DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1ba

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_021331853.2 Gene:cacna1ba / 555941 ZFINID:ZDB-GENE-060531-44 Length:2365 Species:Danio rerio


Alignment Length:3044 Identity:643/3044 - (21%)
Similarity:1094/3044 - (35%) Gaps:1028/3044 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            :|::|   :::|.|...|:.        .|..:|||:|...:..|:....|.....|:|.::|||
Zfish    39 VYKQT---MAQRARTMAIYNPIPVKQNCLTVNRSLFIFSEDNIIRKYAKKITEWPPFEYMILATI 100

  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189
            :.|||.|.            |::.:::.|..|:.|:..|..|||||.||..:|.:||||.||.:|
Zfish   101 IANCIVLGLEQHLPALDKTPMSKRLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMD 165

  Fly   190 FVVITSGYATIGMEVG---NLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIF 251
            |||:.:|..||   ||   :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|
Zfish   166 FVVVLTGILTI---VGPDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFF 227

  Fly   252 CLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGAR 316
            .:::||:..|..|||:....|.|   ||      |..|:            ||.|  ||..:.|.
Zfish   228 AILMFAIIGLDFYMGKFHRTCFR---TD------TGEQV------------DEFP--CGLESPAW 269

  Fly   317 HCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVV 380
            .|.....|......||.|.|||||.::::||.||.||::.|.:: ||...|:....:..:|..::
Zfish   270 TCENGTECREYWIGPNFGITNFDNILFAVLTVFQCITMEGWVDILYNANDASGNTWNWLYFIPLI 334

  Fly   381 FFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDS 445
            ..|||:::||:|.|::..:.:|.|  ..|::::.|..|...         .:::......:.|..
Zfish   335 IIGSFFMLNLVLGVLSGEFAKERE--RVEKRQEFLKLRRQQ---------QIERELTGYLEWICK 388

  Fly   446 RKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTM 510
            .:.|:||...|                    |..:.||                        :..
Zfish   389 AEEVMLAEEDK--------------------NAEDKDD------------------------VAW 409

  Fly   511 QAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQ 575
            ..:|                  .||                          |..:...|.|:.|.
Zfish   410 YKRK------------------CNN--------------------------PGGFTRSLGADFGL 430

  Fly   576 PSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVY 640
            |      |.:.:.:..:.:::..|.:|...|:..|       :|:.....:.:...::|::.:.:
Zfish   431 P------VLKRAKKSKNDLINAEEGEDHFTDISSV-------APQGSPFTRTSVKSSKIESLSYF 482

  Fly   641 ALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIV-LNTAF 704
            ...::                              :|:..:.::|:...|...: |||| |||..
Zfish   483 RRKEK------------------------------RFRFFIRRMVKAQSFYWTV-LCIVGLNTLC 516

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768
            :|:.|:...|....||.:...||..:|..|..:|:..|. :.:|...:|.||..::..|:.::|:
Zfish   517 VAIVHYDQPEWLTYALYLAEFVFLGLFLIEMSLKMYGLGPRTYFHSSFNCFDFGVIVGSIFEVIW 581

  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828
            ..|.     |:||||.|||||:.|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::||
Zfish   582 AAVKPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 646

  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQG----ASTCF 888
            |||...:..|    |..|..||:.|..:.:.:|:||.|| |...::   ...|.||    ...|.
Zfish   647 QLFGGQFNFE----DETPTTNFDTFPAAILTVFQILTGEDWNAVMY---HGIESQGGVHRGMFCS 704

  Fly   889 AIFLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKK--RQER 950
            ..|:...:.||:.:||:|||:.: |..|::|| :|.||..||:            |.||  .|:.
Zfish   705 VYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL-TKDEEEQEEA------------ISKKLALQKA 756

  Fly   951 KDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLA-------------------- 995
            |:.||             .....|..:|..|.:    ...||.|:                    
Zfish   757 KEVKE-------------VSPMSAANISITAFI----RPNPGALSCSSSNSSSHSPKEQQRSLKM 804

  Fly   996 ---------ETKFHRLS-----YQESMNRPVSGSDFGFQIPLHDGLHTIV----------DGLEY 1036
                     :.:.|.|:     |||.:|..::.:     :||...:.|.:          ||...
Zfish   805 MSVWEQRTTQIRKHMLASSEALYQEELNPRLTSN-----LPLRTDIKTHLDRPLVVEPRCDGPIS 864

  Fly  1037 DDTG-DLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQH 1100
            .::| |.|:.:|.:.   ....:.:||.:|                                   
Zfish   865 PNSGWDKPQDLQGEG---STPEERVPPVFE----------------------------------- 891

  Fly  1101 QISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRY--- 1162
                  ..|.:..|:...:.|.:       |.:|:             ..||:......|.:   
Zfish   892 ------PPQSHPPRKHHRHRERL-------SNETN-------------ENGDTGHAKEGRHHIHH 930

  Fly  1163 -GSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIE 1226
             .|:|||....|                      .|:..||  :|.|...|.|            
Zfish   931 SRSKEHDGTRCK----------------------EGKGDRS--RSREGGRRHH------------ 959

  Fly  1227 QDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVE 1291
                                        .:..:.:|                  :|..|.|....
Zfish   960 ----------------------------HQSSVDEG------------------VGGGEREHRHH 978

  Fly  1292 HSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEV 1356
            ||...|                                                           
Zfish   979 HSHRHN----------------------------------------------------------- 984

  Fly  1357 VLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPF 1421
                            |....|.:|..    |.:|||.:|:                        
Zfish   985 ----------------REGNGVVSAGG----KSERRSRQKE------------------------ 1005

  Fly  1422 VAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESE 1486
                    .:.|.::                                               |.|
Zfish  1006 --------GSRSGTR-----------------------------------------------EGE 1015

  Fly  1487 KMPR--------KFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE 1543
            :..|        :..|.|                                               
Zfish  1016 RCSRGENGGNGGRRRHRP----------------------------------------------- 1033

  Fly  1544 PPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAH------SMA------- 1595
                      :|:...:.|...:||.:          ......||:|.|      |||       
Zfish  1034 ----------RTSKAQSTLEGEEQHVN----------GEEEGKSQSHRHMDMGGDSMAVNPHQPS 1078

  Fly  1596 -GQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFT 1659
             |.|..:|.|:.:.:|....|:....:|            :.:...:...::|........|...
Zfish  1079 VGSRWCLEKPEDSDNKRNIGQTGGMSTH------------IPVTVTSPPGETTLIPMNSIDSETV 1131

  Fly  1660 RLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPS---YGATKAAKVPDDCFPQKCYDHFYFR 1721
            .:|||       .::||       :|.:....:.|.|   :..|.         |.:...|:   
Zfish  1132 PMTEK-------NLEDL-------NQSSIRPILPFSSMFIFNPTN---------PVRRLCHY--- 1170

  Fly  1722 CPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKR 1783
                                     :|....||..:||:|..|||.|..||   .|..:|..|| 
Zfish  1171 -------------------------IVSLRYFEMCILVVIAMSSIALAAEDPVQANAPRNNVLK- 1209

  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV--FVSVFSLLIEENENLKV 1842
               ::::.|..:|..||::|.:.||.    ..||...|.|||||:|  .:..|:....:.:::..
Zfish  1210 ---YLDYVFTGVFTFEMVIKMVDLGLILHPGSYFRDLWNILDFIVVSGALVAFAFSGTKGKDIST 1271

  Fly  1843 LRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKC 1907
            ::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::.||.|.||||.|
Zfish  1272 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFYC 1336

  Fly  1908 VNE--------MGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMA 1964
            .:|        .|..|..    ||.|...|...|...:..:|:|...:|.|..|:|.|||..|:.
Zfish  1337 TDESKGLEKDCRGLFLDY----DKDDVTAQPREWKKYEFHYDNVLWAFLTLFTVSTGEGWPTVLK 1397

  Fly  1965 DAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTE 2029
            .:|||...|..|.....:...|::|::.|...||.:|:|:.:||..|   :::.:..:.|..|.:
Zfish  1398 HSVDATFEDQGPSPGYRIEMSIFYVVYFVVFPFFFVNIFVALIIITF---QEQGDKVLSECSLEK 1459

  Fly  2030 SQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYD 2091
            :::   .:....|.|.|..||..     ..|....:....|..||.:|.::|.||.:.:.::.:.
Zfish  1460 NERACIDFAINAKPLTRYMPQNQ-----QSFQYRLWKFVVSPPFEYSIMIMIALNTVVLMMKFHG 1519

  Fly  2092 QPHAVFFILEVSNAFFTTVFGLEAIVKIVGL-RYHYFTVPWNVFDFLLVLASIFGILMEDIMIDL 2155
            .|.....:|:..|..||.:|.||.|:||:.. ..:|....||||||:.||.||..||:.:|. :.
Zfish  1520 APDFYEAMLKYLNIVFTVLFSLECILKIIAFGPLNYLKDAWNVFDFVTVLGSITDILVTEIN-ER 1583

  Fly  2156 PISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFG 2220
            .::.:.|   |:||..|:::|::....||.||:..|.|..||..:..|:.::.|||||:||.:||
Zfish  1584 QLNFSFL---RLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1645

  Fly  2221 NVKLQG--ALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPL 2283
            |:.|..  |::...||:||.:::.||||..|...|:|::.|.:.: ..||| ..|.....||.. 
Zfish  1646 NIDLNDDTAINRHNNFRTFLQALMLLFRSATGEAWHDIMLSCLSE-RTCDP-SSGTLGKECGSD- 1707

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            .|..||.|||.:...:::|:::|:|::||....::..| :....|:.|...|::|||.|...|.:
Zfish  1708 FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFIRVWAEYDPAACGRIKY 1771

  Fly  2349 SQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL------GHV 2402
            ..:.:.:..:.||||:.|  |..:|   ||..|:||:..|.:|....|.||::..|      |.|
Zfish  1772 LDMYEMLLHMSPPLGLGKKCPPRIAYKRLVKMNMPIADDNSVHFTSTLMALIRTALEIKLASGMV 1836

  Fly  2403 EETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKR-QEKAAKTIQTGWK------------- 2453
                    .|...|.:.||:..|           :|.. .:|....:.|..|             
Zfish  1837 --------AQRLSDAELKKELST-----------VWPNLSQKTMDLLVTPHKPNELTVGKVYAAL 1882

  Fly  2454 ---EYLRRKREKERSNSGDSATQTSSPGGWQSKLSA-----LNFFHLQ---VSRRGTACSSRASS 2507
               :|.::.|.|..........:.:.||. |:|:||     |...|:|   |:...:|...:|.:
Zfish  1883 MIFDYYKQNRAKRLQMQQQQLKEQAGPGS-QNKVSALLEPILPLTHMQDQPVNGVDSASECQAQT 1946

  Fly  2508 RKSSRA-----SDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRR 2567
            |.||..     :...:..:.:..|          |.|..|::::.......||            
Zfish  1947 RPSSTTLNNGRTTLDNTIKGSSSW----------ASEKSKEVQKSKRRPMSRG------------ 1989

  Fly  2568 RSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASS------------TATAP 2620
                    :.:||.:.:....||..:...|:....||......|.|:|            :..:|
Zfish  1990 --------QSEDASNANTAQESVEMRKMENSANTVTSGGLEGQGRAASMPKLNAEMQRSHSRQSP 2046

  Fly  2621 ATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAP 2685
            .|...|...|               |.|:.||:|..::|.           .||.|.::.|    
Zfish  2047 GTLLEPIPDS---------------PMRRSASTFAPQRPH-----------EVNLNDYILE---- 2081

  Fly  2686 EVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSK 2750
                 :|..|:..|.|.           |...|...:..|::.....|.:|:....|...|.:.:
Zfish  2082 -----KPVQERHHHHHH-----------HHRCHHRRDRDKKQRSLDRSPTGHHKTTGTATDSVEE 2130

  Fly  2751 QPPPQIR-------ITTGSVE--------SSMDTCAMPT-VQIMVDSPKDPPRGDFSSAPIDDVG 2799
            :...:.|       .::|..:        :|.:.|:..: |.....||.:               
Zfish  2131 RAHDRGRSHERKHHSSSGEKQRYYSCDRYASREHCSSKSAVASCATSPSE--------------- 2180

  Fly  2800 APIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQF-----ESLPDRQRXPPVNTPLRDSEKRS 2859
                              ..|...:.||:|..:.:..     .|.|.|.|.....|||......:
Zfish  2181 ------------------TQEANLNKQGSGWAKGSPVLLTSGASTPSRGRRQLPQTPLTPRPSVA 2227

  Fly  2860 SRGSRSSS----SSTSSI---------RSCSSSS----SSSAASAAAPSARRTS 2896
            .|.:.||.    ::|:|:         |..|..:    |.|.:|:.||.:|..|
Zfish  2228 YRTANSSPVQLLATTTSLLPPSPGRLSRGLSEHNALLLSGSISSSPAPVSRINS 2281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 91/261 (35%)
Ion_trans 687..902 CDD:459842 68/226 (30%)
Ion_trans 1751..2019 CDD:459842 91/284 (32%)
Na_channel_gate 2009..2063 CDD:240441 9/56 (16%)
Ion_trans 2067..2320 CDD:459842 88/255 (35%)
GPHH 2332..2378 CDD:465306 16/50 (32%)
cacna1baXP_021331853.2 None

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