DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1sb

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_999891.1 Gene:cacna1sb / 405791 ZFINID:ZDB-GENE-051227-1 Length:1847 Species:Danio rerio


Alignment Length:2930 Identity:574/2930 - (19%)
Similarity:959/2930 - (32%) Gaps:1273/2930 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 KRFRKNYIHRFTGT-------KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC----IFL 143
            ||.::..:.:...|       ::||.|...:|.|:.|..|...:.|:..::.||..||    :||
Zfish    31 KRKQREKLKKLLATGGNPRPPRTLFFFKLRNPFRKACTNIVEWKPFEIIILLTIFANCVALAVFL 95

  Fly   144 AMTE--------TVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
            .|.|        |:|..|||||.|:::|..:||||.|.|.::..||||.||.||||::..|..|:
Zfish    96 PMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTL 160

  Fly   201 GME-VGNLAG-------------LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIF 251
            .:: :..:.|             ||.|||||.|:.||.:|.|:.:::::|.|...|..::.|..|
Zfish   161 VVDTIDTITGVQKEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFF 225

  Fly   252 CLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGAR 316
            .:.::|:..|:::..::...|..|    .||:.              ...|:|.|..|......|
Zfish   226 MVTIYAIMGLELFKCKMHKTCYYQ----GTNII--------------ALRENEKPSPCAQAGNGR 272

  Fly   317 HCPFEYV-CLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV---YNMVLATCGPMSVSFFT 377
            .|..... |......||.|.|:||||.::|||.||.||.:.|.:|   .|..:....|.  .:|.
Zfish   273 RCTINGTECRDGWPGPNFGITHFDNFGFAMLTVFQCITTESWTDVLYWINDAMGNDWPW--IYFL 335

  Fly   378 VVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKK 442
            .::..|||:::||:|                                                  
Zfish   336 SLIMLGSFFILNLVL-------------------------------------------------- 350

  Fly   443 IDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSA 507
                 |||...::|:   |:|::             |.|:                         
Zfish   351 -----GVLSGEFTKE---REKSR-------------SRGE------------------------- 369

  Fly   508 LTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL--I 570
              .|..::.|||::                                          |.||.:  |
Zfish   370 --WQVLRERQQMDE------------------------------------------DLKGYMEWI 390

  Fly   571 ANSGQPSSNSSGVNRESSQDDSGVV-----DDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGN 630
            .::            |....||..:     |...|.|:...|..::.|..               
Zfish   391 THA------------EVMDGDSDAMLLLRKDTGSETDSLYKMEGINKVVY--------------- 428

  Fly   631 IARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAIT 695
                    .|.|.:.::   :||    .|.|          ..|          |:...|...:.
Zfish   429 --------FYRLARRWN---IVI----RRKC----------HGW----------VKSKSFNWWVL 458

  Fly   696 LCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIV 759
            :.::|||..:|.|||..:|...|..|..|.:..:.||.|.|:|:.|.. :.:|:..:|.||..:|
Zfish   459 IVVLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPRSYFMSIFNRFDCFVV 523

  Fly   760 TASLLDIIFELVD-------GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILV 817
            |..:|:||  ||.       |:||:|.:||||:.||.:.||::..|:..:::::.::.:|.|:|.
Zfish   524 TIGILEII--LVGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSLLNSVKSIASLLLLLF 586

  Fly   818 IVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCG-EWIEPLWDCMRAE-- 879
            :.|.|||::|||:|...:   .|...|:.|.||::|..:.:.:|::|.| ||...:::.:.|.  
Zfish   587 LFIVIFALLGMQVFGGKF---NFPDRPIQRSNFDNFPQALISVFQVLTGEEWDTIMYNGIMAHGG 648

  Fly   880 -EEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLI 943
             :..|..... .|:...|.|||::||:|||:.:            :.:.|...||.:        
Zfish   649 PKSPGILVSI-YFIILYVCGNFVLLNVFLAIAV------------DNLAEAESLAAA-------- 692

  Fly   944 RKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESM 1008
            :|:|.|.:.||:                                                    :
Zfish   693 QKERAEERARKK----------------------------------------------------L 705

  Fly  1009 NRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTG 1073
            .:|                              |||:.:                .|.|:||   
Zfish   706 MKP------------------------------LPEKTE----------------EEKALMA--- 721

  Fly  1074 GSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYA 1138
                                                                             
Zfish   722 ----------------------------------------------------------------- 721

  Fly  1139 NDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSL 1203
                                                                             
Zfish   722 ----------------------------------------------------------------- 721

  Fly  1204 LKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRI 1268
                                                       |.|.:..|:.|.:....||:  
Zfish   722 -------------------------------------------KRLMESRQKTEGMPTTAKLK-- 741

  Fly  1269 SNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEA 1333
                                          |..||..:.|:|              :|.|.||  
Zfish   742 ------------------------------IDEFESNVNEVK--------------DPFPPAD-- 760

  Fly  1334 TKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQR 1398
                                       .|.|                                  
Zfish   761 ---------------------------FPGD---------------------------------- 764

  Fly  1399 KIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLS 1463
              ||                                                             
Zfish   765 --DE------------------------------------------------------------- 766

  Fly  1464 LIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPP 1528
                     |||                                                    |
Zfish   767 ---------EEE----------------------------------------------------P 770

  Fly  1529 AVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHS 1593
            .:|.:|        .|..:|.:...:|..|:                                  
Zfish   771 EIPISP--------RPRPMADLQLKETVVPM---------------------------------- 793

  Fly  1594 MAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAF 1658
                                                                   |:|:      
Zfish   794 -------------------------------------------------------PEAS------ 797

  Fly  1659 TRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCP 1723
                                              :|..:|       |.:.|.:.|:        
Zfish   798 ----------------------------------SFFIFG-------PQNKFRKLCH-------- 813

  Fly  1724 WFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWI 1788
                                  .:::...|...:|:.|..|||:|..|| .:|.:....:||.:.
Zfish   814 ----------------------RIINHTTFTNIILLFILLSSISLAAED-PIDPHSFRNKVLAYA 855

  Fly  1789 NFSFCLIFVVEMILKWLALGFSKYFTSF----WTILDFIIVFVSVFSLLIEENENLKVLRSLRTL 1849
            :..|..:|.:|::||....|...:..||    :.|||.|:|.||:.|:.: |:..:.|::.||.|
Zfish   856 DIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLIVVAVSLLSMGM-ESSTISVVKILRVL 919

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM--- 1911
            |.|||||||:|.:|::.||..:..||.:|.|::||.::...:||.:|||.|.|..|.|.:.:   
Zfish   920 RVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFSCIGVQLFKGTLFYCTDPLQKT 984

  Fly  1912 -----GELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
                 |..|...: |...|.......|:||...||:|..|.|||..::|||||.|::..|:|:..
Zfish   985 AEQCQGTFLKHVQ-NSLHDTEIHQRRWVNSDFNFDNVLNGMLALFTISTFEGWPEILYKAIDSYD 1048

  Fly  1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYT 2036
            ||..|.....:...|:|:|:|:..:||.:|:|:|.:|..|     :.:|         .|::...
Zfish  1049 VDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTF-----QRQG---------EQEYKNC 1099

  Fly  2037 AMKKLGRKKPQKVIK-RPIN-------HFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQP 2093
            .:.|..|:..|..:| ||:.       |...::| |..|..||..:|.||.||.|::|:::.:||
Zfish  1100 ELDKNQRQCVQYALKARPLKCYIPENPHQYRVWY-LVTSCYFEYLMFFLIMLNTLSLGMQYCNQP 1163

  Fly  2094 HAVFFILEVS---NAFFTTVFGLEAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMID 2154
               |:|.::|   |..||.:|..|.|||::..:.. ||..|||||||::|:.||..:::.::...
Zfish  1164 ---FYITKLSDNLNVIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFVIVIGSIVDVVLSEVDRT 1225

  Fly  2155 LPISPTL------------------------LRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLP 2195
            |..|..|                        :...|:||:.|:::|:..::|||.||:..:.|..
Zfish  1226 LEASGGLWCLHGCSEVDPMQAIAEAENVKLSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQ 1290

  Fly  2196 ALFNIGALLGLITFIYAILGMSLFGNVKLQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLE 2258
            ||.::|.|:.::.||||::||.:||.:.|...  ::...|||||.:::.||||:.|...|..::.
Zfish  1291 ALPHVGLLIVMLFFIYAVIGMQMFGKIALVDGTEINRNNNFQTFPQAVLLLFRVATGEQWPKIML 1355

  Fly  2259 SLMIQPPDCDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQ-AHQEE 2319
            :.|.... |||   :..|. ...||.. :|:.||.||.::...:|||:::|||::||:. .|...
Zfish  1356 ASMYGKL-CDPKSDYGPGE-EYTCGSS-IAVCYFLSFYMLCAFLVINLFVAIIMDNFDYLTHDWS 1417

  Fly  2320 EIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPI 2379
            .:|  ...|:.|...|.:|||.||..|....:...:..:.||||..|  |::.|   |:|.|:|:
Zfish  1418 ILG--PHHLDEFKKIWGEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHHAACKRLISMNMPL 1480

  Fly  2380 SKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK- 2443
            :....:.....|.|||:..| .::...||:|..|::....|.               ||||... 
Zfish  1481 NSDGTVTFNATLFALVRTAL-KIKTEGNFEQANEELRAIIKS---------------IWKRTSMK 1529

  Fly  2444 --------------------AAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALN 2488
                                |...||..::::::|:.|                           
Zfish  1530 LLDQVIPPIGEDEVTVGKFYATFLIQEHFRKFMQRQEE--------------------------- 1567

  Fly  2489 FFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGK 2553
            .:..:.::: .|...:|..|         .:.|.|.|.|:   ..:|| |.:.:|..::..|.|:
Zfish  1568 LYGYRPTKK-NADEIKAGLR---------SIEEEAAPELH---RAISG-DLIAEDEMERAMESGE 1618

  Fly  2554 RG-------------SIFVEAP------RASRRRSFYNFFLRHQDA--VDDSLTSPSVHRKTAMN 2597
            .|             ..|...|      :.:.:|.......|.:||  ..||:..|:........
Zfish  1619 EGIYRRTGGLFGLNADPFSSEPSSPLSTQVTSQRPLQFAENRPEDAGSPPDSVFLPNTEFFPDNM 1683

  Fly  2598 NTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLE 2662
            .||:.|:|:|:.....:..:.:.:.....:.....||..:  |||.|..:.:|.|.|        
Zfish  1684 PTTSNTNNNANFIEEFTFESESLSASRNYSYEDIRDSSLY--VGGASNVNDRRLSDF-------- 1738

  Fly  2663 RGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEE 2727
                   .::.|...|                     |::.|.             .||:..:..
Zfish  1739 -------NVKTNSTQF---------------------PYNPSC-------------EESKNQRSA 1762

  Fly  2728 DESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSS 2792
            .|:||:.           |.|.:|     .:..|.:||..:               ||   .|.|
Zfish  1763 AEASPAT-----------DKLIQQ-----ALRDGGLESLAE---------------DP---QFVS 1793

  Fly  2793 APIDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQG--NGQDETAQFESLPDRQRXPPVNTPLRDS 2855
            ....::...:::.:| |...|           .||  |||.     ..:..|:| |....|.:..
Zfish  1794 VTRKELAEAVNIGLQ-DIESV-----------AQGIVNGQS-----GKVTKRKRRPIPVPPSKTK 1841

  Fly  2856 EKRSS 2860
            |..|:
Zfish  1842 EATSA 1846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 74/236 (31%)
Ion_trans 705..902 CDD:278921 67/208 (32%)
Ion_trans 1768..2019 CDD:278921 90/262 (34%)
Na_channel_gate 2009..2063 CDD:240441 10/61 (16%)
Ion_trans 2085..2320 CDD:278921 85/268 (32%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
cacna1sbNP_999891.1 Ion_trans 91..365 CDD:278921 94/351 (27%)
Ion_trans 468..682 CDD:278921 72/231 (31%)
Ion_trans 836..1095 CDD:278921 91/275 (33%)
Ion_trans 1155..1417 CDD:278921 85/267 (32%)
GPHH 1425..1488 CDD:293510 19/62 (31%)
Ca_chan_IQ 1490..1561 CDD:285917 17/86 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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