DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and TPCN1

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_001137291.1	Gene:	TPCN1 / 53373	HGNCID:	18182	Length:	888	Species:	Homo sapiens

Alignment Length:	977	Identity:	189/977 - (19%)
Similarity:	345/977 - (35%)	Gaps:	287/977 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1607 TLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVS 1671
            |||:..|...|  .|:..|..:..|....:.|....|:.|.:......||:.....|..:.....
Human    86 TLDEGGSAPLA--PSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAI 148

  Fly  1672 YVDDLTVGGRRNSQGAYNDP-MTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAK 1735
            |:          .:|..||. .|.|......||.:       ..::|.::       .|:..:|
Human   149 YL----------QEGENNDKFFTHPKDAKALAAYL-------FAHNHLFY-------LMELATA- 188

  Fly  1736 HWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEM 1800
                :...:|::.:.||.....|.:...:::.|.              .|..:.|..|      |
Human   189 ----LLLLLLSLCEAPAVPALRLGIYVHATLELF--------------ALMVVVFELC------M 229

  Fly  1801 ILKWLAL-GFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGM 1864
            .|:||.| .|.::..:.......::.||....:|:.:..:::|.|:||.: .|...|...   |:
Human   230 KLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCI-FLVDCRYCG---GV 290

  Fly  1865 RIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFF----GGKFFKCVNEMGELLPITEVNDKWD 1925
            |..:..:..::|...::||:.|.|.:||:|:|...|    ...:|.
Human   291 RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFS------------------- 336

  Fly  1926 CIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
                         |.::..:....||..|.|.   :||           .|....|.::.::|::
Human   337 -------------TLENSIVSLFVLLTTANFP---DVM-----------MPSYSRNPWSCVFFIV 374

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHY-------------YTAMKKLG 2042
            ::....:|.:||.:.|:.|.||.::|:....:|....|..|..|             |...:.|.
Human   375 YLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLM 439

  Fly  2043 R-KKPQKVIKRPINHFLAM------------FYD------------------------------- 2063
            | .||:...:.....|.|:            |||
Human   440 RFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFK 504

  Fly  2064 ----LSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEV--SNAFFTTVFGLEAIVKIVGL 2122
                |..|:.|:..:::::.:|.:.:.:|.:......||...|  |...|.|::|:|..:|:.||
Human   505 GINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 569

  Fly  2123 -RYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKL 2186
             ...|.:..||:|||.:.:.:..|:|    .:.|.:.|....|  |.|..::|||.|..:..|.:
Human   570 GPVEYLSSGWNLFDFSVTVFAFLGLL----ALALNMEPFYFIV--VLRPLQLLRLFKLKERYRNV 628

  Fly  2187 LFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDD--------------------- 2230
            |..:...||.:.::|..|.:..:.:||:||..|..:......:.
Human   629 LDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVE 693

  Fly  2231 -----MVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFT 2290
                 :.||.....|...||.|.....|..::|.:..|.        .|.:.         .||.
Human   694 EGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT--------SHWSR---------LYFM 741

  Fly  2291 SFIIISYMIVINMYIAIILE------NFNQAHQEEEI--GIVEDDLEMFYIRWSKYDPHATQFIH 2347
            :|.|:: |:|:.:.:|.|||      |:::.:|:.|:  ||.   ||.
Human   742 TFYIVT-MVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGIT---LEK----------------- 785

  Fly  2348 FSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQ 2412
                           .|||...||:    |.:.:..:....|:...|        |.....::.|
Human   786 ---------------EISKEELVAV----LELYREARGASSDVTRLL--------ETLSQMERYQ 823

  Fly  2413 EQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSP 2477
            :...|...::..|:.:|    |.::::.:      ||. |.|...|::|::|..|..:|.....|
Human   824 QHSMVFLGRRSRTKSDL----SLKMYQEE------IQE-WYEEHAREQEQQRQLSSSAAPAAQQP 877

  Fly  2478 GG 2479
            .|
Human   878 PG 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	50/255 (20%)
		Na_channel_gate	2009..2063	CDD:240441	16/79 (20%)
		Ion_trans	2085..2320	CDD:278921	62/269 (23%)
		GPHH	2331..2386	CDD:293510	6/54 (11%)
TPCN1	NP_001137291.1	Ion_trans	214..402	CDD:278921	50/257 (19%)
TPCN1	NP_001137291.1	Ion_trans	552..763	CDD:278921	55/234 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810