Protein Alignment NaCP60E and scn1laa

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_956426.2
• Gene: scn1laa / 393101
• ZFINID: ZDB-GENE-040426-751
• Length: 1955
• Species: Danio rerio
• Alignment Length: 2559
• Identity: 801/2559 - (31%)
• Similarity: 1155/2559 - (45%)
• Gaps: 804/2559 - (31%)

  Fly    46 RTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYEE-TFCVVSKRFRKNYIHRFTGTKSLFLF 109
            :..:.:|.|..||..:...|:.:...|||::|.|.... ||.||||   |..|:||..|.:|::|
Zfish    51 KPNSGLEAGKTLPFIYGEVPKGLVSTPLEDLDQFYSNHTTFIVVSK---KKEIYRFNATPALYIF 112

  Fly   110 YPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAK 171
            ..::..||:.:.|..:..|::.::.|||.||.|:..|:|   .:..||:|..||::|.::||.|:
Zfish   113 SSFNLLRRISIQILVHFLFNFIIICTILANCAFMVYTQTPDWAKNVEYVFTGIYTLEALVKITAR 177

  Fly   172 GFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALL 236
            ||.:.::|:||:|||||||:||...|.|..:::|:::.||.|||||||||:|::||||||:.||:
Zfish   178 GFCVGRFTFLRDPWNWLDFIVIVMAYVTEFVDLGSVSALRAFRVLRALKTISVVPGLKTIVGALI 242

  Fly   237 HSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT--------NVSHTDWQIWVN 293
            .|.::|::||.||:|||.||||..||::||.|:.|||  ..|.:|        |.:..|   ::|
Zfish   243 QSVKKLSDVMILTLFCLSVFALVGLQLFMGILKQKCV--YSTSFTENKEACYKNKTCRD---YIN 302

  Fly   294 DTDNWLYDEDELP-----VLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLIT 353
            :..|..:    ||     ::|||.:.|..||..|.||..|:||::|||:||:|.|:.|:.|:|:|
Zfish   303 NPSNQYF----LPGKKDALICGNSSDAGQCPEGYTCLKAGKNPDYGYTSFDSFGWAFLSLFRLMT 363

  Fly   354 LDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT-NEERKKD---- 413
            .|:|||:|...|...|...:.||.:|:|.|||||:||:|||||::|:|:.:.| :|..||:
Zfish   364 QDFWENLYQQTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIDEALKKEEEFN 428

  Fly   414 -LLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEG------- 470
             :|:.........:.:....|....:.:|...|.....|:|.|.|:.|.:|.|...:|
Zfish   429 AMLEQITRQEQEAEAAAEQSKCEGLSGEKTDSSSDASKLSSKSAKERRNRKKKRQHQGESEKEED 493

  Fly   471 ----GTNGNGNGSNGDDNKSHSATPSPGPSPRHSATE-RPSALT---------------MQAQKQ 515
                |.:...|.:...|.|...:......|||.|... :.|.||               :.:...
Zfish   494 SIKEGNDRKPNFTFAVDGKIRRSRDRSYTSPRQSPLSFQGSLLTPRRDSKASVFSFRGRIHSDNN 558

  Fly   516 YQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPS--------DYKGQLIAN 572
            |.. ::|....::|| ..::...||...|: |.:.......|::|.||        |..|.::..
Zfish   559 YAD-DEQSMFEETGS-RRDSLFLPTRPERL-FSNVSKSSLTPHLLLPSNGKARYVDDSNGMVMVT 620

  Fly   573 SG--QPSS-----NSSGVNRESSQ-DDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNG 629
            ||  .|:|     |:..|:|:.:. ||:....|.|.:...|..........::..|.:.:...:.
Zfish   621 SGASAPNSPVIALNTPEVSRKRAMFDDTCADSDDERRSRCNSQNFSKAYRQSMRERALSVASGSN 685

  Fly   630 NIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDY----------ESWLQFQNCLYKV 684
            |.|.             .||:..         .||..|..::          .:||:.:..::.:
Zfish   686 NPAE-------------CSEIFK---------QRCEEWWFEFAENYLIWDCSPTWLRIKEVVHMI 728

  Fly   685 VRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFL 748
            |.||..:|.||:|||:||.|:|||.:.|...:.:.|...|.||..|||.|.|.|::||.. .:||
Zfish   729 VMDPFADLFITICIVINTVFMAMECYPMDGPYSSMLSTANVVFIGIFTAEMIFKVIALDPYSYFL 793

  Fly   749 CGWNIFDLLIVTASLLDI-IFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNL 812
            .||||||.:|||.||::: :..::.|:..||..|||||.|||:||.|:.:|:.||.:::|||.||
Zfish   794 EGWNIFDSIIVTLSLMELCLANVLSGIGFLRPFRLLRVFKLAKSWPTLNMLIKIIGNSLGALSNL 858

  Fly   813 TLILVIVIYIFAVIGMQLFSKDY--TPEKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWD 874
            ||:|.|:::||||:|||||.|.|  ...|...| .:|||:.|||||||:::||:|||||||.:||
Zfish   859 TLVLAIIVFIFAVVGMQLFGKSYGECVCKISSDCMLPRWHMNDFFHSFLIVFRVLCGEWIETMWD 923

  Fly   875 CMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERV 939
            ||   |..|...|..:|:..:|:||.:||||||||||:||:::.|....||  :|:.|..::.|:
Zfish   924 CM---EVAGQPLCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAVSGEE--DENNLQIAVRRI 983

  Fly   940 RDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSY 1004
            |.
Zfish   984 RK--------------------------------------------------------------- 985

  Fly  1005 QESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMM 1069
                         ||         |.:.
Zfish   986 -------------GF---------TFIK------------------------------------- 991

  Fly  1070 ATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDT 1134
                          ||  |..|.
Zfish   992 --------------TC--LQSFF------------------------------------------ 998

  Fly  1135 DPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQS 1199
                   ||||                          |:.:|         :||.|
Zfish   999 -------RSGC--------------------------LRKKK---------QKSAD--------- 1012

  Fly  1200 QRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTK 1264
                                               ||:   ::||
Zfish  1013 -----------------------------------GNM---IVNC-------------------- 1019

  Fly  1265 LRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPA 1329
                    :.|:.|:      |.|.:|      :::|
Zfish  1020 --------KERKDST------NHTTIE------LVKS---------------------------- 1036

  Fly  1330 ADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSL 1394
                           ||.::..:           |:.:..|.|..:.||..||:
Zfish  1037 ---------------TGGTDLDS-----------DTENFISNPSLTVSVPIAAE----------- 1064

  Fly  1395 EKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRF 1459
                  :.||...|                                            |..|
Zfish  1065 ------ESDFECLN--------------------------------------------TEDF--- 1076

  Fly  1460 KRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGM 1524
                                                                             
Zfish  1077 ----------------------------------------------------------------- 1076

  Fly  1525 ATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQA 1589
                       :||.|.:|
Zfish  1077 -----------SSLSSDLE---------------------------------------------- 1084

  Fly  1590 HAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQK 1654
                        |..:...|.|:||....|........|...||.|.:.::
Zfish  1085 ------------EDKEKLSDVASSFSEGSTVDLRPLGKDGEDALELVLEEE-------------- 1123

  Fly  1655 PSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFY 1719
                                            ||                 |:.||...|...
Zfish  1124 --------------------------------AY-----------------PEPCFTAGCVRR-- 1137

  Fly  1720 FRCPWFMSC-MDTQSA--KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTL 1781
            |||     | :|.:..  |.|..:|.....:|:...||.|::.:|..||..|.||||.||..|::
Zfish  1138 FRC-----CQVDEEKGIWKKWWLLRQTCYNIVEHSWFETFIVFMILLSSGALAFEDIYLDTRKSV 1197

  Fly  1782 KRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIE--ENENLKVLR 1844
            |.:|.:.:..|..||::||:|||:|.||:||||:.|..|||:||.||:.||:..  ....|..::
Zfish  1198 KTILEFADKVFTYIFILEMLLKWVAYGFAKYFTNLWCWLDFVIVDVSLISLVANALNYSELSAIK 1262

  Fly  1845 SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN 1909
            |||||||.|||||:||:.|||:|||||:.|||||.|||||||:|||||||:||.||.|||.:|:|
Zfish  1263 SLRTLRAFRPLRALSRFDGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIVGVNFFAGKFSECIN 1327

  Fly  1910 EMGE-LLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
            ...| .||::||.:|.||  :.:...|.|..|.||:||.|||||||||||:|||.:|..|||:|.
Zfish  1328 ITTEQRLPVSEVYNKTDCERMGKGVRWRNVIINFDNVGNGYLALLQVATFKGWMPIMYAAVDSRN 1392

  Fly  1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYT 2036
            .:.||:.|.|||.|:||||||:.|:||||||||||||||||..|||:.|  .::|:||.||.||.
Zfish  1393 PEEQPEYEVNLYMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYN 1455

  Fly  2037 AMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ----PHAVF 2097
            ||||||.|||||.|.||.|....:.:||...:.|:|.|.|||:|||:||.:|..||    ..|::
Zfish  1456 AMKKLGSKKPQKPIPRPKNKIQGLIFDLVTKQAFDIFIMVLIWLNMVTMMLETEDQSIEMTRALY 1520

  Fly  2098 FILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLL 2162
            :|    |..|..:|..|.::|::.||:::|||.||||||::|:.||.|:.:.:::....:||||.
Zfish  1521 WI----NVIFIVLFTTECVLKMIALRHYFFTVGWNVFDFIVVILSIVGMSLTEVIKKYFVSPTLF 1581

  Fly  2163 RVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGA 2227
            ||:|:.||||:||||::|||||.|||||::|||||||||.||.|:.|||||.|||.|..||....
Zfish  1582 RVIRLARIGRVLRLIRSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKTAG 1646

  Fly  2228 LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP---FIHGHTNGNCGHPLLAITY 2288
            :|||.||:||..||..||::.||.||:.:|..:: .:||||||   |......|:||:|.:.|.:
Zfish  1647 IDDMFNFETFPNSMLCLFQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGSSVVGDCGNPSIGIFF 1711

  Fly  2289 FTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSD 2353
            |.|:|||.::||:|||||:|||||:.|.:|....:.|||.:.||..|.|:||.||||:.:.:|||
Zfish  1712 FVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFDRFYEVWEKFDPKATQFMEYGKLSD 1776

  Fly  2354 FIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVK 2418
            |..||||||.|.|||...|:|.:||:..|::|||||||.|..|.|||...|.|   .|..||:.:
Zfish  1777 FADSLDPPLRIPKPNRFQLMSMDLPMVTGDRIHCLDILFAFTKRVLGEGGEMD---MLHGQMEDR 1838

  Fly  2419 FKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYL--------RRKREKERSNSG------- 2468
            |.:..|::...|.:::|...|.::.:|..||..::::|        |..::|.:..:|
Zfish  1839 FMQSNPSKSSYEPITTTLRRKHEDMSAAVIQRAFRKHLVRDSMKKVRNFKKKNKHQNGKVPSNQS 1903

  Fly  2469 ----------DSATQTSSPGGWQS 2482
                      |:...||||..:.|
Zfish  1904 MDKDMCNEDSDATAATSSPPSYSS 1927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	114/261 (44%)
		Ion_trans	687..902	CDD:459842	109/219 (50%)
		Ion_trans	1751..2019	CDD:459842	159/272 (58%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	131/260 (50%)
		GPHH	2332..2378	CDD:465306	25/45 (56%)
scn1laa	NP_956426.2	Ion_trans	128..416	CDD:459842	132/296 (45%)
		Na_trans_cytopl	527..682	CDD:463401	31/157 (20%)
		Ion_trans	731..945	CDD:459842	107/216 (50%)
		Na_trans_assoc	974..1161	CDD:461936	71/817 (9%)
		Ion_trans	1166..1438	CDD:459842	157/271 (58%)
		Na_channel_gate	1430..1482	CDD:240441	30/53 (57%)
		Ion_trans	1487..1742	CDD:459842	130/258 (50%)
		GPHH	1753..1801	CDD:465306	26/47 (55%)