DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1aa

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_021330047.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2371 Species:Danio rerio


Alignment Length:3079 Identity:660/3079 - (21%)
Similarity:1106/3079 - (35%) Gaps:1012/3079 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 GDVLPRKFEPFPEHMYGKP---------LEEIDTFIYEETFCVVSKRFRKNYIHR--------FT 101
            ||.:|.::...|.|..|.|         .......:|:::   :::|.|...::.        ||
Zfish     5 GDEVPSRYGGGPGHAQGGPGRGGSRQGGPPGAQQRMYKQS---MAQRARTMALYNPIPVRQNCFT 66

  Fly   102 GTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEAEY 154
            ..:|||:|...:..|:....|.....|:|.::|||:.|||.||            |:|.:|:.|.
Zfish    67 VNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLEDTEP 131

  Fly   155 IFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVGNLAGLRTFRVLRA 218
            .|:.|:..|..|||:|.||..:|.:||||.||.:||||:.:| .:|:|.:. :|..||..||||.
Zfish   132 YFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSDF-DLRTLRAVRVLRP 195

  Fly   219 LKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNV 283
            ||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|||:....|..::       
Zfish   196 LKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDKI------- 253

  Fly   284 SHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTT 348
                       ||.   ..:|.|  ||....||.||...||......||:|.|.|||.::::||.
Zfish   254 -----------TDE---IREEFP--CGEEVPARICPNGTVCKKYWLGPNYGITQFDNILFAVLTV 302

  Fly   349 FQLITLDYWEN-VYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKK 412
            ||.||::.|.: :|....|.....:..:|..::..|||:::||:|.|::..:.:|.|  ..|.:.
Zfish   303 FQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLVLGVLSGEFAKERE--RVENRS 365

  Fly   413 DLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGN 477
            :.|..:......        ::|| ...:.|...:.|:||.                        
Zfish   366 EFLKLKRQQQIE--------RELN-GYLEWICKAEEVILAD------------------------ 397

  Fly   478 GSNGDDNKSHSATPSPG----PSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMA 538
                :||......|..|    |:.:.|.|:...                   |:.|.|...:|.|
Zfish   398 ----EDNDPDDRMPFDGSRRRPTIKKSKTDLLD-------------------AEDGDGDIGSPFA 439

  Fly   539 PTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDT 603
                                       :|.|.::..:.||                  .|:::  
Zfish   440 ---------------------------RGSLKSSKLEGSS------------------FHKKE-- 457

  Fly   604 TNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWC 668
                            |.:|..     |.||.....:                         :| 
Zfish   458 ----------------RRLRFF-----IRRIVKTQAF-------------------------YW- 475

  Fly   669 TDYESWLQFQNCLYKVVRDPLFELAITLCIV-LNTAFLAMEHHGMSESFRNALDVGNKVFTSIFT 732
                                     ..||:| |||..:|:.|:...|:..:.|.....:|..||.
Zfish   476 -------------------------TVLCLVGLNTLCVAVVHYDQPETLSDFLYFAEFIFLGIFM 515

  Fly   733 FECIVKLMAL-SKDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQS 791
            .|..:|:..| ::.:|...:|.||.:::..|:.::::.::.     |:||||.|||||:.|:.:.
Zfish   516 SEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMIQPGTSFGISVLRALRLLRIFKVTKY 580

  Fly   792 WTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHS 856
            |.:::.|:..:::::.::.:|..:|.:.|.:||::|||||...:..|.    ..|..||:.|..:
Zfish   581 WASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEA----GTPPTNFDTFPAA 641

  Fly   857 FMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSEE 918
            .|.:|:||.|| |...::|.:.::........|::|...|.: ||:.:||:|||:.: |..|::|
Zfish   642 IMTVFQILTGEDWNMVMYDGIESQGGVKKGMVFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQE 706

  Fly   919 LKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQA-A 982
            |                        .|..||.:....:|.|.:..:.|.:.....|..||..| .
Zfish   707 L------------------------TKDEQEEEQAANKKMALQTAKEVAEVSPLSAANLSIAAVT 747

  Fly   983 VGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQ 1047
            |..||.|       ...|.|..:|....             |.|..::.:    ..|.:|..|..
Zfish   748 VNSERLD-------ATEHFLDCKEQQKN-------------HKGCKSVWE----QRTSELRRQTL 788

  Fly  1048 LQA-----HPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQA--ERRL-----QH 1100
            :.:     :.|.| .|....:|.                    :::.|.::.  :|.|     ::
Zfish   789 VNSREALYNELDP-EDRWKVSYS--------------------RHIRPDMKTHLDRPLVVDPQEN 832

  Fly  1101 QISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCG-------SFNRGDSLQDNS 1158
            :.::...|:..|.:.:    .|.:||.:      .|..|:..:|.|       :..||||   ..
Zfish   833 RNNNTNKTRPGDGQPQ----HSHQLLHK------QPNFNEAETGGGGGSESWPALERGDS---TG 884

  Fly  1159 SRR--YGSEEHD---EAFLKYQKSL-LTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSG 1217
            |||  .|||.::   |:..::|.|. .:::..:||:.:...:..|:..||..|....|......|
Zfish   885 SRRSLLGSEHYEEGRESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGG 949

  Fly  1218 QSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMG 1282
            :                                                      |..|.....|
Zfish   950 E------------------------------------------------------RKHRRHRHEG 960

  Fly  1283 QPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGA 1347
            :...|..|.|.                       .|:..:.|.|:                    
Zfish   961 EGRKERGVRHR-----------------------NRRDGHASGPT-------------------- 982

  Fly  1348 SERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRK 1412
                                ||:    ::.:.....||         :.|...|.|.:::|   |
Zfish   983 --------------------LST----TRPIQKTLSRQ---------DSQYSEDLDNAMNN---K 1011

  Fly  1413 ICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKP 1477
            :..|   |..::..:|..|.||..|......                   |||            
Zfish  1012 LATQ---PHDSLLNLANTAHSAGLAHTGTES-------------------SLI------------ 1042

  Fly  1478 ISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSI 1542
                           |..|      |.::.:..|..:|.::.:...:..||..|::         
Zfish  1043 ---------------LTNP------SSTIANVTSIGHLGMKPEYTAVDIPPMFPSS--------- 1077

  Fly  1543 EPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQST 1607
              ..:.|::....|.||                  |....|                        
Zfish  1078 --NAILQVNKNANTEPL------------------PKKEDT------------------------ 1098

  Fly  1608 LDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKP-----SAFTRLTEKPWH 1667
                                            |.:.......|...||     |.|...|..|:.
Zfish  1099 --------------------------------KGDDDDDEKDDGGPKPMPPYTSMFILTTTNPFR 1131

  Fly  1668 CLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQ 1732
            .|..|                                                            
Zfish  1132 RLCHY------------------------------------------------------------ 1136

  Fly  1733 SAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFV 1797
                          :|....||..:|::|..|||.|..|| .:........||.:.::.|..:|.
Zfish  1137 --------------IVTLRYFEMCILLVIAMSSIALAAED-PVWPESPRNNVLRYFDYVFTGVFT 1186

  Fly  1798 VEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLI-------EENENLKVLRSLRTLRA 1851
            .||::|.:.||.    ..||...|.|||||:|..::.:...       .:.:::..::|||.||.
Zfish  1187 FEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGALVAFAFTGGSGGSSKGKDISTIKSLRVLRV 1251

  Fly  1852 LRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNE------ 1910
            ||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::.||.|.|:||.|.:|      
Zfish  1252 LRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFER 1316

  Fly  1911 --MGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVD 1973
              .||.|.....|   :...|...|......:|:|....|.|..|:|.|||.:|:..:|||...:
Zfish  1317 DCRGEYLVYERDN---EVRSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATYEN 1378

  Fly  1974 LQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH- 2033
            ..|    :.|.:::..:|||:|    .||.:|:|:.:||..|.....|    ::|.:..|..:. 
Zfish  1379 QGPSPGYRMEMSIFYVVYFVVF----PFFFVNIFVALIIITFQEQGDK----MMEDYSLEKNERA 1435

  Fly  2034 ---YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHA 2095
               :....|.|.|..||..     ..|....::...|..||..|..||.||.:.:.:: ||....
Zfish  1436 CIDFAINAKPLTRHMPQNK-----QTFQYRMWEFVVSPPFEYTIMALIALNTIVLMMK-YDGASL 1494

  Fly  2096 VF-FILEVSNAFFTTVFGLEAIVKIVGL-RYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPIS 2158
            .: .:|:..|..||::|.:|.|:||:.. ..:||...||:||.:.||.||..||:.::.::..|:
Zfish  1495 TYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKDAWNIFDCVTVLGSITDILVTELGMNNFIN 1559

  Fly  2159 PTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223
               |..:|:||..|:::|::..:.||.||:..|.|..||..:..|:.::.|||||:||.||||:|
Zfish  1560 ---LSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQLFGNIK 1621

  Fly  2224 LQGALDDMV----NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLL 2284
            ::...|..:    ||:||.:::.||||..|...|:|::.|.:.:.| || .:..:....||.. .
Zfish  1622 IEENSDSAITQHNNFRTFFQALMLLFRSATGEAWHDIMLSCLGKKP-CD-ILSDNPKPECGSE-F 1683

  Fly  2285 AITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFS 2349
            |..||.|||.:...:::|:::|:|::||....::..| :....|:.:...|::|||.|...||:.
Zfish  1684 AYLYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEYVRIWAEYDPAACGRIHYK 1747

  Fly  2350 QLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL---------G 2400
            .:...:..:|||||:.|  |:.||   |:..:||::..|.:|....|.||::..|         |
Zfish  1748 DMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGEG 1812

  Fly  2401 HVEETDNFKQLQEQMDVKFKKQ----FP--TRKELEIV-----SSTRIWKRQEKAAKTIQTGWKE 2454
            .|:        :.|||.:.:|:    :|  ::|.|:::     |:|.:...:..||..|.    |
Zfish  1813 GVD--------KHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIM----E 1865

  Fly  2455 YLRRKREKERSNSGD---------------SATQTSSPG--GW-QSKLSALNFFHLQVSRRGTAC 2501
            |.|:.:.|......|               |.:|...||  |. .:::...|  ||.|..|....
Zfish  1866 YYRQSKAKRTQALHDEQNRTPLMFQRLEPPSPSQDVGPGLTGLPDTQMHPAN--HLPVDERIPES 1928

  Fly  2502 SSRASSRKSSRASDASDLSELAGPWLNLPLMLVSG--ADEVVKDIKQQND----ELGKRGSIFVE 2560
            .|..::|       |.::|:.||.|      ...|  .|:...:.:|...    |:|:.|....|
Zfish  1929 QSWVTAR-------AQEISQKAGNW------SPEGQHPDDTTDNRRQSQTVEMREMGRDGYSDTE 1980

  Fly  2561 -------------APR------ASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNS 2606
                         .||      ..||:.      ||:   .::||.|             .|.||
Zfish  1981 QYLPMEGHGRAASMPRLPADNQQPRRKG------RHR---GENLTQP-------------ITDNS 2023

  Fly  2607 ASTSGTASSTATAPATGCGPAATSASDSD------------RHQAVGGGSAPSRKRASSFIRKKP 2659
                   ....:|.:.|.|.|..|....|            ||        ..|.|..|....:.
Zfish  2024 -------PMKRSASSLGHGRAGRSMRGEDYAMERVIPEEGHRH--------GHRHRDRSHRASER 2073

  Fly  2660 PLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEY 2724
            .|.|...|.:.|..:.:........|.....|...:.:.|.|.......:....|....|:..||
Zfish  2074 SLSRYTDADTGLGTDLSTTTQSGDLPSKERDRGRAKDRKHHHHHHHHHGSLDKEHYGHERDRGEY 2138

  Fly  2725 -----KEED-----------------ESSPSVSGNGNGFGVGLDM-------------------- 2747
                 :|.|                 :.|.||||:......|...                    
Zfish  2139 GHRQSRERDRRWSRSPSEGRECLTHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPATPRPHVT 2203

  Fly  2748 --------LSKQPPP--QIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPI 2802
                    :|..|||  |.|:.|            ||.:....:..:||............|:| 
Zfish  2204 YSPVVRKPISSTPPPGQQSRLPT------------PTSRRFSPTGPEPPLPPHHHPSPPHHGSP- 2255

  Fly  2803 DVNVQGDTSQVFYDYNPEKATDDQGNG----QD------ETAQFESLP------------DRQRX 2845
                   .|.....:.||.|...:|:|    ||      |...:|..|            .|.. 
Zfish  2256 -------RSGRHAHWGPEPAESVEGDGFYDDQDYEFNHHEPPSYEQSPVQGNPHPHSPRTSRHNT 2313

  Fly  2846 PPVNTPLRDSEKRSSRGSRSSSSS 2869
            ||..   :...:|...|.||||.|
Zfish  2314 PPQG---QAHPRRMPNGYRSSSPS 2334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/220 (34%)
Ion_trans 705..902 CDD:278921 56/204 (27%)
Ion_trans 1768..2019 CDD:278921 80/273 (29%)
Na_channel_gate 2009..2063 CDD:240441 10/57 (18%)
Ion_trans 2085..2320 CDD:278921 80/240 (33%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
cacna1aaXP_021330047.1 Ion_trans 90..362 CDD:306908 98/297 (33%)
Ion_trans 471..709 CDD:306908 72/316 (23%)
Ion_trans 1141..1377 CDD:306908 73/239 (31%)
Ion_trans 1467..1719 CDD:306908 88/258 (34%)
GPHH 1720..1790 CDD:318993 22/70 (31%)
Ca_chan_IQ 1792..1870 CDD:312334 21/89 (24%)
SOBP <2151..2361 CDD:317654 40/207 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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