DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1fb

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_021333942.1 Gene:cacna1fb / 559964 ZFINID:ZDB-GENE-031104-1 Length:2068 Species:Danio rerio


Alignment Length:2948 Identity:585/2948 - (19%)
Similarity:946/2948 - (32%) Gaps:1288/2948 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 NYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFL------------AMTE 147
            |.:.|  ..::|:.....:|.||..:::...:.||..::..|..||:.|            |...
Zfish    86 NQVQR--APRALYCLKLNNPIRRAALHLVEWKPFDIFILLAIFANCVALGVSKPFPEDDSNATNH 148

  Fly   148 TVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV-------- 204
            .:|:.||:||.|::||..:||:|.|.:::..:|:||.||.||||::..|..::.:|.        
Zfish   149 DLEQVEYVFLIIFTIETFLKILAYGLVMHPSSYIRNGWNLLDFVIVIVGLFSVVLETVTHKSGET 213

  Fly   205 --------GNL--AGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALF 259
                    |.|  ..||.|||||.|:.||.:|.|:.::|:::.:...|..:..|.:|.::::|:.
Zfish   214 TSHTPGKPGGLDVKALRAFRVLRPLRLVSGVPSLQIVLNSIMKAMVPLLHISLLVLFVIIIYAII 278

  Fly   260 ALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYV- 323
            .|::::|.:...|                  :...|||:. |:|.||  |......|.|   || 
Zfish   279 GLELFIGRMHRTC------------------FFIGTDNYA-DDDPLP--CAFAGHGRQC---YVN 319

  Fly   324 ---CLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGS 384
               |....|.||.|.||||||.::|||.||.||::.|.:| |.|..|....:...:|..:|.|||
Zfish   320 GSECRGKWEGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIGFELPWVYFVSLVIFGS 384

  Fly   385 FYLINLMLAVVALSYEEEAEIT-----------NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKN 438
            |:::||:|.|::..:.:|.|..           .::.::||..:.|..|.:.|     :.:.:: 
Zfish   385 FFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLCGYMDWITQAED-----IDEFDE- 443

  Fly   439 NKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATE 503
                 |..:.|.|...:.||.       ||.|..:        ..|::|::.|:           
Zfish   444 -----DGNRRVTLRDLADKKR-------GKFGWFS--------HSNETHASLPA----------- 477

  Fly   504 RPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQ 568
                                                                             
Zfish   478 ----------------------------------------------------------------- 477

  Fly   569 LIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIAR 633
                |...|.|:..:             |.|..|.                       |....||
Zfish   478 ----SETASENTENI-------------DEEHTDC-----------------------CAACCAR 502

  Fly   634 I-KNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLC 697
            | |.....||                |..:||:.           :|| ...|:...|...:.:.
Zfish   503 IMKIPCCRAL----------------RRWNRCIR-----------RNC-RTAVKSVTFYWLVLIL 539

  Fly   698 IVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTA 761
            :.||||..|.||:...|...:..|:.|||..|:||.|.::|:.:|. :.:|:..:|.||..:|..
Zfish   540 VFLNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEMLLKMYSLGLQVYFVAFFNRFDCFVVCG 604

  Fly   762 SLLDIIFELVD-------GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIV 819
            .:|:.:  ||:       |:||||.:||||:.|:.:.||.:..|::.:::::.::.:|.|:|.:.
Zfish   605 GILETV--LVEMEIMPPLGISVLRCVRLLRIFKVTRHWTALSNLVASLLNSMKSIASLLLLLFLF 667

  Fly   820 IYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EE 880
            :.|||::|||||...:   .||.....|..|:.|..:.:..|:||.|| |...::|.:.|   ..
Zfish   668 LIIFALLGMQLFGGKF---NFDETQTKRSTFDSFPQALLTCFQILTGEDWNVVMYDGIMAYGGPV 729

  Fly   881 EQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRK 945
            ..|...|. .|:...:.||:::||:|||:                                    
Zfish   730 FPGMIVCL-YFVILFICGNYILLNVFLAI------------------------------------ 757

  Fly   946 KRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNR 1010
                                                                             
Zfish   758 ----------------------------------------------------------------- 757

  Fly  1011 PVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGS 1075
                               .||.|                                     .|| 
Zfish   758 -------------------AVDNL-------------------------------------AGG- 765

  Fly  1076 FSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYAND 1140
                                                                     |.|...|:
Zfish   766 ---------------------------------------------------------DGDNKKNE 773

  Fly  1141 QRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLK 1205
            ::                                                              |
Zfish   774 EK--------------------------------------------------------------K 776

  Fly  1206 SEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISN 1270
            ..|||.....:|:    :.::.||                       ..||||            
Zfish   777 EGEAEPAEEENGE----VKVDMDE-----------------------EYEEEE------------ 802

  Fly  1271 VMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATK 1335
                                                                  ||....||..|
Zfish   803 ------------------------------------------------------EPEEGDDEEGK 813

  Fly  1336 AIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKI 1400
                   |....::.:...|.:||:                                        
Zfish   814 -------IQLNVADFAPPKEKILPI---------------------------------------- 831

  Fly  1401 DEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLI 1465
                                                  |..|.|                     
Zfish   832 --------------------------------------PEGSAF--------------------- 837

  Fly  1466 ERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAV 1530
                                                  ..|..||                    
Zfish   838 --------------------------------------FCLSKTN-------------------- 844

  Fly  1531 PATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMA 1595
                                                             |.....|:..|.|   
Zfish   845 -------------------------------------------------PIRVGCHTLIHHH--- 857

  Fly  1596 GQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTR 1660
                                                                         .||.
Zfish   858 -------------------------------------------------------------IFTN 861

  Fly  1661 LTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWF 1725
            |                                                                
Zfish   862 L---------------------------------------------------------------- 862

  Fly  1726 MSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINF 1790
                                           :||.|..|||:|..|| .:..:.....||.:.::
Zfish   863 -------------------------------ILVFIILSSISLAAED-PIRAHSFRNNVLGYADY 895

  Fly  1791 SFCLIFVVEMILKWLALGFSKYFTSF---W-TILDFIIVFVSVFSLLIEENENLKVLRSLRTLRA 1851
            :|..||.||::||....|...:..||   | .:||.::|.||:.|..:..:. :.|::.||.||.
Zfish   896 AFTSIFTVEILLKMTVHGAFLHEGSFCRNWFNLLDLLVVSVSLVSFFLHSSA-ISVVKILRVLRV 959

  Fly  1852 LRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNE------ 1910
            |||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||::|.:|      
Zfish   960 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKNTPE 1024

  Fly  1911 --MGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVD 1973
              .|..: :.:..|....:.:...|:||...||:|.||.:||..|:|||||..::..|:||.|.:
Zfish  1025 QCKGTFV-VYKDGDVSHPMVRERIWLNSDFNFDNVLMGMMALFTVSTFEGWPALLYKAIDANGEN 1088

  Fly  1974 LQPQREANLYAY-----IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH 2033
            ..|     :|.|     |:|:::|:..:||.:|:|:|.:|..|.      |.|..|....|..|:
Zfish  1089 HGP-----IYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITFR------EQGEAEFKNCELDKN 1142

  Fly  2034 YYTAMKKLGRKKPQK--VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAV 2096
            ....::...:.:|.|  :.|.|:.:   .|:.:.||..||..:||||.||.:|:.::||||....
Zfish  1143 QRQCVEYALKAQPLKLYIPKNPVQY---KFWSIINSTGFEYVMFVLILLNTVTLAVQHYDQSKFF 1204

  Fly  2097 FFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPT 2160
            ..::::.|..||.:|.:|.|:|::.||. |||...||.||.|:|:.|:..|::.:.......|..
Zfish  1205 SQVMDILNMVFTGLFTVEMIIKLMALRLRHYFVDAWNSFDALIVVGSVVDIVVTEFSSSEDSSRV 1269

  Fly  2161 LLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ 2225
            .:...|:||:.|:::|:...:|||.||:..|.||.||..:..|:.:|.||||::||..||.:.:|
Zfish  1270 SITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFFIYAVIGMQTFGKIAMQ 1334

  Fly  2226 G--ALDDMVNFQTFGRSMQLLFRLMTSAGWNDV-LESLMIQPPDCDPFIHGHTNGNCGHPLLAIT 2287
            .  .::...|||||.:::.||||..|...|.:: |.||..:..|.:.........:||.. :||.
Zfish  1335 DHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGKRCDAESDFEPGEEFSCGSN-IAIV 1398

  Fly  2288 YFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLS 2352
            ||.||.::...::||:::|:|::||:...::..| :....|:.|...||:|||.|...|....:.
Zfish  1399 YFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWSEYDPEAKGRIKHLDVV 1462

  Fly  2353 DFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQ 2412
            ..:..:.||||..|  |:.||   ||:.|:|::....:.....|.|||:..| .::...|..|..
Zfish  1463 ALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNADGTVTFNATLFALVRTAL-KIKTDGNPDQEN 1526

  Fly  2413 EQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGWKEYL 2456
            |::.:..||               ||||.:.                     |...||..::::.
Zfish  1527 EELRIIIKK---------------IWKRTKPKVLDEVIPPPAEEEVTVGKFYATFLIQDYFRKFR 1576

  Fly  2457 RRKRE---KERSNSGDSATQTSSPG-------GWQSKLSALNFFHLQVSRRG------------- 2498
            :||.:   :|..|...:|.|....|       |.:.:| |:| ..|:....|             
Zfish  1577 KRKEKVGLEEEGNGNPTALQLCQAGLRTLQELGPEMRL-AMN-EDLEEEEEGLDEEQEEDDAHYK 1639

  Fly  2499 -------TACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGS 2556
                   |...||  ||:||.|:     :.:..|   :|   |.| |.::      |..||:|.|
Zfish  1640 NENGYAHTEPLSR--SRRSSLAT-----TPIGAP---VP---VPG-DGIL------NGGLGRRSS 1684

  Fly  2557 IFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPA 2621
            : .:.|..:......||..|      ||:.| |:|.:              ..:|........|:
Zfish  1685 L-AKTPNGNGALENENFRRR------DSMRS-SIHYQ--------------HKNGVIDQLPKRPS 1727

  Fly  2622 TGCGPAATS----ASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEA 2682
            ....|...|    :|...|.:.  ||..|..:|                           |..:.
Zfish  1728 YYKYPRRDSRDRFSSPLSRREE--GGEYPGEQR---------------------------FYGKD 1763

  Fly  2683 SAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGN--GNGFGVGL 2745
            ...|.:::|     :.|.:     |:::|:..  .||:.  |.......| |.||  ||.:|.|.
Zfish  1764 EDSESVISR-----ERHGY-----PEDSTIFQ--GHRDM--YDGHSMRHP-VYGNHYGNSYGDGR 1813

  Fly  2746 DMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDT 2810
            ....::..|                |.||                        |.....|:|   
Zfish  1814 RTARRRLLP----------------ATPT------------------------GRKASFNIQ--- 1835

  Fly  2811 SQVFYDYNPEKATDDQGNGQDETAQFESLP----DRQRXPPVNTPLRDSEKRSSRGSRSSSSSTS 2871
                       ....||:..|       ||    ..|..||            .|......||..
Zfish  1836 -----------CLRRQGSSDD-------LPIPGTYHQNSPP------------CRARSQGYSSYD 1870

  Fly  2872 SIRSCSSSSSSSAASAAAPSARR 2894
            |.||.:.||:.|.||.|....||
Zfish  1871 SRRSSARSSTGSTASWANTGPRR 1893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 79/241 (33%)
Ion_trans 705..902 CDD:278921 64/208 (31%)
Ion_trans 1768..2019 CDD:278921 88/267 (33%)
Na_channel_gate 2009..2063 CDD:240441 11/55 (20%)
Ion_trans 2085..2320 CDD:278921 80/238 (34%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
cacna1fbXP_021333942.1 Ion_trans 114..407 CDD:306908 99/316 (31%)
Ion_trans 532..763 CDD:306908 77/393 (20%)
Ion_trans 856..1093 CDD:306908 86/403 (21%)
Ion_trans 1178..1431 CDD:306908 89/253 (35%)
GPHH 1432..1502 CDD:318993 22/70 (31%)
Ca_chan_IQ 1504..1575 CDD:312334 17/86 (20%)
CAC1F_C 1601..2067 CDD:318975 90/454 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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