DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and scn1lab

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001038360.2 Gene:scn1lab / 559447 ZFINID:ZDB-GENE-060906-1 Length:1996 Species:Danio rerio


Alignment Length:2674 Identity:835/2674 - (31%)
Similarity:1212/2674 - (45%) Gaps:824/2674 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DDQATFNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEH 67
            |....|..|...|..|.:|.....:.|.|.|... ..|.|  |:....:|.|..||..:...|.|
Zfish    12 DSFRPFLPESLAAIEQRIAEEVAQRPKGERRPDD-DDENG--PKPNRDLEAGKPLPFIYGDVPPH 73

  Fly    68 MYGKPLEEIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYC 131
            |...|||::||:. .::||.|::   |...|.||..|.:|::..|::|.||:.:.:..:..|.:.
Zfish    74 MLSVPLEDLDTYYSNQKTFIVLN---RGKAIFRFNATPALYILSPFNPLRRISIRVLVHSLFSFV 135

  Fly   132 VMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVI 193
            :|.|||.||.|:.::   |..:..||.|..||:.|.:|||:|:||.:.|:|:||:|||||||.||
Zfish   136 IMCTILTNCAFMTLSNPPEWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFSVI 200

  Fly   194 TSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFAL 258
            ...|.|..:.:||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||
Zfish   201 LMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 265

  Fly   259 FALQVYMGELRNKCVRQVP--------TDWTNVSHT---DWQIWVNDTDNWLYDEDELP-----V 307
            ..||::||.||.|||: :|        ||::...|.   :|..:::|::|:.:    :|     :
Zfish   266 IGLQLFMGNLRQKCVK-MPEVNVTDNLTDYSTELHNSTFNWTEYISDSNNYYF----IPGRRDAL 325

  Fly   308 LCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMS 372
            ||||.:.|..||..:.|:..|.||::|||:||.|.|:.|:.|:|:|.|:|||:|...|...|...
Zfish   326 LCGNSSDAGQCPEGFTCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLYQQTLRAAGKPY 390

  Fly   373 VSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNK 437
            :.||.:|:|.|||||:||:|||||::|:|:.:.|.||.:      :.:..|.        ..|.:
Zfish   391 MIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQ------QKEEEFQ--------AMLEQ 441

  Fly   438 NNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSAT 502
            ..:::.:::.....|           |:.|:..|..|....|:...::..|          .||.
Zfish   442 LKRQQEEAQVAAAAA-----------TESGEYSGRGGLSEESSSGGSRLSS----------KSAK 485

  Fly   503 ERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVK----NPNMLYPS 563
            ||.:....:.|::.::...|.|..||.|..|    ...|..|.|...:.:..:    .||....|
Zfish   486 ERRNRRKKRKQREEEEKADQEKFHKSASEDS----IRRPGFRFSIDANRLSYEKKCSTPNQSLLS 546

  Fly   564 DYKGQLIANSGQPSSNS-------SGVNRESSQDDSGVVDDH---EEQDT--------------T 604
             .:|.|.:    |..||       .|..|:...::....|:|   |:.|:              :
Zfish   547 -IRGSLFS----PRRNSRASLFSFRGRARDFGSENDFADDEHSTFEDSDSRRGSLFVPRCVERRS 606

  Fly   605 NDMGHVS-TVELALSPREVRL---IKCNGNIARIKNHNV-----------------------YAL 642
            :.:.|.| |....:.|...::   :.|||.::.:...:|                       ...
Zfish   607 STVSHCSLTAPRIMLPANGKMHCTVDCNGVVSLVGGTSVPTSPIGRLLPEGTTTESDVRKKRSGS 671

  Fly   643 HQ--EFSSEVV--------------VIDDLPD--RNCDRCVH--------W-CTDYESWLQFQNC 680
            ||  ::..|.|              .:::|.:  :.|..|.:        | |:  .:||:.:..
Zfish   672 HQPSDYLEETVARKRAMSVASILTNTMEELEESRQKCPPCWYKFANSFLIWDCS--PAWLKVKEI 734

  Fly   681 LYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK- 744
            :..:|.||..:||||:||||||.|:||||:.|:..|.:.|.|||.|||.|||.|..:|::||.. 
Zfish   735 MNMIVMDPFVDLAITICIVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTGIFTAEMCLKVIALDPY 799

  Fly   745 DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGAL 809
            .:|..||||||.:||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.:::|||
Zfish   800 YYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 864

  Fly   810 GNLTLILVIVIYIFAVIGMQLFSKDYTP---EKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEP 871
            |||||:|.|:::||||:|||||.|.|..   :..:...:|||:.:||||||:::||:|||||||.
Zfish   865 GNLTLVLAIIVFIFAVVGMQLFGKSYRECVCKISESCELPRWHMDDFFHSFLIVFRVLCGEWIET 929

  Fly   872 LWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSI 936
            :||||   |..|.|.|..:|:..:|:||.:||||||||||:||:::.|.                
Zfish   930 MWDCM---EVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLA---------------- 975

  Fly   937 ERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHR 1001
                                                                             
Zfish   976 ----------------------------------------------------------------- 975

  Fly  1002 LSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYES 1066
                                                                             
Zfish   976 ----------------------------------------------------------------- 975

  Fly  1067 AMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNS 1131
                                                                            :
Zfish   976 ----------------------------------------------------------------A 976

  Fly  1132 TDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSS 1196
            ||.|...|:.:...|...:|.:|..::.|::    ....||...|   .||....|.||.|    
Zfish   977 TDDDSEMNNLQIAVGRIQKGIALVKSTLRQF----LQSLFLAGSK---PRSLDEEKPLDDL---- 1030

  Fly  1197 GQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQK 1261
                             ||.|:.                       ||                 
Zfish  1031 -----------------HSDGKE-----------------------NC----------------- 1038

  Fly  1262 GTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEP 1326
                                                                         ||..
Zfish  1039 -------------------------------------------------------------LSNH 1042

  Fly  1327 SPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKR 1391
            :|.|.:.||..::              :..|.|.|..:|:                         
Zfish  1043 APVAVDLTKDYLK--------------EGCVSPGNGVESH------------------------- 1068

  Fly  1392 RSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQF 1456
                                                                          |::
Zfish  1069 --------------------------------------------------------------VKY 1071

  Fly  1457 DRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQK 1521
            .       ||                 |.:.|  .|:|.|                         
Zfish  1072 G-------IE-----------------EGDYM--SFIHNP------------------------- 1085

  Fly  1522 LGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAH 1586
                                          ||..|.|:|                          
Zfish  1086 ------------------------------SLTVTVPIA-------------------------- 1094

  Fly  1587 SQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDA 1651
                    .|:              :.|::..||..||.::|            .|.|:...|..
Zfish  1095 --------VGE--------------SDFENLNTEDFSSESSD------------VEGSKEKLPVD 1125

  Fly  1652 TQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN---DPMTFPSYGATKAAKVPDDCFPQK 1713
            |                ::|..:..||..|...:||.:   :|         :.:..|:.||.:.
Zfish  1126 T----------------VLSSSEGSTVDIRPPGEGAESVELEP---------EESLDPEACFTEG 1165

  Fly  1714 CYDHFYFRCPWFMSC-MDTQSA--KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINL 1775
            |.  ..|:|     | :|.:..  |.|..:|.....:|:...||.|::.:|..||..|.||||.:
Zfish  1166 CV--MRFQC-----CQVDVEKGKWKSWWILRKTCFIIVEHNWFESFIIFMILLSSGALAFEDIYI 1223

  Fly  1776 DKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NE 1838
            ::.||:|.||.:.:..|..||::||:|||:|.||:||||:.|..|||:||.||:.||:...  ..
Zfish  1224 EQRKTIKTVLEYADKVFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVANALGYS 1288

  Fly  1839 NLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGK 1903
            .|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||..|.||
Zfish  1289 ELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1353

  Fly  1904 FFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WINSKITFDHVGMGYLALLQVATFEGWMEV 1962
            ::.||| ...||.|::.||:|.||   |:.|.|  |.|.||.||:||.|||||||||||:|||::
Zfish  1354 YYYCVNITNDELFPVSVVNNKSDCYALIQNNDTARWKNVKINFDNVGAGYLALLQVATFKGWMDI 1418

  Fly  1963 MADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFL 2027
            |..|||:|.::.||..|.|||.|:||||||:.||||||||||||||||||..|||..|  .::|:
Zfish  1419 MYAAVDSRDLEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFM 1481

  Fly  2028 TESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ 2092
            ||.||.||.||||||.|||||.|.||.|.|..:.:||...:.|:|.|.:||.|||:||.:|..||
Zfish  1482 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDIIIMILICLNMVTMMVETDDQ 1546

  Fly  2093 PHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPI 2157
            ...:..||...|..|..:|..|.::|::.||:::||:.||||||::|:.||.|:.:.:::....:
Zfish  1547 TEDMDNILYWINLVFIILFTGECVLKMISLRHYFFTIGWNVFDFVVVILSIVGMFLSEMIEKYFV 1611

  Fly  2158 SPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV 2222
            ||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.|||.|..|
Zfish  1612 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1676

  Fly  2223 KLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDPFIH---GHTNGNCGHPL 2283
            |.:..:|||.||:|||.||..||::.|||||:.:|..:: .|.||||..:.   ....||||:|.
Zfish  1677 KREAGIDDMFNFETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDCDSEMEHPGSFYRGNCGNPS 1741

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            :.|.:|.|:|||.::||:|||||:|||||:.|.:|....:.|||.||||..|.::||:||||:.:
Zfish  1742 VGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPNATQFVEY 1806

  Fly  2349 SQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQE 2413
            ::||||..:|||||.|:|||.:.|::.:||:..|::|||||||.|....|||...|.|   .|:.
Zfish  1807 NKLSDFADALDPPLRIAKPNKIQLIAMDLPMVSGDRIHCLDILFAFTLRVLGEEGEMD---ALRG 1868

  Fly  2414 QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPG 2478
            ||:.:|....|::...|.:::|...|::|.:|..||..::.:..|:..|:.|.:  ...|....|
Zfish  1869 QMEDRFMASNPSKVSYEPITTTLRRKQEEMSAVVIQRAFRRHRIRQTVKKASEA--YRKQLQDGG 1931

  Fly  2479 GWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDL--SELAGPWLNLPLMLVSGADEVV 2541
            |...:...|.....|                .:.|||.:|:  |..:.|..|  .:..|..|:..
Zfish  1932 GHIPEKEVLVIGKFQ----------------ENSASDKTDMTPSSASPPSYN--SVAKSEKDKYE 1978

  Fly  2542 KDIKQQNDE 2550
            |:.:::.|:
Zfish  1979 KERREKEDK 1987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 109/234 (47%)
Ion_trans 705..902 CDD:278921 103/200 (52%)
Ion_trans 1768..2019 CDD:278921 159/258 (62%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 123/238 (52%)
GPHH 2331..2386 CDD:293510 26/54 (48%)
scn1labNP_001038360.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.720

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