DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Cacna1e

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_038946935.1 Gene:Cacna1e / 54234 RGDID:2246 Length:2465 Species:Rattus norvegicus


Alignment Length:2892 Identity:631/2892 - (21%)
Similarity:1076/2892 - (37%) Gaps:931/2892 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEA 152
            ||..:|||:|...:..|:....:.....|:|.::|||:.|||.||            |:..:|:.
  Rat   210 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 274

  Fly   153 EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTF 213
            |..|:.|:..|..|||:|.||:.:|.:||||.||.:||:|:.|| .||.|....   :|..||..
  Rat   275 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAV 339

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|...|      
  Rat   340 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------ 398

  Fly   279 DWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFM 342
                        ::|::.  :.:..:.|..|    |.:.||..|.|. .:|  ||.|.|.|||.:
  Rat   399 ------------FMNNSG--ILEGFDPPHPC----GVQGCPAGYECKDWIG--PNDGITQFDNIL 443

  Fly   343 WSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT 406
            :::||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|  
  Rat   444 FAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE-- 506

  Fly   407 NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGG 471
            ..|.::..:..|......        ::|| ..:..||..:.|:||                   
  Rat   507 RVENRRAFMKLRRQQQIE--------RELN-GYRAWIDKAEEVMLA------------------- 543

  Fly   472 TNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNP 536
                      ::||             :|.|   |||                            
  Rat   544 ----------EENK-------------NSGT---SAL---------------------------- 554

  Fly   537 MAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQ 601
                                           :::..:....|.:..:.|:||  |...||     
  Rat   555 -------------------------------EVLRRATIKRSRTEAMTRDSS--DEHCVD----- 581

  Fly   602 DTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVH 666
                    :|:|...|:...::..|.:|        ..|..|:|....:                
  Rat   582 --------ISSVGTPLARASIKSTKVDG--------ASYFRHKERLLRI---------------- 614

  Fly   667 WCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIF 731
                         .:..:|:..:|...:...:.||||.:|:.||...:...:.|.....:|..:|
  Rat   615 -------------SIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLF 666

  Fly   732 TFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQ 790
            ..|..:|:..:. :.:|...:|.||..:...|:.::::.:..     |:||||.|||||:.|:.:
  Rat   667 LLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITK 731

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFH 855
            .|.:::.|:..::|::.::.:|..:|.:.|.:||::|||||...:   .|: |..|..||:.|..
  Rat   732 YWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF---NFN-DGTPSANFDTFPA 792

  Fly   856 SFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSE 917
            :.|.:|:||.|| |.|.:::.:|::....:....||:...|.: ||:.:||:|||:.: |..|::
  Rat   793 AIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 857

  Fly   918 ELKSKKEEVGEESKLARSIERVRDL----------IRKKRQER-------------KDRKERKFA 959
            ||...::|..|......::::.:::          |.:.|:.|             ::|:.|...
  Rat   858 ELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHM 922

  Fly   960 EKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMN---------RPVSGS 1015
            ..::|.....:: |.|..|.:|   |.:.:.|.:......:.||....:|         ||:.|.
  Rat   923 SVWEQRTSQLRR-HMQMSSQEA---LNKEEAPPMNPLNPLNPLSPLNPLNAHPSLYRRPRPIEGL 983

  Fly  1016 DFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPL------PPTSDSMPPTYESAMMATTGG 1074
            ..|..:...:.......|....|.|.|...:..|..||      ||.   :|             
  Rat   984 ALGLGLEKCEEERISRGGSLKGDIGGLTSVLDNQRSPLSLGKREPPW---LP------------- 1032

  Fly  1075 SFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYAN 1139
              .|.:||  |.                    .|||.....|...|                   
  Rat  1033 --RSCHGN--CD--------------------PTQQETGGGETVVT------------------- 1054

  Fly  1140 DQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLL 1204
                          .:|.:..|                     .|.|:|..|..::.|:...|..
  Rat  1055 --------------FEDRARHR---------------------QSQRRSRHRRVRTEGKESASAS 1084

  Fly  1205 KSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRIS 1269
            :|..|                                            .:|..|.:|..:.   
  Rat  1085 RSRSA--------------------------------------------SQERSLDEGVSID--- 1102

  Fly  1270 NVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEAT 1334
                        |:.|:|....|       :|.|..:.|.:| |..|.|               |
  Rat  1103 ------------GEKEHEPQSSH-------RSKEPTIHEEER-TQDLRR---------------T 1132

  Fly  1335 KAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRK 1399
            .::|                                |||.|..|.|                   
  Rat  1133 NSLM--------------------------------VPRGSGLVGA------------------- 1146

  Fly  1400 IDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSL 1464
            :||                           |.|...|.||               :.:..|..:|
  Rat  1147 LDE---------------------------AETPLVQPQP---------------ELEVGKDAAL 1169

  Fly  1465 IERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPA 1529
            .|:..|...|:..::.::::..:       |..|...| ||..:|| .:....:...:.:|.|..
  Rat  1170 TEQEAEGSSEQALLADVQLDVGR-------GISQSEPD-LSCMTTN-MDKATTESTSVTVAIPDM 1225

  Fly  1530 VPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSM 1594
            .|....|.:  :|...|..:.|.||                             .|.::.....:
  Rat  1226 DPLVDSTVV--NISNKTDGEASPLK-----------------------------EAETKEEEEEV 1259

  Fly  1595 AGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFT 1659
            ..::::.|                                     |.|..::..|.:    |.|.
  Rat  1260 EKKKQKKE-------------------------------------KRETGKAMVPHS----SMFI 1283

  Fly  1660 RLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPW 1724
            ..|..|                                                           
  Rat  1284 FSTTNP----------------------------------------------------------- 1289

  Fly  1725 FMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKRVLY 1786
                           :|.|...:|:...||..:|::|.||||.|..||   .|.::||    ||.
  Rat  1290 ---------------IRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK----VLR 1335

  Fly  1787 WINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV------FVSVFSLLIEENENLK 1841
            :.::.|..:|..||::|.:..|.    ..||...|.||||::|      |....:|...:..::|
  Rat  1336 YFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIK 1400

  Fly  1842 VLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFK 1906
            .::|||.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||:::.||.|.||||.
  Rat  1401 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY 1465

  Fly  1907 CVNEMGELLPITEVNDKWDCIEQNYT-------------WINSKITFDHVGMGYLALLQVATFEG 1958
            |.:...:    ||.    :|| .||.             |...:..:|::....|.|..|:|.||
  Rat  1466 CTDSSKD----TEK----ECI-GNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEG 1521

  Fly  1959 WMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVL 2023
            |.:|:..:||....|..|.|...:...|::|::.|...||.:|:|:.:||..|   :::.:..:.
  Rat  1522 WPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF---QEQGDKMME 1583

  Fly  2024 EMFLTESQK---HYYTAMKKLGRKKPQK--VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNML 2083
            |..|.::::   .:..:.|.|.|..||.  ..:..:.||:.       |..||..|..:|.||.:
  Rat  1584 ECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV-------SPSFEYTIMAMIALNTV 1641

  Fly  2084 TMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGIL 2147
            .:.:::|..|......|:..|..||.||.||.::|::...: :||...||:|||:.|:.||..|:
  Rat  1642 VLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEII 1706

  Fly  2148 MEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYA 2212
            :.|..: :..|...:..:::||..|:::|::....||.||:..|.|..||..:..|:.::.||||
  Rat  1707 LTDSKL-VNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1770

  Fly  2213 ILGMSLFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHT 2275
            |:||.:|||:||  :..::...||::|..|:.||||..|...|.:::.|.:.: ..|:|.....:
  Rat  1771 IIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE-KGCEPDTTAPS 1834

  Fly  2276 NGN----CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWS 2336
            ..|    ||.. ||..||.|||.....:::|:::|:|::||....::..| :....|:.|...|:
  Rat  1835 GQNESERCGTD-LAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRVWA 1897

  Fly  2337 KYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVK 2396
            :||..|...||::::.:.:..:.||||:.|  |:.||   ||..|:|:::...:|....|.||::
  Rat  1898 EYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIR 1962

  Fly  2397 HVL------GHVEETDNFKQLQEQ------------------------------------MDV-- 2417
            ..|      |..:......:||::                                    ||.  
  Rat  1963 TALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYK 2027

  Fly  2418 --KFKKQFPTRKELEIVSSTRIWKRQEKAA--KTIQTGWKEYLRRKREKERSNSGDSATQTSSPG 2478
              |.|||   |::||...:..:::|.|.::  :.|.:..|.....:::.....||.|...:.|| 
  Rat  2028 QSKVKKQ---RQQLEEQKNAPMFQRMEPSSLPQEIISNAKALPYLQQDPVSGLSGRSGYPSMSP- 2088

  Fly  2479 GWQSKLSALNFFHL---------QVSRRGTACSSR---ASSRKSSRASD-----ASDLSELAG-- 2524
                 ||....|.|         |...:.:..:.|   .|..||.::|:     ..|..|.||  
  Rat  2089 -----LSPQEIFQLACMDPADDGQFQEQQSLVNEREPEVSELKSVQSSNHGIYLPPDTQEHAGSG 2148

  Fly  2525 -----PWLNLPLMLVSGADEV------VKDIKQQN----DELG-KRGSIFVEAPRASRRRSFYNF 2573
                 |.|.:...:|:....:      ::| |:.|    :|.. :|.|   |....||||| |:.
  Rat  2149 RASSMPRLTMDPQVVTDPSSMRRSFSTIRD-KRSNSSWLEEFSMERSS---ENTYKSRRRS-YHS 2208

  Fly  2574 FLR-----------HQDAVDDS-------------LTSPSVHRKTAMNNTTNT------TSNSAS 2608
            .||           |:.....|             |.||.|.|..:....|..      ...|.|
  Rat  2209 SLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRS 2273

  Fly  2609 TSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRV 2673
            .|...|.|.....||....::..|.||.       |.|.|.|..  :...||..|.|.:.|:|..
  Rat  2274 PSEGRSQTPNRQGTGSLSESSIPSISDT-------STPRRSRRQ--LPPVPPKPRPLLSYSSLMR 2329

  Fly  2674 NKNAFV-----SEASAP---------EVIVTRPS----PEQQTHP---HSLSLRPDNATLVHVLV 2717
            :.....     ||..:|         ...:|..|    |:|..||   |.:| .|      ::.:
  Rat  2330 HTGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQGQHPSPQHYIS-EP------YLAL 2387

  Fly  2718 HRES--EEYKEED----ESSPSVS-GNGNGFG 2742
            |.:|  .:..||:    |::.:.| |..|..|
  Rat  2388 HEDSHASDCGEEETLTFEAAVATSLGRSNTIG 2419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/224 (33%)
Ion_trans 705..902 CDD:278921 57/204 (28%)
Ion_trans 1768..2019 CDD:278921 83/276 (30%)
Na_channel_gate 2009..2063 CDD:240441 10/58 (17%)
Ion_trans 2085..2320 CDD:278921 77/241 (32%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
Cacna1eXP_038946935.1 Ion_trans 235..509 CDD:395416 97/301 (32%)
Ion_trans 622..861 CDD:395416 71/242 (29%)
Ion_trans 1301..1535 CDD:395416 78/246 (32%)
Ion_trans 1625..1882 CDD:395416 84/259 (32%)
GPHH 1891..1944 CDD:407139 18/52 (35%)
Ca_chan_IQ 1955..2028 CDD:400901 9/72 (13%)
Atrophin-1 2170..>2429 CDD:397323 64/271 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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