DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and cacna1da

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_021335251.1 Gene:cacna1da / 403310 ZFINID:ZDB-GENE-030616-135 Length:2093 Species:Danio rerio


Alignment Length:2988 Identity:568/2988 - (19%)
Similarity:964/2988 - (32%) Gaps:1306/2988 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156
            ::||.....:|.||.|:.:...:.||..::..|..||:.||:            ...:|..||.|
Zfish    56 RALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAF 120

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV------------GNLA- 208
            |.|::||..:||||.|.::::..|:||.||.||||::..|..::.:||            .||: 
Zfish   121 LIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSA 185

  Fly   209 -------------GLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFA 260
                         .||.|||||.|:.||.:|.|:.::|:::.:...|..:..|.:|.::::|:..
Zfish   186 HGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIG 250

  Fly   261 LQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVC 324
            |::::|::...|                  :...||   ..||| |..|......|.||.. .:|
Zfish   251 LELFIGKMHASC------------------YFQGTD---ILEDE-PAPCAVNGHGRTCPINGTLC 293

  Fly   325 LCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLI 388
            ....:.||.|.|||||||::|||.||.||::.|.:| |.|..|....:...:|..:|.||||:::
Zfish   294 KEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVIFGSFFVL 358

  Fly   389 NLMLAVVALSYEEEAEIT-----------NEERKKDLLDHRDDSTFS--FDPSVLNVKKLNKNNK 440
            ||:|.|::..:.:|.|..           .::.::||..:.|..|.:  .||         :|.:
Zfish   359 NLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP---------ENEE 414

  Fly   441 KKIDSRKG-VLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATER 504
            ::.:|::. |.|||..:||                                              
Zfish   415 EEEESKRNRVTLASLMEKK---------------------------------------------- 433

  Fly   505 PSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL 569
                                  |.|.|.              |..|            ||     
Zfish   434 ----------------------KKGFGW--------------FSQS------------SD----- 445

  Fly   570 IANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARI 634
             .::..|:|.:..:|.|:.:.:       :|:.|.                      |.....:|
Zfish   446 -THASMPASETESMNTENEKGE-------DEKATC----------------------CGPTCQKI 480

  Fly   635 KNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESW--LQFQNCLYKVVRDPLFELAITLC 697
            ..       .:||..                     :..|  |..:||...|...|.:.|.|.| 
Zfish   481 SK-------SKFSRR---------------------WRRWNRLCRRNCRLAVKSVPFYWLVIIL- 516

  Fly   698 IVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTA 761
            :.|||..::.||:..........||.|||..::||.|.:||:.:|. :.:|:..:|.||..:|..
Zfish   517 VFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 581

  Fly   762 SLLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIY 821
            .:.:.|   ||::.  |:||.|.:||||:.|:.:.|.::..|::.:::::.::.:|.|:|.:.|.
Zfish   582 GITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFII 646

  Fly   822 IFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQ 882
            ||:::|||:|...:   .||.....|..|::|..:.:.:|:||.|| |...::|.:.|   ....
Zfish   647 IFSLLGMQVFGGKF---NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSS 708

  Fly   883 GASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKR 947
            |...|. .|:...:.||:::||:|||:.:::                                  
Zfish   709 GMIVCI-YFIILFICGNYILLNVFLAIAVDN---------------------------------- 738

  Fly   948 QERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPV 1012
                                                                  |:..||:|.  
Zfish   739 ------------------------------------------------------LADAESLNT-- 747

  Fly  1013 SGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFS 1077
                                    ||| ..|::|                               
Zfish   748 ------------------------DDT-KKPDEI------------------------------- 756

  Fly  1078 SVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQR 1142
                                                                             
Zfish   757 ----------------------------------------------------------------- 756

  Fly  1143 SGCGSFNRGDSLQDNSSRRYGSE-EHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKS 1206
                     |.::|.:  :.|.| |.|.|                                    
Zfish   757 ---------DEIEDEA--KAGEEDEKDNA------------------------------------ 774

  Fly  1207 EEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNV 1271
                               |:||                         ||.::..|         
Zfish   775 -------------------EEDE-------------------------EEPDVPAG--------- 786

  Fly  1272 MRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKA 1336
                                                                  |.|...|..| 
Zfish   787 ------------------------------------------------------PRPKISELVK- 796

  Fly  1337 IMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKID 1401
                             .|.:.|:....::.:                                 
Zfish   797 -----------------KEKITPIPEGSAFFI--------------------------------- 811

  Fly  1402 EDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIE 1466
              ||.:|.:|..|                                                    
Zfish   812 --FSNTNPVRVAC---------------------------------------------------- 822

  Fly  1467 RVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVP 1531
                                                                             
Zfish   823 ----------------------------------------------------------------- 822

  Fly  1532 ATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAG 1596
                                                                  |...:.|    
Zfish   823 ------------------------------------------------------HKLINHH---- 829

  Fly  1597 QRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRL 1661
                                                                        .||.|
Zfish   830 ------------------------------------------------------------IFTNL 834

  Fly  1662 TEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFM 1726
                                                                             
Zfish   835 ----------------------------------------------------------------- 834

  Fly  1727 SCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR-VLYWINF 1790
                                          :||.|..||.:|..||  ..:|.:.:. :|.:.::
Zfish   835 ------------------------------ILVFIMLSSASLAAED--PIRNFSARNIILGYFDY 867

  Fly  1791 SFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRA 1851
            :|..||.||::||....|.    ..:..:::.:||.::|.||:.|..|:.:. :.|::.||.||.
Zfish   868 AFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSA-ISVVKILRVLRV 931

  Fly  1852 LRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNE------ 1910
            |||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||::|.:|      
Zfish   932 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPE 996

  Fly  1911 --MGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVD 1973
              .|..:...|.:.....|::.: |.||...||:|.|..:||..|:|||||..::..|:|:...:
Zfish   997 ECKGTYIMYKEGDVNQPIIQKRH-WHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNREN 1060

  Fly  1974 LQPQREANLYAY-----IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH 2033
            :.|     :|.|     |:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:
Zfish  1061 MGP-----IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ------EQGEKEYKNCELDKN 1114

  Fly  2034 YYTAMKKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAV 2096
            ....::...:.:|   ::|  |.|.:...|:.:.||..||..:||||.||.:.:.::||.|....
Zfish  1115 QRQCVEYALKARP---LRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELF 1176

  Fly  2097 FFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPT 2160
            .:::::.|..||.||.:|.::|::..: .||||..||.||.|:|:.|:..|.:.:      ::||
Zfish  1177 NYVMDILNMVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVDIAITE------VNPT 1235

  Fly  2161 -----------------LLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLIT 2208
                             .:...|:||:.|:::|:...:|||.||:..:.|..||..:..|:.::.
Zfish  1236 EAPQVDESGNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLF 1300

  Fly  2209 FIYAILGMSLFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD--CDP 2269
            ||||::||.:||.:.:  ...::...|||||.:::.||||..|...|.:::.:.|   |.  |||
Zfish  1301 FIYAVIGMQVFGKIAMVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACM---PGKLCDP 1362

  Fly  2270 FIHGHTNGNCGHPL-----LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLE 2329
                .::.|.|..:     .||.||.:|.::...::||:::|:|::||:...::..| :....|:
Zfish  1363 ----ESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLD 1422

  Fly  2330 MFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLD 2389
            .|...||:|||.|...|....:...:..:.||||..|  |:.||   ||:.|:|::....:....
Zfish  1423 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNA 1487

  Fly  2390 ILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK----------- 2443
            .|.|||:..| .::...|.:|..|::....||               ||||...           
Zfish  1488 TLFALVRTAL-KIKTEGNLEQANEELRAVIKK---------------IWKRTSMKLLDQVVPPAG 1536

  Fly  2444 ----------AAKTIQTGWKEYLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRR 2497
                      |...||    :|.|: |:.||....|....|.::....|:.|..|:....:: ||
Zfish  1537 DDEVTVGKFYATFLIQ----DYFRKFKKRKEEGLVGVHPAQNNTAIALQAGLRTLHDIGPEI-RR 1596

  Fly  2498 GTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKR-GSIF--- 2558
            ..:|                ||.:                ||:|..|.::::|:.:| |.:|   
Zfish  1597 AISC----------------DLQD----------------DELVDFIPEEDEEIYRRNGGLFGNH 1629

  Fly  2559 VEAPRASRRRSFYNFFLRHQ-DAVDDSL-TSPSVH------------RKTAM------------- 2596
            :.......|||     ..|| :|....| ..|..|            |..||             
Zfish  1630 INHINGDPRRS-----SGHQTNATQRPLQVQPPPHYVHMEQPVGRLGRANAMAQQNHHRHHHHHH 1689

  Fly  2597 -----NNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIR 2656
                 ||:.|.:..|.:.:...::.::.|..|          .:|:..    .||:.....|:..
Zfish  1690 HHHHHNNSYNKSPKSTNINLNNANVSSLPNGG----------HNRYYE----HAPANGYPGSYYG 1740

  Fly  2657 K--KPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHR 2719
            :  ||....|                               |:...:...:|...:......:.|
Zfish  1741 EYDKPRTPHG-------------------------------QRRRYYETYIRSQGSDRRRPTIRR 1774

  Fly  2720 ESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSM----------------- 2767
            | |||:|:..|....|  |..|.....|||....|.   :....|:..                 
Zfish  1775 E-EEYEEDRYSGEYYS--GEEFYEDDSMLSGDRYPN---SDQEYETPRGYHHPDSYYEDDEQPLY 1833

  Fly  2768 -DTCAMPTVQIMVDSPKDPPRGDFS-----------SAPIDDVGAPID------VNVQGDTSQVF 2814
             |:...|..:::..:|:...|..|:           ..|......|:.      :.|.|..|...
Zfish  1834 HDSHRSPKRRLLPPTPQGNRRPSFNFECLRRQSSQDDLPHQRTALPLHLMQHQVMAVAGLDSSRA 1898

  Fly  2815 YDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSSTSSIRSCS 2877
            :..:|.::|....:.....|..:..|.... ..|:.||||          |:|||.||||..|
Zfish  1899 HRLSPTRSTRSWASPPPTPASKDRTPYYTPLIRVDRPLRD----------SASSSHSSIRKSS 1951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 79/246 (32%)
Ion_trans 705..902 CDD:278921 60/206 (29%)
Ion_trans 1768..2019 CDD:278921 85/268 (32%)
Na_channel_gate 2009..2063 CDD:240441 11/55 (20%)
Ion_trans 2085..2320 CDD:278921 75/261 (29%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
cacna1daXP_021335251.1 Ion_trans 77..377 CDD:306908 99/321 (31%)
Ion_trans 509..744 CDD:306908 72/327 (22%)
Ion_trans 828..1105 CDD:306908 96/450 (21%)
Ion_trans 1150..1414 CDD:306908 83/276 (30%)
GPHH 1415..1485 CDD:318993 22/70 (31%)
Ca_chan_IQ 1487..1558 CDD:312334 19/90 (21%)
CAC1F_C 1583..2092 CDD:318975 85/468 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.