Protein Alignment NaCP60E and Cacna1e

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_038946935.1
• Gene: Cacna1e / 54234
• RGDID: 2246
• Length: 2465
• Species: Rattus norvegicus
• Alignment Length: 2892
• Identity: 631/2892 - (21%)
• Similarity: 1076/2892 - (37%)
• Gaps: 931/2892 - (32%)

  Fly   100 FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEA 152
            ||..:|||:|...:..|:....:.....|:|.::|||:.|||.||            |:..:|:.
  Rat   210 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 274

  Fly   153 EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTF 213
            |..|:.|:..|..|||:|.||:.:|.:||||.||.:||:|:.|| .||.|....   :|..||..
  Rat   275 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAV 339

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|...|
  Rat   340 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------ 398

  Fly   279 DWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFM 342
                        ::|::.  :.:..:.|..|    |.:.||..|.|. .:|  ||.|.|.|||.:
  Rat   399 ------------FMNNSG--ILEGFDPPHPC----GVQGCPAGYECKDWIG--PNDGITQFDNIL 443

  Fly   343 WSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT 406
            :::||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|
  Rat   444 FAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE-- 506

  Fly   407 NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGG 471
            ..|.::..:..|......        ::|| ..:..||..:.|:||
  Rat   507 RVENRRAFMKLRRQQQIE--------RELN-GYRAWIDKAEEVMLA------------------- 543

  Fly   472 TNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNP 536
                      ::||             :|.|   |||
  Rat   544 ----------EENK-------------NSGT---SAL---------------------------- 554

  Fly   537 MAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQ 601
                                           :::..:....|.:..:.|:||  |...||
  Rat   555 -------------------------------EVLRRATIKRSRTEAMTRDSS--DEHCVD----- 581

  Fly   602 DTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVH 666
                    :|:|...|:...::..|.:|        ..|..|:|....:
  Rat   582 --------ISSVGTPLARASIKSTKVDG--------ASYFRHKERLLRI---------------- 614

  Fly   667 WCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIF 731
                         .:..:|:..:|...:...:.||||.:|:.||...:...:.|.....:|..:|
  Rat   615 -------------SIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLF 666

  Fly   732 TFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQ 790
            ..|..:|:..:. :.:|...:|.||..:...|:.::::.:..     |:||||.|||||:.|:.:
  Rat   667 LLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITK 731

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFH 855
            .|.:::.|:..::|::.::.:|..:|.:.|.:||::|||||...:   .|: |..|..||:.|..
  Rat   732 YWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF---NFN-DGTPSANFDTFPA 792

  Fly   856 SFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSE 917
            :.|.:|:||.|| |.|.:::.:|::....:....||:...|.: ||:.:||:|||:.: |..|::
  Rat   793 AIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 857

  Fly   918 ELKSKKEEVGEESKLARSIERVRDL----------IRKKRQER-------------KDRKERKFA 959
            ||...::|..|......::::.:::          |.:.|:.|             ::|:.|...
  Rat   858 ELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHM 922

  Fly   960 EKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMN---------RPVSGS 1015
            ..::|.....:: |.|..|.:|   |.:.:.|.:......:.||....:|         ||:.|.
  Rat   923 SVWEQRTSQLRR-HMQMSSQEA---LNKEEAPPMNPLNPLNPLSPLNPLNAHPSLYRRPRPIEGL 983

  Fly  1016 DFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPL------PPTSDSMPPTYESAMMATTGG 1074
            ..|..:...:.......|....|.|.|...:..|..||      ||.   :|
  Rat   984 ALGLGLEKCEEERISRGGSLKGDIGGLTSVLDNQRSPLSLGKREPPW---LP------------- 1032

  Fly  1075 SFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYAN 1139
              .|.:||  |.                    .|||.....|...|
  Rat  1033 --RSCHGN--CD--------------------PTQQETGGGETVVT------------------- 1054

  Fly  1140 DQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLL 1204
                          .:|.:..|                     .|.|:|..|..::.|:...|..
  Rat  1055 --------------FEDRARHR---------------------QSQRRSRHRRVRTEGKESASAS 1084

  Fly  1205 KSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRIS 1269
            :|..|                                            .:|..|.:|..:.
  Rat  1085 RSRSA--------------------------------------------SQERSLDEGVSID--- 1102

  Fly  1270 NVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEAT 1334
                        |:.|:|....|       :|.|..:.|.:| |..|.|               |
  Rat  1103 ------------GEKEHEPQSSH-------RSKEPTIHEEER-TQDLRR---------------T 1132

  Fly  1335 KAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRK 1399
            .::|                                |||.|..|.|
  Rat  1133 NSLM--------------------------------VPRGSGLVGA------------------- 1146

  Fly  1400 IDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSL 1464
            :||                           |.|...|.||               :.:..|..:|
  Rat  1147 LDE---------------------------AETPLVQPQP---------------ELEVGKDAAL 1169

  Fly  1465 IERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPA 1529
            .|:..|...|:..::.::::..:       |..|...| ||..:|| .:....:...:.:|.|..
  Rat  1170 TEQEAEGSSEQALLADVQLDVGR-------GISQSEPD-LSCMTTN-MDKATTESTSVTVAIPDM 1225

  Fly  1530 VPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSM 1594
            .|....|.:  :|...|..:.|.||                             .|.::.....:
  Rat  1226 DPLVDSTVV--NISNKTDGEASPLK-----------------------------EAETKEEEEEV 1259

  Fly  1595 AGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFT 1659
            ..::::.|                                     |.|..::..|.:    |.|.
  Rat  1260 EKKKQKKE-------------------------------------KRETGKAMVPHS----SMFI 1283

  Fly  1660 RLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPW 1724
            ..|..|
  Rat  1284 FSTTNP----------------------------------------------------------- 1289

  Fly  1725 FMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKRVLY 1786
                           :|.|...:|:...||..:|::|.||||.|..||   .|.::||    ||.
  Rat  1290 ---------------IRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK----VLR 1335

  Fly  1787 WINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV------FVSVFSLLIEENENLK 1841
            :.::.|..:|..||::|.:..|.    ..||...|.||||::|      |....:|...:..::|
  Rat  1336 YFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1400

  Fly  1842 VLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFK 1906
            .::|||.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||:::.||.|.||||.
  Rat  1401 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY 1465

  Fly  1907 CVNEMGELLPITEVNDKWDCIEQNYT-------------WINSKITFDHVGMGYLALLQVATFEG 1958
            |.:...:    ||.    :|| .||.             |...:..:|::....|.|..|:|.||
  Rat  1466 CTDSSKD----TEK----ECI-GNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEG 1521

  Fly  1959 WMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVL 2023
            |.:|:..:||....|..|.|...:...|::|::.|...||.:|:|:.:||..|   :::.:..:.
  Rat  1522 WPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF---QEQGDKMME 1583

  Fly  2024 EMFLTESQK---HYYTAMKKLGRKKPQK--VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNML 2083
            |..|.::::   .:..:.|.|.|..||.  ..:..:.||:.       |..||..|..:|.||.:
  Rat  1584 ECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV-------SPSFEYTIMAMIALNTV 1641

  Fly  2084 TMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGIL 2147
            .:.:::|..|......|:..|..||.||.||.::|::...: :||...||:|||:.|:.||..|:
  Rat  1642 VLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1706

  Fly  2148 MEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYA 2212
            :.|..: :..|...:..:::||..|:::|::....||.||:..|.|..||..:..|:.::.||||
  Rat  1707 LTDSKL-VNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1770

  Fly  2213 ILGMSLFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHT 2275
            |:||.:|||:||  :..::...||::|..|:.||||..|...|.:::.|.:.: ..|:|.....:
  Rat  1771 IIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE-KGCEPDTTAPS 1834

  Fly  2276 NGN----CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWS 2336
            ..|    ||.. ||..||.|||.....:::|:::|:|::||....::..| :....|:.|...|:
  Rat  1835 GQNESERCGTD-LAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRVWA 1897

  Fly  2337 KYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVK 2396
            :||..|...||::::.:.:..:.||||:.|  |:.||   ||..|:|:::...:|....|.||::
  Rat  1898 EYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIR 1962

  Fly  2397 HVL------GHVEETDNFKQLQEQ------------------------------------MDV-- 2417
            ..|      |..:......:||::                                    ||.
  Rat  1963 TALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYK 2027

  Fly  2418 --KFKKQFPTRKELEIVSSTRIWKRQEKAA--KTIQTGWKEYLRRKREKERSNSGDSATQTSSPG 2478
              |.|||   |::||...:..:::|.|.::  :.|.:..|.....:::.....||.|...:.||
  Rat  2028 QSKVKKQ---RQQLEEQKNAPMFQRMEPSSLPQEIISNAKALPYLQQDPVSGLSGRSGYPSMSP- 2088

  Fly  2479 GWQSKLSALNFFHL---------QVSRRGTACSSR---ASSRKSSRASD-----ASDLSELAG-- 2524
                 ||....|.|         |...:.:..:.|   .|..||.::|:     ..|..|.||
  Rat  2089 -----LSPQEIFQLACMDPADDGQFQEQQSLVNEREPEVSELKSVQSSNHGIYLPPDTQEHAGSG 2148

  Fly  2525 -----PWLNLPLMLVSGADEV------VKDIKQQN----DELG-KRGSIFVEAPRASRRRSFYNF 2573
                 |.|.:...:|:....:      ::| |:.|    :|.. :|.|   |....||||| |:.
  Rat  2149 RASSMPRLTMDPQVVTDPSSMRRSFSTIRD-KRSNSSWLEEFSMERSS---ENTYKSRRRS-YHS 2208

  Fly  2574 FLR-----------HQDAVDDS-------------LTSPSVHRKTAMNNTTNT------TSNSAS 2608
            .||           |:.....|             |.||.|.|..:....|..      ...|.|
  Rat  2209 SLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRS 2273

  Fly  2609 TSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRV 2673
            .|...|.|.....||....::..|.||.       |.|.|.|..  :...||..|.|.:.|:|..
  Rat  2274 PSEGRSQTPNRQGTGSLSESSIPSISDT-------STPRRSRRQ--LPPVPPKPRPLLSYSSLMR 2329

  Fly  2674 NKNAFV-----SEASAP---------EVIVTRPS----PEQQTHP---HSLSLRPDNATLVHVLV 2717
            :.....     ||..:|         ...:|..|    |:|..||   |.:| .|      ::.:
  Rat  2330 HTGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQGQHPSPQHYIS-EP------YLAL 2387

  Fly  2718 HRES--EEYKEED----ESSPSVS-GNGNGFG 2742
            |.:|  .:..||:    |::.:.| |..|..|
  Rat  2388 HEDSHASDCGEEETLTFEAAVATSLGRSNTIG 2419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	87/263 (33%)
		Ion_trans	687..902	CDD:459842	62/222 (28%)
		Ion_trans	1751..2019	CDD:459842	91/293 (31%)
		Na_channel_gate	2009..2063	CDD:240441	10/58 (17%)
		Ion_trans	2067..2320	CDD:459842	84/259 (32%)
		GPHH	2332..2378	CDD:465306	17/50 (34%)
Cacna1e	XP_038946935.1	Ion_trans	235..509	CDD:459842	97/301 (32%)
		Ion_trans	622..861	CDD:459842	71/242 (29%)
		Ion_trans	1301..1535	CDD:459842	78/246 (32%)
		Ion_trans	1625..1882	CDD:459842	84/259 (32%)
		GPHH	1891..1944	CDD:465306	18/52 (35%)
		Ca_chan_IQ	1954..2030	CDD:462591	9/75 (12%)