DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Cacna1f

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_062528.2 Gene:Cacna1f / 54652 MGIID:1859639 Length:1984 Species:Mus musculus


Alignment Length:2761 Identity:542/2761 - (19%)
Similarity:891/2761 - (32%) Gaps:1185/2761 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156
            ::||.....:|.||.|:.|...:.||..::.||..||:.|.:            ...:|:.||:|
Mouse    70 RALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVF 134

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVG---------------- 205
            |.|:::|.|:||:|.|.:|:...|:||.||.|||:::..|..::.:|.|                
Mouse   135 LVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGG 199

  Fly   206 -NLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
             ::..||.|||||.|:.||.:|.|..::|:::.:...|..:..|.:|.::::|:..|::::|.:.
Mouse   200 FDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMH 264

  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE--NPN 332
            ..|                  :...:|   .:.:|.|..|.:....|.|...:. .|.|.  .||
Mouse   265 KTC------------------YFLGSD---MEAEEDPSPCASSGSGRSCTLNHT-ECRGRWPGPN 307

  Fly   333 HGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVA 396
            .|.||||||.::|||.||.||::.|.:| |.|..|....:...:|..:|.||||:::||:|.|::
Mouse   308 GGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLS 372

  Fly   397 LSYEEEAEIT-----------NEERKKDLLDHRDDSTFS-----FDPSVLNVKKLNKNNKKKIDS 445
            ..:.:|.|..           .::.::||..:.|..|.:     .||||              |.
Mouse   373 GEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSV--------------DG 423

  Fly   446 RKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERP--SAL 508
            .    |||.:::         |:.|                                .||  |.|
Mouse   424 N----LASLAEE---------GRAG--------------------------------HRPQLSEL 443

  Fly   509 TMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANS 573
            |.:.:.:.:......:...|.|..::.|.:          |:|                      
Mouse   444 TNRRRGRLRWFSHSTRSTHSTSSHASLPAS----------DTG---------------------- 476

  Fly   574 GQPSSNSSGVNRESSQDDSGVVDDHEEQDT-------------TNDMGHVSTVELALSPREVRLI 625
                         |..|..|  |:.||:.|             |....|.......|..|..|.:
Mouse   477 -------------SMTDTPG--DEDEEEGTMASCTRCLNKIMKTRICRHFRRANRGLRARCRRAV 526

  Fly   626 KCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLF 690
            |.|.                                  | :|                       
Mouse   527 KSNA----------------------------------C-YW----------------------- 533

  Fly   691 ELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSKDFFLCG-WNIF 754
              |:.|.:.|||..:|.||||.........:..|||...:||.|.::||..|....::.. :|.|
Mouse   534 --AVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRF 596

  Fly   755 DLLIVTASLLDIIFELVD-------GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNL 812
            |..:|...:|:.  .||:       |:||||.:||||:.|:.:.|.::..|::.:::::.::.:|
Mouse   597 DCFVVCGGILET--TLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASL 659

  Fly   813 TLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCM 876
            .|:|.:.|.||:::|||||...:   .||.....|..|:.|..:.:.:|:||.|| |...::|.:
Mouse   660 LLLLFLFIIIFSLLGMQLFGGKF---NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGI 721

  Fly   877 RAEEE---QGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIER 938
            .|...   .|...| ..|:...:.||:::||:|||:.:::..|.:..:.|               
Mouse   722 MAYGGPFFPGMLVC-VYFIILFICGNYILLNVFLAIAVDNLASGDAGTAK--------------- 770

  Fly   939 VRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLS 1003
              |..|:|..|....||.|        ||              ..|.|..|..|..:|       
Mouse   771 --DKGREKSSEGNPPKENK--------VL--------------VPGGENEDAKGARSE------- 804

  Fly  1004 YQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAM 1068
                                                |..|                         
Mouse   805 ------------------------------------GAAP------------------------- 808

  Fly  1069 MATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTD 1133
                                                                             
Mouse   809 ----------------------------------------------------------------- 808

  Fly  1134 TDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQ 1198
                                         |.||.:|                             
Mouse   809 -----------------------------GMEEEEE----------------------------- 815

  Fly  1199 SQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGT 1263
                                       |::|                        :||||     
Mouse   816 ---------------------------EEEE------------------------EEEEE----- 824

  Fly  1264 KLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSP 1328
                                 |.|....|.|.          |:|:                   
Mouse   825 ---------------------EEENGAGHVEL----------LQEV------------------- 839

  Fly  1329 AADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRS 1393
                                                      ||:                    
Mouse   840 ------------------------------------------VPK-------------------- 842

  Fly  1394 LEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDR 1458
                                                                             
Mouse   843 ----------------------------------------------------------------- 842

  Fly  1459 FKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLG 1523
                   |:|..:||...                          ...|..||             
Mouse   843 -------EKVVPIPEGSA--------------------------FFCLSQTN------------- 861

  Fly  1524 MATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQ 1588
                                                                    |.....|:.
Mouse   862 --------------------------------------------------------PLRKACHTL 870

  Fly  1589 AHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQ 1653
            .|.|                                                             
Mouse   871 IHHH------------------------------------------------------------- 874

  Fly  1654 KPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHF 1718
               .||.|                                                         
Mouse   875 ---IFTSL--------------------------------------------------------- 879

  Fly  1719 YFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR 1783
                                                  :||.|..||::|..|| .:..:.....
Mouse   880 --------------------------------------ILVFIILSSVSLAAED-PIRAHSFRNH 905

  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLR 1844
            :|.:.:::|..||.||::||....|.    ..:..|::.:||.::|.||:.|..|..:. :.|::
Mouse   906 ILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSA-ISVVK 969

  Fly  1845 SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN 1909
            .||.||.|||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||:.|.:
Mouse   970 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTD 1034

  Fly  1910 EMGELL----------PITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMA 1964
            |....|          |..:|:..   :.:...|:||...||:|....:||..|:|||||..::.
Mouse  1035 EAKHTLKECKGSFLIYPDGDVSRP---LVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLY 1096

  Fly  1965 DAVDARGVDLQPQREANLYAY-----IYFVIFIVCGSFFTLNLFIGVIIDNFNML-KKKYEGGVL 2023
            .|:||...|     |..:|.|     ::|:::|:..:||.:|:|:|.:|..|... :::|:...|
Mouse  1097 KAIDANAED-----EGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCEL 1156

  Fly  2024 EMFLTESQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTM 2085
            :    ::|:   .|....:.|.|..|    |.|..:   ..:...||..||..:|:||.||.:.:
Mouse  1157 D----KNQRQCVEYALKAQPLRRYIP----KNPHQY---RVWATVNSAAFEYLMFLLILLNTVAL 1210

  Fly  2086 GIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIF----- 2144
            .::||:|.....:.:::.|..||.:|.:|.::||:..: .|||...||.||.|:|:.|:.     
Mouse  1211 AMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVT 1275

  Fly  2145 -----GILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALL 2204
                 |.|.|.......||.|..   |:||:.|:::|:...:|||.||:..:.|..||..:..|:
Mouse  1276 EVNNGGHLGESSEDSSRISITFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLI 1337

  Fly  2205 GLITFIYAILGMSLFGNVKLQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD- 2266
            .:|.||||::||.:||.|.||..  ::...|||||.:::.||||..|...|.:::  |...|.: 
Mouse  1338 AMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM--LASLPGNR 1400

  Fly  2267 CDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDL 2328
            |||   |..|. ...||.. .||.||.||.::...::||:::|:|::||:...::..| :....|
Mouse  1401 CDPESDFGPGE-EFTCGSS-FAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHL 1462

  Fly  2329 EMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCL 2388
            :.|...||:|||.|...|....:...:..:.||||..|  |:.||   ||:.|:|::....:...
Mouse  1463 DEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFN 1527

  Fly  2389 DILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------- 2443
            ..|.|||:..| .::...|..|..:::.:..||               ||||.::          
Mouse  1528 ATLFALVRTSL-KIKTEGNLDQANQELRMVIKK---------------IWKRIKQKLLDEVIPPP 1576

  Fly  2444 -----------AAKTIQTGWKEYLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSR 2496
                       |...||    :|.|: :|.||:...|..| .||:....|:.|.:|.....::.:
Mouse  1577 DEEEVTVGKFYATFLIQ----DYFRKFRRRKEKGLLGREA-PTSTSSALQAGLRSLQDLGPEIRQ 1636

  Fly  2497 RGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEA 2561
            ..|..:......:.:...:|.:......|             |..||              .:::
Mouse  1637 ALTYDTEEEEEEEEAVGQEAEEEEAENNP-------------EPYKD--------------SIDS 1674

  Fly  2562 PRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGP 2626
            ...||..|..:..|..::.:.|||                               :|.|:...|.
Mouse  1675 QPQSRWNSRISVSLPVKEKLPDSL-------------------------------STGPSDDDGL 1708

  Fly  2627 AATSASDSDRHQAVGGGSAPSRKRASSF---IRKKPPLE-RGLSAQSALRVNKNAFVSEASAPEV 2687
            |..|...|    .:..||.|.|:.:..|   |.::..:: :|...|.    |:|   .|...|: 
Mouse  1709 APNSRQPS----VIQAGSQPHRRSSGVFMFTIPEEGSIQLKGTQGQD----NQN---EEQEVPD- 1761

  Fly  2688 IVTRPSPEQQTHPHSLSLRPDNATLVHVLVH 2718
             .|....||...|.:..|.|.:.:..||..|
Mouse  1762 -WTPDLDEQAGTPSNPVLLPPHWSQQHVNGH 1791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 72/238 (30%)
Ion_trans 705..902 CDD:278921 62/208 (30%)
Ion_trans 1768..2019 CDD:278921 84/270 (31%)
Na_channel_gate 2009..2063 CDD:240441 10/57 (18%)
Ion_trans 2085..2320 CDD:278921 84/251 (33%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
Cacna1fNP_062528.2 Ion_trans 109..383 CDD:278921 86/295 (29%)
Ion_trans 546..763 CDD:278921 67/222 (30%)
Ion_trans 891..1110 CDD:278921 73/228 (32%)
Ion_trans 1210..1455 CDD:278921 84/251 (33%)
GPHH 1463..1526 CDD:293510 20/62 (32%)
Ca_chan_IQ 1528..1599 CDD:285917 18/90 (20%)
CAC1F_C 1623..1981 CDD:293490 42/240 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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