DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1bb

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_017208482.3 Gene:cacna1bb / 562796 ZFINID:ZDB-GENE-090514-4 Length:2447 Species:Danio rerio


Alignment Length:3111 Identity:638/3111 - (20%)
Similarity:1114/3111 - (35%) Gaps:1012/3111 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DDQATFNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEH 67
            |||.....|  ...|.||...:||.:|:.:    .:..:......:.....||.||.:       
Zfish    77 DDQTQRAGE--CKYHSVVELERRSDLKNTD----FISAHEMCDEQERMARFGDDLPTR------- 128

  Fly    68 MYGKPL-----------EEIDTFIYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWS 113
             ||.|.           ......:|:::   :::|.|...::.        ||..:|||:|...:
Zfish   129 -YGGPAGAGRGGARAGGPSGGQRMYKQS---MAQRARTMALYNPKQTKQNCFTVNRSLFIFSEDN 189

  Fly   114 PARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEAEYIFLAIYSIEMVI 166
            ..|:....|.....|:|.::.||:.|||.||            |:|.:::.|..|:.|:..|..|
Zfish   190 VIRKYAKRITEWPPFEYLILTTIIANCIVLALEQHLPALDKTPMSERLDDTEPYFIGIFCFEAGI 254

  Fly   167 KIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKT 230
            ||||.||:.:|.:||||.||.:||||:.:| ..|:|.:. :|..||..||||.||.||.:|.|:.
Zfish   255 KIIALGFVFHKDSYLRNGWNIMDFVVVVTGILTTVGSQF-DLRTLRAVRVLRPLKLVSGIPSLQV 318

  Fly   231 IINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDT 295
            ::.:::.:...|.::..|..|.:::||:..::.|||:....|.:.                  ||
Zfish   319 VLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKFHFTCFKV------------------DT 365

  Fly   296 DNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV 360
                 .|..:...||....:|.||....|....:.||.|.|||||.::::||.||.||::.|.:|
Zfish   366 -----GEKAVDYPCGAEPPSRSCPVGTNCTEYWKGPNFGITNFDNILFAILTVFQCITMEGWTDV 425

  Fly   361 -YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFS 424
             |:...|.....:..:|..::..|||:::||:|.|::..:.:|.|  ..|::::.|..|...   
Zfish   426 LYHTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE--RVEKRQEFLKLRRQQ--- 485

  Fly   425 FDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSA 489
                  .:::......:.|...:.||||.                            :|..:...
Zfish   486 ------QIERELTGYLEWICKAEEVLLAE----------------------------EDQNAEEK 516

  Fly   490 TPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGV 554
            :|..|                   ..|::.:....|.::.|....|.:....:|...|.|     
Zfish   517 SPLDG-------------------AWYRRKQNNPVLKRTKSRKGRNDLISAEEGDEHFTD----- 557

  Fly   555 KNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSP 619
                           |::...|.|..:..:.:||::||......:|                   
Zfish   558 ---------------ISSVAPPGSPFARASLKSSKNDSSSYFRRKE------------------- 588

  Fly   620 REVRLIKCNGNIAR-IKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYK 683
            :.:|..     |.| :|..:.|                                 |         
Zfish   589 KRIRFF-----IRRMVKAQSFY---------------------------------W--------- 606

  Fly   684 VVRDPLFELAITLCIV-LNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDF 746
                      |.||:| |||..:|:.|:...|....||.:...||..:|..|..:|:..|. :::
Zfish   607 ----------IVLCLVGLNTMCVAIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLGPRNY 661

  Fly   747 FLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTI 806
            |...:|.||..::..|:.::|:..:.     |:||||.|||||:.|:.:.|.:::.|:..:::::
Zfish   662 FHSSFNCFDFGVIVGSIFEVIWAAIQPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSM 726

  Fly   807 GALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIE 870
            .::.:|..:|.:.|.:||::|||||...:..|    |..|..||:.|..:.|.:|:||.|| |..
Zfish   727 KSIISLLFLLFLFIVVFALLGMQLFGGQFNFE----DETPTTNFDSFPAAIMTVFQILTGEDWNA 787

  Fly   871 PLWDCMRAE-EEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLA 933
            .::..:.:: ..:|.......|:...:.||:.:||:|||:.: |..|::||...:|:..|.:|  
Zfish   788 VMYHGIESQGGVRGGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEQQEEAAK-- 850

  Fly   934 RSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDA-QQAHAQTLSHQAAVGLERGDKPGVLAET 997
                  :.|..:|..|.|:......|    .|.:.| .:.:...:|.:::|......|.   .:.
Zfish   851 ------KSLALQKAMEVKEVSPMSAA----NISIAAFVKQNRDAISRRSSVCSVHSPKE---QQR 902

  Fly   998 KFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPP 1062
            ...:||..|....                                    ||:.|.|..:|:::  
Zfish   903 SLQKLSIWEQRTN------------------------------------QLRRHNLRSSSEAL-- 929

  Fly  1063 TYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQ-----QYDSREEATYTES 1122
             |..                         ::.|.||  ::||.:..:     .:|......:.:|
Zfish   930 -YNE-------------------------LEPEERL--RVSSALHLRPDMKTHHDRPLVVEHRDS 966

  Fly  1123 IELLGQYNSTDT---DPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPS 1184
            ::.|......||   .|.:|.||                              ||.|        
Zfish   967 VDNLRSDKDGDTSEGQPASNHQR------------------------------KYHK-------- 993

  Fly  1185 YRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKEL 1249
                      ..|::.    .:.|..:.||.|....|...:|:..  ||.|..|           
Zfish   994 ----------CRGENG----DTGEGRLHRHHSQNRENQGGLERSN--SQDGGQR----------- 1031

  Fly  1250 FQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTT 1314
                               ::...|..|...:|..|.|....||          :...|:..:..
Zfish  1032 -------------------NHHRSSGSPEEGIGIEEREHRHHHS----------RRPREVNGNGN 1067

  Fly  1315 SLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVS 1379
            .:   :.|                      .|..||....                  |..:..:
Zfish  1068 GV---IGN----------------------GGRGERIRGH------------------REGEGGN 1089

  Fly  1380 AAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPF 1444
            ...:|...::|.:|     .:|.|....|..::                       :::|.::. 
Zfish  1090 GERRRHRPRVKAQS-----TLDGDECRENGGKR-----------------------RSRPTETD- 1125

  Fly  1445 LRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKST 1509
                              ||.....:.|.||||     .:.:.:......||.            
Zfish  1126 ------------------SLTTSPLQSPSEEKP-----EDKDNLKNSTRVGPS------------ 1155

  Fly  1510 NSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSI 1574
                         |:..|..:.|.|..:                 |..|:               
Zfish  1156 -------------GVNIPVTITAPPGET-----------------TVIPM--------------- 1175

  Fly  1575 QAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQ 1639
                             :::.|....:...:..||                              
Zfish  1176 -----------------NNIDGDSLLLNEEKKDLD------------------------------ 1193

  Fly  1640 KTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAK 1704
              |.:|:.                 |.|.|                 .|:....|   |.|.   
Zfish  1194 --ELNQNA-----------------PKHIL-----------------PYSSMFVF---GPTN--- 1216

  Fly  1705 VPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLC 1769
                  |.:...|:                            ||:...||..:|.:|..|||.|.
Zfish  1217 ------PVRRLCHY----------------------------VVNLRYFEMCILTVITMSSIALA 1247

  Fly  1770 FED---INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV-- 1825
            .||   .:..:|..||    ::::.|..:|..||::|.:.||.    ..||...|.|||||:|  
Zfish  1248 AEDPVQAHAPRNDVLK----YLDYVFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSG 1308

  Fly  1826 FVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWL 1890
            .:..|:....:.:::..::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..
Zfish  1309 ALVAFACSGTKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMF 1373

  Fly  1891 IFSIMGVQFFGGKFFKCVNE--------MGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGY 1947
            ||:::.||.|.||||.|.:|        .|:.|   |.......:.|...|......:|:|...:
Zfish  1374 IFAVIAVQLFKGKFFHCTDESKALEKDCRGQFL---EYGSDGVAMTQPREWKKYDFHYDNVLWAF 1435

  Fly  1948 LALLQVATFEGWMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVII 2008
            |.|..|:|.|||..|:..:|||...|..|    :.|.:::..:||::|    .||.:|:|:.:||
Zfish  1436 LTLFTVSTGEGWPLVLKHSVDATYEDQGPSPGYRMETSIFYVVYFIVF----PFFFVNIFVALII 1496

  Fly  2009 DNFNMLKKKYEGGVLEMFLTESQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRF 2070
            ..|   :::.:..:.|..|.::::   .:....|.|.|..||..     |.:....:....|..|
Zfish  1497 ITF---QEQGDKAMSECSLEKNERACIDFAINAKPLTRYMPQDK-----NSYQYKMWKFVVSTPF 1553

  Fly  2071 EIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL-RYHYFTVPWNVF 2134
            |.:|..:|.:|.:.:.::.:..|.....:|:..|..||.:|.||.::|::.. ..:|....||:|
Zfish  1554 EYSILTMIAINTVVLMMKFHGAPKPYEDMLKWLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIF 1618

  Fly  2135 DFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFN 2199
            ||:.||.||..||:.:|. |..|:   |..:|:||..|:::|::....||.||:..|.|..||..
Zfish  1619 DFVTVLGSITDILVTEIK-DKRIN---LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1679

  Fly  2200 IGALLGLITFIYAILGMSLFGNVKL---QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM 2261
            :..|:.::.|||||:||.:|||:.|   ..|::...||:||.:::.||||..|...|::::.:.:
Zfish  1680 VCLLIAMLFFIYAIIGMQVFGNIALNNEDSAINIHNNFRTFFQALMLLFRSATGEAWHEIMLACL 1744

  Fly  2262 IQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326
            .: ..|| ...|::...||.. .|..||.|||.:...:::|:::|:|::||....::..| :...
Zfish  1745 SE-RYCD-IESGYSGKECGSD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDASI-LGPH 1805

  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIH 2386
            .|:.|...|::|||.|...:.:..:.:.:..:.||||:.|  |..:|   ||..|:||::.|.:|
Zfish  1806 HLDEFIRVWAEYDPAACGRMSYLDMYEMLRHMSPPLGLGKKCPPRIAYKRLVRMNMPIAEDNTVH 1870

  Fly  2387 CLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKK--------QFPTRKELEIVSSTRIW-KRQE 2442
            ....|.||::..|                ::|...        ....|||:     .:|| ....
Zfish  1871 FTSTLMALIRTAL----------------EIKLASGVLAQRICDAELRKEI-----NKIWPSLSS 1914

  Fly  2443 KAAKTIQTGWK----------------EYLRRKREKERSNSGDSATQTSSPGGWQSKLSAL---- 2487
            |....:.|..|                :|.::.|.|....      |.::| |.|||:..|    
Zfish  1915 KTVDLLVTPHKHNELTVGKVYAALMIFDYYKQNRAKRLQQ------QQAAP-GTQSKVGVLFRPM 1972

  Fly  2488 --------------------------------NFFHLQVSRRGTACSSRASSRKSSRASDASDLS 2520
                                            ..|||   ..|.|..|::|:.|.|.:...|  .
Zfish  1973 LPLTHLHDQEPLVPKGPPPSHLDITPQSDATPTSFHL---TNGDAVQSQSSAMKKSPSGGPS--Q 2032

  Fly  2521 ELAGPWLNLPLMLVSGAD--------EVVKDIKQQNDE----------LGKRGSIFVEAPRASRR 2567
            |:.......|:......|        |:|:....:||.          .|:..|:    ||.:  
Zfish  2033 EVTQETNRRPIQRGQSEDVPNTYRSQELVEMTDMENDSDVGGYHVLEGHGRAASM----PRLN-- 2091

  Fly  2568 RSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSAS 2632
            ..|....|||   ...:..:| :...:.|..:|::.:..........|..........|:.|.|.
Zfish  2092 AGFQRSHLRH---TAGAYLAP-IADVSPMRRSTSSLTPQRGAREVNLSEYDLERPRMSPSQTFAQ 2152

  Fly  2633 DSDR-----------HQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPE 2686
            |.:|           |:.       .|:|.    :|...|:|.:|.:..         ..|:.|.
Zfish  2153 DRERERVHHHHHHHHHRC-------QRRRD----KKHKSLDRAISEEQP---------PPAADPN 2197

  Fly  2687 VIVTRPSPEQQT-----------------------------------HPHSLSLRPDNATLVHVL 2716
               |..:|.::.                                   |.||||..|..:|     
Zfish  2198 ---TESTPRERARERDRGRSHERKHHSSSAAERKQRYYSCDRYGSHEHGHSLSAGPSRST----- 2254

  Fly  2717 VHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDS 2781
            ...|..:..::..::...|..|:..|.......::..||..:|                      
Zfish  2255 SPGEPHDRLKQGINAAKGSSVGHTSGTSTPCRGRRQLPQTPLT---------------------- 2297

  Fly  2782 PKDPPRGDFSSAPIDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXP 2846
            |:  |...:.:|.    .:|:.:|....|       .|..|...:|..:.:|....|: .||...
Zfish  2298 PR--PAVAYKTAN----SSPVQLNTAQST-------GPCPARLSRGLSEHDTLLSGSI-HRQSPV 2348

  Fly  2847 PVNT--------PL-RDS---------EKRSSRGSRSSSSSTSSIRSCSSSSSSSA 2884
            ||..        || :||         :..|:.|:..|..:|:.|...||.:::::
Zfish  2349 PVTRIGSDPSLGPLQQDSHLSEAEDFHDALSTYGTGRSPRTTAIIAHTSSGATATS 2404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 85/259 (33%)
Ion_trans 687..902 CDD:459842 64/223 (29%)
Ion_trans 1751..2019 CDD:459842 88/288 (31%)
Na_channel_gate 2009..2063 CDD:240441 9/56 (16%)
Ion_trans 2067..2320 CDD:459842 83/256 (32%)
GPHH 2332..2378 CDD:465306 15/50 (30%)
cacna1bbXP_017208482.3 None

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