Protein Alignment NaCP60E and na

DIOPT Version :9

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Alignment Length: 2807
• Identity: 494/2807 - (17%)
• Similarity: 862/2807 - (30%)
• Gaps: 1209/2807 - (43%)

  Fly   140 CIFLAMT----------ETVEEAEYIFLA-------IYSIEMVIKIIAKGFLLNKYTYLRNPWNW 187
            |..:::|          |.....::|..|       :::.||:.|:..:|.|..:..||::.|..
  Fly   365 CALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQ 429

  Fly   188 LDFVVITSGYATIGMEV----------GNLAGLRTFRVLRALKTVSI-----MPGLKTIINALL- 236
            .|..:::..:.:|.:::          ..|:.:|..|.|..::.:.:     ||  |:.||.:.
  Fly   430 FDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMP--KSRINQIFK 492

  Fly   237 HSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYD 301
            .|.:|:..|....:|.:.::.|..:| :.|||:|.||                  :|:|:   ||
  Fly   493 RSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCV------------------MNNTE---YD 535

  Fly   302 EDELPVLCGNL------------TGARHCPFEYVCLCVGENPNH--GYTNFDNFMWSMLTTFQLI 352
            ..:.|:|..|.            .....|....||:.:....::  |:..|::...|:.|.:|..
  Fly   536 LYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAA 600

  Fly   353 TLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLD 416
            :.:.|..: |..:.:.....:..:|:.::||.::.:.|:.:||:..::.|
  Fly   601 SQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNE--------------- 650

  Fly   417 HRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNG 481
                                                                             
  Fly   651 ----------------------------------------------------------------- 650

  Fly   482 DDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRIS 546
                                          .:.|:|||           .|:...:..|
  Fly   651 ------------------------------IRVQFQQM-----------WGARGHIQKT------ 668

  Fly   547 FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVS 611
                                                   .:||..||           ||.|.
  Fly   669 ---------------------------------------AASQILSG-----------NDTGW-- 681

  Fly   612 TVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQ 676
                                                 .:|.|||              :....|.
  Fly   682 -------------------------------------RLVTIDD--------------NKHGGLA 695

  Fly   677 FQNCLYKVVRDPLFELAITLCIVLN---TAFLAMEHHGMSESFRNALDVGNKVFTSI-FTFECIV 737
            .:.| :.::|.|.|.:.:...|:.|   ||.:..:|.|...      ||..:.:..| ..|.|::
  Fly   696 PETC-HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPR------DVFYERYYYIELVFTCLL 753

  Fly   738 KLMALSKDFFLCGW--------NIFDLLIVTASLLDII-FELVDGLSVLRGLRLLRVLKLAQSWT 793
            .|..|.|.:.| ||        :.|:||:...:.|.|: .....||:..:.||::|::|.:
  Fly   754 DLETLFKIYCL-GWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKAS---- 813

  Fly   794 TMKVLLSIIISTIG---ALGNLTLILVIVIYIFAVIGMQLFS--KDYTPEKFDPDPVPRWNFNDF 853
              .:|...:....|   .||:|.:..:.::.|.:.|.||||.  .|:|            .|..|
  Fly   814 --PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFT------------KFESF 864

  Fly   854 FHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSE 917
            ..:||.:|:||..| |:|.:.:.|....:.........|:...:....:||:||:|::|::...:
  Fly   865 PEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELD 929

  Fly   918 ELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAA 982
            |                              :.|..|:.||.|:..:|        .:||..:..
  Fly   930 E------------------------------DIKKLKQLKFREQSAEI--------KETLPFRLR 956

  Fly   983 VGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQ 1047
            :..:..|.|.:   |..||:
  Fly   957 IFEKFPDSPQM---TILHRI--------------------------------------------- 973

  Fly  1048 LQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYD 1112
                   |....:|...||.|                              :|.:
  Fly   974 -------PNDFMLPKVRESFM------------------------------KHFV---------- 991

  Fly  1113 SREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKS 1177
                      |||       :|:                |||.:|..|............:.||.
  Fly   992 ----------IEL-------ETE----------------DSLVENCKRPMSECWESNVVFRKQKP 1023

  Fly  1178 LLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELL 1242
            :                        .:.::.|::|  ::|.||..::|  ..:::...|.|  |:
  Fly  1024 V------------------------RIMNKTAKVR--AAGSSLRKLAI--THIINDSNNQR--LM 1058

  Fly  1243 NCDQKELFQFLQEEEELQKGTK----LRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFE 1303
            ..|...|         ...|||    |:....:..|:           ...|:..:|.:
  Fly  1059 LGDSAML---------PVVGTKGGGGLKSQGTITHSK-----------PWRVDQKKFGS------ 1097

  Fly  1304 KELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDL 1368
               ..|:||..|...||              |...||:                     .::.|:
  Fly  1098 ---RSIRRSVRSGSIKL--------------KQTYEHL---------------------MENGDI 1124

  Fly  1369 SSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATS 1433
            ::.||.:   |..|:...:.:|....::|:.         |:|:
  Fly  1125 AAAPRAN---SGRARPHDLDIKLLQAKRQQA---------EMRR--------------------- 1156

  Fly  1434 ASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQ 1498
                  ||.....|:..||   ||....|        ||.|.:        ..|:.:|.:|....
  Fly  1157 ------NQREEDLRENHPF---FDTPLFL--------VPRESR--------FRKICQKIVHARYD 1196

  Fly  1499 LRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALT 1563
            .||..                              |.|..:..::..:|
  Fly  1197 ARLKD------------------------------PLTGKERKVQYKSL---------------- 1215

  Fly  1564 EHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAAD 1628
                                        |:..|
  Fly  1216 ----------------------------HNFLG-------------------------------- 1220

  Fly  1629 ASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMT 1693
                                                    ||:|:|
  Fly  1221 ----------------------------------------LVTYLD------------------- 1226

  Fly  1694 FPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVL 1758
                                                                         |
  Fly  1227 -------------------------------------------------------------W--- 1227

  Fly  1759 VLIFA---SSITLCFEDIN---LDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYF 1813
            |:|||   |.|::.||..|   :| :.||:...|    .|.:...:|:.||.||.|.    ..|.
  Fly  1228 VMIFATTLSCISMMFETPNYRVMD-HPTLQIAEY----GFVIFMSLELALKILADGLFFTPKAYI 1287

  Fly  1814 TSFWTILDFIIVFVSV-----FSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMY 1873
            ......||..|..||.     ..|.|..|...::   |..||.:||||..:....||.||..|..
  Fly  1288 KDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQL---LMILRCVRPLRIFTLVPHMRKVVYELCR 1349

  Fly  1874 AIPSIF--NVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCI--------- 1927
            ....|.  :.||:.|:|  ||:..|||.:||:..:| |:       ..::.:.||:
  Fly  1350 GFKEILLVSTLLILLMF--IFASYGVQLYGGRLARC-ND-------PTISRREDCVGVFMRRVFV 1404

  Fly  1928 ---------EQNY-------TWIN-SKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQ 1975
                     :::|       .|.| .:..||::|...|.|.:|.:|:||::|....:.|.|
  Fly  1405 TKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG---- 1465

  Fly  1976 PQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKK 2040
                 .::| :|..|:|..|....|.||:||:|.|::    :.:|..|   ||..|:.:....|:
  Fly  1466 -----PVHA-VYIHIYIFLGCMIGLTLFVGVVIANYS----ENKGTAL---LTVDQRRWCDLKKR 1517

  Fly  2041 LGRKKPQKVIKRPINHFLAMF-YDLSNSRRFEIAIFVLIFLNMLTMGIE------HYDQPHAVFF 2098
            |...:|..:..||....:..| ||::....|:..|.|::.:|.:.:.|.      |.::
  Fly  1518 LKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTER------ 1576

  Fly  2099 ILEVSNAFFTTVFGLEAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLL 2162
             |.:.:|..|.||.:|.::|.:..... |:....|.:|.|:.:|.:..|:::          |:|
  Fly  1577 -LVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQ----------TIL 1630

  Fly  2163 R------------VVRVFRI-GRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAIL 2214
            |            ::|.|.| |:...|       :.|:..:.||:...|.|...:.|:.|.||:.
  Fly  1631 RNDLSYFFGFMVVILRFFTITGKHTTL-------KMLMLTVGVSVCKSFFIIFGMFLLVFFYALA 1688

  Fly  2215 GMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGN- 2278
            |..|||.||....:....||.:....:.:|||::|...||.::...|:|||.|       |.||
  Fly  1689 GTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYC-------TLGNN 1746

  Fly  2279 -----CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVE-DDLEMFYIRWSK 2337
                 ||:...::.||.:|.:|...||:|:.:|||:|||:..:..||..::. .|:..|...|:.
  Fly  1747 YWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNI 1811

  Fly  2338 YDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHC---LDILHALVKHVL 2399
            .|.|....|                      .|..|.|.|.:.|| ::.|   .|.|  |.|::.
  Fly  1812 VDIHQRGVI----------------------PVRRVKFILRLLKG-RLECDPQKDRL--LFKYMC 1851

  Fly  2400 GHVEETDNFKQL----------QEQMDVKFKKQFP---TRKELEIVSSTRIWKRQEKAAKTIQTG 2451
            ..:::..|.:.:          ...:|::...|..   .|:|.|.:      ..:|.|..||:|.
  Fly  1852 YELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYL------VEEEVAKMTIRTW 1910

  Fly  2452 WKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDA 2516
            .:..|::.|.:..|...:|.            ::.|...:.|...|......:|    ...|.|.
  Fly  1911 LEGCLKKIRAQNASKQQNSL------------IAGLRATNEQPVMRPNIQEDKA----PLGAVDK 1959

  Fly  2517 SDLSELAGPWLNLPLMLVSGADEVVKDI------KQQNDELGKRGSIFVEAPRASRRRSFYNFFL 2575
            |.:|.::|        .|:||.....|.      ..:|:|.....|..|:.|
  Fly  1960 SAISTISG--------AVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLP------------- 2003

  Fly  2576 RHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPAT-----------GCGPAAT 2629
                           |.:|::..|.::.:.:|:.:||:|.....|.|           |....|.
  Fly  2004 ---------------HSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYAL 2053

  Fly  2630 SASDSDRHQAVGGGSAPSRKRASSFI--RKKPPLERG-LSAQSALRVNKNAFVSEASAPEVIVTR 2691
            :.|||.       ||:..||    |:  ....|.:|. ||.:..|.:.
  Fly  2054 NRSDST-------GSSAGRK----FLAPTSSDPQQRSTLSDKERLHIT----------------- 2090

  Fly  2692 PSPEQQTHPHSLSLRPDNATLVHVLVHR-------ESEEYKEEDESS------PSVS-------- 2735
               .||...:|::..|....|..:...|       :|..:..:..|.      |:::
  Fly  2091 ---SQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAAL 2152

  Fly  2736 ---GNGNGFGVG 2744
               |:|:|.|.|
  Fly  2153 HGYGHGHGHGHG 2164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	50/256 (20%)
		Ion_trans	705..902	CDD:278921	49/212 (23%)
		Ion_trans	1768..2019	CDD:278921	78/290 (27%)
		Na_channel_gate	2009..2063	CDD:240441	12/54 (22%)
		Ion_trans	2085..2320	CDD:278921	69/260 (27%)
		GPHH	2331..2386	CDD:293510	11/54 (20%)
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	58/414 (14%)
		Ion_trans	734..927	CDD:278921	53/217 (24%)
		Ion_trans	1240..1497	CDD:278921	78/288 (27%)
		Ion_trans	1571..1793	CDD:278921	68/252 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439090
Domainoid	1	1.000	91	1.000	Domainoid score	I1740
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.870