..:::......|   |||.||.
Zfish  1104 IFTAIFVGEMTLKVVSMGLYIGEQAYLRSSWNILDGFLVFVSLIDIVVSMAGGAKILGVLRVLRL 1168

  Fly  1849 LRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGE 1913
            ||.|||||.|||..|:::||..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|:.
Zfish  1169 LRTLRPLRVISRAPGLKLVVETLITSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYYCLG---- 1229

  Fly  1914 LLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQR 1978
             |.:..:.:|.||:..||.|::.|..||::|...::|..:|:.:||:.:|...:||..||.||..
Zfish  1230 -LDVKNITNKSDCLLANYKWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYHGLDAVAVDQQPIT 1293

  Fly  1979 EANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGR 2043
            ..|.:..:||:.|::..|||.||:|:||:::||:..::..|        .|..|......::...
Zfish  1294 NNNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQE--------VEEAKRREEKRQRRME 1350

  Fly  2044 KKPQKVIKRP----INHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSN 2104
            ||.:|..|.|    .:|...|.:.|..|...:|.|..:|.:|::||.:|||.|||::...|:..|
Zfish  1351 KKRRKAQKLPYYASYSHVRLMIHTLCTSHYLDIFITFIICVNVVTMSLEHYSQPHSLEIALKYCN 1415

  Fly  2105 AFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVR 2166
            .|||:.|.|||::|::...: .:|...||..|..:||.|:.||.:|:|.|.  |||:||::|::|
Zfish  1416 YFFTSTFVLEAVLKLIAFGFRRFFKDRWNQLDLAIVLLSVMGITLEEIEISAALPINPTIIRIMR 1480

  Fly  2167 VFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV------KLQ 2225
            |.||.|:|:|:|.|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.:      ..:
Zfish  1481 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGELVCNEDYPCE 1545

  Fly  2226 GALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PP---DCDPFIHGHTNGNCGHPLLAI 2286
            | :.....|:.||.:...||::.|...||.:::..:.: ||   .|:|.:.          .::.
Zfish  1546 G-MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRECPPGEYTCNPSLQ----------FISP 1599

  Fly  2287 TYFTSFIIISYMIVINMYIAIILENFNQAHQE-EEIGIVEDDLEM-------FYIRWSKYDPHAT 2343
            .||.||::.:..::||:.:|:::::.:.:::| :|...::.::||       ..|.........|
Zfish  1600 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEEAEMDAEIEMELAQGTLCCIGGGVAVADRT 1664

  Fly  2344 QFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNF 2408
            ...|....|   .|:.||                              |:.:.|.:.|  |.::.
Zfish  1665 GMGHQGAAS---CSVVPP------------------------------HSPITHPVAH--EPNSI 1694

  Fly  2409 KQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKER----SNSGD 2469
            ::|..          |.::.|.:.|.:.:                  ::...|.|.    :.||.
Zfish  1695 RRLYS----------PAQENLWLDSVSLL------------------IKDSFEGEMLMIDNLSGS 1731

  Fly  2470 SATQTSSPGGWQS-KLSALNFFHLQVSRRGTACSSRASSRKSSRA-SDASDLSELAGPWLNLPLM 2532
            .....|||...:. :.......|:....:.:..|.:.|.:.||.| .|...|.|     .::..|
Zfish  1732 VFHHYSSPPVCKDCRTHPQEQIHMAELEQASLRSEQLSDKSSSPALPDDLSLDE-----QSVYQM 1791

  Fly  2533 LVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMN 2597
            ......|.|.|....::|.|.||:..:.  |:||         .|....:|..|..|.|..|...
Zfish  1792 AAKEGKERVCDECHHSEEPGGRGNSRLR--RSSR---------VHSSGTEDGGTCQSPHHNTPAR 1845

  Fly  2598 NTTN---TTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKP 2659
            ::..   .:|:|....|.:..::.:....|.||...      |.|.....||.|.|..    .||
Zfish  1846 HSIGGVPCSSSSQEHPGVSGGSSRSNTPVCLPAEFF------HPAAAALPAPPRGRTG----HKP 1900

  Fly  2660 PLERGL-----SAQSALR---VNKNAFV---------------SEASAP-------EVIVTRPSP 2694
               |||     ::.::||   .|.....               ||.|.|       ..||:.|.|
Zfish  1901 ---RGLRLTSPASWASLRSPGANTRLLTTQYPSHSDSSLATGSSEGSLPTTMEEGLSFIVSTPQP 1962

  Fly  2695 ------EQQTHPHSLSLRPDNATLVHVLV----HRESEEYKEEDESSPSVSGNGNGFGVGLDMLS 2749
                  :::|...:.:||| :....|:|.    |:.|....|.|.::.|:. .|:...|||...|
Zfish  1963 LLDTLLDERTSLSTETLRP-SPPATHILQTTRGHQRSRSSCETDINTGSIR-QGSEADVGLVWCS 2025

  Fly  2750 KQ---PPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDTS 2811
            .:   ...|:..|..|:  |:.:..:|:..:                       |:.|.....|.
Zfish  2026 SEQTCDSQQLSETQSSL--SLTSLLLPSSLV-----------------------PLSVKKCNSTG 2065

  Fly  2812 QVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSR-SSSSSTSSIRS 2875
            .:           |||.   .||| |.:..::....:.:|.::.::|.|..:: :...|||.|..
Zfish  2066 SL-----------DQGT---LTAQ-EKVFTKEPQGNITSPWKERKERQSEAAQGTDGESTSQITI 2115

  Fly  2876 CSS 2878
            ..|
Zfish  2116 AGS 2118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	67/283 (24%)
		Ion_trans	705..902	CDD:278921	65/199 (33%)
		Ion_trans	1768..2019	CDD:278921	94/257 (37%)
		Na_channel_gate	2009..2063	CDD:240441	12/57 (21%)
		Ion_trans	2085..2320	CDD:278921	85/248 (34%)
		GPHH	2331..2386	CDD:293510	7/54 (13%)
cacna1ia	XP_009297749.2	Ion_trans	12..350	CDD:306908	86/344 (25%)
		Ion_trans	547..774	CDD:306908	74/230 (32%)
		Ion_trans	1063..1334	CDD:306908	101/275 (37%)
		Ion_trans	1378..1633	CDD:306908	91/265 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910