DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and cacna1e

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_017212914.2 Gene:cacna1e / 564274 -ID:- Length:2444 Species:Danio rerio


Alignment Length:2885 Identity:643/2885 - (22%)
Similarity:1051/2885 - (36%) Gaps:974/2885 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEA 152
            ||..:|||:|...:..|:....|.....|:|.::|||:.|||.||            |.:.:|:.
Zfish   222 FTVNRSLFIFGEDNIVRKYAKKIIEWPPFEYMILATIIANCIVLALEQHLPGEDKTPMAKRLEKT 286

  Fly   153 EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTF 213
            |..|:.::..|..|||||.||:.:|.:||||.||.:||:|::|| .||.|..:.   :|..||..
Zfish   287 EPYFIGMFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFIVVSSGILATAGAHMNISLDLRTLRAV 351

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|..:|   .|.
Zfish   352 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHKQC---EPV 413

  Fly   279 DWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343
            .             .|::.....|:|.|  |    |::.||..|.|......||.|.|.|||.::
Zfish   414 G-------------KDSERADSPENEFP--C----GSKLCPDHYNCSGYWTGPNDGITQFDNILF 459

  Fly   344 SMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITN 407
            |:||.||.||::.|..: |....|.....:..:|..::..|||:::||:|.|::..:.:|.|  .
Zfish   460 SLLTVFQCITMEGWTTILYYTNDALGSTWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE--R 522

  Fly   408 EERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGT 472
            .|.::..:..|......        ::|| ..:..||..:.|:||                    
Zfish   523 VENRRAFMKLRRQQQIE--------RELN-GYRAWIDRAEEVMLA-------------------- 558

  Fly   473 NGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPM 537
                     ::||:..                ||||.:..:                        
Zfish   559 ---------EENKNSG----------------PSALDVLKR------------------------ 574

  Fly   538 APTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQD 602
            |.|.|.|        ||.:........|..  |::.|.|      :||.|.:             
Zfish   575 ATTIKRR--------GVDDARRAPEEQYAD--ISSLGMP------LNRASIR------------- 610

  Fly   603 TTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHW 667
             :...|..|...     |:.||::.:                                       
Zfish   611 -SAKRGPTSYFR-----RKERLLRIS--------------------------------------- 630

  Fly   668 CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFT 732
                         :.::|:...|...:...:.|||..:|:.||...:...:.|.....:|..:|.
Zfish   631 -------------VRRMVKTQTFYWTVLGLVALNTLCVAIVHHKQPQWLSSLLYYAEFLFLGLFL 682

  Fly   733 FECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQS 791
            .|..:|:..|. :.:|...:|.||..::..|:.::.:....     |:||||.|||||:.|:.:.
Zfish   683 TEMFLKMYGLGPRLYFHSSFNCFDCGVIVGSIFEVFWGFFRPGTSFGISVLRALRLLRIFKITKY 747

  Fly   792 WTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFS-----KDYTPEKFDPDPVPRWNFN 851
            |.:::.|:..:::::.::.:|..:|.:.|.:||::|||||.     .:|||..||..|.      
Zfish   748 WASLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGMQLFGGRFIFDEYTPTNFDTFPA------ 806

  Fly   852 DFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NS 913
                :.|.:|:||.|| |.|.:::.:|::....:....:::...|.: ||:.:||:|||:.: |.
Zfish   807 ----AIMTVFQILTGEDWNEVMYNGIRSQGGVKSGMWSSVYFIVLTLFGNYTLLNVFLAIAVDNL 867

  Fly   914 FNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLS 978
            .|::||...:||                            :|..|.:|           ||    
Zfish   868 ANAQELTKDEEE----------------------------EEEAFNQK-----------HA---- 889

  Fly   979 HQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLP 1043
                  |::..:.|                  |:|.                             
Zfish   890 ------LQKAKEVG------------------PMSS----------------------------- 901

  Fly  1044 EQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVST 1108
                                                           |:.:|||          .
Zfish   902 -----------------------------------------------FMSSERR----------R 909

  Fly  1109 QQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLK 1173
            :.|..|:.|.:...    ..|:..|.:..| |.|    .||..:|......||            
Zfish   910 RPYLYRKRAIHRSR----AAYSFEDAESLA-DAR----PFNASNSFMSRRERR------------ 953

  Fly  1174 YQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLR 1238
                            .||:.|..:.:.|       ::|||   :.::|..|             
Zfish   954 ----------------RRLTMSVWEQRTS-------QLRRH---RQMSSREI------------- 979

  Fly  1239 EELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPS-SQMGQPENETMVEHSEFDNIIQSF 1302
                      ||....||::...|..|.        |:|. |..|.....|              
Zfish   980 ----------LFSSPSEEQDGPPGCPLH--------RKPGLSPSGSKRRAT-------------- 1012

  Fly  1303 EKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYD 1367
                     .|||.........||....|                   ...||..||::..:...
Zfish  1013 ---------ETTSTTIMPEGTLEPPMPMD-------------------MPVDEQALPISIPEPPL 1049

  Fly  1368 LSSVPRRSQSVSAAAQRQSVKLKRRSLE-KQRKIDEDFSISNEIRKICDQI-----------HAP 1420
            ...:|.....|.|......|.|.....| .:.|...:.::  :|...|.::           |.|
Zfish  1050 AIPIPEPPMPVDACLPEPPVTLNLPLTEPSESKTSPEGAL--DINNHCPRLNGNRRQRAVRKHRP 1112

  Fly  1421 FVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEV-------PEEEKPI 1478
                .||....|      |:..|..||         .|.:.|....|.:|.       .:|:||.
Zfish  1113 ----PAMGDMLT------PDMGPRPRR---------PRHRELHTDPRGKETLQGDGVDGKEQKPG 1158

  Fly  1479 STLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE 1543
            |.   ..||...:.  .||...|:....|..|:            .::..:.||..|..:     
Zfish  1159 SE---GDEKSDGEI--SPDGRGLEQRQNKPDNT------------ESSTESKPANSPRKI----- 1201

  Fly  1544 PPTLAQISSLKTTPPLAALTEH--QQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQS 1606
            ||       |.:.|....||::  ||....|                    :.||:.....|...
Zfish  1202 PP-------LDSEPATLQLTDNTLQQSSQGT--------------------TCAGETDNNNHGSL 1239

  Fly  1607 TLDKAASFQSARTESHSSGAADASSALALAM---------AQKTEQSQSTAPDATQKPSAFTRLT 1662
            ..||::...|...|     ..|...::.|..         |.|.|:.:.| |||.:.|...:...
Zfish  1240 NQDKSSLNTSIVIE-----VTDTQPSMELTSITGNSKDVEASKPEKEEET-PDAPKGPPPVSMFI 1298

  Fly  1663 EKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMS 1727
            .||                       |:|                                    
Zfish  1299 FKP-----------------------NNP------------------------------------ 1304

  Fly  1728 CMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKRVLYWIN 1789
                        ||.|...||:...||..:|::|.||||.|..||   .|.|:||    ||.:.:
Zfish  1305 ------------VRRACHYVVNLRYFEMSILLVIAASSIALAAEDPVNTNSDRNK----VLRYFD 1353

  Fly  1790 FSFCLIFVVEMILKW----LALGFSKYFTSFWTILDFIIVFVSVFSLLI------EENENLKVLR 1844
            :.|..:|..|||:|.    |.|.:..||...|.|||||:|..::.:..:      ....::|.::
Zfish  1354 YVFTGVFTFEMIIKMIDQGLVLHYGSYFRDPWNILDFIVVVGALVAFALTNVMGSNTGRDIKTIK 1418

  Fly  1845 SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN 1909
            |||.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||:::.||.|.|||:.|.:
Zfish  1419 SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFYYCTD 1483

  Fly  1910 EMGELLPITEVN--------DKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADA 1966
            ...:    ||..        || |..::...|......:|:|....|.|..|:|.|||.:|:..:
Zfish  1484 SSKD----TENECKGYYIDYDK-DKKKEKREWKRRDFHYDNVVWALLTLFTVSTGEGWPQVLQHS 1543

  Fly  1967 VDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQ 2031
            ||....|..|.:...:...|::||:.|...||.:|:|:.:||..|   :::.:..:.|..|.:::
Zfish  1544 VDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFVNIFVALIIITF---QEQGDKMMEECSLEKNE 1605

  Fly  2032 K---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQP 2093
            :   .:..:.|.|.|..||.  ::.:.:.|..|.   .|..||..:..:|.||.:.:.::|:| |
Zfish  1606 RACIDFAISAKPLTRYMPQN--RQTLQYRLWQFV---VSPSFEYTVLTMIALNTIVLMMKHHD-P 1664

  Fly  2094 HAVFF--ILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDL 2155
            ....:  :|:..|..||.:|.:|.::||:... .:||...||:|||:.||.||..||::......
Zfish  1665 RLEGYDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFRDTWNIFDFITVLGSITEILVDKFQTGK 1729

  Fly  2156 PISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFG 2220
            ..:   :..:::||..|:::|::....||.||:..|.|..||..:..|:.::.|||||:||.:||
Zfish  1730 TFN---MGFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1791

  Fly  2221 NVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDC--DPFIHGHT---NGN 2278
            |:|:  :..:::..||:||..::.||||..|...|.:::.|.:.: .:|  |..::..|   ..:
Zfish  1792 NIKINEKTQINEHNNFRTFFGALMLLFRSATGESWQEIMLSCLGE-KECEIDTSVNSTTKTIKND 1855

  Fly  2279 CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHAT 2343
            ||.. .|..||.|||..|..:::|:::|:|::||....::..| :....|:.|...|.:||..|.
Zfish  1856 CGTD-FAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRIWGEYDRAAC 1918

  Fly  2344 QFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVE 2403
            ..:|:.::...:.::.||||..|  |..||   ||..|:|:.:...:|....|.||::..|    
Zfish  1919 GKLHYKEMYKVVRTISPPLGFGKNCPYRVACKRLVLMNMPVDEDMSVHFTSTLMALIRTAL---- 1979

  Fly  2404 ETDNFK-----QLQEQMDVKFKKQFP------TRKELEIV------SSTRIWK-----------R 2440
               :.|     :.:.||||:.:|:..      ::|.|:::      |...|.|           :
Zfish  1980 ---DIKIARGGEDRGQMDVELQKEISVIWPHLSQKSLDLLVPIHKASDMTIGKIYAAMMIMDYYK 2041

  Fly  2441 QEKAAKTIQTGWKEYLRRKREKER----------------------------SNSGDSATQTSSP 2477
            |.||.|         ||::.|:::                            .::|.:.|:    
Zfish  2042 QNKAKK---------LRQQLEEQKHAPMFQRMDASSLPQDILCSAKALPFLTHSAGSALTR---- 2093

  Fly  2478 GGW--QSKLSALNFF---------------------------H----------------LQVSRR 2497
            ||:  .|.:|..:.|                           |                |||..|
Zfish  2094 GGFVALSPISPQDLFMQPMTQDSMEEREEYQHPYHLQSMVPEHKEFSSVMCPTSMQADPLQVPGR 2158

  Fly  2498 GTACSSRASSRKSSRASDASDLSELA-GPWLNLPLMLVSGA-----DEVVKDIKQQNDELGKRGS 2556
            |.  |.||||           :..|| .|..:|...|:..:     |:.|....|:...|.:...
Zfish  2159 GV--SIRASS-----------MPRLAVEPQASLENKLMKRSFSTIGDQCVNGDWQEEFSLERVSP 2210

  Fly  2557 IFVEAPRASRRRSFYNFFLRHQDAVDDS---------LTSPSVHR-------------------- 2592
            ..:|.|   |:|||.......::.||..         |.||.|.|                    
Zfish  2211 DRLERP---RQRSFRGVRSNLREPVDKERGRSKERRHLLSPDVSRCNSEERSQSQERRHSPSPSE 2272

  Fly  2593 ---KTAMNNTTNTTSNSAST--SGTASSTATAPATGCGP---AATSASDSDRHQAVGGGSAPSRK 2649
               .||:....||.|..|||  |||.......|.|...|   .:.|......|.|.|    ..|.
Zfish  2273 GRKHTALRQGNNTGSPIASTSDSGTPRGRRQLPQTPSRPRPHISYSPLVCRAHPAPG----DDRP 2333

  Fly  2650 RASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVH 2714
            ||       ||.|.|                    .|...|.|                ...:.|
Zfish  2334 RA-------PPAEEG--------------------EEPTATGP----------------GTAMAH 2355

  Fly  2715 VLVHRE-SEEY--KEEDESSPSVSG 2736
            ...||. ||.|  .:||.:||..||
Zfish  2356 STPHRYISEPYLPLQEDVNSPDSSG 2380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 76/223 (34%)
Ion_trans 705..902 CDD:278921 55/209 (26%)
Ion_trans 1768..2019 CDD:278921 84/271 (31%)
Na_channel_gate 2009..2063 CDD:240441 10/56 (18%)
Ion_trans 2085..2320 CDD:278921 76/244 (31%)
GPHH 2331..2386 CDD:293510 18/59 (31%)
cacna1eXP_017212914.2 Ion_trans 247..524 CDD:306908 98/300 (33%)
Ion_trans 640..875 CDD:306908 68/244 (28%)
Atrophin-1 887..>1210 CDD:331285 94/617 (15%)
Ion_trans 1316..1549 CDD:306908 79/241 (33%)
Ion_trans 1639..1896 CDD:306908 82/262 (31%)
GPHH 1897..1967 CDD:318993 20/70 (29%)
Ca_chan_IQ 1969..2043 CDD:312334 15/80 (19%)
Transformer 2203..2368 CDD:253769 48/214 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.