Protein Alignment NaCP60E and scn4ab

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_073798670.1
• Gene: scn4ab / 564977
• ZFINID: ZDB-GENE-051201-1
• Length: 1836
• Species: Danio rerio
• Alignment Length: 2506
• Identity: 778/2506 - (31%)
• Similarity: 1096/2506 - (43%)
• Gaps: 882/2506 - (35%)

  Fly    24 QRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFI-YEETFCV 87
            ::.::|.:|  :::..|  ..|:..:.:|.|.|||..:...|.::...|:||:|.:. .::||.|
Zfish    86 EQERMKEQN--VKVAEE--DLPKPTSDLEAGKVLPFIYGDPPPNLLNVPIEELDPYYKAQKTFIV 146

  Fly    88 VSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQF-FDYCVMATILFNCIFLAMTET--- 148
            :.|   ||.|:||....:.:...|::|.||..:.|..:.: ....:|.|||.||:|:||::.
Zfish   147 IDK---KNTIYRFNTEPACYCLSPFNPVRRAAIRILIHSYPIHLVIMLTILTNCVFMAMSDPPGW 208

  Fly   149 VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTF 213
            .:..||:|..||:.|.::|::::||.:..:|:||:|||||||:||:..|.|..:::||::.||||
Zfish   209 SKILEYVFTGIYTFEAMVKVLSRGFCIGDFTFLRDPWNWLDFMVISMAYLTEFVDLGNISALRTF 273

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||||||::::||||||:.||:.|.::||:||.||:|||.||||..||::||.||.|||...|.
Zfish   274 RVLRALKTITVIPGLKTIVGALIQSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKCVLWPPV 338

  Fly   279 DW------------------TNVSHTDWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVC 324
            .|                  |..|..|:|.::|..:|:.|...:: |::|||.:.|..||..|:|
Zfish   339 GWYSDNLTVLSNYTDINGNGTANSTFDYQKYINSEENYYYVPGQMDPLVCGNSSDAGLCPEGYIC 403

  Fly   325 LCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLIN 389
            |..|.|||:|||::|||.|:.|..|:|:|.|:|||::.:.|...|...:.||.|::|.|||||||
Zfish   404 LKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLIN 468

  Fly   390 LMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
            |:|||||::|.|:.|.|..|.|:                           |::          .|
Zfish   469 LILAVVAMAYAEQNEATAAEAKE---------------------------KEE----------EY 496

  Fly   455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQM 519
            :|...:.||....|.|..||                               |..::.::|:
Zfish   497 AKIMEQLKKQAEQKNGMVNG-------------------------------SKTSLSSKKK---- 526

  Fly   520 EQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVN 584
                        |.|:.|                        .|||.|..:    :|.|.|:|
Zfish   527 ------------GDNDQM------------------------QSDYDGIAL----KPLSKSNG-- 549

  Fly   585 RESSQDDSGVVDDHEEQDT-TNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSS 648
                  ..|.::..|..|: ......||.||.||..:|        :|.|......|.....|
Zfish   550 ------SKGNINYLEVPDSQIRKPSVVSAVESALDAQE--------DIERPCPPGWYKFADIF-- 598

  Fly   649 EVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMS 713
                      ...|.|:       .|::|:..:|..|.||..:|.|||||||||.|:||||:.||
Zfish   599 ----------LKWDCCI-------PWVKFKRIVYLFVMDPFVDLGITLCIVLNTVFMAMEHYPMS 646

  Fly   714 ESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVL 777
            ......|.:||.|||.||..|.::||:||.. .:|..||||||.:|||.||::::...|:|||||
Zfish   647 VHVEEVLAIGNLVFTGIFAAEMVLKLIALDPYYYFQVGWNIFDSIIVTMSLVELMLADVEGLSVL 711

  Fly   778 RGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPE--KF 840
            |..||:||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.||..  |.
Zfish   712 RSFRLMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYTDSVCKI 776

  Fly   841 DPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLN 904
            ..| .:|||:..||||:|::|||:|||||||.:||||   |..|...|..:|:..:|:||.:|||
Zfish   777 SSDCELPRWHMADFFHAFLIIFRVLCGEWIETMWDCM---EVAGQGMCIIVFMMVMVIGNLVVLN 838

  Fly   905 LFLALLLNSFNSEELKSKKEEVGEE------SKLARSIERVRDLIRKKRQERKDRKERKFAEKFQ 963
            |||||||:||:.:.| |..::.||.      |::.|.|:.:                :.||.|..
Zfish   839 LFLALLLSSFSGDNL-SASDDDGENNLQIAISRITRGIDWI----------------KAFANKHV 886

  Fly   964 QIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLH 1028
            :..|:.:..             |.|.|.....:.|         ||..::.|....::|:.:|
Zfish   887 RQCLNLKPK-------------EEGAKVNGEGDAK---------MNAIMNSSSSMVKVPIANG-- 927

  Fly  1029 TIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQ 1093
                  |.||.                                        :|||:
Zfish   928 ------ESDDD----------------------------------------DGNGS--------- 937

  Fly  1094 AERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNS 1158
                                                                             
Zfish   938 ----------------------------------------------------------------- 937

  Fly  1159 SRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSM 1223
                 ||:.|:                                              .|..:|..
Zfish   938 -----SEDEDD----------------------------------------------EGGDINMK 951

  Fly  1224 SIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENET 1288
            ....||
Zfish   952 KKNGDE----------------------------------------------------------- 957

  Fly  1289 MVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAA 1353
                                   |:|
Zfish   958 -----------------------SST--------------------------------------- 960

  Fly  1354 DEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIH 1418
                                                                        |..:.
Zfish   961 ------------------------------------------------------------CSTVD 965

  Fly  1419 APFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRI 1483
            .|                                             ..||::.|||:
Zfish   966 KP---------------------------------------------PEVEDLVEEEE------- 978

  Fly  1484 ESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLA 1548
                                                                             
Zfish   979 ----------------------------------------------------------------- 978

  Fly  1549 QISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAAS 1613
                                                                             
Zfish   979 ----------------------------------------------------------------- 978

  Fly  1614 FQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTV 1678
                                                                        :|||
Zfish   979 ------------------------------------------------------------EDLT- 982

  Fly  1679 GGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQ----SAKHWTR 1739
                                      .|:||:.:.|..    |||    |:|..    ..|.|..
Zfish   983 --------------------------SPEDCYTENCIR----RCP----CLDLDVSQGKGKAWWN 1013

  Fly  1740 VRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKW 1804
            .|.....:|:...||.|::.:|..||..|.||||.:::.:.:|.:|.:.:..|..:|||||:|||
Zfish  1014 FRKTCFAIVEHSYFETFIIFMILLSSGALAFEDIYIEQRRMIKIILEYADQVFTYVFVVEMLLKW 1078

  Fly  1805 LALGFSKYFTSFWTILDFIIVFVSVFSLL--IEENENLKVLRSLRTLRALRPLRAISRWQGMRIV 1867
            :|.||..|||:.|..|||:||.||:.||.  |.....|..::|||||||||||||:||::|||:|
Zfish  1079 VAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1143

  Fly  1868 VNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMG-ELLPITEVNDKWDCIE--- 1928
            ||||:.|||||||||||||:||||||||||..|.|||:.|.||.. |:....|||:|.||.|
Zfish  1144 VNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYYCFNETSEEVFDHNEVNNKTDCYELME 1208

  Fly  1929 --QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIF 1991
              ....|:|.||.||:||||||||||||||:|||::|..|||:|.::.||..|||||.|||||||
Zfish  1209 FHPEVRWMNGKINFDNVGMGYLALLQVATFKGWMDIMYSAVDSRAIESQPVYEANLYMYIYFVIF 1273

  Fly  1992 IVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINH 2056
            |:.||||||||||||||||||..|.|..|  .::|:||.||.||.||||||.|||||.|.||.|.
Zfish  1274 IIFGSFFTLNLFIGVIIDNFNQQKAKIRG--TDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPTNC 1336

  Fly  2057 FLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVG 2121
            ...:.:|....:.|:|.|.|:|.|||:||.:|..||...:..||...|..|..:|..|.::||..
Zfish  1337 CQGLVFDFVTQQFFDIFIMVMICLNMVTMMVETDDQSPEIEEILFYINFAFIILFTGECVLKITA 1401

  Fly  2122 LRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKL 2186
            ||||||::.||:|||::|:.||.||.:.|::....:||||.||:|:.||||:||||:.|||||.|
Zfish  1402 LRYHYFSIGWNIFDFVVVILSILGIGLADLIEKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTL 1466

  Fly  2187 LFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSA 2251
            ||||::|||||||||.||.||.||::|.|||.|..||.:..:|||:||:|||.|:..:|.:.|||
Zfish  1467 LFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEVGIDDMMNFETFGNSIICMFMITTSA 1531

  Fly  2252 GWNDVLESLMIQPPDCDPFIH---GHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFN 2313
            ||:.:|..::..||||||.:.   ..|.||||:..:.|.:|.|:|::|:::|:||||||||||||
Zfish  1532 GWDGLLAPILNSPPDCDPDVDNPGSTTRGNCGNAAVGIVFFCSYIVMSFLVVVNMYIAIILENFN 1596

  Fly  2314 QAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLP 2378
            .|.:|....:.|||.||||..|.|:||.|:|||.:::||:|..:|..||.|.|||.:.|::.::|
Zfish  1597 VATEESSDPLCEDDFEMFYETWEKFDPTASQFIDYNRLSEFCDTLKDPLRIPKPNTLKLITMDIP 1661

  Fly  2379 ISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK 2443
            :..|:||||||:|.||...|||..::.|..|...|:   ||....|::...|.::||...|::|.
Zfish  1662 MVTGDKIHCLDLLLALTGEVLGGSDQMDGMKATMEE---KFMANNPSKASYEPITSTLKRKQEEV 1723

  Fly  2444 AAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGG 2479
            ||.|||..::.::.::..|:.|......|.:..|.|
Zfish  1724 AASTIQRAYRSHILKRCVKQASYMYRDKTGSKKPTG 1759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	117/268 (44%)
		Ion_trans	687..902	CDD:459842	117/218 (54%)
		Ion_trans	1751..2019	CDD:459842	164/275 (60%)
		Na_channel_gate	2009..2063	CDD:240441	29/53 (55%)
		Ion_trans	2067..2320	CDD:459842	132/255 (52%)
		GPHH	2332..2378	CDD:465306	20/45 (44%)
scn4ab	XP_073798670.1	None