Protein Alignment NaCP60E and Scn3a

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_008760137.1
• Gene: Scn3a / 497770
• RGDID: 3635
• Length: 1983
• Species: Rattus norvegicus
• Alignment Length: 2597
• Identity: 818/2597 - (31%)
• Similarity: 1178/2597 - (45%)
• Gaps: 843/2597 - (32%)

  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||..|:.:.....:...:..||:           |:..:.:|.|..||..:...|..|..:|||:
  Rat    26 EKRAAEEKAKKPKKEQDIDDENK-----------PKPNSDLEAGKNLPFIYGDIPPEMVSEPLED 79

  Fly    76 IDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|. ::.::||.|::|   ...|.||:.|.:|::..|.:|.|::.:.|..:..|...:|.|||.|
  Rat    80 LDPYYVSKKTFVVLNK---GKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTN 141

  Fly   140 CIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201
            |:|:.::   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.||...|.|..
  Rat   142 CVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEF 206

  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266
            :::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||::||
  Rat   207 VDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

  Fly   267 ELRNKCVRQVPTD--------------------WTNV--SHTDWQIWV-NDTDNWLYDEDELPVL 308
            .|||||::..|:|                    :.||  |..:|:.:: :|:..::.|..:.|:|
  Rat   272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLL 336

  Fly   309 CGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSV 373
            |||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|||||:|.:.|...|...:
  Rat   337 CGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM 401

  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKN 438
            .||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.::.|         :::.:.
  Rat   402 IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE------QKEAEF---------QQMLEQ 451

  Fly   439 NKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHS-ATPSPGPSPRHSAT 502
            .||:.:..:.|..||.:.:               :.:|.|..|:..:|.| |:.....|.:....
  Rat   452 LKKQQEEAQAVAAASAASR---------------DFSGIGGLGELLESSSEASKLSSKSAKEWRN 501

  Fly   503 ERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSD--- 564
            .|      :.::|.:.:|..|:     :.|...|.:.:       :||   ||..:.|...|
  Rat   502 RR------KKRRQREHLEGNHR-----ADGDRFPKSES-------EDS---VKRRSFLLSLDGNP 545

  Fly   565 ----------------YKGQLIANSGQPSSNSS-------------GVNRESSQDDSGVVDDHEE 600
                            .:|.|.:    |..||.             |...:.:.|:....:|.|.
  Rat   546 LTGDKKLCSPHQSLLSIRGSLFS----PRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSES 606

  Fly   601 QDTTNDMGH-------VSTVELALSPREV----------RLIKCNGNIARIKNHNVYALHQEFSS 648
            :..:..:.|       .:..:.::|.|.|          ..:.|||.::...........:..||
  Rat   607 RRDSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLGTTTETEVRKRRLSS 671

  Fly   649 EVVVIDDLPD-------------------------RNCDRCVH--------W-CTDYESWLQFQN 679
            ..:.::.|.|                         :.|..|.:        | |.|  :||:.::
  Rat   672 YQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCD--AWLKVKH 734

  Fly   680 CLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK 744
            .:..:|.||..:||||:||||||.|:||||:.|::.|.:.|.|||.|||.|||.|.::|::|:..
  Rat   735 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTQQFSSVLTVGNLVFTGIFTAEMVLKIIAMDP 799

  Fly   745 -DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGA 808
             .:|..||||||.:||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.:::||
  Rat   800 YYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 864

  Fly   809 LGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIE 870
            ||||||:|.|:::||||:|||||.|.|..  .|.:.| .:|||:.|||||||:::||:|||||||
  Rat   865 LGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIE 929

  Fly   871 PLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARS 935
            .:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:.|.:..:: .|.:.|..:
  Rat   930 TMWDCM---EVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD-NEMNNLQIA 990

  Fly   936 IERVR---DLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAET 997
            :.|::   |.::.|.:|       .|.:.|.:                         ||.|:
  Rat   991 VGRMQKGIDFVKNKIRE-------CFRKAFFR-------------------------KPKVI--- 1020

  Fly   998 KFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPP 1062
                                           .|.:|.:.|
  Rat  1021 -------------------------------EIQEGNKID------------------------- 1029

  Fly  1063 TYESAMMATTGGSFSS-----VNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTES 1122
               |.|...||...|.     .:||||                  :|||.|
  Rat  1030 ---SCMSNNTGIEISKELNYLKDGNGT------------------TSGVGT-------------- 1059

  Fly  1123 IELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRK 1187
                                                                             
  Rat  1060 ----------------------------------------------------------------- 1059

  Fly  1188 SLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQF 1252
                                         |.|:....|::::.:|...|
  Rat  1060 -----------------------------GSSVEKYVIDENDYMSFINN---------------- 1079

  Fly  1253 LQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEKELEEIKRSTT 1314
                                    ||..:..|   ..|..|:|:|:..   |.|.||||.|....
  Rat  1080 ------------------------PSLTVTVP---IAVGESDFENLNTEEFSSESELEESKEKLN 1117

  Fly  1315 SLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVS 1379
            :                             |.:||.|..|  |.|            ||..
  Rat  1118 A-----------------------------TSSSEGSTVD--VAP------------PREG---- 1135

  Fly  1380 AAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPF 1444
                                                                             
  Rat  1136 ----------------------------------------------------------------- 1135

  Fly  1445 LRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKST 1509
                                 |:.|..|||:
  Rat  1136 ---------------------EQAEIEPEED---------------------------------- 1145

  Fly  1510 NSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSI 1574
                                                       ||
  Rat  1146 -------------------------------------------LK-------------------- 1147

  Fly  1575 QAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQ 1639
                                                                             
  Rat  1148 ----------------------------------------------------------------- 1147

  Fly  1640 KTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAK 1704
                                                                             
  Rat  1148 ----------------------------------------------------------------- 1147

  Fly  1705 VPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLC 1769
             |:.||.:.|...|    |:.....:....|.|..:|....::|:...||.|::.:|..||..|.
  Rat  1148 -PEACFTEGCIKKF----PFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALA 1207

  Fly  1770 FEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLI 1834
            ||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:.
  Rat  1208 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVA 1272

  Fly  1835 EE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGV 1897
            ..  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||
  Rat  1273 NALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1337

  Fly  1898 QFFGGKFFKCVN-EMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLALLQVATFEGW 1959
            ..|.|||:.||| ..|.:..|.|||:..||  :.:...|.|.|:.||:||.|||||||||||:||
  Rat  1338 NLFAGKFYHCVNTTTGNMFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGW 1402

  Fly  1960 MEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLE 2024
            |::|..|||:|.|.|||..|.|||.|:||||||:.||||||||||||||||||..|||:.|  .:
  Rat  1403 MDIMYAAVDSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QD 1465

  Fly  2025 MFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEH 2089
            :|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.|||:||.:|.
  Rat  1466 IFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET 1530

  Fly  2090 YDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMID 2154
            .||...:..:|...|..|..:|..|.::|::.|||:|||:.||:|||::|:.||.|:.:.:::..
  Rat  1531 DDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEK 1595

  Fly  2155 LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF 2219
            ..:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.|||.|
  Rat  1596 YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1660

  Fly  2220 GNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCG 2280
            ..||.:..:|||.||:|||.||..||::.|||||:.:|..:: ..|||||| .||  ....|:||
  Rat  1661 AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIHPGSSVKGDCG 1725

  Fly  2281 HPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQF 2345
            :|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|.|:||.||||
  Rat  1726 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQF 1790

  Fly  2346 IHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQ 2410
            |.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||...|.|   .
  Rat  1791 IEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD---A 1852

  Fly  2411 LQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSAT 2472
            |:.||:.:|....|::...|.:::|...|::|.:|..||..::.||.::|.|..|:..|..|
  Rat  1853 LRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISSKYDKET 1914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	121/271 (45%)
		Ion_trans	687..902	CDD:459842	117/218 (54%)
		Ion_trans	1751..2019	CDD:459842	161/272 (59%)
		Na_channel_gate	2009..2063	CDD:240441	32/53 (60%)
		Ion_trans	2067..2320	CDD:459842	134/256 (52%)
		GPHH	2332..2378	CDD:465306	27/45 (60%)
Scn3a	XP_008760137.1	Ion_trans	127..434	CDD:459842	140/306 (46%)
		Na_trans_cytopl	558..693	CDD:463401	20/138 (14%)
		Ion_trans	742..955	CDD:459842	115/215 (53%)
		Na_trans_assoc	981..1183	CDD:461936	71/830 (9%)
		Ion_trans	1188..1460	CDD:459842	159/271 (59%)
		Na_channel_gate	1452..1504	CDD:240441	32/53 (60%)
		Ion_trans	1508..1764	CDD:459842	133/255 (52%)