Protein Alignment NaCP60E and cacna1da

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_021335251.2
• Gene: cacna1da / 403310
• ZFINID: ZDB-GENE-030616-135
• Length: 2093
• Species: Danio rerio
• Alignment Length: 2988
• Identity: 569/2988 - (19%)
• Similarity: 963/2988 - (32%)
• Gaps: 1306/2988 - (43%)

  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156
            ::||.....:|.||.|:.:...:.||..::..|..||:.||:            ...:|..||.|
Zfish    56 RALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAF 120

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV------------GNLA- 208
            |.|::||..:||||.|.::::..|:||.||.||||::..|..::.:||            .||:
Zfish   121 LIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSA 185

  Fly   209 -------------GLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFA 260
                         .||.|||||.|:.||.:|.|:.::|:::.:...|..:..|.:|.::::|:..
Zfish   186 HGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIG 250

  Fly   261 LQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVC 324
            |::::|::...|                  :...||   ..||| |..|......|.||.. .:|
Zfish   251 LELFIGKMHASC------------------YFQGTD---ILEDE-PAPCAVNGHGRTCPINGTLC 293

  Fly   325 LCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLI 388
            ....:.||.|.|||||||::|||.||.||::.|.:| |.|..|....:...:|..:|.||||:::
Zfish   294 KEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVIFGSFFVL 358

  Fly   389 NLMLAVVALSYEEEAEIT-----------NEERKKDLLDHRDDSTFS--FDPSVLNVKKLNKNNK 440
            ||:|.|::..:.:|.|..           .::.::||..:.|..|.:  .||         :|.:
Zfish   359 NLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP---------ENEE 414

  Fly   441 KKIDSRKG-VLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATER 504
            ::.:|::. |.|||..:||
Zfish   415 EEEESKRNRVTLASLMEKK---------------------------------------------- 433

  Fly   505 PSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL 569
                                  |.|.|.              |..|            ||
Zfish   434 ----------------------KKGFGW--------------FSQS------------SD----- 445

  Fly   570 IANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARI 634
             .::..|:|.:..:|.|:.:.:       :|:.|.                      |.....:|
Zfish   446 -THASMPASETESMNTENEKGE-------DEKATC----------------------CGPTCQKI 480

  Fly   635 KNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESW--LQFQNCLYKVVRDPLFELAITLC 697
            ..       .:||..                     :..|  |..:||...|...|.:.|.|.|
Zfish   481 SK-------SKFSRR---------------------WRRWNRLCRRNCRLAVKSVPFYWLVIIL- 516

  Fly   698 IVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTA 761
            :.|||..::.||:..........||.|||..::||.|.:||:.:|. :.:|:..:|.||..:|..
Zfish   517 VFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 581

  Fly   762 SLLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIY 821
            .:.:.|   ||::.  |:||.|.:||||:.|:.:.|.::..|::.:::::.::.:|.|:|.:.|.
Zfish   582 GITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFII 646

  Fly   822 IFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQ 882
            ||:::|||:|...:   .||.....|..|::|..:.:.:|:||.|| |...::|.:.|   ....
Zfish   647 IFSLLGMQVFGGKF---NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSS 708

  Fly   883 GASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKR 947
            |...|. .|:...:.||:::||:|||:.:::
Zfish   709 GMIVCI-YFIILFICGNYILLNVFLAIAVDN---------------------------------- 738

  Fly   948 QERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPV 1012
                                                                  |:..||:|.
Zfish   739 ------------------------------------------------------LADAESLNT-- 747

  Fly  1013 SGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFS 1077
                                    ||| ..|::|
Zfish   748 ------------------------DDT-KKPDEI------------------------------- 756

  Fly  1078 SVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQR 1142
                                                                             
Zfish   757 ----------------------------------------------------------------- 756

  Fly  1143 SGCGSFNRGDSLQDNSSRRYGSE-EHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKS 1206
                     |.::|.:  :.|.| |.|.|
Zfish   757 ---------DEIEDEA--KAGEEDEKDNA------------------------------------ 774

  Fly  1207 EEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNV 1271
                               |:||                         ||.::..|
Zfish   775 -------------------EEDE-------------------------EEPDVPAG--------- 786

  Fly  1272 MRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKA 1336
                                                                  |.|...|..|
Zfish   787 ------------------------------------------------------PRPKISELVK- 796

  Fly  1337 IMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKID 1401
                             .|.:.|:....::.:
Zfish   797 -----------------KEKITPIPEGSAFFI--------------------------------- 811

  Fly  1402 EDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIE 1466
              ||.:|.:|..|
Zfish   812 --FSNTNPVRVAC---------------------------------------------------- 822

  Fly  1467 RVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVP 1531
                                                                             
Zfish   823 ----------------------------------------------------------------- 822

  Fly  1532 ATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAG 1596
                                                                  |...:.|
Zfish   823 ------------------------------------------------------HKLINHH---- 829

  Fly  1597 QRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRL 1661
                                                                        .||.|
Zfish   830 ------------------------------------------------------------IFTNL 834

  Fly  1662 TEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFM 1726
                                                                             
Zfish   835 ----------------------------------------------------------------- 834

  Fly  1727 SCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR-VLYWINF 1790
                                          :||.|..||.:|..||  ..:|.:.:. :|.:.::
Zfish   835 ------------------------------ILVFIMLSSASLAAED--PIRNFSARNIILGYFDY 867

  Fly  1791 SFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRA 1851
            :|..||.||::||....|.    ..:..:::.:||.::|.||:.|..|:.:. :.|::.||.||.
Zfish   868 AFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSA-ISVVKILRVLRV 931

  Fly  1852 LRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLP 1916
            |||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||::| |:..:..|
Zfish   932 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRC-NDEAKSSP 995

  Fly  1917 --------ITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVD 1973
                    :.:..|....|.|...|.||...||:|.|..:||..|:|||||..::..|:|:...:
Zfish   996 EECKGTYILYKEGDVNQPIIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNREN 1060

  Fly  1974 LQPQREANLYAY-----IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH 2033
            :.|     :|.|     |:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:
Zfish  1061 MGP-----IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ------EQGEKEYKNCELDKN 1114

  Fly  2034 YYTAMKKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAV 2096
            ....::...:.:|   ::|  |.|.:...|:.:.||..||..:||||.||.:.:.::||.|....
Zfish  1115 QRQCVEYALKARP---LRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELF 1176

  Fly  2097 FFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPT 2160
            .:::::.|..||.||.:|.::|::..: .||||..||.||.|:|:.|:..|.:.:      ::||
Zfish  1177 NYVMDILNMVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVDIAITE------VNPT 1235

  Fly  2161 -----------------LLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLIT 2208
                             .:...|:||:.|:::|:...:|||.||:..:.|..||..:..|:.::.
Zfish  1236 EAPQVDESGNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLF 1300

  Fly  2209 FIYAILGMSLFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD--CDP 2269
            ||||::||.:||.:.:  ...::...|||||.:::.||||..|...|.:::.:.|   |.  |||
Zfish  1301 FIYAVIGMQVFGKIAMVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACM---PGKLCDP 1362

  Fly  2270 FIHGHTNGNCGHPL-----LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLE 2329
                .::.|.|..:     .||.||.:|.::...::||:::|:|::||:...::..| :....|:
Zfish  1363 ----ESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLD 1422

  Fly  2330 MFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLD 2389
            .|...||:|||.|...|....:...:..:.||||..|  |:.||   ||:.|:|::....:....
Zfish  1423 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNA 1487

  Fly  2390 ILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK----------- 2443
            .|.|||:..| .::...|.:|..|::....||               ||||...
Zfish  1488 TLFALVRTAL-KIKTEGNLEQANEELRAVIKK---------------IWKRTSMKLLDQVVPPAG 1536

  Fly  2444 ----------AAKTIQTGWKEYLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRR 2497
                      |...||    :|.|: |:.||....|....|.::....|:.|..|:....:: ||
Zfish  1537 DDEVTVGKFYATFLIQ----DYFRKFKKRKEEGLVGVHPAQNNTAIALQAGLRTLHDIGPEI-RR 1596

  Fly  2498 GTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKR-GSIF--- 2558
            ..:|                ||.:                ||:|..|.::::|:.:| |.:|
Zfish  1597 AISC----------------DLQD----------------DELVDFIPEEDEEIYRRNGGLFGNH 1629

  Fly  2559 VEAPRASRRRSFYNFFLRHQ-DAVDDSL-TSPSVH------------RKTAM------------- 2596
            :.......|||     ..|| :|....| ..|..|            |..||
Zfish  1630 INHINGDPRRS-----SGHQTNATQRPLQVQPPPHYVHMEQPVGRLGRANAMAQQNHHRHHHHHH 1689

  Fly  2597 -----NNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIR 2656
                 ||:.|.:..|.:.:...::.::.|..|          .:|:..    .||:.....|:..
Zfish  1690 HHHHHNNSYNKSPKSTNINLNNANVSSLPNGG----------HNRYYE----HAPANGYPGSYYG 1740

  Fly  2657 K--KPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHR 2719
            :  ||....|                               |:...:...:|...:......:.|
Zfish  1741 EYDKPRTPHG-------------------------------QRRRYYETYIRSQGSDRRRPTIRR 1774

  Fly  2720 ESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSM----------------- 2767
            | |||:|:..|....|  |..|.....|||....|.   :....|:..
Zfish  1775 E-EEYEEDRYSGEYYS--GEEFYEDDSMLSGDRYPN---SDQEYETPRGYHHPDSYYEDDEQPLY 1833

  Fly  2768 -DTCAMPTVQIMVDSPKDPPRGDFS-----------SAPIDDVGAPID------VNVQGDTSQVF 2814
             |:...|..:::..:|:...|..|:           ..|......|:.      :.|.|..|...
Zfish  1834 HDSHRSPKRRLLPPTPQGNRRPSFNFECLRRQSSQDDLPHQRTALPLHLMQHQVMAVAGLDSSRA 1898

  Fly  2815 YDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSSTSSIRSCS 2877
            :..:|.::|....:.....|..:..|.... ..|:.||||          |:|||.||||..|
Zfish  1899 HRLSPTRSTRSWASPPPTPASKDRTPYYTPLIRVDRPLRD----------SASSSHSSIRKSS 1951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	87/285 (31%)
		Ion_trans	687..902	CDD:459842	67/224 (30%)
		Ion_trans	1751..2019	CDD:459842	91/285 (32%)
		Na_channel_gate	2009..2063	CDD:240441	11/55 (20%)
		Ion_trans	2067..2320	CDD:459842	84/279 (30%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)
cacna1da	XP_021335251.2	None