Protein Alignment NaCP60E and cacna1ha

DIOPT Version :9

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_021330381.1
• Gene: cacna1ha / 560875
• ZFINID: ZDB-GENE-130103-1
• Length: 2198
• Species: Danio rerio
• Alignment Length: 2938
• Identity: 642/2938 - (21%)
• Similarity: 1063/2938 - (36%)
• Gaps: 1075/2938 - (36%)

  Fly   133 MATILFNCIFLAMTETVE----EAEYIFL---------AIYSIEMVIKIIAKG-FLLNKYTYLRN 183
            |..||.||:.|.|.:..|    ::|:..:         |.:::|||||:||.| |.:|  .||.:
Zfish     1 MLVILLNCVTLGMYQPCEDLKCQSEWCIVLQAFDDCIFAFFAVEMVIKMIALGIFGIN--GYLGD 63

  Fly   184 PWNWLDFVVITSGYATIGMEVGN--LAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVM 246
            .||.|||.::.:|.....::..|  |:.:||.||||.|:.::.:|.::.::..||.:...|..|:
Zfish    64 TWNRLDFFIVMAGMMEYSLDGHNASLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVL 128

  Fly   247 TLTIFCLMVFALFALQVYMGELRNKCVRQVPT---DWTNVSHTDWQIWVNDTDNWLY----DEDE 304
            .|..|...:|.:..:|::.|.|||:|.  :|:   |..|:|:..           ||    |.::
Zfish   129 LLCFFVFFIFGIVGVQLWAGLLRNRCF--MPSKVRDQYNLSYMS-----------LYYENEDGED 180

  Fly   305 LPVLCGNL--TGARHC----PFE------------------------YVCL--------C-VGE- 329
            .|.:|.:.  .|.:.|    |.:                        |.|:        | .|:
Zfish   181 NPFICSSSKDNGMKRCSAVPPLKEGVECTLNASFLGHVYSGLSGTGNYSCVNWNQYYSECKPGDL 245

  Fly   330 NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAV 394
            ||:.|..||||..::.:..||:|||:.|.::...|:......:..:|.:::..|||::|||.|.|
Zfish   246 NPHKGAVNFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 310

  Fly   395 VALSYEEEAEITNEERKKDLLDHR-DDSTFS--------FDPSVLNVKKLNKNNKKKIDSRKGVL 450
            :|..:.|..:..|...|:....:| :|||.:        ::..:..|..|.:..|::: ||   :
Zfish   311 IATQFAETKQRENMLMKEQRARYRSNDSTLASYSEPGSCYEEMLKYVSHLYRKVKRRL-SR---I 371

  Fly   451 LASYSKKKTRRKKTKGGKEGGTNGN----GNG----------SNGDDNKSHSATPSPGPSPRHSA 501
            ..|:..|:.::.....|..||.||:    |.|          ........|.:..||.|.....:
Zfish   372 YNSWQSKRRKKVNPNTGAGGGANGHSRHRGYGHWVQSIHSLIQQHQRQHCHLSNGSPSPVATTGS 436

  Fly   502 TERPSALTMQAQKQYQQM------EQQHKLAKSGSGGSN--------NPMAPTPKG----RISFQ 548
            :|   ||.|::....||:      ...|.|:.|.....:        .|...||..    .:|..
Zfish   437 SE---ALEMRSITAGQQLTVSSQPTATHNLSSSTQSVHSIYQGDFREAPQERTPTNVAVPALSRL 498

  Fly   549 DSGMGVKNPNMLYPSDYKGQLIAN-SGQPSSNSSGVNRESSQDDSG--VVDD----------HEE 600
            :.||..  |.:| ||     ||.| ||   ..|.|..|..|..::|  |:.|          |..
Zfish   499 NGGMNY--PTIL-PS-----LICNYSG---GGSLGKERGKSDANTGHEVIQDFDKLHQQIEAHSH 552

  Fly   601 QDTTNDMGHVSTVELALS----PREVRLIKC------NGNIARIKNHNVYALHQEFSSEVVVI-- 653
            ......|..|...:|.|.    |..||.::.      :.:..|.:...||    |||.:...|
Zfish   553 SRVLLQMAGVVPTQLLLEVMSCPYCVRALESMDLEIGDSDYPRSEGDMVY----EFSYDAGFITG 613

  Fly   654 ----DDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSE 714
                ..:.::. :|.|.:      |..|:..|.::|....|...|.:.|::||..:.:|:|...|
Zfish   614 RSAHHKMQEKQ-NRLVQF------WEDFRERLTRIVDSKYFNRGIMIAILINTLSMGIEYHEQPE 671

  Fly   715 SFRNALDVGNKVFTSIFTFECIVKLMALSKDFFLCG-----WNIFDLLIVTASLLDIIFELVDGL 774
            ...|.|::.|.||||:|..|.:.||:|    |.:.|     :||||.:||..|:.:||.....||
Zfish   672 ELTNILEISNIVFTSMFVLEMLFKLLA----FGIFGYIRNPYNIFDGVIVVISVWEIIGHADGGL 732

  Fly   775 SVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEK 839
            ||||..||||||||.:....::..|.:::.|:..:....::|::.|:.|:::||.||...::.:.
Zfish   733 SVLRTFRLLRVLKLVRFLPALRRQLLVLMKTMDNVATFCMLLMLFIFTFSILGMHLFGCKFSLKM 797

  Fly   840 FDPDPVP-RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMV 902
            .:.|.:| |.||:....:.:.:|:||..| |...|::.|.:.....|    ..|:..:..||:::
Zfish   798 ENGDTIPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAA----LYFVALMTFGNYVL 858

  Fly   903 LNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVL 967
            .||.:|:|:..|.:|...:|.:  |:|.|.:.:.|                      ||.:|:
Zfish   859 FNLLVAILVEGFQAEGDANKSD--GDEEKTSVNSE----------------------EKMEQL-- 897

  Fly   968 DAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVD 1032
                        |::..|...|     .:.||:.|..  |.|..|
Zfish   898 ------------QSSEPLSISD-----PDLKFYSLML--SANGHV-------------------- 923

  Fly  1033 GLEYDDTGDLPEQIQLQ--AHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
                |..|.||..|.::  |.|:|....|:.|  ||....|.....|:|:
Zfish   924 ----DPCGTLPPPIIMRTAATPMPTPKSSLGP--ESVFDLTESRRGSAVS--------------- 967

  Fly  1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
                                                  .||.|.||:| ..|..|.......|..
Zfish   968 --------------------------------------IDPNAFDQKS-LSSPRRSPCHPRGSGS 993

  Fly  1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSI 1225
            .:||.       :...:.|.|:||.:                         |:.:||
Zfish   994 NWGSR-------RSSWNSLGRAPSLK-------------------------RKDTSG-------- 1018

  Fly  1226 EQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMV 1290
            |::.|||.:|                         :|
Zfish  1019 ERESLLSGEG-------------------------RG---------------------------- 1030

  Fly  1291 EHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADE 1355
                      |||.:..|.:        ||:|:|..|          ::|.:
Zfish  1031 ----------SFEDDDIEAE--------KLTNISGGS----------LQHPS------------- 1054

  Fly  1356 VVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAP 1420
                     |.|:..:|:..:.:....:.|.:
Zfish  1055 ---------SLDIPELPQMGEYLDCNGRSQHI--------------------------------- 1077

  Fly  1421 FVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIES 1485
                    :|..|||                             :.:.:.:.||:
Zfish  1078 --------LADLSAS-----------------------------LNKEDSIAEED---------- 1095

  Fly  1486 EKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQI 1550
                                                                             
Zfish  1096 ----------------------------------------------------------------- 1095

  Fly  1551 SSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQ 1615
                                                                     ||.:..|:
Zfish  1096 ---------------------------------------------------------LDDSFCFR 1103

  Fly  1616 SARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGG 1680
            ..||                                                 |.:|.
Zfish  1104 LRRT-------------------------------------------------LAAYK------- 1112

  Fly  1681 RRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDH----FYFRCP---WFMSCMDTQSAKHWT 1738
                                          |:.|.||    .|...|   :.|.|....|.|
Zfish  1113 ------------------------------PKWCKDHEEWSLYLFSPHNKFRMMCQKLISHK--- 1144

  Fly  1739 RVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILK 1803
                         .|::.|||.||.:.||:..|..::.:::.|  .|...|:.|.:|||.||.:|
Zfish  1145 -------------MFDYVVLVFIFLNCITIALERPHIQQSERL--FLLVSNYVFTVIFVAEMTVK 1194

  Fly  1804 WLALGF----SKYFTSFWTILDFIIVFVSVFSLLIE----ENENLKVLRSLRTLRALRPLRAISR 1860
            .:||||    ..|..|.|.:||.::||||:..:|:.    .|....:||.||.||.|||||.|||
Zfish  1195 VVALGFYSGNQSYLKSTWNVLDGVLVFVSLIDILVSLAWTGNRIFGILRVLRLLRTLRPLRVISR 1259

  Fly  1861 WQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWD 1925
            ..|:::||..|:.::..|.|::|:|..|:::|.|:|||.|.||||.|  |.|:...||   :|.|
Zfish  1260 APGLKLVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKFFHC--EGGDTRNIT---NKSD 1319

  Fly  1926 CIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
            |::.|..||..|..||::|...::|..::..:||:.:|.|.:||.|||.||:|..|.:..:||:.
Zfish  1320 CLQANLKWIRRKYNFDNLGQALMSLFVLSCKDGWVNIMYDGLDAVGVDQQPERNHNPWMLLYFIS 1384

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKP---QKVIKR 2052
            |::..|||.||:|:||:::||:..::..|.....:...:.||    .|:|..|.|.   .:.::|
Zfish  1385 FLLIVSFFVLNMFVGVVVENFHKCRQDQEEVEARLLELKRQK----LMEKKRRSKENCGSEALRR 1445

  Fly  2053 P----------------INHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILE 2101
            |                .||:|.:|            |..:|.:|::||.|||::||..:...|:
Zfish  1446 PYYADYSPARLYIHTLCTNHYLDLF------------ITGIICINVVTMSIEHFNQPSYLDEALK 1498

  Fly  2102 VSNAFFTTVFGLEAIVKIV--GLRYHYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLL 2162
            ..|..||.:|.:||::|:|  |:| .:|...||..|..:||.||.||.:|:|.::  |||:||::
Zfish  1499 YCNYVFTIIFIIEALLKLVAFGIR-RFFKDRWNQLDLAIVLLSIMGITLEEIKMNAALPINPTII 1562

  Fly  2163 RVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFG------N 2221
            |::||.||.|:|:|:|.|.|:|.||..::.:||.:.|:|.|..|:.||||.||:.|||      |
Zfish  1563 RIMRVLRIARVLKLLKMATGMRSLLDTVMQALPQVGNLGLLFMLLFFIYAALGVELFGKLECTEN 1627

  Fly  2222 VKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWN----DVLESLMIQPPDCDPFIHGHTNGNCGHP 2282
            ...:| |.....|:.||.:...|||:.|...||    |.|...:.....|..::          |
Zfish  1628 NPCEG-LSPHATFENFGMAFLTLFRVSTGDNWNGIMKDTLRECLPSETQCLSYL----------P 1681

  Fly  2283 LLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEE----------EIGIVEDDLEMFYI---- 2333
            .::..||.:|::::..:::|:.:|:::::..::::|.          ::.|:::...:..|
Zfish  1682 WVSPIYFVTFVLMAQFVLVNVVVAVLMKHLEESNKEAKEDAEMDAAIKLAILKETRRLSTISASA 1746

  Fly  2334 ------RWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCL---- 2388
                  |.:..:||..             |.:...|:.:.....|....:.:|   ::|.|
Zfish  1747 TAGPEGRATYIEPHPD-------------SPEQDEGMQRTQGNLLSPRKMSVS---RMHSLPNDS 1795

  Fly  2389 ----DILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQ 2449
                .:..|...:.|..||...::                    ||:.|.|.:..:..::...:|
Zfish  1796 YMFRPVRPASAPYPLEEVETCQDY--------------------LELGSITSVHSQPCESLSLLQ 1840

  Fly  2450 -----------------------TGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFH 2491
                                   |...:.:.|::...:::|.|.....|.....:.|......|.
Zfish  1841 VPGVPPHSQFNCLPKIPPPMPSPTHSIDRILRRQRAIKNDSIDMHNFDSKENVERQKGITTGSFK 1905

  Fly  2492 LQVSR-------------RGTACSS--------RASSRKSSRASDASDLSELAGPWLNLPLMLVS 2535
            |.|.:             ||.:..:        ..|||..|.||.:...|....        :..
Zfish  1906 LHVPQITGISQGSPLLPPRGPSVHTFQQPHSQHNISSRPPSLASSSRSTSPSGS--------MFD 1962

  Fly  2536 GADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTT 2600
            .||...::::..|                |..|.:...   |.:|...|| ||
Zfish  1963 SADPTDEEVRHIN----------------STARLWIGV---HAEARSHSL-SP------------ 1995

  Fly  2601 NTTSNSASTSGTASSTATAPATGCGPAAT---------------------SASDSDRHQAV---G 2641
                  .|||||   ....|...|..||.                     .|||..|..::   .
Zfish  1996 ------YSTSGT---LLPIPVKNCSSAANLTIKDPKKCFSVDTEGFLERPYASDDHRRHSIEICS 2051

  Fly  2642 GGS-------------APSRKRASSFIRK----------KPPLERGLS-AQSALRVNKNAFVSEA 2682
            .|.             .|:|.::....||          :||.|:.:| :.::::...::.:...
Zfish  2052 SGDDGLFGQELCEKRHVPTRGKSLHIPRKTKMSPPCISIEPPFEKDVSPSHASMKKLSDSMLLRR 2116

  Fly  2683 SAP--EVIVTRPS---PEQQTHPHSLSLRPDNATLVHVLVH-RESEEYKEEDESSPSVSGNGNGF 2741
            ..|  ::.:.|.|   ||.|     ||.:|    |:.|..| ....||......:| :||.
Zfish  2117 RTPSYDLALQRDSLDLPENQ-----LSTQP----LIKVERHPSHCAEYLSLPHPAP-MSGL---- 2167

  Fly  2742 GVGLDMLSKQPPP 2754
             .|:...|.||||
Zfish  2168 -AGVLCESTQPPP 2179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	73/277 (26%)
		Ion_trans	705..902	CDD:278921	65/203 (32%)
		Ion_trans	1768..2019	CDD:278921	101/258 (39%)
		Na_channel_gate	2009..2063	CDD:240441	15/72 (21%)
		Ion_trans	2085..2320	CDD:278921	85/258 (33%)
		GPHH	2331..2386	CDD:293510	8/64 (13%)
cacna1ha	XP_021330381.1	Ion_trans	1..323	CDD:306908	92/336 (27%)
		Ion_trans	644..871	CDD:306908	74/234 (32%)
		Ion_trans	1143..1413	CDD:306908	110/292 (38%)
		Ion_trans	1464..1695	CDD:306908	90/254 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810