Protein Alignment NaCP60E and TPCN1

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001137291.1
• Gene: TPCN1 / 53373
• HGNCID: 18182
• Length: 888
• Species: Homo sapiens
• Alignment Length: 977
• Identity: 189/977 - (19%)
• Similarity: 345/977 - (35%)
• Gaps: 287/977 - (29%)

  Fly  1607 TLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVS 1671
            |||:..|...|  .|:..|..:..|....:.|....|:.|.:......||:.....|..:.....
Human    86 TLDEGGSAPLA--PSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAI 148

  Fly  1672 YVDDLTVGGRRNSQGAYNDP-MTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAK 1735
            |:          .:|..||. .|.|......||.:       ..::|.::       .|:..:|
Human   149 YL----------QEGENNDKFFTHPKDAKALAAYL-------FAHNHLFY-------LMELATA- 188

  Fly  1736 HWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEM 1800
                :...:|::.:.||.....|.:...:::.|.              .|..:.|..|      |
Human   189 ----LLLLLLSLCEAPAVPALRLGIYVHATLELF--------------ALMVVVFELC------M 229

  Fly  1801 ILKWLAL-GFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGM 1864
            .|:||.| .|.::..:.......::.||....:|:.:..:::|.|:||.: .|...|...   |:
Human   230 KLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCI-FLVDCRYCG---GV 290

  Fly  1865 RIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFF----GGKFFKCVNEMGELLPITEVNDKWD 1925
            |..:..:..::|...::||:.|.|.:||:|:|...|    ...:|.
Human   291 RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFS------------------- 336

  Fly  1926 CIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVI 1990
                         |.::..:....||..|.|.   :||           .|....|.::.::|::
Human   337 -------------TLENSIVSLFVLLTTANFP---DVM-----------MPSYSRNPWSCVFFIV 374

  Fly  1991 FIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHY-------------YTAMKKLG 2042
            ::....:|.:||.:.|:.|.||.::|:....:|....|..|..|             |...:.|.
Human   375 YLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLM 439

  Fly  2043 R-KKPQKVIKRPINHFLAM------------FYD------------------------------- 2063
            | .||:...:.....|.|:            |||
Human   440 RFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFK 504

  Fly  2064 ----LSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEV--SNAFFTTVFGLEAIVKIVGL 2122
                |..|:.|:..:::::.:|.:.:.:|.:......||...|  |...|.|::|:|..:|:.||
Human   505 GINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 569

  Fly  2123 -RYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKL 2186
             ...|.:..||:|||.:.:.:..|:|    .:.|.:.|....|  |.|..::|||.|..:..|.:
Human   570 GPVEYLSSGWNLFDFSVTVFAFLGLL----ALALNMEPFYFIV--VLRPLQLLRLFKLKERYRNV 628

  Fly  2187 LFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDD--------------------- 2230
            |..:...||.:.::|..|.:..:.:||:||..|..:......:.
Human   629 LDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVE 693

  Fly  2231 -----MVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFT 2290
                 :.||.....|...||.|.....|..::|.:..|.        .|.:.         .||.
Human   694 EGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT--------SHWSR---------LYFM 741

  Fly  2291 SFIIISYMIVINMYIAIILE------NFNQAHQEEEI--GIVEDDLEMFYIRWSKYDPHATQFIH 2347
            :|.|:: |:|:.:.:|.|||      |:::.:|:.|:  ||.   ||.
Human   742 TFYIVT-MVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGIT---LEK----------------- 785

  Fly  2348 FSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQ 2412
                           .|||...||:    |.:.:..:....|:...|        |.....::.|
Human   786 ---------------EISKEELVAV----LELYREARGASSDVTRLL--------ETLSQMERYQ 823

  Fly  2413 EQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSP 2477
            :...|...::..|:.:|    |.::::.:      ||. |.|...|::|::|..|..:|.....|
Human   824 QHSMVFLGRRSRTKSDL----SLKMYQEE------IQE-WYEEHAREQEQQRQLSSSAAPAAQQP 877

  Fly  2478 GG 2479
            .|
Human   878 PG 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842
		Ion_trans	687..902	CDD:459842
		Ion_trans	1751..2019	CDD:459842	53/272 (19%)
		Na_channel_gate	2009..2063	CDD:240441	16/79 (20%)
		Ion_trans	2067..2320	CDD:459842	65/287 (23%)
		GPHH	2332..2378	CDD:465306	5/45 (11%)
TPCN1	NP_001137291.1	Ion_trans	214..402	CDD:459842	50/257 (19%)
		Ion_trans	512..763	CDD:459842	63/274 (23%)